Progressing from Recurring Tissue Injury to Genomic Instability: A New Mechanism of Neutrophil Pathogenesis.

abstract：:Plants, being sessile organisms, have evolved several dynamic mechanisms of gene regulation. Epigenetic modification especially cytosine methylation and demethylation actively regulates the expression of genes. To understand the role of cytosine methylation during isoflavonoid biosynthesis and accumulation, we perform...

journal_title：DNA and cell biology

authors： Gupta OP,Dahuja A,Sachdev A,Jain PK,Kumari S,T V,Praveen S

更新日期：2019-06-01 00:00:00

abstract：:A subtractive cloning procedure was used to characterize the molecular changes involved in transformation of normal myoblasts to rhabdomyosarcoma (RMS) cells. Here we describe the cloning of DRAL, a novel LIM-domain protein expressed in primary myoblasts but down-regulated in the RMS cell line RD. DRAL is a LIM-only p...

journal_title：DNA and cell biology

authors： Genini M,Schwalbe P,Scholl FA,Remppis A,Mattei MG,Schäfer BW

更新日期：1997-04-01 00:00:00

abstract：:Signal transducer and activator of transcription 3 (STAT3) is an important oncogenic transcription factor residing in the cytoplasm in the resting cells. Upon stimulation, STAT3 is activated and translocated to the nucleus to regulate target genes. Although the canonical transcriptional function of STAT3 has been inte...

journal_title：DNA and cell biology

authors： Yan B,Xie S,Liu Z,Luo Y,Zhou J,Li D,Liu M

更新日期：2015-04-01 00:00:00

abstract：:The human spermidine synthase (EC 2.5.1.16) gene was isolated from a genomic library constructed with DNA obtained from a human immunoglobulin G (IgG) myeloma cell line. Subsequent sequence analyses revealed that the gene comprised of 5,818 nucleotides from the cap site to the last A of the putative polyadenylation si...

journal_title：DNA and cell biology

authors： Myöhänen S,Kauppinen L,Wahlfors J,Alhonen L,Jänne J

更新日期：1991-07-01 00:00:00

abstract：:Sestrin2 is involved in a different cellular response to stress conditions. However, the function of Sestrin2 in the cardiovascular system remains unknown. In the present study, we tested whether Sestrin2 has a beneficial effect on macrophage cell apoptosis induced by oxidized low-density lipoprotein (oxLDL). We found...

journal_title：DNA and cell biology

authors： Hu HJ,Shi ZY,Lin XL,Chen SM,Wang QY,Tang SY

更新日期：2015-04-01 00:00:00

abstract：:A human growth hormone expression construct was delivered intracellularly into the abdominal skin of mice by particle bombardment-mediated gene transfer. Using this technology, the in vivo delivery of antigen-encoding expression vectors affixed to gold microprojectiles results in de novo antigen production in target s...

journal_title：DNA and cell biology

authors： Eisenbraun MD,Fuller DH,Haynes JR

更新日期：1993-11-01 00:00:00

abstract：:In an effort to develop a more effective genetic immunization strategy for HIV, we developed an HIV-2 env DNA vaccine and evaluated three adjuvant formulations. The gp140 gene from HIV-2(UC2 )was synthesized using mammalian codons and cloned into a plasmid vector that expresses eukaryotic genes at high levels. We foun...

journal_title：DNA and cell biology

authors： Locher CP,Witt SA,Ashlock BM,Levy JA

更新日期：2004-02-01 00:00:00

abstract：:Multiple sclerosis (MS) is a chronic and debilitating autoimmune disorder of the central nervous system in which the autoimmune T cells destroy myelin, thus causing lesion, damage, and neuronal dysfunction. Experimental autoimmune encephalomyelitis (EAE) is an animal model of MS that is particularly useful for testing...

