Abstract:
:Peroxisomes are membrane-bound organelles that are best known for their roles in lipid metabolism. Mounting evidence indicates that they are also important nodes for antiviral signaling. While research over the past few decades has revealed effective viral strategies to block antiviral signalling pathways from the plasma membrane, mitochondria and/or the nucleus, until recently, very little was known about how viruses interfere with peroxisome-based antiviral signaling. In this essay, we review how viruses use a variety of strategies to interfere with peroxisome biogenesis, a phenomenon that has implications for evasion of the host immune system as well as pathogenesis.
journal_name
DNA Cell Bioljournal_title
DNA and cell biologyauthors
Wong CP,Xu Z,Power C,Hobman TCdoi
10.1089/dna.2018.4153subject
Has Abstractpub_date
2018-05-01 00:00:00pages
417-421issue
5eissn
1044-5498issn
1557-7430journal_volume
37pub_type
杂志文章,评审abstract::Leber congenital amaurosis (LCA) causes severe visual impairment and blindness very early in life. Mutant alleles of several genes acting in different pathways, of which all have critical roles for normal retinal function, were involved in LCA development. The purpose of this study was to use genome-wide genotyping to...
journal_title:DNA and cell biology
pub_type: 杂志文章
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journal_title:DNA and cell biology
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journal_title:DNA and cell biology
pub_type: 杂志文章
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journal_title:DNA and cell biology
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journal_title:DNA and cell biology
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journal_title:DNA and cell biology
pub_type: 杂志文章,评审
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journal_title:DNA and cell biology
pub_type: 杂志文章,评审
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journal_title:DNA and cell biology
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journal_title:DNA and cell biology
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abstract::In the promoters of many immediate early genes, including c-fos, CArG DNA regulatory elements mediate basal constituitive expression and rapid and transient serum induction. CArG boxes also occur in the promoters of muscle-specific genes, including skeletal alpha-actin, where it confers muscle-specific expression. The...
journal_title:DNA and cell biology
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doi:10.1089/dna.1997.16.653
更新日期:1997-05-01 00:00:00
abstract::Mouse vimentin intermediate filaments (IFs) reconstituted in vitro were analyzed for their capacity to select certain DNA sequences from a mixture of about 500-bp-long fragments of total mouse genomic DNA. The fragments preferentially bound by the IFs and enriched by several cycles of affinity binding and polymerase c...
journal_title:DNA and cell biology
pub_type: 杂志文章
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更新日期:1996-03-01 00:00:00
abstract::The aim of this study was to determine the role of polymorphic variants of apolipoprotein E (APOE) and peroxisome proliferator-activated receptor delta (PPARD) genes in the development of coronary heart disease (CHD), and the PPARD and APOE gene-gene interaction in a Turkish population. This study was carried out usin...
journal_title:DNA and cell biology
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abstract::Most mammalian species express high concentrations of ALDH3A1 in corneal epithelium with the exception of the rabbit, which expresses high amounts of ALDH1A1 rather than ALDH3A1. Several hypotheses that involve catalytic and/or structural functions have been postulated regarding the role of these corneal ALDHs. The ai...
journal_title:DNA and cell biology
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更新日期:2003-05-01 00:00:00
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journal_title:DNA and cell biology
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journal_title:DNA and cell biology
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journal_title:DNA and cell biology
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journal_title:DNA and cell biology
pub_type: 杂志文章
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abstract::The linkage of rheumatoid arthritis (RA) to HLA-DR haplotypes, high levels of HLA-DR expression, and T-cell infiltration in the joints, indicate a central role for the interaction of T-cell receptors (TCR) with antigen (Ag) + major histocompatibility complex (MHC) complexes in pathogenesis. Receptor analysis in RA has...
journal_title:DNA and cell biology
pub_type: 杂志文章
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abstract::In this study, we isolated two cDNA molecules encoding putative glutamate receptor subunits, fGluR1 alpha and fGluR1 beta, from an Oreochromis sp. brain cDNA library by hybridizing with the glutamate receptor cDNA, fGluR2 beta, of the same fish. The deduced amino acid sequence of the fGluR1 alpha consists of 908 resid...
journal_title:DNA and cell biology
pub_type: 杂志文章
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journal_title:DNA and cell biology
pub_type: 杂志文章
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更新日期:1996-10-01 00:00:00
abstract::Previous studies showed that when growth hormone-releasing hormone (GHRH) was administered to either pregnant rats or pigs as a plasmid-mediated therapy, pituitary weight, somatotroph and lactotroph numbers, and postnatal growth rate of the offspring increased. To determine if these responses resulted from direct effe...
journal_title:DNA and cell biology
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更新日期:2006-08-01 00:00:00
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journal_title:DNA and cell biology
pub_type: 杂志文章,评审
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更新日期:2019-08-01 00:00:00
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journal_title:DNA and cell biology
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abstract::Interferon gamma (IFN-γ) is one of the key cytokines that plays a major role against viral and intracellular bacterial infection. In addition to the IFN-γ gene, teleost fish possess a second copy known as IFN-γ-related (IFN-γrel) gene. This report describes structural and functional properties of IFN-γrel gene in the ...
journal_title:DNA and cell biology
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更新日期:2015-05-01 00:00:00