Abstract:
:Non-Hodgkin lymphoma (NHL) is the most common hematologic malignancy worldwide. Interleukin-2 (IL-2) plays a key role in the proliferation of T cells and natural killer cells. It has been reported that polymorphisms in the IL-2 gene are associated with various cancers. The aim of this study was to examine the effect of polymorphisms in the IL-2 gene on the development of NHL in the Chinese population. IL-2-330T/G and +114T/G polymorphisms were detected by polymerase chain reaction-restriction fragment length polymorphism in 438 NHL cases and 482 age-matched healthy controls. Data were analyzed using the Chi-square test. Results showed that individuals with -330TG genotype or -330GG genotype had significantly increased susceptibility to NHL (Odds ratio [OR] = 1.40, 95% confidence interval [CI]: 1.05-1.85, p = 0.020 and OR = 2.04, 95%CI: 1.28-3.24, p = 0.002). Meanwhile, the +114T/G polymorphism did not show any correlation with NHL. When analyzing the haplotypes of these two polymorphisms, the prevalence of -330G/+114T haplotype was significantly higher in NHL cases than in controls (OR = 1.45, 95%CI: 1.12-1.88, p = 0.005). These data indicate that IL-2 gene polymorphisms may be new risk factors for NHL.
journal_name
DNA Cell Bioljournal_title
DNA and cell biologyauthors
Song H,Chen L,Cha Z,Bai Jdoi
10.1089/dna.2011.1603subject
Has Abstractpub_date
2012-07-01 00:00:00pages
1279-84issue
7eissn
1044-5498issn
1557-7430journal_volume
31pub_type
杂志文章abstract::DNA methylation of CYP17 (steroid 17 alpha-hydroxylase) was studied in bovine adrenocortical cells, which lose the capacity to express this tissue-specific gene in culture by phenotypic switching. Restriction enzyme digestions, and sequencing of a lambda clone of a second CYP17 gene (CYP17A2), showed that there are at...
journal_title:DNA and cell biology
pub_type: 杂志文章
doi:10.1089/dna.1992.11.385
更新日期:1992-06-01 00:00:00
abstract::Human monoclonal antibodies (HuMAbs) demonstrate great potential for passive immunotherapy against HIV-1. The gp41 transmembrane envelope glycoprotein of HIV has an important role in the pathogenicity of AIDS and importantly displays considerably less hypervariability than the gp120 surface envelope HIV glycoprotein, ...
journal_title:DNA and cell biology
pub_type: 杂志文章
doi:10.1089/dna.2004.23.836
更新日期:2004-12-01 00:00:00
abstract::Human immunodeficiency virus type 1 (HIV-1) is known for its ability to infect immune cells, including T-cells and macrophages. The 96-amino acid Vpr, a virion-associated protein, is essential for viral replication in monocytes/macrophages and increases viral replication in primary and established T-cell lines. The Vp...
journal_title:DNA and cell biology
pub_type: 杂志文章
doi:10.1089/104454900314564
更新日期:2000-03-01 00:00:00
abstract::Traditional histological classification of lung cancer subtypes is informative, but incomplete. Recent studies of gene expression suggest that molecular classification can be used for effective diagnostic and prediction of the treatment outcome. We attempt to build a molecular classification based on the public data a...
journal_title:DNA and cell biology
pub_type: 杂志文章
doi:10.1089/dna.2004.23.715
更新日期:2004-10-01 00:00:00
abstract::Heme plays a significant pathogenic role in several diseases involving the kidney. The cellular content of heme, derived either from the delivery of filtered heme proteins such as hemoglobin and myoglobin, or from the breakdown of ubiquitous intracellular heme proteins, is regulated via the heme oxygenase enzyme syste...
journal_title:DNA and cell biology
pub_type: 杂志文章,评审
doi:10.1089/104454902753759726
更新日期:2002-04-01 00:00:00
abstract::The G0S19 genes are members of the "small inducible" family of genes, which have similar exon-intron organizations and encode secreted proteins with similar dispositions of cysteine and proline residues. G0S19-1 mRNA is increased shortly after the addition of lectin or cycloheximide to cultured human blood mononuclear...
journal_title:DNA and cell biology
pub_type: 杂志文章
doi:10.1089/dna.1990.9.589
更新日期:1990-10-01 00:00:00
abstract::Ovarian cancer (OC) is the most lethal gynecological cancer. The molecular mechanism of it is complicated, and numerous researches suggest that microRNAs are key regulators for it. This study was to investigate the pivotal role of miR-629 in the progression of OC and to reveal the possible molecular mechanism of its a...
journal_title:DNA and cell biology
pub_type: 杂志文章
doi:10.1089/dna.2017.3904
更新日期:2017-12-01 00:00:00
abstract::ERGIC2 (formerly known as PTX1) is a gene identified by subtractive hybridization on the basis that it is expressed in normal human prostate, but not in prostate carcinoma. It is unrelated to the gene encoding pituitary homeobox protein (Ptx1 or Pitx1), which regulates pituitary hormone gene expression. Based on seque...
