Erk2 in ovarian development of green mud crab Scylla paramamosain.

abstract：:Hepatocellular carcinoma (HCC) is a life-threatening disease that is often associated with chronic infection by hepatitis B and C viruses. Genetic polymorphisms have been reported to alter the risk for HCC development. Genetic studies based on the haplotype have an increased power for detecting disease associations co...

journal_title：DNA and cell biology

authors： Kiran M,Chawla YK,Jain M,Kaur J

更新日期：2009-11-01 00:00:00

abstract：:Apoptotic endonuclease G (EndoG) is responsible for DNA fragmentation both during and after cell death. Previous studies demonstrated that genetic inactivation of EndoG is cytoprotective against various pro-apoptotic stimuli; however, specific inhibitors for EndoG are not available. In this study, we have developed a ...

journal_title：DNA and cell biology

authors： Jang DS,Penthala NR,Apostolov EO,Wang X,Crooks PA,Basnakian AG

更新日期：2015-02-01 00:00:00

abstract：:The aim of this study was to determine the role of polymorphic variants of apolipoprotein E (APOE) and peroxisome proliferator-activated receptor delta (PPARD) genes in the development of coronary heart disease (CHD), and the PPARD and APOE gene-gene interaction in a Turkish population. This study was carried out usin...

journal_title：DNA and cell biology

authors： Yılmaz-Aydogan H,Kucukhuseyin O,Kurnaz O,Akadam-Teker B,Kurt O,Tekeli A,Ozturk O,Isbir T

更新日期：2012-05-01 00:00:00

abstract：:Hearing loss in Ménière's disease (MD) is associated with loss of spiral ganglion neurons and hair cells. In a guinea pig model of endolymphatic hydrops, nitric oxide synthases (NOS) and oxidative stress mediate loss of spiral ganglion neurons. To test the hypothesis that functional variants of NOS1 and NOS2A are asso...

journal_title：DNA and cell biology

authors： Gazquez I,Lopez-Escamez JA,Moreno A,Campbell CA,Meyer NC,Carey JP,Minor LB,Gantz BJ,Hansen MR,Della Santina CC,Aran I,Soto-Varela A,Santos S,Batuecas A,Perez-Garrigues H,Lopez-Nevot A,Smith RJ,Lopez-Nevot MA

更新日期：2011-09-01 00:00:00

abstract：:A safe and effective adjuvant is important to develop vaccines against highly pathogenic avian influenza virus. Chitosan, a derivative from the natural amino polysaccharide chitin, has been proved to be an effective adjuvant for inactivated influenza virus vaccine. In this study, protective immunity in mice provided b...

journal_title：DNA and cell biology

authors： Chang H,Li X,Teng Y,Liang Y,Peng B,Fang F,Chen Z

更新日期：2010-09-01 00:00:00

abstract：:Electroporation has proven to be a highly effective technique for the in vivo delivery of genes to a number of solid tissues. In most of the reported methods, DNA is injected into the target tissue and electrodes are placed directly on or in the tissue for application of the electric field. While this works well for s...

journal_title：DNA and cell biology

authors： Dean DA

更新日期：2003-12-01 00:00:00

abstract：:DNA condensed agents can improve the transfection efficiency of the cationic liposome delivery system. However, various condensed agents have distinct transfection efficiency and cellular cytotoxicity. The object of this study was to screen the optimal agents with the high transfection efficiency and low cytotoxicity ...

journal_title：DNA and cell biology

authors： Wang J,Ye X,Ni H,Zhang J,Ju S,Ding W

更新日期：2019-10-01 00:00:00

abstract：:Temporal coordination of meiosis with spermatid morphogenesis is crucial for successful generation of mature sperm cells. We identified a recessive male sterile Drosophila melanogaster mutant, mitoshell, in which events of spermatid morphogenesis are initiated too early, before meiotic onset. Premature mitochondrial a...

journal_title：DNA and cell biology

authors： Bergner LM,Hickman FE,Wood KH,Wakeman CM,Stone HH,Campbell TJ,Lightcap SB,Favors SM,Aldridge AC,Hales KG

更新日期：2010-09-01 00:00:00

abstract：:Global antibiotic resistance, driven by intensive antibiotic exposure/abuse, constitutes a serious challenge to all health care, particularly in an era when new antimicrobial development has slowed to a trickle. Recently, we published work demonstrating the discovery and partial mechanism of action of a novel bacteric...

journal_title：DNA and cell biology

authors： Hassett DJ,Meyer TJ

更新日期：2020-09-01 00:00:00

abstract：:The nuclear factor of κB (NFκB) family has been well known for its significant role in regulating the expression of numerous genes that control many biological processes. However, it is unclear whether NFκB could regulate milk synthesis. In this study, we identified NFκB1 as a critical regulator for milk synthesis in ...

