Intradermal delivery of interleukin-12 plasmid DNA by in vivo electroporation.

abstract：:This study aimed to construct a breast cancer model that could continuously express the genes of luciferase and green fluorescent protein. The genes luciferase, EGFP, and Neo were obtained by fusion polymerase chain reaction (PCR) and inserted into pAAV-MCS. The pAAV-Luciferase-EGFP-Neo vector was transfected into MDA...

journal_title：DNA and cell biology

authors： Huang C,Lan W,Wang F,Zhang C,Liu X,Chen Q

更新日期：2017-01-01 00:00:00

abstract：:Hearing loss in Ménière's disease (MD) is associated with loss of spiral ganglion neurons and hair cells. In a guinea pig model of endolymphatic hydrops, nitric oxide synthases (NOS) and oxidative stress mediate loss of spiral ganglion neurons. To test the hypothesis that functional variants of NOS1 and NOS2A are asso...

journal_title：DNA and cell biology

authors： Gazquez I,Lopez-Escamez JA,Moreno A,Campbell CA,Meyer NC,Carey JP,Minor LB,Gantz BJ,Hansen MR,Della Santina CC,Aran I,Soto-Varela A,Santos S,Batuecas A,Perez-Garrigues H,Lopez-Nevot A,Smith RJ,Lopez-Nevot MA

更新日期：2011-09-01 00:00:00

abstract：:Hepatic fibrosis is a reversible process involving plenty of transcription factors and pathways. Vitamin D receptor (VDR) as a member of ligand-induced transcription factors can interact with 9-cis retinoid X receptor (RXR) and VDR-interacting repressor (VDIR) to mediate transactivation or transrepression in the absen...

journal_title：DNA and cell biology

authors： Wan LY,Zhang YQ,Li JM,Tang HQ,Chen MD,Ni YR,Huang H,Liu CB,Wu JF

更新日期：2016-09-01 00:00:00

abstract：:The development of the pancreas is a complicated process that is regulated on several levels. Pancreas transcription factor 1, alpha subunit (Ptf1a), also known as p48, is a pancreas-specific basic helix-loop-helix transcription factor that is critical for both exocrine pancreas development and maintenance of acinar c...

journal_title：DNA and cell biology

authors： Lu CK,Lai YC,Chen HR,Chiang MK

更新日期：2012-07-01 00:00:00

abstract：:BRCA1-associated protein-1 (BAP1) is an important nuclear-localized deubiquitinating enzyme. Dysregulation of BAP1 has been reported in many types of cancers. However, there are few articles on the role of BAP1 in osteosarcoma (OS) and the molecular mechanisms of BAP1 in OS remain largely unknown. In this study, we ex...

journal_title：DNA and cell biology

authors： Gao S,Sun H,Cheng C,Wang G

更新日期：2017-05-01 00:00:00

abstract：:Type 1 diabetes results in most cases from the destruction of insulin-secreting beta cells by the immune system. Several immunization methods based on administration of autoantigenic polypeptides such as insulin and glutamic acid decarboxylase (GAD) have been used to prevent autoimmune diabetes in the non-obese diabet...

journal_title：DNA and cell biology

authors： Filippova M,Liu J,Escher A

更新日期：2001-03-01 00:00:00

abstract：:Metallothioneins (MT) are expressed during early development in species of several groups. To understand MT function in developmental processes, we studied the MT system of Xenopus laevis, a model vertebrate species in experimental embryology. We first purified and sequenced the liver MT from copper-treated animals. T...

journal_title：DNA and cell biology

authors： Muller JP,Wouters-Tyrou D,Erraiss NE,Vedel M,Touzet N,Mesnard J,Sautiere P,Wegnez M

更新日期：1993-05-01 00:00:00

abstract：:Mitochondrial FAD-linked glycerol-3-phosphate dehydrogenase (mtGPDH) is one of the two enzymes of the glycerol phosphate shuttle. This shuttle transfers reducing equivalents from the cytoplasm to the mitochondria in a unidirectional, exothermic manner. Here, the isolation and characterization of the rat nuclear gene (...

journal_title：DNA and cell biology

authors： Gong DW,Bi S,Weintraub BD,Reitman M

更新日期：1998-03-01 00:00:00

abstract：:The linkage of rheumatoid arthritis (RA) to HLA-DR haplotypes, high levels of HLA-DR expression, and T-cell infiltration in the joints, indicate a central role for the interaction of T-cell receptors (TCR) with antigen (Ag) + major histocompatibility complex (MHC) complexes in pathogenesis. Receptor analysis in RA has...

journal_title：DNA and cell biology

authors： Keiber-Emmons T,Fang Q,Cai W,Friedman SM,Crow MK,Lotke P,Williams WV

更新日期：1998-02-01 00:00:00

abstract：:Protein-RNA complexation is essential in cell biological functions. Transfer RNAs are bound to aminoacyl-tRNA synthetases for the translation of the genetic code during protein synthesis, while ribonucleoproteins bind RNA in posttranscriptional regulation of gene expression. A recent report showed the interacton of hu...