journal_title：DNA and cell biology

authors： Pahan S,Pahan K

更新日期：2019-07-01 00:00:00

abstract：:Sufficient levels of gene expression are required for effective gene therapy. One of the major obstacles in gene therapy is the low transgene expression obtained from currently available vector systems. To address this issue, we employed a transcriptional amplifier strategy in a single construct to enhance transgene e...

journal_title：DNA and cell biology

authors： Luo P,Tsang TC,He X,Gonzalez-Pena V,Jaramillo M,Takeuchi C,Harris DT

更新日期：2005-09-01 00:00:00

abstract：:Viral factor has been implicated in the etiopathogenesis of vitiligo. To elucidate the effects of viral double-stranded RNA (dsRNA) on melanocytes and to explore the underlying mechanisms, primary cultured normal human melanocytes were treated with synthetic viral dsRNA analog poly(I:C). The results demonstrated that ...

journal_title：DNA and cell biology

authors： Wang S,Liu D,Jin R,Zhu Y,Xu A

更新日期：2015-06-01 00:00:00

abstract：:Endothelin-converting enzyme-1 (ECE1) plays a key role in the development of a subset of neural crest lineages such as cardiogenesis. Genetic variants of ECE1 C338A (rs213045) and T839G (rs213046) have been shown to alter ECE1 expression. This observation led us to hypothesize that two polymorphisms might influence th...

journal_title：DNA and cell biology

authors： Wang Y,Liu Y,Peng W,Wang M,Sun J,Zhang Z,Mo X

更新日期：2012-08-01 00:00:00

abstract：:The aim of this work was to express a eukaryotic pre-protein in Escherichia coli so that it could be obtained intact, without cleavage, by bacterial leader peptidase. To this end, cDNA coding for honeybee prepromelittin was ligated to the 3' end of genes coding for truncated forms of either Protein A or beta-galactosi...

journal_title：DNA and cell biology

authors： He M,Liu H,Austen B

更新日期：1994-08-01 00:00:00

abstract：:Increasing evidence suggested that long noncoding RNAs (lncRNAs) variants may be involved in the progression of various cancers. However, the association of the lncRNAs polymorphisms with the risk for esophagogastric junction adenocarcinoma (EGJA) is still unknown. In this case-control study, we selected two cancer-re...

journal_title：DNA and cell biology

authors： Cao R,Chen Y,Wang J,Chen M,Chen S,Tang W

更新日期：2020-05-01 00:00:00

abstract：:Insulin-like growth factor I (IGF-I) plays a major role in development and metabolism. Currently, the cDNA-derived primary structure of IGF-I is known for some mammals and for chicken, frog, and salmon. Additionally, the organization of the human, rat, and chicken IGF-I genes has been established. The investigation of...

journal_title：DNA and cell biology

authors： Kavsan VM,Koval AP,Grebenjuk VA,Chan SJ,Steiner DF,Roberts CT Jr,LeRoith D

更新日期：1993-10-01 00:00:00

abstract：:Herpes simplex virus (HSV) is a neurotropic DNA virus with many favorable properties as a gene delivery vector. HSV is highly infectious, so HSV vectors are efficient vehicles for the delivery of exogenous genetic material to cells. Viral replication is readily disrupted by null mutations in immediate early genes that...

journal_title：DNA and cell biology

authors： Burton EA,Fink DJ,Glorioso JC

更新日期：2002-12-01 00:00:00

abstract：:We previously showed that the human AKNA gene encodes an AT-hook transcription factor that regulates the expression of costimulatory cell surface molecules on lymphocytes. However, AKNA cDNA probes hybridize with multiple transcripts, suggesting either the existence of other homologous genes or a complex regulation op...

journal_title：DNA and cell biology

authors： Sims-Mourtada JC,Bruce S,McKeller MR,Rangel R,Guzman-Rojas L,Cain K,Lopez C,Zimonjic DB,Popescu NC,Gordon J,Wilkinson MF,Martinez-Valdez H

