Haplotypes of microsomal epoxide hydrolase and x-ray cross-complementing group 1 genes in Indian hepatocellular carcinoma patients.

abstract：:Previously we cloned a polyspecific transporter from rat (rOCT1) that is expressed in renal proximal tubules and hepatocytes and mediates electrogenic uptake of organic cations with different molecular structures. Recently a homologous transporter from rat kidney (rOCT2) was cloned but not characterized in detail. We ...

journal_title：DNA and cell biology

authors： Gorboulev V,Ulzheimer JC,Akhoundova A,Ulzheimer-Teuber I,Karbach U,Quester S,Baumann C,Lang F,Busch AE,Koepsell H

更新日期：1997-07-01 00:00:00

abstract：:At supramolecular resolution, DNA synthesis begins at preferred replication origins in the chromosomes of metazoan cells. To characterize one of these origins in detail, the initiation of replication was examined in the HeLa c-myc origin. Polymerase chain reaction (PCR) amplification of size-fractionated nascent chrom...

journal_title：DNA and cell biology

authors： Trivedi A,Waltz SE,Kamath S,Leffak M

更新日期：1998-10-01 00:00:00

abstract：:We have determined the expression pattern of all 11 human replication-dependent histone H3 genes in three fetal human tissues (bladder, liver, and lung) and in eight human cell lines by RNase protection assay. In the fetal human tissues, all 11 genes were expressed to a varied extent. However, the relative contributio...

journal_title：DNA and cell biology

authors： Koessler H,Doenecke D,Albig W

更新日期：2003-04-01 00:00:00

abstract：:Human monoclonal antibodies (HuMAbs) demonstrate great potential for passive immunotherapy against HIV-1. The gp41 transmembrane envelope glycoprotein of HIV has an important role in the pathogenicity of AIDS and importantly displays considerably less hypervariability than the gp120 surface envelope HIV glycoprotein, ...

journal_title：DNA and cell biology

authors： Cao C,Bai Y,Holloway MJ,Edgeworth RL,Jackson EA Jr,Cotropia J,Ugen KE

更新日期：2004-12-01 00:00:00

abstract：:We previously showed that the human AKNA gene encodes an AT-hook transcription factor that regulates the expression of costimulatory cell surface molecules on lymphocytes. However, AKNA cDNA probes hybridize with multiple transcripts, suggesting either the existence of other homologous genes or a complex regulation op...

journal_title：DNA and cell biology

authors： Sims-Mourtada JC,Bruce S,McKeller MR,Rangel R,Guzman-Rojas L,Cain K,Lopez C,Zimonjic DB,Popescu NC,Gordon J,Wilkinson MF,Martinez-Valdez H

更新日期：2005-05-01 00:00:00

abstract：:The Wilms' tumor gene 1 (WT1) protein is a transcriptional regulator that is highly expressed in immature hematopoietic progenitor cells and in the majority of patients with acute and chronic myeloid leukemia. However, it is still unclear how WT1 exerts its function(s) in hematopoietic cells. The aim of this work was ...

journal_title：DNA and cell biology

authors： Svensson E,Vidovic K,Olofsson T,Vallon-Christersson J,Borg A,Gullberg U

更新日期：2007-08-01 00:00:00

abstract：:This study aimed to construct a breast cancer model that could continuously express the genes of luciferase and green fluorescent protein. The genes luciferase, EGFP, and Neo were obtained by fusion polymerase chain reaction (PCR) and inserted into pAAV-MCS. The pAAV-Luciferase-EGFP-Neo vector was transfected into MDA...

journal_title：DNA and cell biology

authors： Huang C,Lan W,Wang F,Zhang C,Liu X,Chen Q

更新日期：2017-01-01 00:00:00

abstract：:In this study, we isolated two cDNA molecules encoding putative glutamate receptor subunits, fGluR1 alpha and fGluR1 beta, from an Oreochromis sp. brain cDNA library by hybridizing with the glutamate receptor cDNA, fGluR2 beta, of the same fish. The deduced amino acid sequence of the fGluR1 alpha consists of 908 resid...

journal_title：DNA and cell biology

authors： Wu YM,Kung SS,Chen J,Chow WY

更新日期：1996-09-01 00:00:00

abstract：:Protein-RNA complexation is essential in cell biological functions. Transfer RNAs are bound to aminoacyl-tRNA synthetases for the translation of the genetic code during protein synthesis, while ribonucleoproteins bind RNA in posttranscriptional regulation of gene expression. A recent report showed the interacton of hu...

journal_title：DNA and cell biology

authors： Malonga H,Neault JF,Tajmir-Riahi HA

更新日期：2006-07-01 00:00:00

abstract：:Our previous study showed that the mutation hotspots of the K-ras proto-oncogene in human functional adrenocortical tumors are in codons 15, 16, 18, and 31, thus differing from the sites in other tumors. In addition, analyzing the K-Ras protein by a recombinant DNA technique showed that the activity of endogenic GTPas...

