Regulation of insulin gene transcription by multiple histone acetyltransferases.

abstract：:We examined the chromosomal basis for the synthesis of tissue (ovary, endometrium/placenta, and peri-implantation blastocyst) isoforms of cytochrome P450 aromatase in the pig. DNA fragments derived from three distinct porcine aromatase chromosomal genes were cloned and characterized. The porcine type III aromatase gen...

journal_title：DNA and cell biology

authors： Choi I,Troyer DL,Cornwell DL,Kirby-Dobbels KR,Collante WR,Simmen FA

更新日期：1997-06-01 00:00:00

abstract：:The upstream transcription control region of the rat alpha-fetoprotein (AFP) gene was analyzed using transient expression of CAT genes in HepG2 cells which express the gene; H4C3 cells which repress the AFP gene but express the albumin gene; and four nonexpressing cell lines. Deletion analysis based on the DNA sequenc...

journal_title：DNA and cell biology

authors： Wen P,Groupp ER,Buzard G,Crawford N,Locker J

更新日期：1991-09-01 00:00:00

abstract：:The rat D2 dopamine receptor gene is transcribed from a TATA-less promoter that has an initiator-like sequence and several putative Sp1 binding sites. We previously reported that a negative modulator is located between nucleotides -116 and -76 (D2Neg-B) in this gene and that Sp1 as well as another unknown factor bind ...

journal_title：DNA and cell biology

authors： Yajima S,Lee SH,Minowa T,Mouradian MM

更新日期：1998-05-01 00:00:00

abstract：:A subtractive cloning procedure was used to characterize the molecular changes involved in transformation of normal myoblasts to rhabdomyosarcoma (RMS) cells. Here we describe the cloning of DRAL, a novel LIM-domain protein expressed in primary myoblasts but down-regulated in the RMS cell line RD. DRAL is a LIM-only p...

journal_title：DNA and cell biology

authors： Genini M,Schwalbe P,Scholl FA,Remppis A,Mattei MG,Schäfer BW

更新日期：1997-04-01 00:00:00

abstract：:Immune dysregulation has been implicated in myelodysplastic syndrome (MDS) pathogenesis. Refractory anemia with ringed sideroblasts (RARS) is a low-risk subtype of MDS. Our previous study has reported an abnormal γδ T cell receptor (TCR) repertoire in patients with intermediate or high-risk MDS. To characterize the st...

journal_title：DNA and cell biology

authors： Geng S,Weng J,Chen S,Li Y,Wu P,Huang X,Lai P,Du X

更新日期：2015-09-01 00:00:00

abstract：:Chromosomal gain on 1q23-24 is a cytogenetic finding found in approximately 30% of bladder tumors. Currently, no defined or candidate tumor-associated genes from this region have been identified. The objective of this study was to identify and quantitate the expression of putative cancer genes located at this chromoso...

journal_title：DNA and cell biology

authors： Huang WC,Taylor S,Nguyen TB,Tomaszewski JE,Libertino JA,Malkowicz SB,McGarvey TW

更新日期：2002-10-01 00:00:00

abstract：:The G0S19 genes are members of the "small inducible" family of genes, which have similar exon-intron organizations and encode secreted proteins with similar dispositions of cysteine and proline residues. G0S19-1 mRNA is increased shortly after the addition of lectin or cycloheximide to cultured human blood mononuclear...

journal_title：DNA and cell biology

authors： Blum S,Forsdyke RE,Forsdyke DR

更新日期：1990-10-01 00:00:00

abstract：:We have cloned and sequenced the cDNA corresponding to the rat preproepidermal growth factor (ppEGF) mRNA. The cDNA contained 4,801 nucleotides, similar to that reported for the mouse (4,749 nucleotides) and the human mRNAs (4,871 nucleotides). The predicted protein sequence would contain 1,133 amino acids, smaller th...

journal_title：DNA and cell biology

authors： Saggi SJ,Safirstein R,Price PM

更新日期：1992-07-01 00:00:00

abstract：:Nd1-S is the nuclear-localizing short variant form of Nd1 (Ivns1abp) encoding a Kelch family transcription factor. While the function of Nd1 has been investigated in the context of metastasis and doxorubicin-induced cardiotoxicity, little is known about its role in hematopoiesis. In this study, we investigated the fun...

journal_title：DNA and cell biology

authors： Lin Y,Luo Y,Hu F,Wang T,Dong Y,Yang D,He X,Chen X,Wang J,Du J,Zhang X

更新日期：2018-10-01 00:00:00

abstract：:Rheumatoid arthritis (RA) is a complex polygenic inflammatory disease associated with accelerated atherosclerosis, which is the main cause of increased cardiovascular (CV) morbidity and mortality in RA patients. CARD8 is a constituent of inflammasome, which regulates interleukin 1-beta production, and has been associa...

