Abstract:
:Mitochondrial ribosomal proteins are important for mitochondrial-encoded protein synthesis and mitochondrial function. In addition to their roles in mitoribosome assembly, several mitochondrial ribosome proteins are also implicated in cellular processes like cell cycle regulation, apoptosis, and mitochondrial homeostasis regulation. Here, we demonstrate that MRPL10 regulates cyclin B1/Cdk1 (cyclin-dependent kinase 1) activity and mitochondrial protein synthesis in mammalian cells. In Drosophila, inactivation of mRpL10 (the Drosophila ortholog of mammalian MRPL10) in eyes results in abnormal eye development. Furthermore, expression of human cyclin B1 suppresses eye phenotypes and mitochondrial abnormality of mRpL10 knockdown Drosophila. This study identified that the physiological regulatory pathway of MRPL10 and providing new insights into the role of MRPL10 in growth control and mitochondrial function.
journal_name
DNA Cell Bioljournal_title
DNA and cell biologyauthors
Li HB,Wang RX,Jiang HB,Zhang ED,Tan JQ,Xu HZ,Zhou RR,Xia XBdoi
10.1089/dna.2016.3271subject
Has Abstractpub_date
2016-11-01 00:00:00pages
680-690issue
11eissn
1044-5498issn
1557-7430journal_volume
35pub_type
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