Upregulation of Sestrin2 expression protects against macrophage apoptosis induced by oxidized low-density lipoprotein.

abstract：:Apelin, an endogenous ligand for apelin receptor (APJ), is reported to be involved in cardiomyocyte hypertrophy. In this study, we explored the mechanism of cardiomyocyte hypertrophy induced by apelin-13/APJ system. Left ventricular hypertrophy (LVH) rat model was established by constricting the abdominal aorta. Weste...

journal_title：DNA and cell biology

authors： Wu D,Xie F,Xiao L,Feng F,Huang S,He L,Liu M,Zhou Q,Li L,Chen L

更新日期：2017-08-01 00:00:00

abstract：:The CDC6 gene product from Saccharomyces cerevisiae is required for transition from late G1 to S phase of the cell cycle. We have investigated the subcellular localization of the CDC6 protein in yeast to explore where Cdc6p exerts its gene function (s). Using affinity-purified sera we localized Cdc6p to the cytoplasm ...

journal_title：DNA and cell biology

authors： Jong A,Young M,Chen GC,Zhang SQ,Chan C

更新日期：1996-10-01 00:00:00

abstract：:Sterol regulatory element-binding proteins (SREBPs) are transcription factors governing transcription of genes related to cholesterol and fatty acid metabolism. To become active, SREBPs must undergo a proteolytic cleavage to allow an active NH(2)-terminal segment to translocate into the nucleus. SKI-1/S1P is the first...

journal_title：DNA and cell biology

authors： De Windt A,Rai M,Bernier L,Thelen K,Soini J,Lefebvre C,Chintawar S,Lavigne J,Saarinen L,Kytömäki L,Munzer JS,Lütjohann D,Pandolfo M,Davignon J,Seidah NG,Laaksonen R

更新日期：2007-11-01 00:00:00

abstract：:Plants, being sessile organisms, have evolved several dynamic mechanisms of gene regulation. Epigenetic modification especially cytosine methylation and demethylation actively regulates the expression of genes. To understand the role of cytosine methylation during isoflavonoid biosynthesis and accumulation, we perform...

journal_title：DNA and cell biology

authors： Gupta OP,Dahuja A,Sachdev A,Jain PK,Kumari S,T V,Praveen S

更新日期：2019-06-01 00:00:00

abstract：:CD36, a surface membrane glycoprotein, functions as a class B scavenger receptor that binds to several distinct ligands. Included among these is oxidized low-density lipoprotein (Ox-LDL), a major trigger of atherosclerotic lesions, and the levels of CD36 activity and Ox-LDL uptake may have an impact on coronary artery...

journal_title：DNA and cell biology

authors： Thorne RF,Zhang X,Song C,Jin B,Burns GF

更新日期：2006-05-01 00:00:00

abstract：:Interstitial lung disease (ILD) is the main reason of death in patients with systemic sclerosis (SSc). The potential microRNA (miRNA)-messenger RNA (mRNA) interaction networks of SSc-ILD from a systematic biological perspective are unclear. To characterize differentially expressed miRNAs (DE-miRNAs) and differentially...

journal_title：DNA and cell biology

authors： He Y,Liu H,Wang S,Chen Y

更新日期：2019-09-01 00:00:00

abstract：:Increasing evidence suggested that long noncoding RNAs (lncRNAs) variants may be involved in the progression of various cancers. However, the association of the lncRNAs polymorphisms with the risk for esophagogastric junction adenocarcinoma (EGJA) is still unknown. In this case-control study, we selected two cancer-re...

journal_title：DNA and cell biology

authors： Cao R,Chen Y,Wang J,Chen M,Chen S,Tang W

更新日期：2020-05-01 00:00:00

abstract：:The nuclear factor of κB (NFκB) family has been well known for its significant role in regulating the expression of numerous genes that control many biological processes. However, it is unclear whether NFκB could regulate milk synthesis. In this study, we identified NFκB1 as a critical regulator for milk synthesis in ...

journal_title：DNA and cell biology

authors： Huang X,Zang Y,Zhang M,Yuan X,Li M,Gao X

更新日期：2017-04-01 00:00:00

abstract：:Glucose-stimulated insulin gene transcription is mainly regulated by a 340-bp promoter region upstream of the transcription start site by beta-cell-enriched transcription factors Pdx-1, MafA, and NeuroD1. Previous studies have shown that histone H4 hyperacetylation is important for acute up-regulation of insulin gene ...

journal_title：DNA and cell biology

authors： Sampley ML,Ozcan S

更新日期：2012-01-01 00:00:00

abstract：:Defective T cell receptor (TCR) signaling resulting in lower T cell function plays a crucial role in the pathogenesis of T cell immunodeficiency in leukemia. Previous studies have indicated that lower TCRζ levels are a common characteristic of patients with leukemia, and upregulating TCRζ could partially recover T cel...

