A major constituent of green tea, EGCG, inhibits the growth of a human cervical cancer cell line, CaSki cells, through apoptosis, G(1) arrest, and regulation of gene expression.

abstract：:Phytoplasmas are nonculturable cell wall-less, obligate intracellular pathogens of plants and insect vectors. In their descent from walled bacterial ancestors, phytoplasmas underwent massive genome reduction, resulting in some of the smallest cellular genomes known in nonsymbiotic bacteria. While requirements for in v...

journal_title：DNA and cell biology

authors： Davis RE,Jomantiene R,Zhao Y

更新日期：2005-12-01 00:00:00

abstract：:The amino acid sequences directing the nuclear transport of the RNA polymerase I transcription factor xUBF have been studied by a novel combination of in oocyte-coupled translation-nuclear transport and selective HCl extraction. Synthetic mRNA was used to direct the translation of labeled xUBF and its mutants in micro...

journal_title：DNA and cell biology

authors： Dimitrov SI,Bachvarov D,Moss T

更新日期：1993-04-01 00:00:00

abstract：:A nomenclature system for the UDP glucuronosyltransferase superfamily is proposed, based on divergent evolution of the genes. A total of 26 distinct cDNAs in five mammalian species have been sequenced to date. Comparison of the deduced amino acid sequences leads to the definition of two families and a total of three s...

journal_title：DNA and cell biology

authors： Burchell B,Nebert DW,Nelson DR,Bock KW,Iyanagi T,Jansen PL,Lancet D,Mulder GJ,Chowdhury JR,Siest G

更新日期：1991-09-01 00:00:00

abstract：:Polyhomeotic is a member of the Polycomb group of genes. The products of this group are chromatin-associated proteins that act together as multimeric complexes. These proteins are required for the maintenance of target gene repression in a permanent and heritable manner during development. In order to better understan...

journal_title：DNA and cell biology

authors： Netter S,Faucheux M,Théodore L

更新日期：2001-08-01 00:00:00

abstract：:CD95 (Fas/APO-1)-mediated apoptosis appears to be regulated by positive and negative signaling molecules. A human CD40/CD95 chimeric receptor was stably transfected into CD95-expressing human Jurkat T cells, and signaling through native and chimeric CD95 was compared in the same cell type to assess contributions of th...

journal_title：DNA and cell biology

authors： Rudert F,Wang Y,Lindridge E,Watson J

更新日期：1997-02-01 00:00:00

abstract：:Regenerative medicine is a new interdisciplinary field in biomedical science, which aims at the repair or replacement of the defective tissue or organ by congenital defects, age, injury, or disease. Various cell-related techniques such as stem cell-based biotherapy are a hot topic in the current press, and stem cell r...

journal_title：DNA and cell biology

authors： Guo J,Wang H,Hu X

更新日期：2013-10-01 00:00:00

abstract：:Nd1-S is the nuclear-localizing short variant form of Nd1 (Ivns1abp) encoding a Kelch family transcription factor. While the function of Nd1 has been investigated in the context of metastasis and doxorubicin-induced cardiotoxicity, little is known about its role in hematopoiesis. In this study, we investigated the fun...

journal_title：DNA and cell biology

authors： Lin Y,Luo Y,Hu F,Wang T,Dong Y,Yang D,He X,Chen X,Wang J,Du J,Zhang X

更新日期：2018-10-01 00:00:00

abstract：:Vascular endothelial growth factor (VEGF) production is regulated by growth factors and inflammatory cytokines, and VEGF plays a role in migraine. We examined for the first time whether three functional polymorphisms in the promoter region of VEGF gene (C(-2578)A, G(-1154)A, and G(-634)C) and VEGF haplotypes are assoc...

journal_title：DNA and cell biology

authors： Gonçalves FM,Martins-Oliveira A,Speciali JG,Izidoro-Toledo TC,Luizon MR,Dach F,Tanus-Santos JE

更新日期：2010-07-01 00:00:00

abstract：:Chromosomal gain on 1q23-24 is a cytogenetic finding found in approximately 30% of bladder tumors. Currently, no defined or candidate tumor-associated genes from this region have been identified. The objective of this study was to identify and quantitate the expression of putative cancer genes located at this chromoso...

journal_title：DNA and cell biology

authors： Huang WC,Taylor S,Nguyen TB,Tomaszewski JE,Libertino JA,Malkowicz SB,McGarvey TW

更新日期：2002-10-01 00:00:00

abstract：:Normal embryo development in oviparous (egg-laying) species requires the coordinated targeting to growing oocytes of nutrients and regulatory molecules such as retinol, the precursor of active retinoids. Serum retinol-binding protein (RBP) is the major carrier protein for retinol in the circulatory system of vertebrat...

