Decreased expression of manganese superoxide dismutase in transformed cells is associated with increased cytosine methylation of the SOD2 gene.

abstract：:RUNX2 is a member of the RUNX family of transcription factors, also containing the RUNX1 and RUNX3 proteins. These factors control the expression of genes essential for proper development in many cell lineages. RUNX2 plays a crucial role in the proliferation and differentiation of osteoblasts, required for bone format...

journal_title：DNA and cell biology

authors： Wysokinski D,Pawlowska E,Blasiak J

更新日期：2015-05-01 00:00:00

abstract：:MicroRNAs (miRNAs) are an important class of small, noncoding, regulatory RNAs found to be involved in regulating a wide variety of important cellular processes by the sequence-specific inhibition of gene expression. Viruses have evolved a number of mechanisms to take advantage of the regulatory potential of this high...

journal_title：DNA and cell biology

authors： Dykxhoorn DM

更新日期：2007-04-01 00:00:00

abstract：:In IL-5 transgenic mice (C3H/HeN-TgN(IL-5)-Imeg), in which 50% of peripheral blood leukocytes are eosinophils, the development of infection by Leishmania amazonensis was clearly suppressed. To determine mechanistically how this protozoan parasite is killed, we performed in vitro killing experiments. Either IL-4 or IFN...

journal_title：DNA and cell biology

authors： Watanabe Y,Hamaguchi-Tsuru E,Morimoto N,Nishio Y,Yagyu K,Konishi Y,Tominaga M,Miyazaki J,Furuya M,Tominaga A

更新日期：2004-07-01 00:00:00

abstract：:Noncanonical transcriptions include transcriptions that systematically exchange nucleotides, also called bijective transformations or swinger transformations. Swinger transformation A↔T+C↔G recovers identities of 8 among 9 unknown RNAs differentially expressed in centroblastic lymphoma, a human immunodeficiency virus ...

journal_title：DNA and cell biology

authors： Warthi G,Fournier PE,Seligmann H

更新日期：2020-08-01 00:00:00

abstract：:A decrease in gap junctional, intercellular communication (GJIC) has been associated with cells neoplastically transformed by a variety of factors. To investigate the role of the Ras oncogene product in gap junction function, a panel of murine C3H10T1/2 (10T1/2) fibroblasts was constructed in which the levels of ras g...

journal_title：DNA and cell biology

authors： Brownell HL,Narsimhan RP,Corbley MJ,Mann VM,Whitfield JF,Raptis L

更新日期：1996-06-01 00:00:00

abstract：:Nitric oxide synthase (NOS) is the enzyme responsible for the conversion of L-arginine to L-citrulline and nitric oxide. Dimerization of the enzyme is an absolute requirement for catalytic activity. Each NOS monomer contains an N-terminal heme-binding domain and a C-terminal reductase domain. It is unclear how the red...

journal_title：DNA and cell biology

authors： Hallmark OG,Phung YT,Black SM

更新日期：1999-05-01 00:00:00

abstract：:Triple-negative breast cancer (TNBC) refers to breast cancer without significant expression of estrogen receptor (ER), progesterone receptor (PR), or human epidermal growth factor receptor 2. We sought to identify the hub genes and find the potential progression mechanism of TNBC as well as immunotherapeutic targets. ...

journal_title：DNA and cell biology

authors： Wang F,Cao X,Yin L,Wang Q,He Z

更新日期：2020-10-01 00:00:00

abstract：:Sterol carrier protein2 (SCP2) is a 13.2-kD protein that is thought to be involved in the intracellular transport of cholesterol. Using synthetic oligonucleotides based on the protein sequence of SCP2, a clone (SP43) was isolated from a rat liver cDNA library. The DNA sequence revealed that the cDNA could encode a pol...

journal_title：DNA and cell biology

authors： Billheimer JT,Strehl LL,Davis GL,Strauss JF 3rd,Davis LG

更新日期：1990-04-01 00:00:00

abstract：:Mammalian cumulus-oocyte complexes (COCs) reach full developmental capability during folliculogenesis and oogenesis. It is well recognized that only gametes achieving MII stage after in vivo or in vitro maturation (IVM) are successfully fertilized by a single spermatozoon. Although the process of oocyte nuclear and/or...

journal_title：DNA and cell biology

authors： Budna J,Bryja A,Celichowski P,Kranc W,Ciesiółka S,Borys S,Rybska M,Kolecka-Bednarczyk A,Jeseta M,Bukowska D,Antosik P,Brüssow KP,Bruska M,Nowicki M,Zabel M,Kempisty B

更新日期：2017-08-01 00:00:00

abstract：:The development of the pancreas is a complicated process that is regulated on several levels. Pancreas transcription factor 1, alpha subunit (Ptf1a), also known as p48, is a pancreas-specific basic helix-loop-helix transcription factor that is critical for both exocrine pancreas development and maintenance of acinar c...

