Significantly increased cortisol secretion in normal adrenocortical cells transfected with K-ras mutants derived from human functional adrenocortical tumors.

abstract：:A human growth hormone expression construct was delivered intracellularly into the abdominal skin of mice by particle bombardment-mediated gene transfer. Using this technology, the in vivo delivery of antigen-encoding expression vectors affixed to gold microprojectiles results in de novo antigen production in target s...

journal_title：DNA and cell biology

authors： Eisenbraun MD,Fuller DH,Haynes JR

更新日期：1993-11-01 00:00:00

abstract：:Human immunodeficiency virus type 1 (HIV-1) is known for its ability to infect immune cells, including T-cells and macrophages. The 96-amino acid Vpr, a virion-associated protein, is essential for viral replication in monocytes/macrophages and increases viral replication in primary and established T-cell lines. The Vp...

journal_title：DNA and cell biology

authors： Muthumani K,Montaner LJ,Ayyavoo V,Weiner DB

更新日期：2000-03-01 00:00:00

abstract：:The gene encoding the mouse cellular retinoic acid-binding protein (CRABP) has been isolated from a mouse genomic library and its structure has been determined. This gene spans approximately 10.5 kb and consists of four exons encoding 24, 59, 38, and 16 amino acid residues, respectively. This gene structure is very si...

journal_title：DNA and cell biology

authors： Wei LN,Tsao JL,Chu YS,Jeannotte L,Nguyen-Huu MC

更新日期：1990-09-01 00:00:00

abstract：:Rheumatoid arthritis (RA) is a complex polygenic inflammatory disease associated with accelerated atherosclerosis, which is the main cause of increased cardiovascular (CV) morbidity and mortality in RA patients. CARD8 is a constituent of inflammasome, which regulates interleukin 1-beta production, and has been associa...

journal_title：DNA and cell biology

authors： García-Bermúdez M,López-Mejías R,González-Juanatey C,Corrales A,Castañeda S,Ortiz AM,Miranda-Filloy JA,Gómez-Vaquero C,Fernández-Gutiérrez B,Balsa A,Pascual-Salcedo D,Blanco R,Llorca J,Martín J,González-Gay MA

更新日期：2013-01-01 00:00:00

abstract：:Apoptotic endonuclease G (EndoG) is responsible for DNA fragmentation both during and after cell death. Previous studies demonstrated that genetic inactivation of EndoG is cytoprotective against various pro-apoptotic stimuli; however, specific inhibitors for EndoG are not available. In this study, we have developed a ...

journal_title：DNA and cell biology

authors： Jang DS,Penthala NR,Apostolov EO,Wang X,Crooks PA,Basnakian AG

更新日期：2015-02-01 00:00:00

abstract：:To study the complexity and structural characteristics of zinc finger proteins expressed during human hematopoiesis and to isolate novel regulators of blood cell development, a degenerate oligonucleotide probe specific for a consensus zinc finger peptide domain was used to isolate 63 cDNA clones for Krüppel-related zi...

journal_title：DNA and cell biology

authors： Abrink M,Aveskogh M,Hellman L

更新日期：1995-02-01 00:00:00

abstract：:Chlamydial infection of the lower genital tract usually spreads to the upper genital tract and is then responsible for more serious consequences, such as infertility, ectopic pregnancy, pelvic pain, and pelvic inflammatory disease. Genital infection with Chlamydia trachomatis and the resulting cytokine response largel...

journal_title：DNA and cell biology

authors： Srivastava P,Bhengraj AR,Jha HC,Vardhan H,Jha R,Singh LC,Salhan S,Mittal A

更新日期：2012-03-01 00:00:00

abstract：:G0S8 is a member of a set of putative G0/G1 switch regulatory genes (G0S genes) selected by screening cDNA libraries prepared from blood mononuclear cells cultured for 2 hr with lectin and cycloheximide. Comparison of a full-length cDNA sequence with the corresponding genomic sequence reveals an open reading frame of ...

journal_title：DNA and cell biology

authors： Siderovski DP,Heximer SP,Forsdyke DR

更新日期：1994-02-01 00:00:00

abstract：:Minimally modified low-density lipoprotein (MM-LDL) is regarded as a major risk factor for the development of atherosclerosis. In this report, we show that this lipoprotein complex can induce expression of an inflammatory protein, serum amyloid A (SAA), in monocyte/macrophage cells, a key cell type implicated in the p...

journal_title：DNA and cell biology

authors： Ray BK,Chatterjee S,Ray A

更新日期：1999-01-01 00:00:00

abstract：:A yeast two-hybrid system was used to identify mutants of Max that exhibit an increased affinity for Myc. Truncated forms of the Max helix-loop-helix/leucine zipper motif (HLH/Zip) were first expressed in a two- hybrid system in which the bait protein was the HLH/Zip motif of Myc. Deletion of amino acids both amino-te...

