Chemoprevention of retroviral infection: success is determined by virus inoculum strength and cellular immunity.

abstract：:Protein-RNA complexation is essential in cell biological functions. Transfer RNAs are bound to aminoacyl-tRNA synthetases for the translation of the genetic code during protein synthesis, while ribonucleoproteins bind RNA in posttranscriptional regulation of gene expression. A recent report showed the interacton of hu...

journal_title：DNA and cell biology

authors： Malonga H,Neault JF,Tajmir-Riahi HA

更新日期：2006-07-01 00:00:00

abstract：:The serotonin (5-hydroxytryptamine) transporter (5HTt) gene has been reported to be associated with suicidal behavior. In this study, we have investigated the 5' promoter region (i.e., 5HTt gene-linked polymorphic region [5-HTTLPR]) and a 17-base pair variable number of tandem repeats polymorphism in the 5HTt gene for...

journal_title：DNA and cell biology

authors： Akar T,Sayin A,Bakkaloğlu Z,Cabuk DK,Küçükyildirim S,Demirel B,Candansayar S,Ozsoy ED,Mergen H

更新日期：2010-08-01 00:00:00

abstract：:Nd1-S is the nuclear-localizing short variant form of Nd1 (Ivns1abp) encoding a Kelch family transcription factor. While the function of Nd1 has been investigated in the context of metastasis and doxorubicin-induced cardiotoxicity, little is known about its role in hematopoiesis. In this study, we investigated the fun...

journal_title：DNA and cell biology

authors： Lin Y,Luo Y,Hu F,Wang T,Dong Y,Yang D,He X,Chen X,Wang J,Du J,Zhang X

更新日期：2018-10-01 00:00:00

abstract：:The liver has an excellent capacity for regeneration when faced with external injury and the damage differs from that of other organs in the body. Our aim was to identify the role of circular RNA (circRNA) during the DNA synthesis phase (36 h) of mice liver regeneration. High-throughput RNA sequencing was conducted to...

journal_title：DNA and cell biology

authors： Zhang J,Xu L,Wang P,Zheng X,Hu Y,Luo J,Zhang M,Xu M

更新日期：2020-11-01 00:00:00

abstract：:Single-nucleotide polymorphisms (SNPs) in pre-miRNAs may alter microRNA (miRNA) expression levels or processing and contribute to susceptibility to a wide range of diseases. We investigated the correlation between four SNPs (rs11614913, rs3746444, rs2910164, and rs229283) in pre-miRNAs and the risk of asthma in 220 as...

journal_title：DNA and cell biology

authors： Su XW,Yang Y,Lv ML,Li LJ,Dong W,Miao-Liao,Gao LB,Luo HB,Yun-Liu,Cong RJ,Liang WB,Li YB

更新日期：2011-11-01 00:00:00

abstract：:Regenerative medicine is a new interdisciplinary field in biomedical science, which aims at the repair or replacement of the defective tissue or organ by congenital defects, age, injury, or disease. Various cell-related techniques such as stem cell-based biotherapy are a hot topic in the current press, and stem cell r...

journal_title：DNA and cell biology

authors： Guo J,Wang H,Hu X

更新日期：2013-10-01 00:00:00

abstract：:Host cell-derived danger-associated molecular patterns (DAMPs), such as the hemoglobin (Hb) can interact with the innate immune system either directly or through binding to pathogen-associated molecular patterns (PAMPs). Hemolysis occurs under various pathological conditions, leading to hemoglobinemia. In the extracel...

journal_title：DNA and cell biology

authors： Lee SK,Ding JL

更新日期：2013-02-01 00:00:00

abstract：:In this study, we isolated two cDNA molecules encoding putative glutamate receptor subunits, fGluR1 alpha and fGluR1 beta, from an Oreochromis sp. brain cDNA library by hybridizing with the glutamate receptor cDNA, fGluR2 beta, of the same fish. The deduced amino acid sequence of the fGluR1 alpha consists of 908 resid...

journal_title：DNA and cell biology

authors： Wu YM,Kung SS,Chen J,Chow WY

更新日期：1996-09-01 00:00:00

abstract：:Zidovudine (AZT) is widely used in the treatment of human immunodeficiency virus (HIV) infection because of its ability to act as a false substrate for the viral reverse transcriptase. AZT in the clinical setting has also been shown to produce significant hematologic and other toxicity, even though prior reports in th...

journal_title：DNA and cell biology

authors： Nusbaum NJ,Joseph PE

更新日期：1996-05-01 00:00:00

abstract：:Epulopiscium sp. type B, a member of the Firmicutes, is a large (up to 300 microm), cigar-shaped bacterial symbiont of surgeonfish that propagates itself by forming multiple intracellular offspring. This unusual form of reproduction is an apparent modification of a developmental program used by some Firmicutes to prod...