journal_title：DNA and cell biology

authors： Malonga H,Neault JF,Tajmir-Riahi HA

更新日期：2006-07-01 00:00:00

abstract：:Treatment with demethylating drugs can induce demethylation and reactivation of abnormally silenced tumor suppressor genes in cancer cells, but it can also induce potentially deleterious loss of methylation of repetitive elements. To enable the observation of unwanted drug effects related to loss of methylation of rep...

journal_title：DNA and cell biology

authors： Huang X,Narayanaswamy R,Fenn K,Szpakowski S,Sasaki C,Costa J,Blancafort P,Lizardi PM

更新日期：2012-10-01 00:00:00

abstract：:Design and synthesis of new small molecules binding to double-stranded RNA necessitate complete understanding of the molecular aspects of the binding of many existing molecules. Toward this goal, in this work we evaluated the biophysical aspects of the interaction of a DNA intercalator (proflavine) and a minor groove ...

journal_title：DNA and cell biology

authors： Sinha R,Hossain M,Kumar GS

更新日期：2009-04-01 00:00:00

abstract：:CD95 (Fas/APO-1)-mediated apoptosis appears to be regulated by positive and negative signaling molecules. A human CD40/CD95 chimeric receptor was stably transfected into CD95-expressing human Jurkat T cells, and signaling through native and chimeric CD95 was compared in the same cell type to assess contributions of th...

journal_title：DNA and cell biology

authors： Rudert F,Wang Y,Lindridge E,Watson J

更新日期：1997-02-01 00:00:00

abstract：:The activation of H-plk (Human-proviral linked Krüppel), a human Krüppel-related zinc finger gene in organs such as placenta, adrenal cortex, and testis, is probably due to insertion of an endogenous retrovirus, ERV3, upstream of the gene. Several differently spliced transcripts originate from this locus, e.g., a tran...

journal_title：DNA and cell biology

authors： Abrink M,Larsson E,Hellman L

更新日期：1998-01-01 00:00:00

abstract：:The murine 18A2/mts1 and its human homolog h-mts1 (S100A4), encoding a Ca2+-binding protein belonging to the S-100 family, are associated with high invasive and metastatic potentials of murine tumors, human tumor cell lines in vitro, and human tumors growing as xenografts. The nm23 is a putative metastasis-suppressor ...

journal_title：DNA and cell biology

authors： Albertazzi E,Cajone F,Leone BE,Naguib RN,Lakshmi MS,Sherbet GV

更新日期：1998-04-01 00:00:00

abstract：:FOXO3 is a member of the Forkhead box class O (FOXO) transcription factor family that modulates the transcription of target genes in a variety of cellular functions in lower animals to mammals. It has been implicated in the attenuation of insulin-signaling pathways, including having a potential role in lifespan contro...

journal_title：DNA and cell biology

authors： Byun SO,Zhou H,Hickford JG

更新日期：2011-07-01 00:00:00

abstract：:ERGIC2 (formerly known as PTX1) is a gene identified by subtractive hybridization on the basis that it is expressed in normal human prostate, but not in prostate carcinoma. It is unrelated to the gene encoding pituitary homeobox protein (Ptx1 or Pitx1), which regulates pituitary hormone gene expression. Based on seque...

journal_title：DNA and cell biology

authors： Kwok SC,Kumar S,Dai G

更新日期：2014-02-01 00:00:00

abstract：:Deer antlers are amazing natural appendages that grow faster than any other known mammalian bone. Antler growth occurs at the tip and is initially cartilage, which is later replaced by bone tissue. However, little is known regarding the precise role of cooperation between cell lineages and functional genes in regulati...

journal_title：DNA and cell biology

authors： Yao B,Zhang M,Liu M,Wang Q,Liu M,Zhao Y

更新日期：2018-01-01 00:00:00

abstract：:Ginsenoside, a natural triterpenoid saponin, exhibits immunomodulatory and anticancer activities. In the present study, we demonstrated that ginsenoside Rg1 induced secretion of cytokines, including interleukin (IL)-6, tumor necrosis factor-alpha (TNF-α), and IL-1β, and chemokines such as IL-8 and IP-10 in a dose-depe...

journal_title：DNA and cell biology

authors： Huang Y,Zou Y,Lin L,Zheng R

更新日期：2017-12-01 00:00:00

abstract：:The aromatic hydrocarbon receptor (AHR) is a ligand-activated transcription factor that regulates the expression of several drug-metabolizing enzymes and has been implicated in immunosuppression, teratogenesis, cell-specific hyperplasia, and certain types of malignancies and toxicities. The mouse Ahr gene 5' proximal ...

