Comparison of intestinal phospholipase A/lysophospholipase and sucrase-isomaltase genes suggest a common structure for enterocyte-specific promoters.

abstract：:The murine 18A2/mts1 and its human homolog h-mts1 (S100A4), encoding a Ca2+-binding protein belonging to the S-100 family, are associated with high invasive and metastatic potentials of murine tumors, human tumor cell lines in vitro, and human tumors growing as xenografts. The nm23 is a putative metastasis-suppressor ...

journal_title：DNA and cell biology

authors： Albertazzi E,Cajone F,Leone BE,Naguib RN,Lakshmi MS,Sherbet GV

更新日期：1998-04-01 00:00:00

abstract：PURPOSE:This case-control study was conducted in order to evaluate the potential role of polymorphic genes encoding enzymes involved in estrogen biosynthesis (CYP19A1) and metabolism (GSTM1, GSTT1, and GSTP1), and their action in modulating individual susceptibility to breast cancer. METHODS:Genomic DNA was extracted ...

journal_title：DNA and cell biology

authors： Ramalhinho AC,Fonseca-Moutinho JA,Breitenfeld Granadeiro LA

更新日期：2012-06-01 00:00:00

abstract：:Hearing loss in Ménière's disease (MD) is associated with loss of spiral ganglion neurons and hair cells. In a guinea pig model of endolymphatic hydrops, nitric oxide synthases (NOS) and oxidative stress mediate loss of spiral ganglion neurons. To test the hypothesis that functional variants of NOS1 and NOS2A are asso...

journal_title：DNA and cell biology

authors： Gazquez I,Lopez-Escamez JA,Moreno A,Campbell CA,Meyer NC,Carey JP,Minor LB,Gantz BJ,Hansen MR,Della Santina CC,Aran I,Soto-Varela A,Santos S,Batuecas A,Perez-Garrigues H,Lopez-Nevot A,Smith RJ,Lopez-Nevot MA

更新日期：2011-09-01 00:00:00

abstract：:Apelin, an endogenous ligand for apelin receptor (APJ), is reported to be involved in cardiomyocyte hypertrophy. In this study, we explored the mechanism of cardiomyocyte hypertrophy induced by apelin-13/APJ system. Left ventricular hypertrophy (LVH) rat model was established by constricting the abdominal aorta. Weste...

journal_title：DNA and cell biology

authors： Wu D,Xie F,Xiao L,Feng F,Huang S,He L,Liu M,Zhou Q,Li L,Chen L

更新日期：2017-08-01 00:00:00

abstract：:This research aims to investigate the immune-associated gene signature from databases to improve the prognostic value in hepatocellular carcinoma (HCC) by multidimensional methods using various bioinformatic methods. Fifty-one immune-associated genes were mined out, which were associated with clinical characters throu...

journal_title：DNA and cell biology

authors： Chen W,Tang D,Ou M,Dai Y

更新日期：2020-04-01 00:00:00

abstract：:The spike (S) protein, a main surface antigen of the SARS coronavirus (SARS-CoV), is considered to be one of the most important protective antigen candidates for targets for vaccine design against the virus. In this study, a secreted recombinant expression plasmid, pVAX-S1, encoding the partial S protein with a signal...

journal_title：DNA and cell biology

authors： He H,Tang Y,Qin X,Xu W,Wang Y,Liu X,Liu X,Xiong S,Li J,Zhang M,Duan M

更新日期：2005-08-01 00:00:00

abstract：:Matrix metalloproteinase-7 (MMP-7) is a small secreted proteolytic enzyme with broad substrate specificity. Its expression is associated with tumor invasion, metastasis, and survival for a number of cancers. However, data from published studies with individually low statistical power are conflicting. Here, we performe...

journal_title：DNA and cell biology

authors： Yuan-Yuan M,Li-Feng Z,Li-Jie Z

更新日期：2012-05-01 00:00:00

abstract：:To investigate the contribution of de novo variants to Tourette disorder (TD) probands in China. Whole-exome sequencing (WES) conducted on 15 child-parent trios (45 samples) detected 25 coding de novo variants, including 2 de novo Likely Gene Disrupting (LGD) variants and 6 Missense3 variants. The de novo LGD variants...

journal_title：DNA and cell biology

authors： Zhao X,Wang S,Hao J,Zhu P,Zhang X,Wu M

更新日期：2020-01-01 00:00:00

abstract：:The sex steroid hormone progesterone modulates the developmental and lactogenic activity of prolactin in the mammary gland. Regulation of the level of prolactin receptor (PRLR) provides one possible mechanism by which this may occur, prompting this investigation of the molecular mechanisms involved in progestin regula...

journal_title：DNA and cell biology

authors： Ormandy CJ,Graham J,Kelly PA,Clarke CL,Sutherland RL

更新日期：1992-12-01 00:00:00

abstract：:Nd1-S is the nuclear-localizing short variant form of Nd1 (Ivns1abp) encoding a Kelch family transcription factor. While the function of Nd1 has been investigated in the context of metastasis and doxorubicin-induced cardiotoxicity, little is known about its role in hematopoiesis. In this study, we investigated the fun...

