Characterization of the cDNA coding for mouse prothrombin and localization of the gene on mouse chromosome 2.

abstract：:Apoptosis, which is usually accompanied by DNA degradation, is important not only for the homeostasis of metazoans but also for mammalian development. If DNA is not properly degraded in these processes, it can cause diverse diseases, such as anemia, cataracts, and some autoimmune diseases. A large effort has been made...

journal_title：DNA and cell biology

authors： Liu MF,Wu XP,Wang XL,Yu YL,Wang WF,Chen QJ,Boireau P,Liu MY

更新日期：2008-05-01 00:00:00

abstract：:Defective T cell receptor (TCR) signaling resulting in lower T cell function plays a crucial role in the pathogenesis of T cell immunodeficiency in leukemia. Previous studies have indicated that lower TCRζ levels are a common characteristic of patients with leukemia, and upregulating TCRζ could partially recover T cel...

journal_title：DNA and cell biology

authors： Shi L,Chen S,Zha X,Xu Y,Xu L,Yang L,Lu Y,Zhu K,Li Y

更新日期：2015-07-01 00:00:00

abstract：:Protein-RNA complexation is essential in cell biological functions. Transfer RNAs are bound to aminoacyl-tRNA synthetases for the translation of the genetic code during protein synthesis, while ribonucleoproteins bind RNA in posttranscriptional regulation of gene expression. A recent report showed the interacton of hu...

journal_title：DNA and cell biology

authors： Malonga H,Neault JF,Tajmir-Riahi HA

更新日期：2006-07-01 00:00:00

abstract：:We have isolated and sequenced cDNA clones that encode human spermine synthase (EC 2.5.1.22). The total length of the sequenced cDNA was 1,612 nucleotides, containing an open reading frame encoding a polypeptide chain of 368 amino acids. All of the previously sequenced peptide fragments of human and bovine spermine sy...

journal_title：DNA and cell biology

authors： Korhonen VP,Halmekytö M,Kauppinen L,Myöhänen S,Wahlfors J,Keinänen T,Hyvönen T,Alhonen L,Eloranta T,Jänne J

更新日期：1995-10-01 00:00:00

abstract：:The promoters of mammalian striated muscle actin gene contain binding sites for a number of transcription factors. Examples are the CArG boxes, which bind a protein identical to or related to serum response factor (SRF), E boxes, which bind myogenic determination factors such as MyoD and myogenin, and -CCGCCC- motifs,...

journal_title：DNA and cell biology

authors： Davey HW,Kelly JK,Wildeman AG

更新日期：1995-07-01 00:00:00

abstract：:The Wilms' tumor gene 1 (WT1) protein is a transcriptional regulator that is highly expressed in immature hematopoietic progenitor cells and in the majority of patients with acute and chronic myeloid leukemia. However, it is still unclear how WT1 exerts its function(s) in hematopoietic cells. The aim of this work was ...

journal_title：DNA and cell biology

authors： Svensson E,Vidovic K,Olofsson T,Vallon-Christersson J,Borg A,Gullberg U

更新日期：2007-08-01 00:00:00

abstract：:A variety of human cancer cells are resistant to Fas ligand and anti-Fas antibody induced apoptosis. Previously, we reported that human gastric carcinoma cell lines were resistant to the anti-Fas antibody, CH-11, without interferon-gamma pretreatment in vitro. Cyclooxygenase (COX)-2 is known to be expressed in many hu...

journal_title：DNA and cell biology

authors： Honjo S,Osaki M,Ardyanto TD,Hiramatsu T,Maeta N,Ito H

更新日期：2005-03-01 00:00:00

abstract：:MicroRNAs (miRNAs) are an important class of small, noncoding, regulatory RNAs found to be involved in regulating a wide variety of important cellular processes by the sequence-specific inhibition of gene expression. Viruses have evolved a number of mechanisms to take advantage of the regulatory potential of this high...

journal_title：DNA and cell biology

authors： Dykxhoorn DM

更新日期：2007-04-01 00:00:00

abstract：:The linkage of rheumatoid arthritis (RA) to HLA-DR haplotypes, high levels of HLA-DR expression, and T-cell infiltration in the joints, indicate a central role for the interaction of T-cell receptors (TCR) with antigen (Ag) + major histocompatibility complex (MHC) complexes in pathogenesis. Receptor analysis in RA has...

journal_title：DNA and cell biology

authors： Keiber-Emmons T,Fang Q,Cai W,Friedman SM,Crow MK,Lotke P,Williams WV

更新日期：1998-02-01 00:00:00

abstract：:Diabetes is a worldwide health problem with increasing prevalence. Some reports indicate the interplay between bone and glucose metabolism. The imbalance between bone resorption and formation resulted in the structural integrity and strength of bone. Glucagon-like peptide-1 (GLP-1) and its agonists (Liraglutide) have ...