journal_title：DNA and cell biology

authors： Lu CK,Lai YC,Chen HR,Chiang MK

更新日期：2012-07-01 00:00:00

abstract：:In the rat, the growth hormone receptor (GH-R) gene generates two transcripts, one encoding the transmembrane GH-R, and a shorter one encoding the GH-binding protein (GH-BP). These transcripts exhibit a high degree of heterogeneity in their 5'-untranslated regions (5'-UTRs). Some of the exons encoding these 5'-UTR var...

journal_title：DNA and cell biology

authors： Domené HM,Cassorla F,Werner H,Roberts CT Jr,Leroith D

更新日期：1995-03-01 00:00:00

abstract：:Cytochrome P450c17 catalyzes the 17alpha-hydroxylase/17,20 lyase activity needed for sex steroid synthesis. We recently characterized the nuclear phosphoprotein SET as a novel transcriptional regulator that binds to the -447/-399 region of the rat P450c17 gene, along with the transcription factors COUP-TF II, NGF-IB, ...

journal_title：DNA and cell biology

authors： Zhang P,Compagnone NA,Fiore C,Vigne JL,Culp P,Musci TJ,Mellon SH

更新日期：2001-10-01 00:00:00

abstract：:The PC12 pheochromocytoma cell line has been a favorite model system for cell and neurobiologists, but has proven relatively refractory to standard DNA transfection methods. We have found that the cationic lipid "lipofectin" provides a simple, gentle, and nontoxic procedure that vastly improves transfection efficienci...

journal_title：DNA and cell biology

authors： Muller SR,Sullivan PD,Clegg DO,Feinstein SC

更新日期：1990-04-01 00:00:00

abstract：:Intracranial aneurysms (IAs) and potential IA rupture are one of the direct causes of permanent brain damage and mortality. Interestingly, the major risk factors of IA development, including hemodynamic stress, hypertension, smoking, and genetic predispositions, are closely associated with a proinflammatory immune sta...

journal_title：DNA and cell biology

authors： Zhang HF,Zhao MG,Liang GB,Yu CY,He W,Li ZQ,Gao X

更新日期：2016-02-01 00:00:00

abstract：:Liver-expressed chemokine (LEC) is a CC chemokine that is selectively expressed in the liver. We report here the structures of the human and mouse genes for LEC. The human LEC gene (SCYA16) was isolated from a bacterial artificial chromosome (BAC) clone that also contained CC chemokine genes for MPIF-1/Ckbeta8, HCC-2/...

journal_title：DNA and cell biology

authors： Fukuda S,Hanano Y,Iio M,Miura R,Yoshie O,Nomiyama H

更新日期：1999-04-01 00:00:00

abstract：:The promoter of the human urokinase plasminogen activator (uPA) gene contains a sequence identical with the retinoblastoma control element (RCE) of the murine c-fos gene, as well as several Sp1 binding sites. In a number of cell lines, the uPA promoter is activated during enforced expression of the retinoblastoma prot...

journal_title：DNA and cell biology

authors： Novak U,Paradiso L,Hamilton JA

更新日期：1994-11-01 00:00:00

abstract：:Apoptosis, which is usually accompanied by DNA degradation, is important not only for the homeostasis of metazoans but also for mammalian development. If DNA is not properly degraded in these processes, it can cause diverse diseases, such as anemia, cataracts, and some autoimmune diseases. A large effort has been made...

journal_title：DNA and cell biology

authors： Liu MF,Wu XP,Wang XL,Yu YL,Wang WF,Chen QJ,Boireau P,Liu MY

更新日期：2008-05-01 00:00:00

abstract：:Electroporation has proven to be a highly effective technique for the in vivo delivery of genes to a number of solid tissues. In most of the reported methods, DNA is injected into the target tissue and electrodes are placed directly on or in the tissue for application of the electric field. While this works well for s...

journal_title：DNA and cell biology

authors： Dean DA

更新日期：2003-12-01 00:00:00

abstract：:Deer antlers are amazing natural appendages that grow faster than any other known mammalian bone. Antler growth occurs at the tip and is initially cartilage, which is later replaced by bone tissue. However, little is known regarding the precise role of cooperation between cell lineages and functional genes in regulati...

journal_title：DNA and cell biology

authors： Yao B,Zhang M,Liu M,Wang Q,Liu M,Zhao Y

更新日期：2018-01-01 00:00:00

abstract：:Genes involved in the production of nitric oxide (NO) have been suggested as genetic factors for migraine. It has been studied whether polymorphisms in the genes encoding for different types of NO synthase (NOS) could be involved in the liability to migraine; however, most studies yield negative results. The pentanucl...