更新日期：2005-05-01 00:00:00

abstract：:Based on the concept of sequence conservation around the active sites of serine proteinases, polymerase chain reaction applied to mRNA amplification allowed us to obtain a 260-bp probe which was used to screen a mouse pituitary cDNA library. The primers used derived from the cDNA sequence of active sites Ser* and Asn*...

journal_title：DNA and cell biology

authors： Seidah NG,Gaspar L,Mion P,Marcinkiewicz M,Mbikay M,Chrétien M

更新日期：1990-07-01 00:00:00

abstract：:Chemokine-like factor (CKLF)-like MARVEL transmembrane domain containing protein 6 (CMTM6) is a ubiquitously expressed protein, which plays a critical role in the stability of programmed death-ligand 1. However, the expression of CMTM6 in a variety of cancer pathological tissues is not clear. Therefore, 109 patients w...

journal_title：DNA and cell biology

authors： Hou X,He S,Zhang D,Yang C,Shi Y,Zhang K

更新日期：2020-10-21 00:00:00

abstract：:Previously we cloned a polyspecific transporter from rat (rOCT1) that is expressed in renal proximal tubules and hepatocytes and mediates electrogenic uptake of organic cations with different molecular structures. Recently a homologous transporter from rat kidney (rOCT2) was cloned but not characterized in detail. We ...

journal_title：DNA and cell biology

authors： Gorboulev V,Ulzheimer JC,Akhoundova A,Ulzheimer-Teuber I,Karbach U,Quester S,Baumann C,Lang F,Busch AE,Koepsell H

更新日期：1997-07-01 00:00:00

abstract：:In IL-5 transgenic mice (C3H/HeN-TgN(IL-5)-Imeg), in which 50% of peripheral blood leukocytes are eosinophils, the development of infection by Leishmania amazonensis was clearly suppressed. To determine mechanistically how this protozoan parasite is killed, we performed in vitro killing experiments. Either IL-4 or IFN...

journal_title：DNA and cell biology

authors： Watanabe Y,Hamaguchi-Tsuru E,Morimoto N,Nishio Y,Yagyu K,Konishi Y,Tominaga M,Miyazaki J,Furuya M,Tominaga A

更新日期：2004-07-01 00:00:00

abstract：:The HIV-1 regulatory proteins Tat and Rev and the accessory proteins Vpr, Vpu, and Vif are essential for viral replication, and their cytoplasmic production suggests that they should be processed for recognition by cytotoxic T lymphocytes. However, only limited data is available evaluating to which extent these protei...

journal_title：DNA and cell biology

authors： Addo MM,Yu XG,Rosenberg ES,Walker BD,Altfeld M

更新日期：2002-09-01 00:00:00

abstract：:Peanut is an important crash crop worldwide, and it is often threatened by drought stress due to unexpected extreme weather events. In this work, NH5 and FH18 were selected as drought-tolerant and drought-sensitive varieties, respectively. Comparison of their physiological responses revealed that NH5 showed less wilti...

journal_title：DNA and cell biology

authors： Ren J,Zhang H,Shi X,Ai X,Dong J,Zhao X,Zhong C,Jiang C,Wang J,Yu H

更新日期：2020-12-29 00:00:00

abstract：:The sex steroid hormone progesterone modulates the developmental and lactogenic activity of prolactin in the mammary gland. Regulation of the level of prolactin receptor (PRLR) provides one possible mechanism by which this may occur, prompting this investigation of the molecular mechanisms involved in progestin regula...

journal_title：DNA and cell biology

authors： Ormandy CJ,Graham J,Kelly PA,Clarke CL,Sutherland RL

更新日期：1992-12-01 00:00:00

abstract：:Administration of endotoxin (LPS) in humans results in profound physiological responses, including activation of peripheral blood mononuclear cells and the release of inflammatory factors. The time course of the response of selected inflammatory proteins was examined in healthy subjects (n = 6) administered a single i...