journal_title：DNA and cell biology

authors： Huang X,Zang Y,Zhang M,Yuan X,Li M,Gao X

更新日期：2017-04-01 00:00:00

abstract：:We have analyzed transcription factor-mediated DNA supercoiling catalyzed by the Xenopus oocyte extract (S-150). Under conditions that inhibit endogenous supercoiling activity (2 mM EDTA), the 5S RNA specific transcription factor, TFIIIA, promotes a negative change in DNA linking number. The SV40 binding protein, T an...

journal_title：DNA and cell biology

authors： Sekiguchi JM,Kmiec EB

更新日期：1991-04-01 00:00:00

abstract：:Mitochondrial dysfunction arises from an inadequate number of mitochondria, an inability to provide necessary substrates to mitochondria, or a dysfunction in their electron transport and a denosine triphosphate synthesis machinery. Occurrences of mitochondrial dysfunction are due to genetic or environmental changes in...

journal_title：DNA and cell biology

authors： Sekar D,Johnson J,Biruntha M,Lakhmanan G,Gurunathan D,Ross K

更新日期：2020-08-01 00:00:00

abstract：:Growth factors are important mediators of proliferation. Deregulation in growth factor mechanisms as well as in its receptors will contribute to cancer development. One of the most important is the epidermal growth factor (EGF), which is encoded by EGF gene. A functional polymorphism at position 61 (A/G) is associated...

journal_title：DNA and cell biology

authors： Araújo AP,Ribeiro R,Pinto D,Pereira D,Sousa B,Mauricio J,Lopes C,Medeiros R

更新日期：2009-05-01 00:00:00

abstract：:Tumor cells express lower levels of manganese superoxide dismutase (MnSOD) than their normal counterparts. Enforced expression of MnSOD reverses the malignant phenotype of many transformed cells, suggesting that SOD2 is a tumor suppressor. The SOD2 gene contains a large CpG island spanning > 3.5 kb that starts near th...

journal_title：DNA and cell biology

authors： Huang Y,He T,Domann FE

更新日期：1999-08-01 00:00:00

abstract：:dTMP kinase (E.C.2.7.4.9.) catalyzes the phosphorylation of dTMP to the corresponding diphosphate. This enzyme is essential for DNA synthesis in vivo and is an important intermediate enzyme in the pathway of many pyrimidine analog drugs. In this report, we describe the isolation of the human dTMP kinase gene by functi...

journal_title：DNA and cell biology

authors： Huang SH,Tang A,Drisco B,Zhang SQ,Seeger R,Li C,Jong A

更新日期：1994-05-01 00:00:00

abstract：:Ovarian cancer (OC) is the most lethal gynecological cancer. The molecular mechanism of it is complicated, and numerous researches suggest that microRNAs are key regulators for it. This study was to investigate the pivotal role of miR-629 in the progression of OC and to reveal the possible molecular mechanism of its a...

journal_title：DNA and cell biology

authors： Shao L,Shen Z,Qian H,Zhou S,Chen Y

更新日期：2017-12-01 00:00:00

abstract：:NADPH: quinone oxidoreductase 1 (NQO1) and dihydronicotinamide riboside: quinone oxidoreductase 2 (NQO2) are cytosolic enzymes that catalyze reductive activation of carcinogens from cigarette smoke, such as nitrosamines and heterocyclic amines. These enzymes also protect cells against oxidative damage from reactive ox...

journal_title：DNA and cell biology

authors： Malik MA,Zargar SA,Mittal B

更新日期：2011-05-01 00:00:00

abstract：:The sex steroid hormone progesterone modulates the developmental and lactogenic activity of prolactin in the mammary gland. Regulation of the level of prolactin receptor (PRLR) provides one possible mechanism by which this may occur, prompting this investigation of the molecular mechanisms involved in progestin regula...

journal_title：DNA and cell biology

authors： Ormandy CJ,Graham J,Kelly PA,Clarke CL,Sutherland RL

更新日期：1992-12-01 00:00:00

abstract：:In the rat, the growth hormone receptor (GH-R) gene generates two transcripts, one encoding the transmembrane GH-R, and a shorter one encoding the GH-binding protein (GH-BP). These transcripts exhibit a high degree of heterogeneity in their 5'-untranslated regions (5'-UTRs). Some of the exons encoding these 5'-UTR var...

journal_title：DNA and cell biology

authors： Domené HM,Cassorla F,Werner H,Roberts CT Jr,Leroith D

更新日期：1995-03-01 00:00:00

abstract：:Intracranial aneurysms (IAs) and potential IA rupture are one of the direct causes of permanent brain damage and mortality. Interestingly, the major risk factors of IA development, including hemodynamic stress, hypertension, smoking, and genetic predispositions, are closely associated with a proinflammatory immune sta...