journal_title：DNA and cell biology

authors： Jia S,Ni J,Chen S,Jiang Y,Dong W,Gao Y

更新日期：2011-02-01 00:00:00

abstract：:Epidemiological evidence on the relationship between IL1A and/or IL1B polymorphisms and periodontal disease is inconsistent. We investigated associations between three IL1 single-nucleotide polymorphisms (SNPs) in genes encoding interleukin (IL) -1α (rs1800587) and IL-1β (rs1143634 and rs16944) and the risk of periodo...

journal_title：DNA and cell biology

authors： Tanaka K,Miyake Y,Hanioka T,Arakawa M

更新日期：2014-04-01 00:00:00

abstract：:The centrosome is a unique organelle that functions as the microtubule organizing center in most animal cells. During cell division, the centrosomes form the poles of the bipolar mitotic spindle. In addition, the centrosomes are also needed for cytokinesis. Each mammalian somatic cell typically contains one centrosome...

journal_title：DNA and cell biology

authors： Wang Q,Hirohashi Y,Furuuchi K,Zhao H,Liu Q,Zhang H,Murali R,Berezov A,Du X,Li B,Greene MI

更新日期：2004-08-01 00:00:00

abstract：:BRCA1-associated protein-1 (BAP1) is an important nuclear-localized deubiquitinating enzyme. Dysregulation of BAP1 has been reported in many types of cancers. However, there are few articles on the role of BAP1 in osteosarcoma (OS) and the molecular mechanisms of BAP1 in OS remain largely unknown. In this study, we ex...

journal_title：DNA and cell biology

authors： Gao S,Sun H,Cheng C,Wang G

更新日期：2017-05-01 00:00:00

abstract：:The linkage of rheumatoid arthritis (RA) to HLA-DR haplotypes, high levels of HLA-DR expression, and T-cell infiltration in the joints, indicate a central role for the interaction of T-cell receptors (TCR) with antigen (Ag) + major histocompatibility complex (MHC) complexes in pathogenesis. Receptor analysis in RA has...

journal_title：DNA and cell biology

authors： Keiber-Emmons T,Fang Q,Cai W,Friedman SM,Crow MK,Lotke P,Williams WV

更新日期：1998-02-01 00:00:00

abstract：:To study the complexity and structural characteristics of zinc finger proteins expressed during human hematopoiesis and to isolate novel regulators of blood cell development, a degenerate oligonucleotide probe specific for a consensus zinc finger peptide domain was used to isolate 63 cDNA clones for Krüppel-related zi...

journal_title：DNA and cell biology

authors： Abrink M,Aveskogh M,Hellman L

更新日期：1995-02-01 00:00:00

abstract：:The transcription factor delta EF1 is a key player in estrogen-signaling cascades in vertebrates. In this pathway, estrogen induces the expression of the gene encoding delta EF1, and then delta EF1 activates transcription of downstream targets. Yet, the molecular mechanisms of transcriptional activation by delta EF1 h...

journal_title：DNA and cell biology

authors： Dillner NB,Sanders MM

更新日期：2004-01-01 00:00:00

abstract：:As a preliminary step toward muscle-mediated gene therapy in the mucopolysaccharidosis (MPS) type VI cat, we have analyzed the transcriptional regulation of feline N-acetylgalactosamine 4-sulfatase (f4S) gene expression from various retroviral constructs in primary cultures of muscle cells. Two retroviral constructs w...

journal_title：DNA and cell biology

authors： Yogalingam G,Muller V,Hopwood JJ,Anson DS

更新日期：1999-03-01 00:00:00

abstract：:DNA methylation of CYP17 (steroid 17 alpha-hydroxylase) was studied in bovine adrenocortical cells, which lose the capacity to express this tissue-specific gene in culture by phenotypic switching. Restriction enzyme digestions, and sequencing of a lambda clone of a second CYP17 gene (CYP17A2), showed that there are at...

journal_title：DNA and cell biology

authors： Hornsby PJ,Yang L,Raju SG,Maghsoudlou SS,Lala DS,Nallaseth FS

更新日期：1992-06-01 00:00:00

abstract：:A variety of human cancer cells are resistant to Fas ligand and anti-Fas antibody induced apoptosis. Previously, we reported that human gastric carcinoma cell lines were resistant to the anti-Fas antibody, CH-11, without interferon-gamma pretreatment in vitro. Cyclooxygenase (COX)-2 is known to be expressed in many hu...

journal_title：DNA and cell biology

authors： Honjo S,Osaki M,Ardyanto TD,Hiramatsu T,Maeta N,Ito H

更新日期：2005-03-01 00:00:00

abstract：:NADPH: quinone oxidoreductase 1 (NQO1) and dihydronicotinamide riboside: quinone oxidoreductase 2 (NQO2) are cytosolic enzymes that catalyze reductive activation of carcinogens from cigarette smoke, such as nitrosamines and heterocyclic amines. These enzymes also protect cells against oxidative damage from reactive ox...

journal_title：DNA and cell biology

authors： Malik MA,Zargar SA,Mittal B

更新日期：2011-05-01 00:00:00