Abstract:
:Mitochondrial dysfunction arises from an inadequate number of mitochondria, an inability to provide necessary substrates to mitochondria, or a dysfunction in their electron transport and a denosine triphosphate synthesis machinery. Occurrences of mitochondrial dysfunction are due to genetic or environmental changes in the mitochondria or in the nuclear DNA that codes mitochondrial components. Currently, drug options are available, yet no treatment exists in sight of this disease and needs a new insight into molecular and signaling pathways for this disease. microRNAs (miRNAs) are small, endogenous, and noncoding RNAs function as a master regulator of gene expression. The evolution of miRNAs in the past two decades emerged as a key regulator of gene expression that controls physiological pathological cellular differentiation processes, and metabolic homeostasis such as development and cancer. It has been known that miRNAs are a potential biomarker in both communicable and noncommunicable diseases. But, in the case of mitochondrial dysfunction in miRNAs, the number of studies and investigations are comparatively less than those on other diseases and dysfunctions. In this review, we have elaborated the roles of miRNAs in the mitochondrial diseases and dysfunctions.
journal_name
DNA Cell Bioljournal_title
DNA and cell biologyauthors
Sekar D,Johnson J,Biruntha M,Lakhmanan G,Gurunathan D,Ross Kdoi
10.1089/dna.2019.5013subject
Has Abstractpub_date
2020-08-01 00:00:00pages
1379-1384issue
8eissn
1044-5498issn
1557-7430journal_volume
39pub_type
杂志文章,评审abstract::A subtractive cloning procedure was used to characterize the molecular changes involved in transformation of normal myoblasts to rhabdomyosarcoma (RMS) cells. Here we describe the cloning of DRAL, a novel LIM-domain protein expressed in primary myoblasts but down-regulated in the RMS cell line RD. DRAL is a LIM-only p...
journal_title:DNA and cell biology
pub_type: 杂志文章
doi:10.1089/dna.1997.16.433
更新日期:1997-04-01 00:00:00
abstract::At supramolecular resolution, DNA synthesis begins at preferred replication origins in the chromosomes of metazoan cells. To characterize one of these origins in detail, the initiation of replication was examined in the HeLa c-myc origin. Polymerase chain reaction (PCR) amplification of size-fractionated nascent chrom...
journal_title:DNA and cell biology
pub_type: 杂志文章
doi:10.1089/dna.1998.17.885
更新日期:1998-10-01 00:00:00
abstract::Thioredoxin peroxidase (TPx) is an antioxidant protein that limits the activity of reactive oxygen species (ROS). We cloned the cDNA encoding the mouse homolog of TPx from an E14.5 brain cDNA library and analyzed its distribution and function in murine tissues. Comparison of the amino acid sequence of mouse TPx with t...
journal_title:DNA and cell biology
pub_type: 杂志文章
doi:10.1089/dna.1997.16.311
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journal_title:DNA and cell biology
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journal_title:DNA and cell biology
pub_type: 杂志文章
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更新日期:1997-02-01 00:00:00
abstract::The potential association of variant surface glycoprotein (VSG) gene expression with clonal expression of virulence in African trypanosomes was addressed. Two populations of clonally related trypanosomes, which differ dramatically in virulence for the infected host, but display the same apparent VSG surface coat pheno...
journal_title:DNA and cell biology
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journal_title:DNA and cell biology
pub_type: 杂志文章
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更新日期:2019-10-01 00:00:00
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journal_title:DNA and cell biology
pub_type: 杂志文章
doi:10.1089/dna.1998.17.811
更新日期:1998-09-01 00:00:00
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journal_title:DNA and cell biology
pub_type: 杂志文章
doi:10.1089/dna.2016.3271
更新日期:2016-11-01 00:00:00
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journal_title:DNA and cell biology
pub_type: 杂志文章
doi:10.1089/dna.2011.1325
更新日期:2012-03-01 00:00:00
abstract::The coupling of viral and arthropod host diversity, with evolving methods of virus discovery, has resulted in the identification and classification of a growing number of novel insect-specific viruses (ISVs) that appear to be evolutionarily related to many human pathogens but have either lost or have yet to gain the a...
journal_title:DNA and cell biology
pub_type: 杂志文章
doi:10.1089/dna.2017.4019
更新日期:2017-12-01 00:00:00
abstract::Congenital cataract refers to a lens opacity caused by multiple etiological factors, including genetic mutation, abnormal metabolism of the lens, and infection. Currently, there are >100 known disease-causing genes as well as 60 known mutations in the Cx46 gene (Gap junction alpha-3, GJA3) associated with congenital c...