journal_title：DNA and cell biology

authors： Wang H,Van Den Bergh F,Spencer E,Wilcox K,Herman T

更新日期：1997-11-01 00:00:00

abstract：:In our previous study, a kind of novel hybrid immunoglobulin (Ig)-binding proteins (IBPs) was obtained with the characteristic structure of alternately arranged Finegoldia magna (formerly Peptostreptococcus magnus) protein L (P. magnus protein L, PpL) B3 domain (B3) and Staphylococcal protein A (SpA) D domain (D). In ...

journal_title：DNA and cell biology

authors： Jiang SH,Wang JF,Xu R,Liu YJ,Wang XN,Cao J,Zhao P,Shen YJ,Yang T,Yang H,Jia JA,Chen QL,Pan W

更新日期：2008-08-01 00:00:00

abstract：:The CAT gene is widely used as a reporter in eukaryotic systems because of the efficient translation of its mRNA. We report here that a sequence occurring in the CAT mRNA at +15 nucleotides from CAT AUG is essential for translation. This sequence includes a stem-loop structure, which, however, exhibits a calculated st...

journal_title：DNA and cell biology

authors： Ciullo M,Del Pozzo G,Autiero M,Guardiola J

更新日期：2000-01-01 00:00:00

abstract：:By using the methodology of both wet and dry biology (i.e., RT-PCR and cycle sequencing, and biocomputational technology, respectively) and the data obtained through the Genome Projects, we have cloned Xenopus laevis SOD2 (MnSOD) cDNA and determined its nucleotide sequence. These data and the deduced protein primary s...

journal_title：DNA and cell biology

authors： Purrello M,Di Pietro C,Ragusa M,Pulvirenti A,Giugno R,Di Pietro V,Emmanuele G,Travali S,Scalia M,Shasha D,Ferro A

更新日期：2005-02-01 00:00:00

abstract：:A recombinant baculovirus vAc beta hCG-luc was constructed that carried the cDNAs encoding firefly luciferase (luc) and beta-subunit of human chorionic gonadotropin (beta hCG) placed under the transcriptional control of individual copies of the baculovirus polyhedrin gene promoter. The simple, rapid, and sensitive det...

journal_title：DNA and cell biology

authors： Hasnain SE,Nakhai B,Ehtesham NZ,Sridhar P,Ranjan A,Talwar GP,Jha PK

更新日期：1994-03-01 00:00:00

abstract：:NADPH: quinone oxidoreductase 1 (NQO1) and dihydronicotinamide riboside: quinone oxidoreductase 2 (NQO2) are cytosolic enzymes that catalyze reductive activation of carcinogens from cigarette smoke, such as nitrosamines and heterocyclic amines. These enzymes also protect cells against oxidative damage from reactive ox...

journal_title：DNA and cell biology

authors： Malik MA,Zargar SA,Mittal B

更新日期：2011-05-01 00:00:00

abstract：:The linkage of rheumatoid arthritis (RA) to HLA-DR haplotypes, high levels of HLA-DR expression, and T-cell infiltration in the joints, indicate a central role for the interaction of T-cell receptors (TCR) with antigen (Ag) + major histocompatibility complex (MHC) complexes in pathogenesis. Receptor analysis in RA has...

journal_title：DNA and cell biology

authors： Keiber-Emmons T,Fang Q,Cai W,Friedman SM,Crow MK,Lotke P,Williams WV

更新日期：1998-02-01 00:00:00

abstract：:Disruption of cell-matrix interactions can lead to anoikis-apoptosis due to loss of matrix contacts. We previously showed that Nerve/glial antigen 2 (NG2) is a novel anoikis receptor. Specifically, overexpression of NG2 leads to anoikis propagation, whereas its suppression leads to anoikis attenuation. Interestingly, ...

journal_title：DNA and cell biology

authors： Joo NE,Miao D,Bermúdez M,Stallcup WB,Kapila YL

更新日期：2014-12-01 00:00:00

abstract：:Most of the signal pathways involved in ultraviolet (UV)-induced skin carcinogenesis are thought to originate at plasma membrane receptors. However, UVA-induced signal transduction to downstream ribosomal protein S6 kinases, p70(S6K) and p90(RSK), is not well understood. In this report, we show that UVA stimulation of...

journal_title：DNA and cell biology

authors： Zhang Y,Dong Z,Bode AM,Ma WY,Chen N,Dong Z

更新日期：2001-12-01 00:00:00

abstract：:Promoter elements located up to 2 kb upstream of the apolipoprotein A-I (apoA-I) gene are necessary for apoA-I expression in liver and intestine cells in tissue culture. In transgenic mice, a distal enhancer located between the apoA-IV and apoC-III genes is additionally necessary for tissue-specific expression of apoA...