journal_title：DNA and cell biology

authors： Fitzgerald CT,Nebert DW,Puga A

更新日期：1998-09-01 00:00:00

abstract：:Gulf War Illness (GWI) affects about 25% of Persian Gulf veterans with a cluster of chronic symptoms, including immune dysfunction and neurological issues. Recent studies implicate gene expression changes in immune function to be associated with GWI. Since DNA methylation can regulate such changes in gene expression, ...

journal_title：DNA and cell biology

authors： Trivedi MS,Abreu MM,Sarria L,Rose N,Ahmed N,Beljanski V,Fletcher MA,Klimas NG,Nathanson L

更新日期：2019-06-01 00:00:00

abstract：:Intestinal phospholipase A/lysophospholipase (IPAL) is an intestine-specific brush-border enzyme expressed during development and along the intestinal crypt-villus axis in a pattern similar to another well characterized brush-border enzyme, sucrase-isomaltase (SI). A tissue-specific DNase I hypersensitive site was ide...

journal_title：DNA and cell biology

authors： Taylor JK,Boll W,Levy T,Suh E,Siang S,Mantei N,Traber PG

更新日期：1997-12-01 00:00:00

abstract：:The mdmx gene was shown to possess high homology to the mdm-2 gene and to encode a protein that can bind p53 and block p53 transactivation. Because Mdm-2 protein blocks the growth-suppressive activity of the p53 tumor-suppressor protein through similar activities, we examined the expression patterns of mdmx to determi...

journal_title：DNA and cell biology

authors： Jackson MW,Berberich SJ

更新日期：1999-09-01 00:00:00

abstract：:Chemokine-like factor (CKLF)-like MARVEL transmembrane domain containing protein 6 (CMTM6) is a ubiquitously expressed protein, which plays a critical role in the stability of programmed death-ligand 1. However, the expression of CMTM6 in a variety of cancer pathological tissues is not clear. Therefore, 109 patients w...

journal_title：DNA and cell biology

authors： Hou X,He S,Zhang D,Yang C,Shi Y,Zhang K

更新日期：2020-10-21 00:00:00

abstract：:RUNX2 is a member of the RUNX family of transcription factors, also containing the RUNX1 and RUNX3 proteins. These factors control the expression of genes essential for proper development in many cell lineages. RUNX2 plays a crucial role in the proliferation and differentiation of osteoblasts, required for bone format...

journal_title：DNA and cell biology

authors： Wysokinski D,Pawlowska E,Blasiak J

更新日期：2015-05-01 00:00:00

abstract：:The distribution and evolutionary pattern of the conserved microsatellite repeat sequences (CA)n, (TGG)6, and (GGAT)4 were studied to determine the divergence time and phylogenetic position of the water buffalo, Bubalus bubalis. The mean allelic frequencies of these repeat loci showed a high level of heterozygosity am...

journal_title：DNA and cell biology

authors： Mattapallil MJ,Ali S

更新日期：1999-06-01 00:00:00

abstract：:The Wilms' tumor gene 1 (WT1) protein is a transcriptional regulator that is highly expressed in immature hematopoietic progenitor cells and in the majority of patients with acute and chronic myeloid leukemia. However, it is still unclear how WT1 exerts its function(s) in hematopoietic cells. The aim of this work was ...

journal_title：DNA and cell biology

authors： Svensson E,Vidovic K,Olofsson T,Vallon-Christersson J,Borg A,Gullberg U

更新日期：2007-08-01 00:00:00

abstract：:Traditional histological classification of lung cancer subtypes is informative, but incomplete. Recent studies of gene expression suggest that molecular classification can be used for effective diagnostic and prediction of the treatment outcome. We attempt to build a molecular classification based on the public data a...

journal_title：DNA and cell biology

authors： Ptitsyn A

更新日期：2004-10-01 00:00:00

abstract：:Temporal coordination of meiosis with spermatid morphogenesis is crucial for successful generation of mature sperm cells. We identified a recessive male sterile Drosophila melanogaster mutant, mitoshell, in which events of spermatid morphogenesis are initiated too early, before meiotic onset. Premature mitochondrial a...

journal_title：DNA and cell biology

authors： Bergner LM,Hickman FE,Wood KH,Wakeman CM,Stone HH,Campbell TJ,Lightcap SB,Favors SM,Aldridge AC,Hales KG

更新日期：2010-09-01 00:00:00

abstract：:The aim of this study is to present a mathematical computer simulation model for multistage carcinogenesis. The population genetic model is developed based on the reaction diffusion, logistic behavior, and Hollings Type II interactions between normal, benign, and premalignant cells. The simple form of the Fisher-Halda...

journal_title：DNA and cell biology

authors： Ahangar R,Ali N,Iqbal K,Altmayer K

更新日期：2004-10-01 00:00:00