journal_title：DNA and cell biology

authors： Ward RJ,Clements KD,Choat JH,Angert ER

更新日期：2009-02-01 00:00:00

abstract：:Viral factor has been implicated in the etiopathogenesis of vitiligo. To elucidate the effects of viral double-stranded RNA (dsRNA) on melanocytes and to explore the underlying mechanisms, primary cultured normal human melanocytes were treated with synthetic viral dsRNA analog poly(I:C). The results demonstrated that ...

journal_title：DNA and cell biology

authors： Wang S,Liu D,Jin R,Zhu Y,Xu A

更新日期：2015-06-01 00:00:00

abstract：:Dilated cardiomyopathy (DCM) is a common type of cardiomyopathy. The pathogenesis of DCM remains unclear and involves varied genes. AXIN1 is a crucial gene in regulating various functions in cells, it encodes protein Axin1, which regulates the assembly and disassembly of β-catenin destruction complex. In addition, Wnt...

journal_title：DNA and cell biology

authors： Li K,Zhong Y,Peng Y,Zhou B,Wang Y,Li Q,Zhang Y,Song H,Rao L

更新日期：2019-05-01 00:00:00

abstract：:The gene encoding the mouse cellular retinoic acid-binding protein (CRABP) has been isolated from a mouse genomic library and its structure has been determined. This gene spans approximately 10.5 kb and consists of four exons encoding 24, 59, 38, and 16 amino acid residues, respectively. This gene structure is very si...

journal_title：DNA and cell biology

authors： Wei LN,Tsao JL,Chu YS,Jeannotte L,Nguyen-Huu MC

更新日期：1990-09-01 00:00:00

abstract：:Signal transducer and activator of transcription 3 (STAT3) is an important oncogenic transcription factor residing in the cytoplasm in the resting cells. Upon stimulation, STAT3 is activated and translocated to the nucleus to regulate target genes. Although the canonical transcriptional function of STAT3 has been inte...

journal_title：DNA and cell biology

authors： Yan B,Xie S,Liu Z,Luo Y,Zhou J,Li D,Liu M

更新日期：2015-04-01 00:00:00

abstract：:Mammalian cumulus-oocyte complexes (COCs) reach full developmental capability during folliculogenesis and oogenesis. It is well recognized that only gametes achieving MII stage after in vivo or in vitro maturation (IVM) are successfully fertilized by a single spermatozoon. Although the process of oocyte nuclear and/or...

journal_title：DNA and cell biology

authors： Budna J,Bryja A,Celichowski P,Kranc W,Ciesiółka S,Borys S,Rybska M,Kolecka-Bednarczyk A,Jeseta M,Bukowska D,Antosik P,Brüssow KP,Bruska M,Nowicki M,Zabel M,Kempisty B

更新日期：2017-08-01 00:00:00

abstract：:Butyrate is a naturally occurring product of colonic microbial fermentation of dietary carbohydrates that escape hydrolysis in the small intestine. Butyrate plays a significant role in the maintenance of colonic tissue homeostasis by regulating the expression of genes associated with the processes of proliferation, di...

journal_title：DNA and cell biology

authors： Daly K,Shirazi-Beechey SP

更新日期：2006-01-01 00:00:00

abstract：:It is well known that the positively charged polyamines have a DNA-stabilizing function and that polyamine depletion alters chromatin function. We have previously shown that polyamine depletion causes an S phase prolongation, and others have shown that there is an accumulation of Okazaki-like fragments in polyamine-de...

journal_title：DNA and cell biology

authors： Johansson VM,Oredsson SM,Alm K

更新日期：2008-09-01 00:00:00

abstract：:The aim of this study is to discuss the hypothesis that expression of plasma atherosclerosis-associated microRNAs (miRNAs) in hyperhomocysteinemia (Hhcy) patients could predict the presence of atherosclerosis from different channels. Six plasma miRNAs (miR-145, miR-155, miR-222, miR-133, miR-217, and miR-30) selected ...

journal_title：DNA and cell biology

authors： Liu K,Xuekelati S,Zhou K,Yan Z,Yang X,Inayat A,Wu J,Guo X

更新日期：2018-03-01 00:00:00

abstract：:We have cloned a putative yeast homolog of the gene encoding the human Tat-binding protein, TBP-1. The gene termed TBPY encodes a 45,243-dalton protein displaying a heptad repeat of hydrophobic amino acids reminiscent of a leucine zipper. Secondary structure predictions suggest the possibility of formation of an amphi...

journal_title：DNA and cell biology

authors： Goyer C,Lee HS,Malo D,Sonenberg N

更新日期：1992-10-01 00:00:00

abstract：:Normal embryo development in oviparous (egg-laying) species requires the coordinated targeting to growing oocytes of nutrients and regulatory molecules such as retinol, the precursor of active retinoids. Serum retinol-binding protein (RBP) is the major carrier protein for retinol in the circulatory system of vertebrat...

