HGF Gene Delivering Alginate/Galactosylated Chitosan Sponge Scaffold for Three-Dimensional Coculture of Hepatocytes/3T3 Cells.

abstract：:Peanut is an important crash crop worldwide, and it is often threatened by drought stress due to unexpected extreme weather events. In this work, NH5 and FH18 were selected as drought-tolerant and drought-sensitive varieties, respectively. Comparison of their physiological responses revealed that NH5 showed less wilti...

journal_title：DNA and cell biology

authors： Ren J,Zhang H,Shi X,Ai X,Dong J,Zhao X,Zhong C,Jiang C,Wang J,Yu H

更新日期：2020-12-29 00:00:00

abstract：:Dilated cardiomyopathy (DCM) is a common type of cardiomyopathy. The pathogenesis of DCM remains unclear and involves varied genes. AXIN1 is a crucial gene in regulating various functions in cells, it encodes protein Axin1, which regulates the assembly and disassembly of β-catenin destruction complex. In addition, Wnt...

journal_title：DNA and cell biology

authors： Li K,Zhong Y,Peng Y,Zhou B,Wang Y,Li Q,Zhang Y,Song H,Rao L

更新日期：2019-05-01 00:00:00

abstract：:Human T cells express HLA class II molecules upon activation. The factors that regulate the induction of expression of these molecules are for the most part unknown. Here we report preliminary results indicating that tumor necrosis factor-alpha (TNF-alpha) regulates the induction of cell-surface HLA-DR, DO, and DP mol...

journal_title：DNA and cell biology

authors： Kamoun M,Zerva L,Sloan S,Zmijewski C,Monos D,Trinchieri G

更新日期：1992-04-01 00:00:00

abstract：:The human spermidine synthase (EC 2.5.1.16) gene was isolated from a genomic library constructed with DNA obtained from a human immunoglobulin G (IgG) myeloma cell line. Subsequent sequence analyses revealed that the gene comprised of 5,818 nucleotides from the cap site to the last A of the putative polyadenylation si...

journal_title：DNA and cell biology

authors： Myöhänen S,Kauppinen L,Wahlfors J,Alhonen L,Jänne J

更新日期：1991-07-01 00:00:00

abstract：:Vascular endothelial growth factor (VEGF) is a key mediator of angiogenesis, which is crucial for development and metastasis of tumors including hepatocellular carcinoma (HCC), and elevated VEGF levels in serum and tissues have been known to be related with poor prognosis in patients with HCC. Polymorphisms in VEGF ma...

journal_title：DNA and cell biology

authors： He Y,Ni J,Chen S,Jiang Y,Jia S,Gao Y

更新日期：2010-07-01 00:00:00

abstract：:The cDNAs encoding the human bone morphogenetic proteins BMP-2 and BMP-4 in an eukaryotic expression vector were permanently transferred into the murine mesenchymal progenitor cell line C3H10T1/2. Originally, these cells are known to differentiate into myotubes, adipocytes, and chondrocytes upon the addition of azacyt...

journal_title：DNA and cell biology

authors： Ahrens M,Ankenbauer T,Schröder D,Hollnagel A,Mayer H,Gross G

更新日期：1993-12-01 00:00:00

abstract：:The transcription factor delta EF1 is a key player in estrogen-signaling cascades in vertebrates. In this pathway, estrogen induces the expression of the gene encoding delta EF1, and then delta EF1 activates transcription of downstream targets. Yet, the molecular mechanisms of transcriptional activation by delta EF1 h...

journal_title：DNA and cell biology

authors： Dillner NB,Sanders MM

更新日期：2004-01-01 00:00:00

abstract：:Butyrate is a naturally occurring product of colonic microbial fermentation of dietary carbohydrates that escape hydrolysis in the small intestine. Butyrate plays a significant role in the maintenance of colonic tissue homeostasis by regulating the expression of genes associated with the processes of proliferation, di...

journal_title：DNA and cell biology

authors： Daly K,Shirazi-Beechey SP

更新日期：2006-01-01 00:00:00

abstract：:The spike (S) protein, a main surface antigen of the SARS coronavirus (SARS-CoV), is considered to be one of the most important protective antigen candidates for targets for vaccine design against the virus. In this study, a secreted recombinant expression plasmid, pVAX-S1, encoding the partial S protein with a signal...

journal_title：DNA and cell biology

authors： He H,Tang Y,Qin X,Xu W,Wang Y,Liu X,Liu X,Xiong S,Li J,Zhang M,Duan M

更新日期：2005-08-01 00:00:00

abstract：:NANOG is a critical homeodomain transcription factor responsible for maintaining embryonic stem cell (ESC) self-renewal and pluripotency. In the present study, we isolated, sequenced, and characterized the NANOG gene in buffalo ESC-like cells. Here, we demonstrated that NANOG mRNA is expressed as multiple isoforms and...