journal_title:DNA and cell biology
pub_type: 杂志文章
doi:10.1089/dna.2013.2225
更新日期:2014-02-01 00:00:00
abstract::Gene delivery from tissue engineering scaffold is a novel strategy in regulating long-term growth and function of cells in vitro culture. In this study, a hepatocyte growth factor plasmid/polyetherimide (pHGF/PEI) polyplex delivering alginate (AL)/galactosylated chitosan (GC) (pHGF/PEI-AL/GC) sponge scaffold was prepa...
journal_title:DNA and cell biology
pub_type: 杂志文章
doi:10.1089/dna.2019.5136
更新日期:2020-03-01 00:00:00
abstract::Most mammalian species express high concentrations of ALDH3A1 in corneal epithelium with the exception of the rabbit, which expresses high amounts of ALDH1A1 rather than ALDH3A1. Several hypotheses that involve catalytic and/or structural functions have been postulated regarding the role of these corneal ALDHs. The ai...
journal_title:DNA and cell biology
pub_type: 杂志文章
doi:10.1089/104454903322216671
更新日期:2003-05-01 00:00:00
abstract::Age-related macular degeneration (AMD) is a disease with multifactorial etiology characterized by irreversible loss of central visual acuity. The discovery of susceptive single-nucleotide polymorphisms (SNPs) has progressed our understanding of AMD. Complement factor H (CFH) gene Y402H polymorphism and high-temperatur...
journal_title:DNA and cell biology
pub_type: 杂志文章
doi:10.1089/dna.2011.1214
更新日期:2012-03-01 00:00:00
abstract::Noncanonical transcriptions include transcriptions that systematically exchange nucleotides, also called bijective transformations or swinger transformations. Swinger transformation A↔T+C↔G recovers identities of 8 among 9 unknown RNAs differentially expressed in centroblastic lymphoma, a human immunodeficiency virus ...
journal_title:DNA and cell biology
pub_type: 杂志文章
doi:10.1089/dna.2019.5066
更新日期:2020-08-01 00:00:00
abstract::Diabetes is a worldwide health problem with increasing prevalence. Some reports indicate the interplay between bone and glucose metabolism. The imbalance between bone resorption and formation resulted in the structural integrity and strength of bone. Glucagon-like peptide-1 (GLP-1) and its agonists (Liraglutide) have ...
journal_title:DNA and cell biology
pub_type: 杂志文章
doi:10.1089/dna.2018.4397
更新日期:2018-12-01 00:00:00
abstract::Liver-expressed chemokine (LEC) is a CC chemokine that is selectively expressed in the liver. We report here the structures of the human and mouse genes for LEC. The human LEC gene (SCYA16) was isolated from a bacterial artificial chromosome (BAC) clone that also contained CC chemokine genes for MPIF-1/Ckbeta8, HCC-2/...
journal_title:DNA and cell biology
pub_type: 杂志文章
doi:10.1089/104454999315330
更新日期:1999-04-01 00:00:00
abstract::Sequence analysis of the 5' end of the thrombomodulin (TM) gene has identified a difference in two strains of laboratory mice, BALB/cBD (maintained at the Oak Ridge National Laboratory) and the strain used for the sequence listed in the GenBank data base. An intracisternal A-particle (IAP) provirus was present in the ...
journal_title:DNA and cell biology
pub_type: 杂志文章
doi:10.1089/dna.1993.12.311
更新日期:1993-05-01 00:00:00
abstract::To investigate the contribution of de novo variants to Tourette disorder (TD) probands in China. Whole-exome sequencing (WES) conducted on 15 child-parent trios (45 samples) detected 25 coding de novo variants, including 2 de novo Likely Gene Disrupting (LGD) variants and 6 Missense3 variants. The de novo LGD variants...
journal_title:DNA and cell biology
pub_type: 杂志文章
doi:10.1089/dna.2019.4746
更新日期:2020-01-01 00:00:00
abstract::We have devised a method to determine gene structure that utilizes the known gene structure of homologous proteins and the polymerase chain reaction (PCR). Because homologous proteins have evolved from a common ancestral gene, it is possible to design primers corresponding to the adjacent exon sequences in the protein...
journal_title:DNA and cell biology
pub_type: 杂志文章
doi:10.1089/dna.1995.14.343
更新日期:1995-04-01 00:00:00
abstract::G0S8 is a member of a set of putative G0/G1 switch regulatory genes (G0S genes) selected by screening cDNA libraries prepared from blood mononuclear cells cultured for 2 hr with lectin and cycloheximide. Comparison of a full-length cDNA sequence with the corresponding genomic sequence reveals an open reading frame of ...
journal_title:DNA and cell biology
pub_type: 杂志文章
doi:10.1089/dna.1994.13.125
更新日期:1994-02-01 00:00:00
abstract::Type 1 diabetes results in most cases from the destruction of insulin-secreting beta cells by the immune system. Several immunization methods based on administration of autoantigenic polypeptides such as insulin and glutamic acid decarboxylase (GAD) have been used to prevent autoimmune diabetes in the non-obese diabet...
