Genomic organization of the genes for human and mouse CC chemokine LEC.

abstract：:The sugars will eventually be exported transporters (SWEET) gene family is a glycoprotein gene family that can regulate the transport of sugar in plants and plays an important role in plant growth and development, as well as in response to environmental stress. In this study, Kentucky bluegrass (cv. Baron) seedlings w...

journal_title：DNA and cell biology

authors： Zhang R,Niu K,Ma H

更新日期：2020-09-01 00:00:00

abstract：:We cloned and sequenced a 1378 bp BamHI satellite DNA fraction from the water buffalo Bubalus bubalis and have studied its expression in different tissues. The GC-rich sequences of the resultant contig pDS5 crosshybridize only with bovid DNA and are not conserved evolutionarily. Typing of buffalo genomic DNA using pDS...

journal_title：DNA and cell biology

authors： Chattopadhyay M,Gangadharan S,Kapur V,Azfer MA,Prakash B,Ali S

更新日期：2001-09-01 00:00:00

abstract：:The human OZF gene encodes a protein consisting essentially of zinc finger motifs of the Krüppel type. Evolutionary studies revealed amplification of the bovine OZF gene in cattle. Domestic cattle includes two major subspecies: taurine (Bos primigenius taurus) and zebu (B. p. indicus). Amplified sequences were found i...

journal_title：DNA and cell biology

authors： Le Chalony C,Apiou F,Pibouin L,Dutrillaux B,Goubin G

更新日期：1996-01-01 00:00:00

abstract：:NADPH: quinone oxidoreductase 1 (NQO1) and dihydronicotinamide riboside: quinone oxidoreductase 2 (NQO2) are cytosolic enzymes that catalyze reductive activation of carcinogens from cigarette smoke, such as nitrosamines and heterocyclic amines. These enzymes also protect cells against oxidative damage from reactive ox...

journal_title：DNA and cell biology

authors： Malik MA,Zargar SA,Mittal B

更新日期：2011-05-01 00:00:00

abstract：:Head and neck cancers (head and neck squamous cell carcinomas [HNSCC]) are a heterogeneous group of neoplasms with varying presenting symptoms, treatment, and expected outcome. There is a need to find an effective way of its treatment at the molecular level. Thus, we should identify the mechanism of cancer cell respon...

journal_title：DNA and cell biology

authors： Walczak A,Rusin P,Dziki L,Zielinska-Blizniewska H,Olszewski J,Majsterek I

更新日期：2012-03-01 00:00:00

abstract：:Single-nucleotide polymorphisms (SNPs) in pre-miRNAs may alter microRNA (miRNA) expression levels or processing and contribute to susceptibility to a wide range of diseases. We investigated the correlation between four SNPs (rs11614913, rs3746444, rs2910164, and rs229283) in pre-miRNAs and the risk of asthma in 220 as...

journal_title：DNA and cell biology

authors： Su XW,Yang Y,Lv ML,Li LJ,Dong W,Miao-Liao,Gao LB,Luo HB,Yun-Liu,Cong RJ,Liang WB,Li YB

更新日期：2011-11-01 00:00:00

abstract：:Mitochondrial aldehyde dehydrogenase-2 (ALDH2) is the principal enzyme involved in alcohol metabolism in humans. Emerging evidence has shown that the common rs671 G>A (Glu504Lys) polymorphism in the ALDH2 gene might play a critical role in increasing the susceptibility to coronary heart disease (CHD), including myocar...

journal_title：DNA and cell biology

authors： Wang Q,Zhou S,Wang L,Lei M,Wang Y,Miao C,Jin Y

更新日期：2013-07-01 00:00:00

abstract：:The role of p53 in mediating nitric oxide (NO)-induced cell death remains uncertain. The exogenous NO donor S-nitrosoglutathione (GSNO) produced a concentration-dependent reduction in cell viability in embryonic chick cardiomyocytes in culture. Western blotting and immunocytochemistry for p53 showed that p53 was incre...

journal_title：DNA and cell biology

authors： Klassen SS,Rabkin SW

更新日期：2007-07-01 00:00:00

abstract：:Diabetes is a worldwide health problem with increasing prevalence. Some reports indicate the interplay between bone and glucose metabolism. The imbalance between bone resorption and formation resulted in the structural integrity and strength of bone. Glucagon-like peptide-1 (GLP-1) and its agonists (Liraglutide) have ...

journal_title：DNA and cell biology

authors： Gao L,Li SL,Li YK

更新日期：2018-12-01 00:00:00

abstract：:Zidovudine (AZT) is widely used in the treatment of human immunodeficiency virus (HIV) infection because of its ability to act as a false substrate for the viral reverse transcriptase. AZT in the clinical setting has also been shown to produce significant hematologic and other toxicity, even though prior reports in th...

