Cloning and characterization of two human polyspecific organic cation transporters.

abstract：:Hepatic fibrosis is a reversible process involving plenty of transcription factors and pathways. Vitamin D receptor (VDR) as a member of ligand-induced transcription factors can interact with 9-cis retinoid X receptor (RXR) and VDR-interacting repressor (VDIR) to mediate transactivation or transrepression in the absen...

journal_title：DNA and cell biology

authors： Wan LY,Zhang YQ,Li JM,Tang HQ,Chen MD,Ni YR,Huang H,Liu CB,Wu JF

更新日期：2016-09-01 00:00:00

abstract：:Heme plays a significant pathogenic role in several diseases involving the kidney. The cellular content of heme, derived either from the delivery of filtered heme proteins such as hemoglobin and myoglobin, or from the breakdown of ubiquitous intracellular heme proteins, is regulated via the heme oxygenase enzyme syste...

journal_title：DNA and cell biology

authors： Hill-Kapturczak N,Chang SH,Agarwal A

更新日期：2002-04-01 00:00:00

abstract：:The sugars will eventually be exported transporters (SWEET) gene family is a glycoprotein gene family that can regulate the transport of sugar in plants and plays an important role in plant growth and development, as well as in response to environmental stress. In this study, Kentucky bluegrass (cv. Baron) seedlings w...

journal_title：DNA and cell biology

authors： Zhang R,Niu K,Ma H

更新日期：2020-09-01 00:00:00

abstract：:The role of p53 in mediating nitric oxide (NO)-induced cell death remains uncertain. The exogenous NO donor S-nitrosoglutathione (GSNO) produced a concentration-dependent reduction in cell viability in embryonic chick cardiomyocytes in culture. Western blotting and immunocytochemistry for p53 showed that p53 was incre...

journal_title：DNA and cell biology

authors： Klassen SS,Rabkin SW

更新日期：2007-07-01 00:00:00

abstract：:The CAT gene is widely used as a reporter in eukaryotic systems because of the efficient translation of its mRNA. We report here that a sequence occurring in the CAT mRNA at +15 nucleotides from CAT AUG is essential for translation. This sequence includes a stem-loop structure, which, however, exhibits a calculated st...

journal_title：DNA and cell biology

authors： Ciullo M,Del Pozzo G,Autiero M,Guardiola J

更新日期：2000-01-01 00:00:00

abstract：:The human immunodeficiency virus type I (HIV-1) accessory protein Vpr has been associated with the induction of programmed cell death (apoptosis) and cell-cycle arrest. Studies have shown the apoptotic effect of Vpr on primary and established cell lines and on diverse tissues including the central nervous system (CNS)...

journal_title：DNA and cell biology

authors： Cheng X,Mukhtar M,Acheampong EA,Srinivasan A,Rafi M,Pomerantz RJ,Parveen Z

更新日期：2007-02-01 00:00:00

abstract：:Gene therapy depends on safe and efficient gene delivery. The skin is an attractive target for gene delivery because of its accessibility. Recently, in vivo electroporation has been shown to enhance expression after injection of plasmid DNA. In this study, we examined the use of electroporation to deliver plasmid DNA ...

journal_title：DNA and cell biology

authors： Heller R,Schultz J,Lucas ML,Jaroszeski MJ,Heller LC,Gilbert RA,Moelling K,Nicolau C

更新日期：2001-01-01 00:00:00

abstract：:Mutations in the mitochondrial genome (mtDNA) are associated with different types of cancer, specifically colorectal cancer (CRC). However, few studies have been performed on precancerous lesions, such as ulcerative colitis (UC) lesions and adenomatous polyps (AP). The aim of this study was to identify mtDNA mutations...

journal_title：DNA and cell biology

authors： Kassem AM,El-Guendy N,Tantawy M,Abdelhady H,El-Ghor A,Abdel Wahab AH

更新日期：2011-11-01 00:00:00

abstract：:The major surface promoter of human hepatitis B virus can produce three distinct groups of S transcripts. The initiation sites of these transcripts are in close proximity. Encompassing the ATG for the middle surface protein, the largest S transcript (+1) encodes the middle surface protein whereas the other two (+20 an...

journal_title：DNA and cell biology

authors： Kuo YL,Ting LP

更新日期：1997-05-01 00:00:00

abstract：:The aim of this study was to determine the role of polymorphic variants of apolipoprotein E (APOE) and peroxisome proliferator-activated receptor delta (PPARD) genes in the development of coronary heart disease (CHD), and the PPARD and APOE gene-gene interaction in a Turkish population. This study was carried out usin...

journal_title：DNA and cell biology

authors： Yılmaz-Aydogan H,Kucukhuseyin O,Kurnaz O,Akadam-Teker B,Kurt O,Tekeli A,Ozturk O,Isbir T