journal_title：DNA and cell biology

authors： Vieira AV,Kuchler K,Schneider WJ

更新日期：1995-05-01 00:00:00

abstract：:Mitochondrial dysfunction arises from an inadequate number of mitochondria, an inability to provide necessary substrates to mitochondria, or a dysfunction in their electron transport and a denosine triphosphate synthesis machinery. Occurrences of mitochondrial dysfunction are due to genetic or environmental changes in...

journal_title：DNA and cell biology

authors： Sekar D,Johnson J,Biruntha M,Lakhmanan G,Gurunathan D,Ross K

更新日期：2020-08-01 00:00:00

abstract：:Hepatocyte nuclear factor-1alpha (HNF-1alpha) is a homeodomain-containing transcription factor regulating the expression of liver and pancreas-specific genes. Mutations in the HNF-1alpha-encoding gene TCF1 cause maturity-onset diabetes of the young, type 3 (MODY3). These mutations may affect nuclear import or reduce t...

journal_title：DNA and cell biology

authors： Bjørkhaug L,Bratland A,Njølstad PR,Molven A

更新日期：2005-11-01 00:00:00

abstract：:The aim of this work was to express a eukaryotic pre-protein in Escherichia coli so that it could be obtained intact, without cleavage, by bacterial leader peptidase. To this end, cDNA coding for honeybee prepromelittin was ligated to the 3' end of genes coding for truncated forms of either Protein A or beta-galactosi...

journal_title：DNA and cell biology

authors： He M,Liu H,Austen B

更新日期：1994-08-01 00:00:00

abstract：:The mammalian CYP2E1 gene encodes a cytochrome P450 enzyme that is markedly increased soon after birth. In vitro evidence suggests that the rat CYP2E1 gene is positively regulated by the transcription factor HNF-1 or a protein displaying DNA-binding properties similar to HNF-1. In contrast to newborn wild-type mice an...

journal_title：DNA and cell biology

authors： Gonzalez FJ,Liu SY,Kozak CA,Nebert DW

更新日期：1990-12-01 00:00:00

abstract：:Most studies on the tissue distribution of actin isoform transcripts have been done in small mammals such as rat and mouse. We have begun a characterization of the actin gene family in a large mammal, the bovine. The alpha skeletal gene was isolated, and an isoform-specific probe to the 3' untranslated region of the t...

journal_title：DNA and cell biology

authors： Davey HW,Wildeman AG

更新日期：1995-06-01 00:00:00

abstract：:Gene delivery from tissue engineering scaffold is a novel strategy in regulating long-term growth and function of cells in vitro culture. In this study, a hepatocyte growth factor plasmid/polyetherimide (pHGF/PEI) polyplex delivering alginate (AL)/galactosylated chitosan (GC) (pHGF/PEI-AL/GC) sponge scaffold was prepa...

journal_title：DNA and cell biology

authors： Gao C,Yang Y,Zhang Y,Qian M,Yang J

更新日期：2020-03-01 00:00:00

abstract：:Insulin-like growth factor I (IGF-I) plays a major role in development and metabolism. Currently, the cDNA-derived primary structure of IGF-I is known for some mammals and for chicken, frog, and salmon. Additionally, the organization of the human, rat, and chicken IGF-I genes has been established. The investigation of...

journal_title：DNA and cell biology

authors： Kavsan VM,Koval AP,Grebenjuk VA,Chan SJ,Steiner DF,Roberts CT Jr,LeRoith D

更新日期：1993-10-01 00:00:00

abstract：:In IL-5 transgenic mice (C3H/HeN-TgN(IL-5)-Imeg), in which 50% of peripheral blood leukocytes are eosinophils, the development of infection by Leishmania amazonensis was clearly suppressed. To determine mechanistically how this protozoan parasite is killed, we performed in vitro killing experiments. Either IL-4 or IFN...

journal_title：DNA and cell biology

authors： Watanabe Y,Hamaguchi-Tsuru E,Morimoto N,Nishio Y,Yagyu K,Konishi Y,Tominaga M,Miyazaki J,Furuya M,Tominaga A

更新日期：2004-07-01 00:00:00

abstract：:Treatment with demethylating drugs can induce demethylation and reactivation of abnormally silenced tumor suppressor genes in cancer cells, but it can also induce potentially deleterious loss of methylation of repetitive elements. To enable the observation of unwanted drug effects related to loss of methylation of rep...

journal_title：DNA and cell biology

authors： Huang X,Narayanaswamy R,Fenn K,Szpakowski S,Sasaki C,Costa J,Blancafort P,Lizardi PM

更新日期：2012-10-01 00:00:00

abstract：:Triple-negative breast cancer (TNBC) refers to breast cancer without significant expression of estrogen receptor (ER), progesterone receptor (PR), or human epidermal growth factor receptor 2. We sought to identify the hub genes and find the potential progression mechanism of TNBC as well as immunotherapeutic targets. ...

journal_title：DNA and cell biology

authors： Wang F,Cao X,Yin L,Wang Q,He Z

更新日期：2020-10-01 00:00:00