journal_title：DNA and cell biology

authors： Jones DR,Leffak M

更新日期：1999-02-01 00:00:00

abstract：:Type 2 cystatins comprise a class of cysteine peptidase inhibitor presumed to mediate protective functions at various locations, including the oral cavity. Seven cystatin genes are clustered within a 300-kb region of human 20p11.2. "Salivary" cystatins, encoded by CST1, 2, 4, and 5, are present in saliva at significan...

journal_title：DNA and cell biology

authors： Dickinson DP,Thiesse M,Hicks MJ

更新日期：2002-01-01 00:00:00

abstract：:A highly conserved aspartic acid residue present in the third membrane-spanning region of adrenergic and muscarinic receptors is directly involved in ligand binding. The five cloned somatostatin receptor subtypes also contain this residue at the same relative position. To test whether Asp-124 of the rat somatostatin r...

journal_title：DNA and cell biology

authors： Nehring RB,Meyerhof W,Richter D

更新日期：1995-11-01 00:00:00

abstract：:Age-related macular degeneration (AMD) is a disease with multifactorial etiology characterized by irreversible loss of central visual acuity. The discovery of susceptive single-nucleotide polymorphisms (SNPs) has progressed our understanding of AMD. Complement factor H (CFH) gene Y402H polymorphism and high-temperatur...

journal_title：DNA and cell biology

authors： Soysal Y,Inan UÜ,Küsbeci T,Imirzalioğlu N

更新日期：2012-03-01 00:00:00

abstract：:Transgenic mice expressing interleukin-12 (IL-12) under the glial fibrillary acidic protein (GFAP) promoter were evaluated for their sensitivity to herpes simplex virus type 1 (HSV-1) infection of the cornea. There was a modest but significant decrease in the infiltration of mononuclear cells in the cornea of the GFAP...

journal_title：DNA and cell biology

authors： Carr DJ,Ash J,Al-Khatib K,Campbell IL

更新日期：2002-05-01 00:00:00

abstract：:The spike (S) protein, a main surface antigen of the SARS coronavirus (SARS-CoV), is considered to be one of the most important protective antigen candidates for targets for vaccine design against the virus. In this study, a secreted recombinant expression plasmid, pVAX-S1, encoding the partial S protein with a signal...

journal_title：DNA and cell biology

authors： He H,Tang Y,Qin X,Xu W,Wang Y,Liu X,Liu X,Xiong S,Li J,Zhang M,Duan M

更新日期：2005-08-01 00:00:00

abstract：:The major surface promoter of human hepatitis B virus can produce three distinct groups of S transcripts. The initiation sites of these transcripts are in close proximity. Encompassing the ATG for the middle surface protein, the largest S transcript (+1) encodes the middle surface protein whereas the other two (+20 an...

journal_title：DNA and cell biology

authors： Kuo YL,Ting LP

更新日期：1997-05-01 00:00:00

abstract：:The development of the pancreas is a complicated process that is regulated on several levels. Pancreas transcription factor 1, alpha subunit (Ptf1a), also known as p48, is a pancreas-specific basic helix-loop-helix transcription factor that is critical for both exocrine pancreas development and maintenance of acinar c...

journal_title：DNA and cell biology

authors： Lu CK,Lai YC,Chen HR,Chiang MK

更新日期：2012-07-01 00:00:00

abstract：:The search for new chemotherapeutics unaffected by efflux pumps would significantly increase life expectancy in patients with malignant cancers. In this study, butylcycloheptylprodigiosin and undecylprodigiosin were HPLC-purified and verified, using nuclear magnetic resonance spectroscopy. Cell cytotoxicity and transp...

journal_title：DNA and cell biology

authors： Mirzaei SA,Safari Kavishahi M,Keshavarz Z,Elahian F

更新日期：2018-06-01 00:00:00

abstract：:2-Arylbenzothiazoles are an important class of bicyclic privileged substructures present in various natural or synthetic compounds that have been shown to possess anticancer, antifungal, antibacterial, anti-inflammatory, and antiallergic activities. This study examined the antiproliferative properties of 2-(3,5-dihydr...

journal_title：DNA and cell biology

authors： Rajabi M

更新日期：2012-03-01 00:00:00

abstract：:Interleukin-6 (IL-6) signaling may play a causal role in the development of coronary heart disease. However, the relationship between IL-6 genotypes and plasma levels of IL-6 appears to be complex. To help clarify the inconsistent findings, we conducted a meta-analysis of the published genetic association studies of t...

journal_title：DNA and cell biology

authors： Huang M,Wang L,Ma H,Wang J,Xiang M

更新日期：2013-11-01 00:00:00

abstract：:Triple-negative breast cancer (TNBC) refers to breast cancer without significant expression of estrogen receptor (ER), progesterone receptor (PR), or human epidermal growth factor receptor 2. We sought to identify the hub genes and find the potential progression mechanism of TNBC as well as immunotherapeutic targets. ...

journal_title：DNA and cell biology

authors： Wang F,Cao X,Yin L,Wang Q,He Z

更新日期：2020-10-01 00:00:00