journal_title：DNA and cell biology

authors： Hsu CH,Yang YC,Lian ST,Lee SC,Shin SJ,Tsai JH,Lin SR

更新日期：2001-04-01 00:00:00

abstract：:A safe and effective adjuvant is important to develop vaccines against highly pathogenic avian influenza virus. Chitosan, a derivative from the natural amino polysaccharide chitin, has been proved to be an effective adjuvant for inactivated influenza virus vaccine. In this study, protective immunity in mice provided b...

journal_title：DNA and cell biology

authors： Chang H,Li X,Teng Y,Liang Y,Peng B,Fang F,Chen Z

更新日期：2010-09-01 00:00:00

abstract：:Long noncoding RNAs (lncRNAs) play important roles in the development of human cancers. This is the first case-control study of the association between specific polymorphisms in lncRNA genes and the risk of lung cancer, as well as the gene-environment interaction between the polymorphisms and cooking oil fume exposure...

journal_title：DNA and cell biology

authors： Gao M,Li H,Lv X,Zhou B,Yin Z

更新日期：2018-08-01 00:00:00

abstract：:Polymerase chain reaction [PCR, reverse transcriptase-PCR (RT-PCR)] has been used to amplify the mRNA subspecies of the plasma membrane calcium pump isoform 1 (PMCA1) in total RNA extracted from hamster tissues. Two primers were synthesized that encompass the site at which a 154-bp exon is included totally (PMCA1a), p...

journal_title：DNA and cell biology

authors： Sarkar FH,Ball DE,Tsang W,Li YW,Kuo TH

更新日期：1993-06-01 00:00:00

abstract：:Single-nucleotide polymorphisms (SNPs) in pre-miRNAs may alter microRNA (miRNA) expression levels or processing and contribute to susceptibility to a wide range of diseases. We investigated the correlation between four SNPs (rs11614913, rs3746444, rs2910164, and rs229283) in pre-miRNAs and the risk of asthma in 220 as...

journal_title：DNA and cell biology

authors： Su XW,Yang Y,Lv ML,Li LJ,Dong W,Miao-Liao,Gao LB,Luo HB,Yun-Liu,Cong RJ,Liang WB,Li YB

更新日期：2011-11-01 00:00:00

abstract：:Chromosomal gain on 1q23-24 is a cytogenetic finding found in approximately 30% of bladder tumors. Currently, no defined or candidate tumor-associated genes from this region have been identified. The objective of this study was to identify and quantitate the expression of putative cancer genes located at this chromoso...

journal_title：DNA and cell biology

authors： Huang WC,Taylor S,Nguyen TB,Tomaszewski JE,Libertino JA,Malkowicz SB,McGarvey TW

更新日期：2002-10-01 00:00:00

abstract：:Gene expression is modulated by epigenetic factors that come in varying forms, such as DNA methylation, histone modifications, microRNAs, and long noncoding RNAs. Recent studies reveal that these epigenetic marks are important regulatory factors in brain function. In particular, DNA methylation dynamics are found to b...

journal_title：DNA and cell biology

authors： Irier HA,Jin P

更新日期：2012-10-01 00:00:00

abstract：:The computer program, SIGSEQ2, was used to select heterologous signal peptides from a catalog of published sequences to express the echistatin gene in insect (Sf9) cells. S-values for each amino acid were determined to select empirically the site of cleavage between the signal peptide and mature echistatin. Five gene ...

journal_title：DNA and cell biology

authors： Daugherty BL,Zavodny SM,Lenny AB,Jacobson MA,Ellis RW,Law SW,Mark GE

更新日期：1990-07-01 00:00:00

abstract：:Matrix metalloproteinase-7 (MMP-7) is a small secreted proteolytic enzyme with broad substrate specificity. Its expression is associated with tumor invasion, metastasis, and survival for a number of cancers. However, data from published studies with individually low statistical power are conflicting. Here, we performe...

journal_title：DNA and cell biology

authors： Yuan-Yuan M,Li-Feng Z,Li-Jie Z

更新日期：2012-05-01 00:00:00

abstract：:Culture of CHO.K1, a Chinese hamster ovary cell line, requires no particular care about the glucocorticoid level in media. Cell growth of CHO.K1 is little affected by dexamethasone at concentrations up to 3 microM. A clone of CHO.K1 stably transfected with an expression vector displayed a favored growth in dexamethaso...

journal_title：DNA and cell biology

authors： Chen GS,Lee CH,Lee YC,Chi CW,Liu YC

更新日期：1996-02-01 00:00:00

abstract：:We have further characterized the most distal of the three alpha-fetoprotein (AFP) enhancers required for expression of the AFP gene in fetal hepatocytes and yolk sac endodermal cells. Almost total rat AFP enhancer 3 (E3) activity is driven by a 160-bp fragment at -6 kb containing three target regions for nuclear prot...