journal_title：DNA and cell biology

authors： Vieira AV,Kuchler K,Schneider WJ

更新日期：1995-05-01 00:00:00

abstract：:Based on the concept of sequence conservation around the active sites of serine proteinases, polymerase chain reaction applied to mRNA amplification allowed us to obtain a 260-bp probe which was used to screen a mouse pituitary cDNA library. The primers used derived from the cDNA sequence of active sites Ser* and Asn*...

journal_title：DNA and cell biology

authors： Seidah NG,Gaspar L,Mion P,Marcinkiewicz M,Mbikay M,Chrétien M

更新日期：1990-07-01 00:00:00

abstract：:Long noncoding RNA (lncRNA) was closely attached to various cancers according to previous studies. In this study we aimed to investigate an lncRNA signature with prognostic value of over survival (OS) outcomes of gastric cancer (GC). Profiles of mRNAs expression and clinical information of 381 GC tissues and 32 nontum...

journal_title：DNA and cell biology

authors： Cai C,Yang L,Tang Y,Wang H,He Y,Jiang H,Zhou K

更新日期：2019-09-01 00:00:00

abstract：:Quantitative determination of T-cell receptor (TCR) V beta expression is necessary to define the changes in TCR-V beta subfamily expression that occur during T-cell maturation and selection and to detect alterations of the TCR-V beta repertoire that may be associated with human diseases. Here we describe and validate ...

journal_title：DNA and cell biology

authors： Duchmann R,Strober W,James SP

更新日期：1993-04-01 00:00:00

abstract：:We have cloned and sequenced the cDNA corresponding to the rat preproepidermal growth factor (ppEGF) mRNA. The cDNA contained 4,801 nucleotides, similar to that reported for the mouse (4,749 nucleotides) and the human mRNAs (4,871 nucleotides). The predicted protein sequence would contain 1,133 amino acids, smaller th...

journal_title：DNA and cell biology

authors： Saggi SJ,Safirstein R,Price PM

更新日期：1992-07-01 00:00:00

abstract：:The transcription factor delta EF1 is a key player in estrogen-signaling cascades in vertebrates. In this pathway, estrogen induces the expression of the gene encoding delta EF1, and then delta EF1 activates transcription of downstream targets. Yet, the molecular mechanisms of transcriptional activation by delta EF1 h...

journal_title：DNA and cell biology

authors： Dillner NB,Sanders MM

更新日期：2004-01-01 00:00:00

abstract：:A primary response of the avian intestine to 1,25-dihydroxyvitamin D3 [1,25-(OH)2D3] is increased synthesis of a 28-kD calcium-binding protein, calbindin-D28k (CaBP). This study examined whether 1,25-(OH)2D3 regulates CaBP gene transcription by an interaction of the vitamin D receptor (VDR) with a vitamin D-responsive...

journal_title：DNA and cell biology

authors： Macdonald PN,Whitfield GK,Haussler CA,Hocker AM,Haussler MR,Komm BS

更新日期：1992-06-01 00:00:00

abstract：:Triple-negative breast cancer (TNBC) refers to breast cancer without significant expression of estrogen receptor (ER), progesterone receptor (PR), or human epidermal growth factor receptor 2. We sought to identify the hub genes and find the potential progression mechanism of TNBC as well as immunotherapeutic targets. ...

journal_title：DNA and cell biology

authors： Wang F,Cao X,Yin L,Wang Q,He Z

更新日期：2020-10-01 00:00:00

abstract：:ERGIC2 (formerly known as PTX1) is a gene identified by subtractive hybridization on the basis that it is expressed in normal human prostate, but not in prostate carcinoma. It is unrelated to the gene encoding pituitary homeobox protein (Ptx1 or Pitx1), which regulates pituitary hormone gene expression. Based on seque...

journal_title：DNA and cell biology

authors： Kwok SC,Kumar S,Dai G

更新日期：2014-02-01 00:00:00

abstract：:The computer program, SIGSEQ2, was used to select heterologous signal peptides from a catalog of published sequences to express the echistatin gene in insect (Sf9) cells. S-values for each amino acid were determined to select empirically the site of cleavage between the signal peptide and mature echistatin. Five gene ...

journal_title：DNA and cell biology

authors： Daugherty BL,Zavodny SM,Lenny AB,Jacobson MA,Ellis RW,Law SW,Mark GE

更新日期：1990-07-01 00:00:00

abstract：:Culture of CHO.K1, a Chinese hamster ovary cell line, requires no particular care about the glucocorticoid level in media. Cell growth of CHO.K1 is little affected by dexamethasone at concentrations up to 3 microM. A clone of CHO.K1 stably transfected with an expression vector displayed a favored growth in dexamethaso...