journal_title：DNA and cell biology

authors： Gao L,Li SL,Li YK

更新日期：2018-12-01 00:00:00

abstract：:We have isolated and characterized a cDNA encoding a chicken beta homolog of c-erbA, or thyroid hormone receptor (TR). Chicken liver cDNA libraries were screened with a rat TR beta-1 cDNA probe, and several cDNA inserts were isolated and characterized. The sequence of one cDNA predicts a 369-amino-acid open reading fr...

journal_title：DNA and cell biology

authors： Showers MO,Darling DS,Kieffer GD,Chin WW

更新日期：1991-04-01 00:00:00

abstract：:CONSTANS (CO)/CONSTANS-like (COL) genes that have been studied in annual model plants such as Arabidopsis thaliana and Oryza sativa play key roles in the photoperiodic flowering pathway. Moso bamboo is a perennial plant characterized by a long vegetative stage and flowers synchronously followed by widespread death. Ho...

journal_title：DNA and cell biology

authors： Liu J,Cheng Z,Li X,Xie L,Bai Y,Peng L,Li J,Gao J

更新日期：2019-07-01 00:00:00

abstract：:Aberrant neutrophil (PMN) infiltration of the intestinal mucosa is a hallmark of inflammatory bowel diseases, including Crohn's disease and ulcerative colitis. While the genotoxic function of PMNs and its implications in carcinogenesis have been primarily associated with oxidative stress, recent work by Butin-Israeli ...

journal_title：DNA and cell biology

authors： Bui TM,Sumagin R

更新日期：2019-08-01 00:00:00

abstract：:To study the elements involved in the pituitary specific transcriptional regulation of the tilapia prolactin I gene (tiPRL I), we have cloned and entirely sequenced a 3.4-kb genomic fragment immediately upstream from the first exon. In footprinting experiments, three tilapia sequences are protected from DNase I digest...

journal_title：DNA and cell biology

authors： Poncelet AC,Levavi-Sivan B,Muller M,Yaron Z,Martial JA,Belayew A

更新日期：1996-08-01 00:00:00

abstract：:Gene delivery from tissue engineering scaffold is a novel strategy in regulating long-term growth and function of cells in vitro culture. In this study, a hepatocyte growth factor plasmid/polyetherimide (pHGF/PEI) polyplex delivering alginate (AL)/galactosylated chitosan (GC) (pHGF/PEI-AL/GC) sponge scaffold was prepa...

journal_title：DNA and cell biology

authors： Gao C,Yang Y,Zhang Y,Qian M,Yang J

更新日期：2020-03-01 00:00:00

abstract：:Intracranial aneurysms (IAs) and potential IA rupture are one of the direct causes of permanent brain damage and mortality. Interestingly, the major risk factors of IA development, including hemodynamic stress, hypertension, smoking, and genetic predispositions, are closely associated with a proinflammatory immune sta...

journal_title：DNA and cell biology

authors： Zhang HF,Zhao MG,Liang GB,Yu CY,He W,Li ZQ,Gao X

更新日期：2016-02-01 00:00:00

abstract：:BRCA1-associated protein-1 (BAP1) is an important nuclear-localized deubiquitinating enzyme. Dysregulation of BAP1 has been reported in many types of cancers. However, there are few articles on the role of BAP1 in osteosarcoma (OS) and the molecular mechanisms of BAP1 in OS remain largely unknown. In this study, we ex...

journal_title：DNA and cell biology

authors： Gao S,Sun H,Cheng C,Wang G

更新日期：2017-05-01 00:00:00

abstract：:In this study we report main properties of Harbinger DNA transposons identified in protists, plants, insects, worms, and vertebrates. This is the first superfamily of eukaryotic DNA transposons where all autonomous transposons, even those that are hosted by species from different kingdoms, encode two proteins: a super...

journal_title：DNA and cell biology

authors： Kapitonov VV,Jurka J

更新日期：2004-05-01 00:00:00

abstract：:At supramolecular resolution, DNA synthesis begins at preferred replication origins in the chromosomes of metazoan cells. To characterize one of these origins in detail, the initiation of replication was examined in the HeLa c-myc origin. Polymerase chain reaction (PCR) amplification of size-fractionated nascent chrom...

journal_title：DNA and cell biology

authors： Trivedi A,Waltz SE,Kamath S,Leffak M

更新日期：1998-10-01 00:00:00

abstract：:Human immunodeficiency virus type I (HIV-1) infection leads to penetration of the central nervous system (CNS) in virtually all infected individuals and HIV-1-induced encephalopathy in a significant number of untreated patients. The molecular mechanisms by which HIV-1 enters the CNS and yields CNS dysfunction are stil...

journal_title：DNA and cell biology

authors： Pomerantz RJ

更新日期：2004-04-01 00:00:00

abstract：:Porifera (sponges) constitute the lowest metazoan phylum. Experiments examined whether sponges can recognize self/nonself molecules. Cells from the marine sponge Suberites domuncula were incubated with membranes from either S. domuncula or another marine sponge, Geodia cydonium, as well as with recombinant alpha-integ...