journal_title：DNA and cell biology

authors： Zhang HF,Zhao MG,Liang GB,Yu CY,He W,Li ZQ,Gao X

更新日期：2016-02-01 00:00:00

abstract：:DNA repair is reduced in patients suffering from systemic lupus erythematosus (SLE), and it can induce the production of autoreactive antibodies due to the accumulation of DNA damage and nucleoprotein that produce immunogenic antigens. The accumulations of anti-Ku and DNA-PKcs antibodies, which are involved in nonhomo...

journal_title：DNA and cell biology

authors： Jahantigh D,Salimi S,Mousavi M,Moossavi M,Mohammadoo-Khorasani M,Narooei-nejad M,Sandoughi M

更新日期：2015-05-01 00:00:00

abstract：:Gallbladder carcinoma (GBC) is a leading cause of cancer deaths in north India. Evidence has highlighted the role of abnormal DNA methylation patterns on inappropriate gene expression in development and progression of various cancers. 5,10-Methylenetetrahydrofolate reductase (MTHFR) plays a major role in provision of ...

journal_title：DNA and cell biology

authors： Srivastava A,Pandey SN,Pandey P,Choudhuri G,Mittal B

更新日期：2008-03-01 00:00:00

abstract：:Transgenic mice expressing interleukin-12 (IL-12) under the glial fibrillary acidic protein (GFAP) promoter were evaluated for their sensitivity to herpes simplex virus type 1 (HSV-1) infection of the cornea. There was a modest but significant decrease in the infiltration of mononuclear cells in the cornea of the GFAP...

journal_title：DNA and cell biology

authors： Carr DJ,Ash J,Al-Khatib K,Campbell IL

更新日期：2002-05-01 00:00:00

abstract：:alpha B-Crystallin, a member of the small heat shock family of proteins, is synthesized as a component of various developmental programs, in response to stress and in a number of pathological states. We have determined the complete structure of the alpha B-crystallin gene (6,806 bp encompassing 2,299 bp upstream from ...

journal_title：DNA and cell biology

authors： Srinivasan AN,Bhat SP

更新日期：1994-06-01 00:00:00

abstract：:Chemokine-like factor (CKLF)-like MARVEL transmembrane domain containing protein 6 (CMTM6) is a ubiquitously expressed protein, which plays a critical role in the stability of programmed death-ligand 1. However, the expression of CMTM6 in a variety of cancer pathological tissues is not clear. Therefore, 109 patients w...

journal_title：DNA and cell biology

authors： Hou X,He S,Zhang D,Yang C,Shi Y,Zhang K

更新日期：2020-10-21 00:00:00

abstract：:Non-Hodgkin lymphoma (NHL) is the most common hematologic malignancy worldwide. Interleukin-2 (IL-2) plays a key role in the proliferation of T cells and natural killer cells. It has been reported that polymorphisms in the IL-2 gene are associated with various cancers. The aim of this study was to examine the effect o...

journal_title：DNA and cell biology

authors： Song H,Chen L,Cha Z,Bai J

更新日期：2012-07-01 00:00:00

abstract：:In the promoters of many immediate early genes, including c-fos, CArG DNA regulatory elements mediate basal constituitive expression and rapid and transient serum induction. CArG boxes also occur in the promoters of muscle-specific genes, including skeletal alpha-actin, where it confers muscle-specific expression. The...

journal_title：DNA and cell biology

authors： Martin KA,Gualberto A,Kolman MF,Lowry J,Walsh K

更新日期：1997-05-01 00:00:00

abstract：:Liver-expressed chemokine (LEC) is a CC chemokine that is selectively expressed in the liver. We report here the structures of the human and mouse genes for LEC. The human LEC gene (SCYA16) was isolated from a bacterial artificial chromosome (BAC) clone that also contained CC chemokine genes for MPIF-1/Ckbeta8, HCC-2/...

journal_title：DNA and cell biology

authors： Fukuda S,Hanano Y,Iio M,Miura R,Yoshie O,Nomiyama H

更新日期：1999-04-01 00:00:00

abstract：:In our previous study, a kind of novel hybrid immunoglobulin (Ig)-binding proteins (IBPs) was obtained with the characteristic structure of alternately arranged Finegoldia magna (formerly Peptostreptococcus magnus) protein L (P. magnus protein L, PpL) B3 domain (B3) and Staphylococcal protein A (SpA) D domain (D). In ...

journal_title：DNA and cell biology

authors： Jiang SH,Wang JF,Xu R,Liu YJ,Wang XN,Cao J,Zhao P,Shen YJ,Yang T,Yang H,Jia JA,Chen QL,Pan W

更新日期：2008-08-01 00:00:00

abstract：:Normal embryo development in oviparous (egg-laying) species requires the coordinated targeting to growing oocytes of nutrients and regulatory molecules such as retinol, the precursor of active retinoids. Serum retinol-binding protein (RBP) is the major carrier protein for retinol in the circulatory system of vertebrat...

journal_title：DNA and cell biology

authors： Vieira AV,Kuchler K,Schneider WJ

更新日期：1995-05-01 00:00:00