journal_title：DNA and cell biology

authors： Lin Y,Luo Y,Hu F,Wang T,Dong Y,Yang D,He X,Chen X,Wang J,Du J,Zhang X

更新日期：2018-10-01 00:00:00

abstract：:This study aimed to investigate the expression and clinical significance of chemokine-like factor-like MARVEL transmembrane domain-containing family member 2 (CMTM2) in hepatocellular carcinoma (HCC) tissues. Bioinformatics analysis showed that CMTM2 was downregulated in HCC tissues and correlated with vascular invasi...

journal_title：DNA and cell biology

authors： Guo X,Zhang S,Tan S,Bei C,Zhang H,Zhu X,Qiu X

更新日期：2020-04-01 00:00:00

abstract：:Head and neck cancers (head and neck squamous cell carcinomas [HNSCC]) are a heterogeneous group of neoplasms with varying presenting symptoms, treatment, and expected outcome. There is a need to find an effective way of its treatment at the molecular level. Thus, we should identify the mechanism of cancer cell respon...

journal_title：DNA and cell biology

authors： Walczak A,Rusin P,Dziki L,Zielinska-Blizniewska H,Olszewski J,Majsterek I

更新日期：2012-03-01 00:00:00

abstract：:NADPH: quinone oxidoreductase 1 (NQO1) and dihydronicotinamide riboside: quinone oxidoreductase 2 (NQO2) are cytosolic enzymes that catalyze reductive activation of carcinogens from cigarette smoke, such as nitrosamines and heterocyclic amines. These enzymes also protect cells against oxidative damage from reactive ox...

journal_title：DNA and cell biology

authors： Malik MA,Zargar SA,Mittal B

更新日期：2011-05-01 00:00:00

abstract：:Minimally modified low-density lipoprotein (MM-LDL) is regarded as a major risk factor for the development of atherosclerosis. In this report, we show that this lipoprotein complex can induce expression of an inflammatory protein, serum amyloid A (SAA), in monocyte/macrophage cells, a key cell type implicated in the p...

journal_title：DNA and cell biology

authors： Ray BK,Chatterjee S,Ray A

更新日期：1999-01-01 00:00:00

abstract：:The mdmx gene was shown to possess high homology to the mdm-2 gene and to encode a protein that can bind p53 and block p53 transactivation. Because Mdm-2 protein blocks the growth-suppressive activity of the p53 tumor-suppressor protein through similar activities, we examined the expression patterns of mdmx to determi...

journal_title：DNA and cell biology

authors： Jackson MW,Berberich SJ

更新日期：1999-09-01 00:00:00

abstract：:Chlamydial infection of the lower genital tract usually spreads to the upper genital tract and is then responsible for more serious consequences, such as infertility, ectopic pregnancy, pelvic pain, and pelvic inflammatory disease. Genital infection with Chlamydia trachomatis and the resulting cytokine response largel...

journal_title：DNA and cell biology

authors： Srivastava P,Bhengraj AR,Jha HC,Vardhan H,Jha R,Singh LC,Salhan S,Mittal A

更新日期：2012-03-01 00:00:00

abstract：:Gene expression is modulated by epigenetic factors that come in varying forms, such as DNA methylation, histone modifications, microRNAs, and long noncoding RNAs. Recent studies reveal that these epigenetic marks are important regulatory factors in brain function. In particular, DNA methylation dynamics are found to b...

journal_title：DNA and cell biology

authors： Irier HA,Jin P

更新日期：2012-10-01 00:00:00

abstract：:A yeast two-hybrid system was used to identify mutants of Max that exhibit an increased affinity for Myc. Truncated forms of the Max helix-loop-helix/leucine zipper motif (HLH/Zip) were first expressed in a two- hybrid system in which the bait protein was the HLH/Zip motif of Myc. Deletion of amino acids both amino-te...

journal_title：DNA and cell biology

authors： Wang H,Van Den Bergh F,Spencer E,Wilcox K,Herman T

更新日期：1997-11-01 00:00:00

abstract：:CYP24A1 is overexpressed in colorectal cancer, and the reason for the dysregulation of CYP24A1 in colorectal cancer is still unknown. In the present study, experiments were designed to test whether CYP24A1 inhibition facilitated the antiproliferative effect of 1,25(OH)2D3. In addition, the role of methylation in the r...

journal_title：DNA and cell biology

authors： Sun H,Jiang C,Cong L,Wu N,Wang X,Hao M,Liu T,Wang L,Liu Y,Cong X

更新日期：2018-09-01 00:00:00

abstract：:Chromosomal gain on 1q23-24 is a cytogenetic finding found in approximately 30% of bladder tumors. Currently, no defined or candidate tumor-associated genes from this region have been identified. The objective of this study was to identify and quantitate the expression of putative cancer genes located at this chromoso...

journal_title：DNA and cell biology

authors： Huang WC,Taylor S,Nguyen TB,Tomaszewski JE,Libertino JA,Malkowicz SB,McGarvey TW

