Abstract:
:Increasing evidence has announced the emerging roles of long noncoding RNAs (lncRNAs) in modulating bone homeostasis due to their potential regulating effects on bone-related cells' proliferation, migration, differentiation and apoptosis. Thus, lncRNAs have been considered as a promising gene tool to facilitate the bone regeneration process and then to predict and cure bone-related diseases such as osteosarcoma, osteoporosis, and osteoarthritis. In this review, we first enumerated several kinds of dysregulated lncRNAs and concisely summarized their regulating role in bone formation as well as resorption process. The related mechanisms were also discussed, respectively. Then, the positive or negative behavior of these lncRNAs in bone-related diseases was elucidated. This review provides an in-depth sight about the lncRNA's clinical values and limitations, which is conducive to explore new gene targets and further establish new therapeutic strategies for bone-related disease.
journal_name
DNA Cell Bioljournal_title
DNA and cell biologyauthors
Song W,Xie J,Li J,Bao C,Xiao Ydoi
10.1089/dna.2020.5391subject
Has Abstractpub_date
2020-06-01 00:00:00pages
926-937issue
6eissn
1044-5498issn
1557-7430journal_volume
39pub_type
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