journal_title：DNA and cell biology

authors： García-Bermúdez M,López-Mejías R,González-Juanatey C,Corrales A,Castañeda S,Ortiz AM,Miranda-Filloy JA,Gómez-Vaquero C,Fernández-Gutiérrez B,Balsa A,Pascual-Salcedo D,Blanco R,Llorca J,Martín J,González-Gay MA

更新日期：2013-01-01 00:00:00

abstract：:At supramolecular resolution, DNA synthesis begins at preferred replication origins in the chromosomes of metazoan cells. To characterize one of these origins in detail, the initiation of replication was examined in the HeLa c-myc origin. Polymerase chain reaction (PCR) amplification of size-fractionated nascent chrom...

journal_title：DNA and cell biology

authors： Trivedi A,Waltz SE,Kamath S,Leffak M

更新日期：1998-10-01 00:00:00

abstract：:Epulopiscium sp. type B, a member of the Firmicutes, is a large (up to 300 microm), cigar-shaped bacterial symbiont of surgeonfish that propagates itself by forming multiple intracellular offspring. This unusual form of reproduction is an apparent modification of a developmental program used by some Firmicutes to prod...

journal_title：DNA and cell biology

authors： Ward RJ,Clements KD,Choat JH,Angert ER

更新日期：2009-02-01 00:00:00

abstract：:In an effort to develop a more effective genetic immunization strategy for HIV, we developed an HIV-2 env DNA vaccine and evaluated three adjuvant formulations. The gp140 gene from HIV-2(UC2 )was synthesized using mammalian codons and cloned into a plasmid vector that expresses eukaryotic genes at high levels. We foun...

journal_title：DNA and cell biology

authors： Locher CP,Witt SA,Ashlock BM,Levy JA

更新日期：2004-02-01 00:00:00

abstract：:The search for new chemotherapeutics unaffected by efflux pumps would significantly increase life expectancy in patients with malignant cancers. In this study, butylcycloheptylprodigiosin and undecylprodigiosin were HPLC-purified and verified, using nuclear magnetic resonance spectroscopy. Cell cytotoxicity and transp...

journal_title：DNA and cell biology

authors： Mirzaei SA,Safari Kavishahi M,Keshavarz Z,Elahian F

更新日期：2018-06-01 00:00:00

abstract：:The breast cancer gene 1 (BRCA1) is a tumor suppressor, and mutations or epigenetic inactivation will increase the risk of breast cancer oncogenesis. The current research aimed to explore the relationship between BRCA1 expression, prognosis, and tumor immunity in hepatocellular carcinoma (HCC). In this study, BRCA1 ex...

journal_title：DNA and cell biology

authors： Mei J,Wang R,Xia D,Yang X,Zhou W,Wang H,Liu C

更新日期：2020-10-01 00:00:00

abstract：:The aromatic hydrocarbon receptor (AHR) is a ligand-activated transcription factor that regulates the expression of several drug-metabolizing enzymes and has been implicated in immunosuppression, teratogenesis, cell-specific hyperplasia, and certain types of malignancies and toxicities. The mouse Ahr gene 5' proximal ...

journal_title：DNA and cell biology

authors： Fitzgerald CT,Nebert DW,Puga A

更新日期：1998-09-01 00:00:00

abstract：:Endogenous phytohormones auxin (indole-3-acetic acid [IAA]), abscisic acid (ABA), gibberellin (GA3), and brassinosteroid (BR) play a role in responses to drought stress in higher plants. Tea plant is one of the major economic corps worldwide. The tender shoots of tea plants are the main source for tea production. The ...

journal_title：DNA and cell biology

authors： Li H,Teng RM,Liu JX,Yang RY,Yang YZ,Lin SJ,Han MH,Liu JY,Zhuang J

更新日期：2019-11-01 00:00:00

abstract：:BRCA1-associated protein-1 (BAP1) is an important nuclear-localized deubiquitinating enzyme. Dysregulation of BAP1 has been reported in many types of cancers. However, there are few articles on the role of BAP1 in osteosarcoma (OS) and the molecular mechanisms of BAP1 in OS remain largely unknown. In this study, we ex...

journal_title：DNA and cell biology

authors： Gao S,Sun H,Cheng C,Wang G

更新日期：2017-05-01 00:00:00

abstract：:dTMP kinase (E.C.2.7.4.9.) catalyzes the phosphorylation of dTMP to the corresponding diphosphate. This enzyme is essential for DNA synthesis in vivo and is an important intermediate enzyme in the pathway of many pyrimidine analog drugs. In this report, we describe the isolation of the human dTMP kinase gene by functi...

journal_title：DNA and cell biology

authors： Huang SH,Tang A,Drisco B,Zhang SQ,Seeger R,Li C,Jong A

更新日期：1994-05-01 00:00:00

abstract：:Screening of a mouse kidney cDNA library with a HNF-3/fork head domain probe revealed cDNA Hfh-1L containing the highly conserved fork head DNA-binding domain. The Hfh1L cDNA shows 92.7% homology at the nucleic acid level with the fork head gene HFH-1 from rat. Southern blot analyses demonstrated that the Hfh-1L gene ...