更新日期：2002-10-01 00:00:00

abstract：:Homomeric and heteromeric interactions among cell-surface tyrosine kinase receptors belonging to the ErbB family lead to intracellular signaling cascades which are involved in cell activation, cytoskeletal interactions, and cellular transformation leading to neoplasia. Monoclonal antibodies which specifically bind to ...

journal_title：DNA and cell biology

authors： Peterson NC,Greene MI

更新日期：1998-12-01 00:00:00

abstract：:Apoptosis, which is usually accompanied by DNA degradation, is important not only for the homeostasis of metazoans but also for mammalian development. If DNA is not properly degraded in these processes, it can cause diverse diseases, such as anemia, cataracts, and some autoimmune diseases. A large effort has been made...

journal_title：DNA and cell biology

authors： Liu MF,Wu XP,Wang XL,Yu YL,Wang WF,Chen QJ,Boireau P,Liu MY

更新日期：2008-05-01 00:00:00

abstract：:We demonstrated earlier that post-exposure prophylaxis with 3'-azido-3'-deoxythymidine (AZT, zidovudine) or with AZT + interferon-alpha (IFN-alpha) prevented viremia and disease in BALB/c mice inoculated with Rauscher murine leukemia virus (RLV). After the 20-day treatment course, most animals were resistant to rechal...

journal_title：DNA and cell biology

authors： Ruprecht RM,Bronson R

更新日期：1994-01-01 00:00:00

abstract：:The globally distributed American cockroach (Periplaneta americana) is considered a pest, but it has been widely used in traditional Chinese medicine. In the past, the American cockroach's genome and transcriptomes were sequenced, but the differential expression transcripts between developmental stages were unavailabl...

journal_title：DNA and cell biology

authors： Zeng C,Li W,Liao Q,Yan T,Wang K,Hu Y,Shen Y,Price M,Fan Z,Zhang X,Yue B,Geng F,Chen L

更新日期：2019-10-01 00:00:00

abstract：:Polymorphisms such as single-nucleotide polymorphisms (SNPs) and insertions/deletions (Indels) can be associated with phenotypic traits and be used as markers for disease diagnosis. Identification of these genetic variations within laboratory mice is crucial to improve our understanding of the genetic background of th...

journal_title：DNA and cell biology

authors： Lo CL,Shen F,Baumgarner K,Cramer MJ,Lossie AC

更新日期：2012-03-01 00:00:00

abstract：:We have screened an Aplysia atrial gland cDNA library using a prohormone convertase (PC)1 probe prepared by polymerase chain reaction (PCR) and have isolated an Aplysia PC1-related full-length 3.6-kb cDNA clone. The cDNA sequence (3,565 bp) encoded a putative preproendoprotease (APC1) of 703 amino acid residues that s...

journal_title：DNA and cell biology

authors： Gorham EL,Nagle GT,Smith JS,Shen H,Kurosky A

更新日期：1996-04-01 00:00:00

abstract：:Endogenous phytohormones auxin (indole-3-acetic acid [IAA]), abscisic acid (ABA), gibberellin (GA3), and brassinosteroid (BR) play a role in responses to drought stress in higher plants. Tea plant is one of the major economic corps worldwide. The tender shoots of tea plants are the main source for tea production. The ...

journal_title：DNA and cell biology

authors： Li H,Teng RM,Liu JX,Yang RY,Yang YZ,Lin SJ,Han MH,Liu JY,Zhuang J

更新日期：2019-11-01 00:00:00

abstract：:Previous studies showed that when growth hormone-releasing hormone (GHRH) was administered to either pregnant rats or pigs as a plasmid-mediated therapy, pituitary weight, somatotroph and lactotroph numbers, and postnatal growth rate of the offspring increased. To determine if these responses resulted from direct effe...

journal_title：DNA and cell biology

authors： Fiorotto ML,Lopez R,Oliver WT,Khan AS,Draghia-Akli R

更新日期：2006-08-01 00:00:00

abstract：:We evaluated the effects of administration of 1,25-dihydroxyvitamin D (1,25(OH)2D) during pregnancy on relieving adverse outcomes of preeclampsia and the pathologic and biochemical changes in reduction in uteroplacental perfusion (RUPP) model of rats. On day 1, 7, and 14 of pregnancy, rats in pregnant RUPP plus 1,25(O...

journal_title：DNA and cell biology

authors： Tian X,Ma S,Wang Y,Hou L,Shi Y,Yao M,Wang X,Zhang H,Jiang L

更新日期：2016-02-01 00:00:00

abstract：:Host cell-derived danger-associated molecular patterns (DAMPs), such as the hemoglobin (Hb) can interact with the innate immune system either directly or through binding to pathogen-associated molecular patterns (PAMPs). Hemolysis occurs under various pathological conditions, leading to hemoglobinemia. In the extracel...

journal_title：DNA and cell biology

authors： Lee SK,Ding JL

更新日期：2013-02-01 00:00:00