更新日期：2012-05-01 00:00:00

abstract：:Proopiomelanocortin (POMC) is expressed predominantly in the corticotrophic cells of the pituitary. Regulatory sequences required for the expression of the human (h) POMC gene were investigated using transient expression of hPOMC-CAT fusion genes in pituitary and nonpituitary cells in combination with DNase I footprin...

journal_title：DNA and cell biology

authors： Kraus J,Buchfelder M,Höllt V

更新日期：1993-07-01 00:00:00

abstract：:Insulin-like growth factor I (IGF-I) plays a major role in development and metabolism. Currently, the cDNA-derived primary structure of IGF-I is known for some mammals and for chicken, frog, and salmon. Additionally, the organization of the human, rat, and chicken IGF-I genes has been established. The investigation of...

journal_title：DNA and cell biology

authors： Kavsan VM,Koval AP,Grebenjuk VA,Chan SJ,Steiner DF,Roberts CT Jr,LeRoith D

更新日期：1993-10-01 00:00:00

abstract：:Most studies on the tissue distribution of actin isoform transcripts have been done in small mammals such as rat and mouse. We have begun a characterization of the actin gene family in a large mammal, the bovine. The alpha skeletal gene was isolated, and an isoform-specific probe to the 3' untranslated region of the t...

journal_title：DNA and cell biology

authors： Davey HW,Wildeman AG

更新日期：1995-06-01 00:00:00

abstract：:Apoptosis, which is usually accompanied by DNA degradation, is important not only for the homeostasis of metazoans but also for mammalian development. If DNA is not properly degraded in these processes, it can cause diverse diseases, such as anemia, cataracts, and some autoimmune diseases. A large effort has been made...

journal_title：DNA and cell biology

authors： Liu MF,Wu XP,Wang XL,Yu YL,Wang WF,Chen QJ,Boireau P,Liu MY

更新日期：2008-05-01 00:00:00

abstract：:Endothelin-converting enzyme-1 (ECE1) plays a key role in the development of a subset of neural crest lineages such as cardiogenesis. Genetic variants of ECE1 C338A (rs213045) and T839G (rs213046) have been shown to alter ECE1 expression. This observation led us to hypothesize that two polymorphisms might influence th...

journal_title：DNA and cell biology

authors： Wang Y,Liu Y,Peng W,Wang M,Sun J,Zhang Z,Mo X

更新日期：2012-08-01 00:00:00

abstract：:The glandular kallikrein family is composed of structurally related serine proteases. Studies show that the mouse family encompasses at least 14 highly conserved functional genes, but of these only the tissue kallikarein has a human ortholog. In man, the tissue kallikrein display high sequence similarity with prostate...

journal_title：DNA and cell biology

authors： Olsson AY,Persson AM,Valtonen-André C,Lundwall A

更新日期：2000-12-01 00:00:00

abstract：:We have further characterized the most distal of the three alpha-fetoprotein (AFP) enhancers required for expression of the AFP gene in fetal hepatocytes and yolk sac endodermal cells. Almost total rat AFP enhancer 3 (E3) activity is driven by a 160-bp fragment at -6 kb containing three target regions for nuclear prot...

journal_title：DNA and cell biology

authors： Thomassin H,Bois-Joyeux B,Delille R,Ikonomova R,Danan JL

更新日期：1996-12-01 00:00:00

abstract：:Rheumatoid arthritis (RA) is a complex polygenic inflammatory disease associated with accelerated atherosclerosis, which is the main cause of increased cardiovascular (CV) morbidity and mortality in RA patients. CARD8 is a constituent of inflammasome, which regulates interleukin 1-beta production, and has been associa...

journal_title：DNA and cell biology

authors： García-Bermúdez M,López-Mejías R,González-Juanatey C,Corrales A,Castañeda S,Ortiz AM,Miranda-Filloy JA,Gómez-Vaquero C,Fernández-Gutiérrez B,Balsa A,Pascual-Salcedo D,Blanco R,Llorca J,Martín J,González-Gay MA

更新日期：2013-01-01 00:00:00

abstract：:Several studies have revealed that miR-205 plays important roles in the development of gynecological cancers and thus may serve as a potential prognostic biomarker, but the current conclusions remain controversial. Therefore, the goal of this study was to explore the prognostic significance and functional mechanisms o...

journal_title：DNA and cell biology

authors： Wu Z,Tang H,Xiong Q,Liu D,Xia T,Liang H,Ye Q

更新日期：2020-05-01 00:00:00

abstract：:dTMP kinase (E.C.2.7.4.9.) catalyzes the phosphorylation of dTMP to the corresponding diphosphate. This enzyme is essential for DNA synthesis in vivo and is an important intermediate enzyme in the pathway of many pyrimidine analog drugs. In this report, we describe the isolation of the human dTMP kinase gene by functi...