journal_title：DNA and cell biology

authors： Shi L,Chen S,Zha X,Xu Y,Xu L,Yang L,Lu Y,Zhu K,Li Y

更新日期：2015-07-01 00:00:00

abstract：:Minimally modified low-density lipoprotein (MM-LDL) is regarded as a major risk factor for the development of atherosclerosis. In this report, we show that this lipoprotein complex can induce expression of an inflammatory protein, serum amyloid A (SAA), in monocyte/macrophage cells, a key cell type implicated in the p...

journal_title：DNA and cell biology

authors： Ray BK,Chatterjee S,Ray A

更新日期：1999-01-01 00:00:00

abstract：:Quantitative determination of T-cell receptor (TCR) V beta expression is necessary to define the changes in TCR-V beta subfamily expression that occur during T-cell maturation and selection and to detect alterations of the TCR-V beta repertoire that may be associated with human diseases. Here we describe and validate ...

journal_title：DNA and cell biology

authors： Duchmann R,Strober W,James SP

更新日期：1993-04-01 00:00:00

abstract：:Mammalian cumulus-oocyte complexes (COCs) reach full developmental capability during folliculogenesis and oogenesis. It is well recognized that only gametes achieving MII stage after in vivo or in vitro maturation (IVM) are successfully fertilized by a single spermatozoon. Although the process of oocyte nuclear and/or...

journal_title：DNA and cell biology

authors： Budna J,Bryja A,Celichowski P,Kranc W,Ciesiółka S,Borys S,Rybska M,Kolecka-Bednarczyk A,Jeseta M,Bukowska D,Antosik P,Brüssow KP,Bruska M,Nowicki M,Zabel M,Kempisty B

更新日期：2017-08-01 00:00:00

abstract：:A primary response of the avian intestine to 1,25-dihydroxyvitamin D3 [1,25-(OH)2D3] is increased synthesis of a 28-kD calcium-binding protein, calbindin-D28k (CaBP). This study examined whether 1,25-(OH)2D3 regulates CaBP gene transcription by an interaction of the vitamin D receptor (VDR) with a vitamin D-responsive...

journal_title：DNA and cell biology

authors： Macdonald PN,Whitfield GK,Haussler CA,Hocker AM,Haussler MR,Komm BS

更新日期：1992-06-01 00:00:00

abstract：:Non-Hodgkin lymphoma (NHL) is the most common hematologic malignancy worldwide. Interleukin-2 (IL-2) plays a key role in the proliferation of T cells and natural killer cells. It has been reported that polymorphisms in the IL-2 gene are associated with various cancers. The aim of this study was to examine the effect o...

journal_title：DNA and cell biology

authors： Song H,Chen L,Cha Z,Bai J

更新日期：2012-07-01 00:00:00

abstract：:Hearing loss in Ménière's disease (MD) is associated with loss of spiral ganglion neurons and hair cells. In a guinea pig model of endolymphatic hydrops, nitric oxide synthases (NOS) and oxidative stress mediate loss of spiral ganglion neurons. To test the hypothesis that functional variants of NOS1 and NOS2A are asso...

journal_title：DNA and cell biology

authors： Gazquez I,Lopez-Escamez JA,Moreno A,Campbell CA,Meyer NC,Carey JP,Minor LB,Gantz BJ,Hansen MR,Della Santina CC,Aran I,Soto-Varela A,Santos S,Batuecas A,Perez-Garrigues H,Lopez-Nevot A,Smith RJ,Lopez-Nevot MA

更新日期：2011-09-01 00:00:00

abstract：:We have screened an Aplysia atrial gland cDNA library using a prohormone convertase (PC)1 probe prepared by polymerase chain reaction (PCR) and have isolated an Aplysia PC1-related full-length 3.6-kb cDNA clone. The cDNA sequence (3,565 bp) encoded a putative preproendoprotease (APC1) of 703 amino acid residues that s...

journal_title：DNA and cell biology

authors： Gorham EL,Nagle GT,Smith JS,Shen H,Kurosky A

更新日期：1996-04-01 00:00:00

abstract：:Genes involved in the production of nitric oxide (NO) have been suggested as genetic factors for migraine. It has been studied whether polymorphisms in the genes encoding for different types of NO synthase (NOS) could be involved in the liability to migraine; however, most studies yield negative results. The pentanucl...

journal_title：DNA and cell biology

authors： Jia S,Ni J,Chen S,Jiang Y,Dong W,Gao Y

更新日期：2011-02-01 00:00:00

abstract：:We have isolated and sequenced cDNA clones that encode human spermine synthase (EC 2.5.1.22). The total length of the sequenced cDNA was 1,612 nucleotides, containing an open reading frame encoding a polypeptide chain of 368 amino acids. All of the previously sequenced peptide fragments of human and bovine spermine sy...

journal_title：DNA and cell biology

authors： Korhonen VP,Halmekytö M,Kauppinen L,Myöhänen S,Wahlfors J,Keinänen T,Hyvönen T,Alhonen L,Eloranta T,Jänne J