journal_title：DNA and cell biology

authors： Singh N,Sharma R,George A,Singla SK,Palta P,Manik R,Chauhan MS,Singh D

更新日期：2012-05-01 00:00:00

abstract：:The promoters of mammalian striated muscle actin gene contain binding sites for a number of transcription factors. Examples are the CArG boxes, which bind a protein identical to or related to serum response factor (SRF), E boxes, which bind myogenic determination factors such as MyoD and myogenin, and -CCGCCC- motifs,...

journal_title：DNA and cell biology

authors： Davey HW,Kelly JK,Wildeman AG

更新日期：1995-07-01 00:00:00

abstract：:Alzheimer's disease (AD) is a neurodegenerative disorder characterized by overproduction of beta-amyloid (Abeta), which is formed from amyloid precursor protein (APP), with the subsequent pathologic deposition of Abeta in regions of the brain important for memory and cognition. Recently, vaccination of murine models o...

journal_title：DNA and cell biology

authors： Dickey CA,Morgan DG,Kudchodkar S,Weiner DB,Bai Y,Cao C,Gordon MN,Ugen KE

更新日期：2001-11-01 00:00:00

abstract：:Eaf2 encodes a tumor suppressor that plays multiple functions in transcriptional activation, apoptosis, and embryonic development. In this study, we utilized GFP-EAF2 fusion protein to describe the dynamic subcellular movement of Eaf2. GFP-EAF2 is preferentially localized to the nucleus, and in the presence of ELL, it...

journal_title：DNA and cell biology

authors： Zhuang F,Yen P,Zhao J,Nguyen M,Jiang M,Liu YH

更新日期：2008-12-01 00:00:00

abstract：:Gene therapy depends on safe and efficient gene delivery. The skin is an attractive target for gene delivery because of its accessibility. Recently, in vivo electroporation has been shown to enhance expression after injection of plasmid DNA. In this study, we examined the use of electroporation to deliver plasmid DNA ...

journal_title：DNA and cell biology

authors： Heller R,Schultz J,Lucas ML,Jaroszeski MJ,Heller LC,Gilbert RA,Moelling K,Nicolau C

更新日期：2001-01-01 00:00:00

abstract：:We identified extracellular signal-regulated kinase 2 (erk2) from green mud crab, Scylla paramamosain, in this article. It was originally identified from an expressed sequence tag fragment from a normalized gonadal cDNA library. 5' Rapid amplification of cDNA end (RACE) technique was used to obtain the 5' untranslated...

journal_title：DNA and cell biology

authors： Ma A,Wang Y,Zou Z,Fu M,Lin P,Zhang Z

更新日期：2012-07-01 00:00:00

abstract：:A variety of human cancer cells are resistant to Fas ligand and anti-Fas antibody induced apoptosis. Previously, we reported that human gastric carcinoma cell lines were resistant to the anti-Fas antibody, CH-11, without interferon-gamma pretreatment in vitro. Cyclooxygenase (COX)-2 is known to be expressed in many hu...

journal_title：DNA and cell biology

authors： Honjo S,Osaki M,Ardyanto TD,Hiramatsu T,Maeta N,Ito H

更新日期：2005-03-01 00:00:00

abstract：:The search for new chemotherapeutics unaffected by efflux pumps would significantly increase life expectancy in patients with malignant cancers. In this study, butylcycloheptylprodigiosin and undecylprodigiosin were HPLC-purified and verified, using nuclear magnetic resonance spectroscopy. Cell cytotoxicity and transp...

journal_title：DNA and cell biology

authors： Mirzaei SA,Safari Kavishahi M,Keshavarz Z,Elahian F

更新日期：2018-06-01 00:00:00

abstract：:Polymorphisms such as single-nucleotide polymorphisms (SNPs) and insertions/deletions (Indels) can be associated with phenotypic traits and be used as markers for disease diagnosis. Identification of these genetic variations within laboratory mice is crucial to improve our understanding of the genetic background of th...

journal_title：DNA and cell biology

authors： Lo CL,Shen F,Baumgarner K,Cramer MJ,Lossie AC

更新日期：2012-03-01 00:00:00

abstract：:Growth regulation of terminal differentiation was studied by analysis of the promoter of the transcription factor D-site binding protein (DBP) using nuclear extracts from rat liver undergoing regeneration or from normal liver early in development. Four proximal binding sites for nuclear proteins were identified, three...

journal_title：DNA and cell biology

authors： Leggett RW,Mueller CR

更新日期：1994-07-01 00:00:00

abstract：:We have cloned a putative yeast homolog of the gene encoding the human Tat-binding protein, TBP-1. The gene termed TBPY encodes a 45,243-dalton protein displaying a heptad repeat of hydrophobic amino acids reminiscent of a leucine zipper. Secondary structure predictions suggest the possibility of formation of an amphi...