journal_title:DNA and cell biology
pub_type: 杂志文章
doi:10.1089/104454901300069022
更新日期:2001-03-01 00:00:00
abstract::Triple-negative breast cancer (TNBC) refers to breast cancer without significant expression of estrogen receptor (ER), progesterone receptor (PR), or human epidermal growth factor receptor 2. We sought to identify the hub genes and find the potential progression mechanism of TNBC as well as immunotherapeutic targets. ...
journal_title:DNA and cell biology
pub_type: 杂志文章
doi:10.1089/dna.2020.5449
更新日期:2020-10-01 00:00:00
abstract::Adipose-derived stem cells/adipose-derived progenitor cells (ADPCs) are multipotent stem cells that can differentiate in vitro into many cell types. However, the vast majority of experimental materials were obtained from human, mouse, rabbit, and other mammals but rarely from poultry. In this study, ADPCs were isolate...
journal_title:DNA and cell biology
pub_type: 杂志文章
doi:10.1089/dna.2010.1154
更新日期:2011-07-01 00:00:00
abstract::We have analyzed the interleukin-1 beta (IL-1 beta) promoter region near the cap site. Specific DNA sequences required for lipopolysaccharide (LPS) induction within this region were identified using transfection of reporter plasmids that contained portions of the proximal IL-1 beta 5'-flanking sequence. An LPS-respons...
journal_title:DNA and cell biology
pub_type: 杂志文章
doi:10.1089/dna.1994.13.561
更新日期:1994-06-01 00:00:00
abstract::We have cloned and sequenced the cDNA corresponding to the rat preproepidermal growth factor (ppEGF) mRNA. The cDNA contained 4,801 nucleotides, similar to that reported for the mouse (4,749 nucleotides) and the human mRNAs (4,871 nucleotides). The predicted protein sequence would contain 1,133 amino acids, smaller th...
journal_title:DNA and cell biology
pub_type: 杂志文章
doi:10.1089/dna.1992.11.481
更新日期:1992-07-01 00:00:00
abstract::We have determined the expression pattern of all 11 human replication-dependent histone H3 genes in three fetal human tissues (bladder, liver, and lung) and in eight human cell lines by RNase protection assay. In the fetal human tissues, all 11 genes were expressed to a varied extent. However, the relative contributio...
journal_title:DNA and cell biology
pub_type: 杂志文章
doi:10.1089/104454903321908629
更新日期:2003-04-01 00:00:00
abstract::The human spermidine synthase (EC 2.5.1.16) gene was isolated from a genomic library constructed with DNA obtained from a human immunoglobulin G (IgG) myeloma cell line. Subsequent sequence analyses revealed that the gene comprised of 5,818 nucleotides from the cap site to the last A of the putative polyadenylation si...
journal_title:DNA and cell biology
pub_type: 杂志文章
doi:10.1089/dna.1991.10.467
更新日期:1991-07-01 00:00:00
abstract::The human OZF gene encodes a protein consisting essentially of zinc finger motifs of the Krüppel type. Evolutionary studies revealed amplification of the bovine OZF gene in cattle. Domestic cattle includes two major subspecies: taurine (Bos primigenius taurus) and zebu (B. p. indicus). Amplified sequences were found i...
journal_title:DNA and cell biology
pub_type: 杂志文章
doi:10.1089/dna.1996.15.83
更新日期:1996-01-01 00:00:00
abstract::Electroporation has proven to be a highly effective technique for the in vivo delivery of genes to a number of solid tissues. In most of the reported methods, DNA is injected into the target tissue and electrodes are placed directly on or in the tissue for application of the electric field. While this works well for s...
journal_title:DNA and cell biology
pub_type: 杂志文章,评审
doi:10.1089/104454903322625000
更新日期:2003-12-01 00:00:00
abstract::Parkinson's disease (PD) is a serious neurodegenerative disorder that lacks effective therapeutic methods. In this research, expressions of PPARα, RXRα, and miR-21 were evaluated in PD patients and normal controls. To investigate the effects of miR-21, docosahexaenoic acid (DHA) and aspirin (ASA) on PD, as well as the...
journal_title:DNA and cell biology
pub_type: 杂志文章
doi:10.1089/dna.2017.3643
更新日期:2017-06-01 00:00:00
abstract::The nuclear factor of κB (NFκB) family has been well known for its significant role in regulating the expression of numerous genes that control many biological processes. However, it is unclear whether NFκB could regulate milk synthesis. In this study, we identified NFκB1 as a critical regulator for milk synthesis in ...
journal_title:DNA and cell biology
pub_type: 杂志文章
doi:10.1089/dna.2016.3610
更新日期:2017-04-01 00:00:00
abstract::In the promoters of many immediate early genes, including c-fos, CArG DNA regulatory elements mediate basal constituitive expression and rapid and transient serum induction. CArG boxes also occur in the promoters of muscle-specific genes, including skeletal alpha-actin, where it confers muscle-specific expression. The...
journal_title:DNA and cell biology
pub_type: 杂志文章
doi:10.1089/dna.1997.16.653
更新日期:1997-05-01 00:00:00