Abstract:
:The centrosome is a unique organelle that functions as the microtubule organizing center in most animal cells. During cell division, the centrosomes form the poles of the bipolar mitotic spindle. In addition, the centrosomes are also needed for cytokinesis. Each mammalian somatic cell typically contains one centrosome, which is duplicated in coordination with DNA replication. Just like the chromosomes, the centrosome is precisely reproduced once and only once during each cell cycle. However, it remains a mystery how this protein-based structure undergoes accurate duplication in a semiconservative manner. Intriguingly, amplification of the centrosome has been found in numerous forms of cancers. Cells with multiple centrosomes tend to form multipolar spindles, which result in abnormal chromosome segregation during mitosis. It has therefore been postulated that centrosome aberration may compromise the fidelity of cell division and cause chromosome instability. Here we review the current understanding of how the centrosome is assembled and duplicated. We also discuss the possible mechanisms by which centrosome abnormality contributes to the development of malignant phenotype.
journal_name
DNA Cell Bioljournal_title
DNA and cell biologyauthors
Wang Q,Hirohashi Y,Furuuchi K,Zhao H,Liu Q,Zhang H,Murali R,Berezov A,Du X,Li B,Greene MIdoi
10.1089/1044549041562276keywords:
subject
Has Abstractpub_date
2004-08-01 00:00:00pages
475-89issue
8eissn
1044-5498issn
1557-7430journal_volume
23pub_type
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