journal_title：DNA and cell biology

authors： Prabhakar U,Conway TM,Murdock P,Mooney JL,Clark S,Hedge P,Bond BC,Jazwinska EC,Barnes MR,Tobin F,Damian-Iordachi V,Greller L,Hurle M,Stubbs AP,Li Z,Valoret EI,Erickson-Miller C,Cass L,Levitt B,Davis HM,Jorkasky DK

更新日期：2005-07-01 00:00:00

abstract：:DNA repair is reduced in patients suffering from systemic lupus erythematosus (SLE), and it can induce the production of autoreactive antibodies due to the accumulation of DNA damage and nucleoprotein that produce immunogenic antigens. The accumulations of anti-Ku and DNA-PKcs antibodies, which are involved in nonhomo...

journal_title：DNA and cell biology

authors： Jahantigh D,Salimi S,Mousavi M,Moossavi M,Mohammadoo-Khorasani M,Narooei-nejad M,Sandoughi M

更新日期：2015-05-01 00:00:00

abstract：:NADPH: quinone oxidoreductase 1 (NQO1) and dihydronicotinamide riboside: quinone oxidoreductase 2 (NQO2) are cytosolic enzymes that catalyze reductive activation of carcinogens from cigarette smoke, such as nitrosamines and heterocyclic amines. These enzymes also protect cells against oxidative damage from reactive ox...

journal_title：DNA and cell biology

authors： Malik MA,Zargar SA,Mittal B

更新日期：2011-05-01 00:00:00

abstract：:Hearing loss in Ménière's disease (MD) is associated with loss of spiral ganglion neurons and hair cells. In a guinea pig model of endolymphatic hydrops, nitric oxide synthases (NOS) and oxidative stress mediate loss of spiral ganglion neurons. To test the hypothesis that functional variants of NOS1 and NOS2A are asso...

journal_title：DNA and cell biology

authors： Gazquez I,Lopez-Escamez JA,Moreno A,Campbell CA,Meyer NC,Carey JP,Minor LB,Gantz BJ,Hansen MR,Della Santina CC,Aran I,Soto-Varela A,Santos S,Batuecas A,Perez-Garrigues H,Lopez-Nevot A,Smith RJ,Lopez-Nevot MA

更新日期：2011-09-01 00:00:00

abstract：:MicroRNAs (miRNA) are a class of small noncoding RNA molecules that have been implicated in a wide variety of cellular functions through post-transcriptional regulations on target genes. Common genetic variants (single-nucleotide polymorphisms, SNPs) in pre-miRNA genes may alter their expression and/or maturation effe...

journal_title：DNA and cell biology

authors： Mittal RD,Gangwar R,George GP,Mittal T,Kapoor R

更新日期：2011-06-01 00:00:00

abstract：:Rheumatoid arthritis (RA) is a complex polygenic inflammatory disease associated with accelerated atherosclerosis, which is the main cause of increased cardiovascular (CV) morbidity and mortality in RA patients. CARD8 is a constituent of inflammasome, which regulates interleukin 1-beta production, and has been associa...

journal_title：DNA and cell biology

authors： García-Bermúdez M,López-Mejías R,González-Juanatey C,Corrales A,Castañeda S,Ortiz AM,Miranda-Filloy JA,Gómez-Vaquero C,Fernández-Gutiérrez B,Balsa A,Pascual-Salcedo D,Blanco R,Llorca J,Martín J,González-Gay MA

更新日期：2013-01-01 00:00:00

abstract：:The computer program, SIGSEQ2, was used to select heterologous signal peptides from a catalog of published sequences to express the echistatin gene in insect (Sf9) cells. S-values for each amino acid were determined to select empirically the site of cleavage between the signal peptide and mature echistatin. Five gene ...

journal_title：DNA and cell biology

authors： Daugherty BL,Zavodny SM,Lenny AB,Jacobson MA,Ellis RW,Law SW,Mark GE

更新日期：1990-07-01 00:00:00