journal_title：DNA and cell biology

authors： Nusbaum NJ,Joseph PE

更新日期：1996-05-01 00:00:00

abstract：:Rheumatoid arthritis (RA) is a complex polygenic inflammatory disease associated with accelerated atherosclerosis, which is the main cause of increased cardiovascular (CV) morbidity and mortality in RA patients. CARD8 is a constituent of inflammasome, which regulates interleukin 1-beta production, and has been associa...

journal_title：DNA and cell biology

authors： García-Bermúdez M,López-Mejías R,González-Juanatey C,Corrales A,Castañeda S,Ortiz AM,Miranda-Filloy JA,Gómez-Vaquero C,Fernández-Gutiérrez B,Balsa A,Pascual-Salcedo D,Blanco R,Llorca J,Martín J,González-Gay MA

更新日期：2013-01-01 00:00:00

abstract：:Voltage-gated potassium channels play important functional roles in the development and maintenance of human lymphocyte functions. One such channel, known as the type n channel, has been well defined in human T cells and exhibits unique functional properties that distinguish it from other species of potassium channels...

journal_title：DNA and cell biology

authors： Cai YC,Osborne PB,North RA,Dooley DC,Douglass J

更新日期：1992-03-01 00:00:00

abstract：:We have cloned and sequenced the cDNA corresponding to the rat preproepidermal growth factor (ppEGF) mRNA. The cDNA contained 4,801 nucleotides, similar to that reported for the mouse (4,749 nucleotides) and the human mRNAs (4,871 nucleotides). The predicted protein sequence would contain 1,133 amino acids, smaller th...

journal_title：DNA and cell biology

authors： Saggi SJ,Safirstein R,Price PM

更新日期：1992-07-01 00:00:00

abstract：:Apicomplexa is a phylum within the kingdom Protista that contains some of the most significant threats to public health. One of the members of this phylum, Toxoplasma gondii, is amenable to molecular genetic analyses allowing for the identification of factors critical for colonization and disease. A pathway found to b...

journal_title：DNA and cell biology

authors： Frankel MB,Knoll LJ

更新日期：2009-06-01 00:00:00

abstract：:To investigate the contribution of de novo variants to Tourette disorder (TD) probands in China. Whole-exome sequencing (WES) conducted on 15 child-parent trios (45 samples) detected 25 coding de novo variants, including 2 de novo Likely Gene Disrupting (LGD) variants and 6 Missense3 variants. The de novo LGD variants...

journal_title：DNA and cell biology

authors： Zhao X,Wang S,Hao J,Zhu P,Zhang X,Wu M

更新日期：2020-01-01 00:00:00

abstract：:Head and neck squamous cell carcinoma (HNSCC) is a malignancy with relatively high incidence and poor prognosis. RNA-binding proteins (RBPs) were reported to be dysregulated in multiple cancers and were closely associated with tumor initiation and progression. However, an integrated analysis of the roles of RBPs in HN...

journal_title：DNA and cell biology

authors： Jin Y,Qin X

更新日期：2020-10-01 00:00:00

abstract：:We have further characterized the most distal of the three alpha-fetoprotein (AFP) enhancers required for expression of the AFP gene in fetal hepatocytes and yolk sac endodermal cells. Almost total rat AFP enhancer 3 (E3) activity is driven by a 160-bp fragment at -6 kb containing three target regions for nuclear prot...

journal_title：DNA and cell biology

authors： Thomassin H,Bois-Joyeux B,Delille R,Ikonomova R,Danan JL

更新日期：1996-12-01 00:00:00

abstract：:The incidence of premature ovarian failure (POF), a condition causing amenorrhea and hypergonadotropic hypoestrogenism in women before the age of 40, has been increasing in recent years. As an irreversible pathological change, improved treatment strategies for this disease are urgently needed. In this study, a type of...

journal_title：DNA and cell biology

authors： Liu T,Qin W,Huang Y,Zhao Y,Wang J

更新日期：2013-12-01 00:00:00

abstract：:Chlamydial infection of the lower genital tract usually spreads to the upper genital tract and is then responsible for more serious consequences, such as infertility, ectopic pregnancy, pelvic pain, and pelvic inflammatory disease. Genital infection with Chlamydia trachomatis and the resulting cytokine response largel...

journal_title：DNA and cell biology

authors： Srivastava P,Bhengraj AR,Jha HC,Vardhan H,Jha R,Singh LC,Salhan S,Mittal A

更新日期：2012-03-01 00:00:00

abstract：:Sufficient levels of gene expression are required for effective gene therapy. One of the major obstacles in gene therapy is the low transgene expression obtained from currently available vector systems. To address this issue, we employed a transcriptional amplifier strategy in a single construct to enhance transgene e...