journal_title：DNA and cell biology

authors： Frank S,Zoll B

更新日期：1998-08-01 00:00:00

abstract：:Traditional histological classification of lung cancer subtypes is informative, but incomplete. Recent studies of gene expression suggest that molecular classification can be used for effective diagnostic and prediction of the treatment outcome. We attempt to build a molecular classification based on the public data a...

journal_title：DNA and cell biology

authors： Ptitsyn A

更新日期：2004-10-01 00:00:00

abstract：:Previous studies showed that when growth hormone-releasing hormone (GHRH) was administered to either pregnant rats or pigs as a plasmid-mediated therapy, pituitary weight, somatotroph and lactotroph numbers, and postnatal growth rate of the offspring increased. To determine if these responses resulted from direct effe...

journal_title：DNA and cell biology

authors： Fiorotto ML,Lopez R,Oliver WT,Khan AS,Draghia-Akli R

更新日期：2006-08-01 00:00:00

abstract：:To study the complexity and structural characteristics of zinc finger proteins expressed during human hematopoiesis and to isolate novel regulators of blood cell development, a degenerate oligonucleotide probe specific for a consensus zinc finger peptide domain was used to isolate 63 cDNA clones for Krüppel-related zi...

journal_title：DNA and cell biology

authors： Abrink M,Aveskogh M,Hellman L

更新日期：1995-02-01 00:00:00

abstract：:Defective T cell receptor (TCR) signaling resulting in lower T cell function plays a crucial role in the pathogenesis of T cell immunodeficiency in leukemia. Previous studies have indicated that lower TCRζ levels are a common characteristic of patients with leukemia, and upregulating TCRζ could partially recover T cel...

journal_title：DNA and cell biology

authors： Shi L,Chen S,Zha X,Xu Y,Xu L,Yang L,Lu Y,Zhu K,Li Y

更新日期：2015-07-01 00:00:00

abstract：:Matrix metalloproteinase-7 (MMP-7) is a small secreted proteolytic enzyme with broad substrate specificity. Its expression is associated with tumor invasion, metastasis, and survival for a number of cancers. However, data from published studies with individually low statistical power are conflicting. Here, we performe...

journal_title：DNA and cell biology

authors： Yuan-Yuan M,Li-Feng Z,Li-Jie Z

更新日期：2012-05-01 00:00:00

abstract：:Ginsenoside, a natural triterpenoid saponin, exhibits immunomodulatory and anticancer activities. In the present study, we demonstrated that ginsenoside Rg1 induced secretion of cytokines, including interleukin (IL)-6, tumor necrosis factor-alpha (TNF-α), and IL-1β, and chemokines such as IL-8 and IP-10 in a dose-depe...

journal_title：DNA and cell biology

authors： Huang Y,Zou Y,Lin L,Zheng R

更新日期：2017-12-01 00:00:00

abstract：:The serotonin (5-hydroxytryptamine) transporter (5HTt) gene has been reported to be associated with suicidal behavior. In this study, we have investigated the 5' promoter region (i.e., 5HTt gene-linked polymorphic region [5-HTTLPR]) and a 17-base pair variable number of tandem repeats polymorphism in the 5HTt gene for...

journal_title：DNA and cell biology

authors： Akar T,Sayin A,Bakkaloğlu Z,Cabuk DK,Küçükyildirim S,Demirel B,Candansayar S,Ozsoy ED,Mergen H

更新日期：2010-08-01 00:00:00

abstract：:The aim of this study was to determine the role of polymorphic variants of apolipoprotein E (APOE) and peroxisome proliferator-activated receptor delta (PPARD) genes in the development of coronary heart disease (CHD), and the PPARD and APOE gene-gene interaction in a Turkish population. This study was carried out usin...

journal_title：DNA and cell biology

authors： Yılmaz-Aydogan H,Kucukhuseyin O,Kurnaz O,Akadam-Teker B,Kurt O,Tekeli A,Ozturk O,Isbir T

更新日期：2012-05-01 00:00:00

abstract：:Most studies on the tissue distribution of actin isoform transcripts have been done in small mammals such as rat and mouse. We have begun a characterization of the actin gene family in a large mammal, the bovine. The alpha skeletal gene was isolated, and an isoform-specific probe to the 3' untranslated region of the t...

journal_title：DNA and cell biology

authors： Davey HW,Wildeman AG

更新日期：1995-06-01 00:00:00

abstract：:Our aim was to evaluate in a cohort of 125 Italian patients with type 2 diabetes (T2D), who underwent neurological evaluation, the possible differences in the number of mitochondrial DNA copies (mtDNA) comparing positive and negative patients for cardiovascular autonomic neuropathy (CAN) or diabetic peripheral neuropa...

journal_title：DNA and cell biology

authors： Latini A,Borgiani P,De Benedittis G,D'Amato C,Greco C,Lauro D,Novelli G,Spallone V,Ciccacci C

更新日期：2020-08-01 00:00:00