journal_title：DNA and cell biology

authors： Chen GS,Lee CH,Lee YC,Chi CW,Liu YC

更新日期：1996-02-01 00:00:00

abstract：:The PC12 pheochromocytoma cell line has been a favorite model system for cell and neurobiologists, but has proven relatively refractory to standard DNA transfection methods. We have found that the cationic lipid "lipofectin" provides a simple, gentle, and nontoxic procedure that vastly improves transfection efficienci...

journal_title：DNA and cell biology

authors： Muller SR,Sullivan PD,Clegg DO,Feinstein SC

更新日期：1990-04-01 00:00:00

abstract：:In this study, we mined out hepatocellular carcinoma (HCC) driver genes from MEDLINE literatures by bioinformatics methods of pathway crosstalk and protein interaction network. Furthermore, the relationship between driver genes and their clinicopathological characteristics, as well as classification effectiveness was ...

journal_title：DNA and cell biology

authors： Chen W,Jiang J,Wang PP,Gong L,Chen J,Du W,Bi K,Diao H

更新日期：2019-10-01 00:00:00

abstract：:The aim of this study is to present a mathematical computer simulation model for multistage carcinogenesis. The population genetic model is developed based on the reaction diffusion, logistic behavior, and Hollings Type II interactions between normal, benign, and premalignant cells. The simple form of the Fisher-Halda...

journal_title：DNA and cell biology

authors： Ahangar R,Ali N,Iqbal K,Altmayer K

更新日期：2004-10-01 00:00:00

abstract：:alpha B-Crystallin, a member of the small heat shock family of proteins, is synthesized as a component of various developmental programs, in response to stress and in a number of pathological states. We have determined the complete structure of the alpha B-crystallin gene (6,806 bp encompassing 2,299 bp upstream from ...

journal_title：DNA and cell biology

authors： Srinivasan AN,Bhat SP

更新日期：1994-06-01 00:00:00

abstract：:Herpes simplex virus (HSV) is a neurotropic DNA virus with many favorable properties as a gene delivery vector. HSV is highly infectious, so HSV vectors are efficient vehicles for the delivery of exogenous genetic material to cells. Viral replication is readily disrupted by null mutations in immediate early genes that...

journal_title：DNA and cell biology

authors： Burton EA,Fink DJ,Glorioso JC

更新日期：2002-12-01 00:00:00

abstract：:In this study we report main properties of Harbinger DNA transposons identified in protists, plants, insects, worms, and vertebrates. This is the first superfamily of eukaryotic DNA transposons where all autonomous transposons, even those that are hosted by species from different kingdoms, encode two proteins: a super...

journal_title：DNA and cell biology

authors： Kapitonov VV,Jurka J

更新日期：2004-05-01 00:00:00

abstract：:The role of p53 in mediating nitric oxide (NO)-induced cell death remains uncertain. The exogenous NO donor S-nitrosoglutathione (GSNO) produced a concentration-dependent reduction in cell viability in embryonic chick cardiomyocytes in culture. Western blotting and immunocytochemistry for p53 showed that p53 was incre...

journal_title：DNA and cell biology

authors： Klassen SS,Rabkin SW

更新日期：2007-07-01 00:00:00

abstract：:Heme plays a significant pathogenic role in several diseases involving the kidney. The cellular content of heme, derived either from the delivery of filtered heme proteins such as hemoglobin and myoglobin, or from the breakdown of ubiquitous intracellular heme proteins, is regulated via the heme oxygenase enzyme syste...

journal_title：DNA and cell biology

authors： Hill-Kapturczak N,Chang SH,Agarwal A

更新日期：2002-04-01 00:00:00

abstract：:The CAT gene is widely used as a reporter in eukaryotic systems because of the efficient translation of its mRNA. We report here that a sequence occurring in the CAT mRNA at +15 nucleotides from CAT AUG is essential for translation. This sequence includes a stem-loop structure, which, however, exhibits a calculated st...

journal_title：DNA and cell biology

authors： Ciullo M,Del Pozzo G,Autiero M,Guardiola J

更新日期：2000-01-01 00:00:00

abstract：:The major surface promoter of human hepatitis B virus can produce three distinct groups of S transcripts. The initiation sites of these transcripts are in close proximity. Encompassing the ATG for the middle surface protein, the largest S transcript (+1) encodes the middle surface protein whereas the other two (+20 an...

journal_title：DNA and cell biology

authors： Kuo YL,Ting LP

更新日期：1997-05-01 00:00:00