更新日期：1995-10-01 00:00:00

abstract：:Herpes simplex virus (HSV) is a neurotropic DNA virus with many favorable properties as a gene delivery vector. HSV is highly infectious, so HSV vectors are efficient vehicles for the delivery of exogenous genetic material to cells. Viral replication is readily disrupted by null mutations in immediate early genes that...

journal_title：DNA and cell biology

authors： Burton EA,Fink DJ,Glorioso JC

更新日期：2002-12-01 00:00:00

abstract：:The aromatic hydrocarbon receptor (AHR) is a ligand-activated transcription factor that regulates the expression of several drug-metabolizing enzymes and has been implicated in immunosuppression, teratogenesis, cell-specific hyperplasia, and certain types of malignancies and toxicities. The mouse Ahr gene 5' proximal ...

journal_title：DNA and cell biology

authors： Fitzgerald CT,Nebert DW,Puga A

更新日期：1998-09-01 00:00:00

abstract：:The sugars will eventually be exported transporters (SWEET) gene family is a glycoprotein gene family that can regulate the transport of sugar in plants and plays an important role in plant growth and development, as well as in response to environmental stress. In this study, Kentucky bluegrass (cv. Baron) seedlings w...

journal_title：DNA and cell biology

authors： Zhang R,Niu K,Ma H

更新日期：2020-09-01 00:00:00

abstract：:A human growth hormone expression construct was delivered intracellularly into the abdominal skin of mice by particle bombardment-mediated gene transfer. Using this technology, the in vivo delivery of antigen-encoding expression vectors affixed to gold microprojectiles results in de novo antigen production in target s...

journal_title：DNA and cell biology

authors： Eisenbraun MD,Fuller DH,Haynes JR

更新日期：1993-11-01 00:00:00

abstract：:Xenotransplantation from pigs to human beings is viewed as a potential solution for the acute organ shortage. However, consequent xenorejection induced by Gal alpha 1,3 Gal (a Gal, Gal antigen) prevents xenotransplantation from clinical application. Thus, the most attracting attempt to prevent xenorejection is the eli...

journal_title：DNA and cell biology

authors： Yu L,Miao H,Guo L

更新日期：2005-04-01 00:00:00

abstract：:ERGIC2 (formerly known as PTX1) is a gene identified by subtractive hybridization on the basis that it is expressed in normal human prostate, but not in prostate carcinoma. It is unrelated to the gene encoding pituitary homeobox protein (Ptx1 or Pitx1), which regulates pituitary hormone gene expression. Based on seque...

journal_title：DNA and cell biology

authors： Kwok SC,Kumar S,Dai G

更新日期：2014-02-01 00:00:00

abstract：:The development of the pancreas is a complicated process that is regulated on several levels. Pancreas transcription factor 1, alpha subunit (Ptf1a), also known as p48, is a pancreas-specific basic helix-loop-helix transcription factor that is critical for both exocrine pancreas development and maintenance of acinar c...

journal_title：DNA and cell biology

authors： Lu CK,Lai YC,Chen HR,Chiang MK

更新日期：2012-07-01 00:00:00

abstract：:Most mammalian species express high concentrations of ALDH3A1 in corneal epithelium with the exception of the rabbit, which expresses high amounts of ALDH1A1 rather than ALDH3A1. Several hypotheses that involve catalytic and/or structural functions have been postulated regarding the role of these corneal ALDHs. The ai...

journal_title：DNA and cell biology

authors： Manzer R,Qamar L,Estey T,Pappa A,Petersen DR,Vasiliou V

更新日期：2003-05-01 00:00:00

abstract：:The rat D2 dopamine receptor gene is transcribed from a TATA-less promoter that has an initiator-like sequence and several putative Sp1 binding sites. We previously reported that a negative modulator is located between nucleotides -116 and -76 (D2Neg-B) in this gene and that Sp1 as well as another unknown factor bind ...

journal_title：DNA and cell biology

authors： Yajima S,Lee SH,Minowa T,Mouradian MM

更新日期：1998-05-01 00:00:00

abstract：:The aims of our research involved to investigate DYS-14 copy number variations in healthy males, to quantify extracellular DNA in maternal circulation in normal versus complicated pregnancies, and to study variations in the DYS-14 copy number in extracellular male fetal DNA. Fifty-five healthy males, 43 uncomplicated ...

journal_title：DNA and cell biology

authors： Hromadnikova I,Benesova M,Zejskova L,Stehnova J,Doucha J,Sedlacek P,Dlouha K,Krofta L

更新日期：2009-07-01 00:00:00

abstract：:Parkinson's disease (PD) is a serious neurodegenerative disorder that lacks effective therapeutic methods. In this research, expressions of PPARα, RXRα, and miR-21 were evaluated in PD patients and normal controls. To investigate the effects of miR-21, docosahexaenoic acid (DHA) and aspirin (ASA) on PD, as well as the...

journal_title：DNA and cell biology

authors： Fu Y,Zhen J,Lu Z

更新日期：2017-06-01 00:00:00