journal_title：DNA and cell biology

authors： Luo P,Tsang TC,He X,Gonzalez-Pena V,Jaramillo M,Takeuchi C,Harris DT

更新日期：2005-09-01 00:00:00

abstract：:Increasing evidence has announced the emerging roles of long noncoding RNAs (lncRNAs) in modulating bone homeostasis due to their potential regulating effects on bone-related cells' proliferation, migration, differentiation and apoptosis. Thus, lncRNAs have been considered as a promising gene tool to facilitate the bo...

journal_title：DNA and cell biology

authors： Song W,Xie J,Li J,Bao C,Xiao Y

更新日期：2020-06-01 00:00:00

abstract：:The present study was to explore whether the polymorphisms of FAM167 A-BLK region are associated with the susceptibility to autoimmune thyroid disease (AITD). The second sequencing technology was undertaken for seven tag loci mapping of the FAM167 A-BLK region, namely, rs11250144, rs2618431, rs4840568, rs13277113, rs2...

journal_title：DNA and cell biology

authors： Song RH,Li Q,Jia X,Yao QM,Wang B,Zhang JA

更新日期：2018-11-01 00:00:00

abstract：:The HIV-1 regulatory proteins Tat and Rev and the accessory proteins Vpr, Vpu, and Vif are essential for viral replication, and their cytoplasmic production suggests that they should be processed for recognition by cytotoxic T lymphocytes. However, only limited data is available evaluating to which extent these protei...

journal_title：DNA and cell biology

authors： Addo MM,Yu XG,Rosenberg ES,Walker BD,Altfeld M

更新日期：2002-09-01 00:00:00

abstract：:Butyrate is a naturally occurring product of colonic microbial fermentation of dietary carbohydrates that escape hydrolysis in the small intestine. Butyrate plays a significant role in the maintenance of colonic tissue homeostasis by regulating the expression of genes associated with the processes of proliferation, di...

journal_title：DNA and cell biology

authors： Daly K,Shirazi-Beechey SP

更新日期：2006-01-01 00:00:00

abstract：:In the promoters of many immediate early genes, including c-fos, CArG DNA regulatory elements mediate basal constituitive expression and rapid and transient serum induction. CArG boxes also occur in the promoters of muscle-specific genes, including skeletal alpha-actin, where it confers muscle-specific expression. The...

journal_title：DNA and cell biology

authors： Martin KA,Gualberto A,Kolman MF,Lowry J,Walsh K

更新日期：1997-05-01 00:00:00

abstract：:Previously we cloned a polyspecific transporter from rat (rOCT1) that is expressed in renal proximal tubules and hepatocytes and mediates electrogenic uptake of organic cations with different molecular structures. Recently a homologous transporter from rat kidney (rOCT2) was cloned but not characterized in detail. We ...

journal_title：DNA and cell biology

authors： Gorboulev V,Ulzheimer JC,Akhoundova A,Ulzheimer-Teuber I,Karbach U,Quester S,Baumann C,Lang F,Busch AE,Koepsell H

更新日期：1997-07-01 00:00:00

abstract：:A safe and effective adjuvant is important to develop vaccines against highly pathogenic avian influenza virus. Chitosan, a derivative from the natural amino polysaccharide chitin, has been proved to be an effective adjuvant for inactivated influenza virus vaccine. In this study, protective immunity in mice provided b...

journal_title：DNA and cell biology

authors： Chang H,Li X,Teng Y,Liang Y,Peng B,Fang F,Chen Z

更新日期：2010-09-01 00:00:00

abstract：:Cytochrome P450 15 beta is a female-specific gene product that catalyzes the hydroxylation of steroid sulfates at the 15 beta position. Isolation and analysis of the gene for rat P450 15 beta reveals nine coding exons and encompasses more than 35 kb of chromosomal DNA. The intron-exon junctions are at similar position...

journal_title：DNA and cell biology

authors： Zaphiropoulos PG,Westin S,Ström A,Mode A,Gustafsson JA

更新日期：1990-01-01 00:00:00

abstract：:It is widely believed that cellular senescence is a tumor suppressor mechanism; however, it has not been understood why it is advantageous for organisms to retain mutant cells is a postmitotic state rather than simply eliminating them by apoptosis. It has recently been proposed that the primary role of cellular senesc...

journal_title：DNA and cell biology

authors： Lynch MD

更新日期：2006-02-01 00:00:00

abstract：:At supramolecular resolution, DNA synthesis begins at preferred replication origins in the chromosomes of metazoan cells. To characterize one of these origins in detail, the initiation of replication was examined in the HeLa c-myc origin. Polymerase chain reaction (PCR) amplification of size-fractionated nascent chrom...

journal_title：DNA and cell biology

authors： Trivedi A,Waltz SE,Kamath S,Leffak M

更新日期：1998-10-01 00:00:00