journal_title：DNA and cell biology

authors： Huang SH,Tang A,Drisco B,Zhang SQ,Seeger R,Li C,Jong A

更新日期：1994-05-01 00:00:00

abstract：:A primary response of the avian intestine to 1,25-dihydroxyvitamin D3 [1,25-(OH)2D3] is increased synthesis of a 28-kD calcium-binding protein, calbindin-D28k (CaBP). This study examined whether 1,25-(OH)2D3 regulates CaBP gene transcription by an interaction of the vitamin D receptor (VDR) with a vitamin D-responsive...

journal_title：DNA and cell biology

authors： Macdonald PN,Whitfield GK,Haussler CA,Hocker AM,Haussler MR,Komm BS

更新日期：1992-06-01 00:00:00

abstract：:Nd1-S is the nuclear-localizing short variant form of Nd1 (Ivns1abp) encoding a Kelch family transcription factor. While the function of Nd1 has been investigated in the context of metastasis and doxorubicin-induced cardiotoxicity, little is known about its role in hematopoiesis. In this study, we investigated the fun...

journal_title：DNA and cell biology

authors： Lin Y,Luo Y,Hu F,Wang T,Dong Y,Yang D,He X,Chen X,Wang J,Du J,Zhang X

更新日期：2018-10-01 00:00:00

abstract：:Head and neck squamous cell carcinoma (HNSCC) is a malignancy with relatively high incidence and poor prognosis. RNA-binding proteins (RBPs) were reported to be dysregulated in multiple cancers and were closely associated with tumor initiation and progression. However, an integrated analysis of the roles of RBPs in HN...

journal_title：DNA and cell biology

authors： Jin Y,Qin X

更新日期：2020-10-01 00:00:00

abstract：:Transgenic mice expressing interleukin-12 (IL-12) under the glial fibrillary acidic protein (GFAP) promoter were evaluated for their sensitivity to herpes simplex virus type 1 (HSV-1) infection of the cornea. There was a modest but significant decrease in the infiltration of mononuclear cells in the cornea of the GFAP...

journal_title：DNA and cell biology

authors： Carr DJ,Ash J,Al-Khatib K,Campbell IL

更新日期：2002-05-01 00:00:00

abstract：:Genomic instability and epigenetic alterations are distinct hallmarks shared by cancer and aging. Sirtuins (SIRTs) are class III histone deacetylases that regulate gene expression in response to cellular metabolic status. SIRTs can modulate chromatin function through direct deacetylation of histones and by promoting a...

journal_title：DNA and cell biology

authors： Wu X,Cao N,Fenech M,Wang X

更新日期：2016-10-01 00:00:00

abstract：:Normal embryo development in oviparous (egg-laying) species requires the coordinated targeting to growing oocytes of nutrients and regulatory molecules such as retinol, the precursor of active retinoids. Serum retinol-binding protein (RBP) is the major carrier protein for retinol in the circulatory system of vertebrat...

journal_title：DNA and cell biology

authors： Vieira AV,Kuchler K,Schneider WJ

更新日期：1995-05-01 00:00:00

abstract：:Endocytosis of the five rat somatostatin receptor subtypes (SSTR1-5) was investigated in transfected HEK cells by biochemical ligand binding assays and confocal microscopic analysis. Phenylarsine oxide-sensitive internalization of SSTR1-3 is dependent on SST-14 or SST-28, whereas only the octacosapeptide triggers this...

journal_title：DNA and cell biology

authors： Roth A,Kreienkamp HJ,Nehring RB,Roosterman D,Meyerhof W,Richter D

更新日期：1997-01-01 00:00:00

abstract：:Genes involved in the production of nitric oxide (NO) have been suggested as genetic factors for migraine. It has been studied whether polymorphisms in the genes encoding for different types of NO synthase (NOS) could be involved in the liability to migraine; however, most studies yield negative results. The pentanucl...

journal_title：DNA and cell biology

authors： Jia S,Ni J,Chen S,Jiang Y,Dong W,Gao Y

更新日期：2011-02-01 00:00:00

abstract：:Accumulating evidence has suggested that microRNAs play important roles in the development of hepatocellular carcinoma (HCC) and are involved in drug resistance. miR-21-5p was overexpressed in a variety of cancers and promoted the tumorigenesis; however, the function of miR-21-5p in HCC still remains unknown. In this ...

journal_title：DNA and cell biology

authors： Chen S,Yang C,Sun C,Sun Y,Yang Z,Cheng S,Zhuge B

更新日期：2019-08-01 00:00:00

abstract：:Six identical cDNA clones corresponding to an RNA of 1685 nucleotides that is enriched in mouse sperm compared with testis were isolated from a mouse testis cDNA library. The sequence of these clones corresponds to the 16S mitochondrial RNA plus an inverted repeat of 120 bp covalently joined to the 5' end of the RNA. ...

journal_title：DNA and cell biology

authors： Villegas J,Zárraga AM,Muller I,Montecinos L,Werner E,Brito M,Meneses AM,Burzio LO

更新日期：2000-09-01 00:00:00