journal_title：DNA and cell biology

authors： Thomassin H,Bois-Joyeux B,Delille R,Ikonomova R,Danan JL

更新日期：1996-12-01 00:00:00

abstract：:Metallothioneins (MT) are expressed during early development in species of several groups. To understand MT function in developmental processes, we studied the MT system of Xenopus laevis, a model vertebrate species in experimental embryology. We first purified and sequenced the liver MT from copper-treated animals. T...

journal_title：DNA and cell biology

authors： Muller JP,Wouters-Tyrou D,Erraiss NE,Vedel M,Touzet N,Mesnard J,Sautiere P,Wegnez M

更新日期：1993-05-01 00:00:00

abstract：:Sepsis is an inflammatory-related disease, and severe sepsis would induce multiorgan dysfunction, which is the most common cause of death of patients in noncoronary intensive care units. Progression of novel therapeutic strategies has proven to be of little impact on the mortality of severe sepsis, and unfortunately, ...

journal_title：DNA and cell biology

authors： Wang Y,Yin X,Yang F

更新日期：2018-02-01 00:00:00

abstract：:The transcription factor delta EF1 is a key player in estrogen-signaling cascades in vertebrates. In this pathway, estrogen induces the expression of the gene encoding delta EF1, and then delta EF1 activates transcription of downstream targets. Yet, the molecular mechanisms of transcriptional activation by delta EF1 h...

journal_title：DNA and cell biology

authors： Dillner NB,Sanders MM

更新日期：2004-01-01 00:00:00

abstract：:The major surface promoter of human hepatitis B virus can produce three distinct groups of S transcripts. The initiation sites of these transcripts are in close proximity. Encompassing the ATG for the middle surface protein, the largest S transcript (+1) encodes the middle surface protein whereas the other two (+20 an...

journal_title：DNA and cell biology

authors： Kuo YL,Ting LP

更新日期：1997-05-01 00:00:00

abstract：:Osteosarcoma is one of the most common primary malignant tumors of the bone and tends to develop in teenage years. Although multitreatments for the diagnosis and therapy of osteosarcoma have been developed, there are still needs of new methods to prevent and treat the osteosarcoma. Here, we performed bioinformatic ana...

journal_title：DNA and cell biology

authors： Zhou X,Fan Y,Ye W,Jia B,Yang Y,Liu Y

更新日期：2020-07-01 00:00:00

abstract：:The aim of this study was to determine the role of polymorphic variants of apolipoprotein E (APOE) and peroxisome proliferator-activated receptor delta (PPARD) genes in the development of coronary heart disease (CHD), and the PPARD and APOE gene-gene interaction in a Turkish population. This study was carried out usin...

journal_title：DNA and cell biology

authors： Yılmaz-Aydogan H,Kucukhuseyin O,Kurnaz O,Akadam-Teker B,Kurt O,Tekeli A,Ozturk O,Isbir T

更新日期：2012-05-01 00:00:00

abstract：:Congenital cataract refers to a lens opacity caused by multiple etiological factors, including genetic mutation, abnormal metabolism of the lens, and infection. Currently, there are >100 known disease-causing genes as well as 60 known mutations in the Cx46 gene (Gap junction alpha-3, GJA3) associated with congenital c...

journal_title：DNA and cell biology

authors： Li H,Jiang H,Rong R,Jiang J,Ji D,Song W,Xia X

更新日期：2020-10-01 00:00:00

abstract：:Several reports have suggested the importance of p73 polymorphisms in tumor behavior. We investigated the role of a p73 gene polymorphism in the susceptibility to cervical lesions in a southwestern European population. Peripheral blood samples were obtained from Radiotherapy and Gynaecology Departments of Portuguese I...

journal_title：DNA and cell biology

authors： Craveiro R,Bravo I,Catarino R,Teixeira AL,Sousa H,Pereira D,Pereira H,Medeiros R

更新日期：2012-02-01 00:00:00

abstract：:Diabetes is a worldwide health problem with increasing prevalence. Some reports indicate the interplay between bone and glucose metabolism. The imbalance between bone resorption and formation resulted in the structural integrity and strength of bone. Glucagon-like peptide-1 (GLP-1) and its agonists (Liraglutide) have ...

journal_title：DNA and cell biology

authors： Gao L,Li SL,Li YK

更新日期：2018-12-01 00:00:00

abstract：:Endogenous phytohormones auxin (indole-3-acetic acid [IAA]), abscisic acid (ABA), gibberellin (GA3), and brassinosteroid (BR) play a role in responses to drought stress in higher plants. Tea plant is one of the major economic corps worldwide. The tender shoots of tea plants are the main source for tea production. The ...

journal_title：DNA and cell biology

authors： Li H,Teng RM,Liu JX,Yang RY,Yang YZ,Lin SJ,Han MH,Liu JY,Zhuang J

更新日期：2019-11-01 00:00:00