journal_title：DNA and cell biology

authors： Müller WE,Perovic S,Wilkesman J,Kruse M,Müller IM,Batel R

更新日期：1999-12-01 00:00:00

abstract：:Interstitial lung disease (ILD) is the main reason of death in patients with systemic sclerosis (SSc). The potential microRNA (miRNA)-messenger RNA (mRNA) interaction networks of SSc-ILD from a systematic biological perspective are unclear. To characterize differentially expressed miRNAs (DE-miRNAs) and differentially...

journal_title：DNA and cell biology

authors： He Y,Liu H,Wang S,Chen Y

更新日期：2019-09-01 00:00:00

abstract：:Accumulating evidence has suggested that microRNAs play important roles in the development of hepatocellular carcinoma (HCC) and are involved in drug resistance. miR-21-5p was overexpressed in a variety of cancers and promoted the tumorigenesis; however, the function of miR-21-5p in HCC still remains unknown. In this ...

journal_title：DNA and cell biology

authors： Chen S,Yang C,Sun C,Sun Y,Yang Z,Cheng S,Zhuge B

更新日期：2019-08-01 00:00:00

abstract：:Eaf2 encodes a tumor suppressor that plays multiple functions in transcriptional activation, apoptosis, and embryonic development. In this study, we utilized GFP-EAF2 fusion protein to describe the dynamic subcellular movement of Eaf2. GFP-EAF2 is preferentially localized to the nucleus, and in the presence of ELL, it...

journal_title：DNA and cell biology

authors： Zhuang F,Yen P,Zhao J,Nguyen M,Jiang M,Liu YH

更新日期：2008-12-01 00:00:00

abstract：:The human OZF gene encodes a protein consisting essentially of zinc finger motifs of the Krüppel type. Evolutionary studies revealed amplification of the bovine OZF gene in cattle. Domestic cattle includes two major subspecies: taurine (Bos primigenius taurus) and zebu (B. p. indicus). Amplified sequences were found i...

journal_title：DNA and cell biology

authors： Le Chalony C,Apiou F,Pibouin L,Dutrillaux B,Goubin G

更新日期：1996-01-01 00:00:00

abstract：:By using the methodology of both wet and dry biology (i.e., RT-PCR and cycle sequencing, and biocomputational technology, respectively) and the data obtained through the Genome Projects, we have cloned Xenopus laevis SOD2 (MnSOD) cDNA and determined its nucleotide sequence. These data and the deduced protein primary s...

journal_title：DNA and cell biology

authors： Purrello M,Di Pietro C,Ragusa M,Pulvirenti A,Giugno R,Di Pietro V,Emmanuele G,Travali S,Scalia M,Shasha D,Ferro A

更新日期：2005-02-01 00:00:00

abstract：:The breast cancer gene 1 (BRCA1) is a tumor suppressor, and mutations or epigenetic inactivation will increase the risk of breast cancer oncogenesis. The current research aimed to explore the relationship between BRCA1 expression, prognosis, and tumor immunity in hepatocellular carcinoma (HCC). In this study, BRCA1 ex...

journal_title：DNA and cell biology

authors： Mei J,Wang R,Xia D,Yang X,Zhou W,Wang H,Liu C

更新日期：2020-10-01 00:00:00

abstract：:Cytochrome P450 15 beta is a female-specific gene product that catalyzes the hydroxylation of steroid sulfates at the 15 beta position. Isolation and analysis of the gene for rat P450 15 beta reveals nine coding exons and encompasses more than 35 kb of chromosomal DNA. The intron-exon junctions are at similar position...

journal_title：DNA and cell biology

authors： Zaphiropoulos PG,Westin S,Ström A,Mode A,Gustafsson JA

更新日期：1990-01-01 00:00:00

abstract：:Antibody-targeting therapy has drawn great interests to the hematologists and oncologists. 3A4, a novel antibody recognizing human CD45RA antigen, is a new target molecule for leukemias and holds a therapeutic potential for myeloid lineage leukemias. However, murine antibodies cannot be safely used in patients because...

journal_title：DNA and cell biology

authors： Li S,Shen D,Guo X,Liao C,Tang Y

更新日期：2018-09-01 00:00:00

abstract：:Human T cells express HLA class II molecules upon activation. The factors that regulate the induction of expression of these molecules are for the most part unknown. Here we report preliminary results indicating that tumor necrosis factor-alpha (TNF-alpha) regulates the induction of cell-surface HLA-DR, DO, and DP mol...

journal_title：DNA and cell biology

authors： Kamoun M,Zerva L,Sloan S,Zmijewski C,Monos D,Trinchieri G

更新日期：1992-04-01 00:00:00