journal_title:DNA and cell biology
pub_type: 杂志文章
doi:10.1089/dna.2020.5605
更新日期:2020-10-01 00:00:00
abstract::Protein-RNA complexation is essential in cell biological functions. Transfer RNAs are bound to aminoacyl-tRNA synthetases for the translation of the genetic code during protein synthesis, while ribonucleoproteins bind RNA in posttranscriptional regulation of gene expression. A recent report showed the interacton of hu...
journal_title:DNA and cell biology
pub_type: 杂志文章
doi:10.1089/dna.2006.25.393
更新日期:2006-07-01 00:00:00
abstract::Cytochrome P450c17 catalyzes the 17alpha-hydroxylase/17,20 lyase activity needed for sex steroid synthesis. We recently characterized the nuclear phosphoprotein SET as a novel transcriptional regulator that binds to the -447/-399 region of the rat P450c17 gene, along with the transcription factors COUP-TF II, NGF-IB, ...
journal_title:DNA and cell biology
pub_type: 杂志文章
doi:10.1089/104454901753340604
更新日期:2001-10-01 00:00:00
abstract::Immune dysregulation has been implicated in myelodysplastic syndrome (MDS) pathogenesis. Refractory anemia with ringed sideroblasts (RARS) is a low-risk subtype of MDS. Our previous study has reported an abnormal γδ T cell receptor (TCR) repertoire in patients with intermediate or high-risk MDS. To characterize the st...
journal_title:DNA and cell biology
pub_type: 杂志文章
doi:10.1089/dna.2015.2925
更新日期:2015-09-01 00:00:00
abstract::The aim of this study was to investigate, for the first time, the effects of using adipose-derived mesenchymal stem cells (AD-MSCs) transfected with an episomal plasmid encoding fibroblast growth factor 1 (FGF1) (AD-MSCsFGF1), in providing the microenvironment required for angiogenic proliferation. The isolated rat AD...
journal_title:DNA and cell biology
pub_type: 杂志文章
doi:10.1089/dna.2016.3546
更新日期:2017-05-01 00:00:00
abstract::Uterine corpus endometrial carcinoma (UCEC) is one of the leading causes of death from gynecological cancer due to the high recurrence rate. A recent study indicated that molecular biomarkers can enhance the recurrence prediction power if they were integrated with clinical information. In this study, we attempted to i...
journal_title:DNA and cell biology
pub_type: 杂志文章
doi:10.1089/dna.2019.5148
更新日期:2020-04-01 00:00:00
abstract::In this study, we isolated two cDNA molecules encoding putative glutamate receptor subunits, fGluR1 alpha and fGluR1 beta, from an Oreochromis sp. brain cDNA library by hybridizing with the glutamate receptor cDNA, fGluR2 beta, of the same fish. The deduced amino acid sequence of the fGluR1 alpha consists of 908 resid...
journal_title:DNA and cell biology
pub_type: 杂志文章
doi:10.1089/dna.1996.15.717
更新日期:1996-09-01 00:00:00
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journal_title:DNA and cell biology
pub_type: 杂志文章
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journal_title:DNA and cell biology
pub_type: 杂志文章
doi:10.1089/dna.1996.15.443
更新日期:1996-06-01 00:00:00
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journal_title:DNA and cell biology
pub_type: 杂志文章,评审
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更新日期:1993-06-01 00:00:00
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journal_title:DNA and cell biology
pub_type: 杂志文章,meta分析
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更新日期:2014-06-01 00:00:00
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journal_title:DNA and cell biology
pub_type: 杂志文章
doi:10.1089/104454900750058080
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journal_title:DNA and cell biology
pub_type: 杂志文章
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journal_title:DNA and cell biology
pub_type: 杂志文章
doi:10.1089/dna.2020.5377
更新日期:2020-07-01 00:00:00
abstract::DNA condensed agents can improve the transfection efficiency of the cationic liposome delivery system. However, various condensed agents have distinct transfection efficiency and cellular cytotoxicity. The object of this study was to screen the optimal agents with the high transfection efficiency and low cytotoxicity ...
journal_title:DNA and cell biology
pub_type: 杂志文章
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更新日期:2019-10-01 00:00:00
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journal_title:DNA and cell biology
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journal_title:DNA and cell biology
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abstract::Transgenic mice expressing interleukin-12 (IL-12) under the glial fibrillary acidic protein (GFAP) promoter were evaluated for their sensitivity to herpes simplex virus type 1 (HSV-1) infection of the cornea. There was a modest but significant decrease in the infiltration of mononuclear cells in the cornea of the GFAP...
journal_title:DNA and cell biology
pub_type: 杂志文章
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