journal_title：DNA and cell biology

authors： Goyer C,Lee HS,Malo D,Sonenberg N

更新日期：1992-10-01 00:00:00

abstract：:The mdmx gene was shown to possess high homology to the mdm-2 gene and to encode a protein that can bind p53 and block p53 transactivation. Because Mdm-2 protein blocks the growth-suppressive activity of the p53 tumor-suppressor protein through similar activities, we examined the expression patterns of mdmx to determi...

journal_title：DNA and cell biology

authors： Jackson MW,Berberich SJ

更新日期：1999-09-01 00:00:00

abstract：:A primary response of the avian intestine to 1,25-dihydroxyvitamin D3 [1,25-(OH)2D3] is increased synthesis of a 28-kD calcium-binding protein, calbindin-D28k (CaBP). This study examined whether 1,25-(OH)2D3 regulates CaBP gene transcription by an interaction of the vitamin D receptor (VDR) with a vitamin D-responsive...

journal_title：DNA and cell biology

authors： Macdonald PN,Whitfield GK,Haussler CA,Hocker AM,Haussler MR,Komm BS

更新日期：1992-06-01 00:00:00

abstract：:CXXC finger protein 1 (CFP1) is a component of the Setd1A and Setd1B methyltransferase complexes, localizes to euchromatic regions of the genome, and specifically binds unmethylated CpG dinucleotides in DNA. Murine embryos lacking CFP1 exhibit peri-implantation lethality, a developmental time that correlates with glob...

journal_title：DNA and cell biology

authors： Butler JS,Lee JH,Skalnik DG

更新日期：2008-10-01 00:00:00

abstract：:Fibroblast growth factor 21 (FGF-21) is a novel regulator for metabolic syndrome (MetS), diabetes, and obesity. However, no study has been performed on the association of these diseases with FGF-21 gene polymorphism. The aim of the study was to investigate the association of 3' untranslated region (UTR) single-nucleot...

journal_title：DNA and cell biology

authors： Zhang M,Zeng L,Wang YJ,An ZM,Ying BW

更新日期：2012-04-01 00:00:00

abstract：:This research aims to investigate the immune-associated gene signature from databases to improve the prognostic value in hepatocellular carcinoma (HCC) by multidimensional methods using various bioinformatic methods. Fifty-one immune-associated genes were mined out, which were associated with clinical characters throu...

journal_title：DNA and cell biology

authors： Chen W,Tang D,Ou M,Dai Y

更新日期：2020-04-01 00:00:00

abstract：:Adipose-derived stem cells/adipose-derived progenitor cells (ADPCs) are multipotent stem cells that can differentiate in vitro into many cell types. However, the vast majority of experimental materials were obtained from human, mouse, rabbit, and other mammals but rarely from poultry. In this study, ADPCs were isolate...

journal_title：DNA and cell biology

authors： Gong X,Hou L,Bai C,Jin D,He X,Guan W,Ma Y

更新日期：2011-07-01 00:00:00

abstract：:MicroRNAs (miRNAs) are small non-coding RNA molecules that regulate mRNAs through a sequence-specific mechanism. By virtue of their structure and mechanism of action, computational methods have been devised to investigate the encoding of miRNA genes and the targets of miRNA action. A variety of assumptions have predic...

journal_title：DNA and cell biology

authors： Doran J,Strauss WM

更新日期：2007-05-01 00:00:00

abstract：:Type 2 cystatins comprise a class of cysteine peptidase inhibitor presumed to mediate protective functions at various locations, including the oral cavity. Seven cystatin genes are clustered within a 300-kb region of human 20p11.2. "Salivary" cystatins, encoded by CST1, 2, 4, and 5, are present in saliva at significan...

journal_title：DNA and cell biology

authors： Dickinson DP,Thiesse M,Hicks MJ

更新日期：2002-01-01 00:00:00

abstract：:Most mammalian species express high concentrations of ALDH3A1 in corneal epithelium with the exception of the rabbit, which expresses high amounts of ALDH1A1 rather than ALDH3A1. Several hypotheses that involve catalytic and/or structural functions have been postulated regarding the role of these corneal ALDHs. The ai...

journal_title：DNA and cell biology

authors： Manzer R,Qamar L,Estey T,Pappa A,Petersen DR,Vasiliou V

更新日期：2003-05-01 00:00:00

abstract：:Epulopiscium sp. type B, a member of the Firmicutes, is a large (up to 300 microm), cigar-shaped bacterial symbiont of surgeonfish that propagates itself by forming multiple intracellular offspring. This unusual form of reproduction is an apparent modification of a developmental program used by some Firmicutes to prod...

journal_title：DNA and cell biology

authors： Ward RJ,Clements KD,Choat JH,Angert ER

更新日期：2009-02-01 00:00:00