Isolation of three novel human genes encoding G protein-coupled receptors.

abstract：:Our aim was to evaluate in a cohort of 125 Italian patients with type 2 diabetes (T2D), who underwent neurological evaluation, the possible differences in the number of mitochondrial DNA copies (mtDNA) comparing positive and negative patients for cardiovascular autonomic neuropathy (CAN) or diabetic peripheral neuropa...

journal_title：DNA and cell biology

authors： Latini A,Borgiani P,De Benedittis G,D'Amato C,Greco C,Lauro D,Novelli G,Spallone V,Ciccacci C

更新日期：2020-08-01 00:00:00

abstract：:Gulf War Illness (GWI) affects about 25% of Persian Gulf veterans with a cluster of chronic symptoms, including immune dysfunction and neurological issues. Recent studies implicate gene expression changes in immune function to be associated with GWI. Since DNA methylation can regulate such changes in gene expression, ...

journal_title：DNA and cell biology

authors： Trivedi MS,Abreu MM,Sarria L,Rose N,Ahmed N,Beljanski V,Fletcher MA,Klimas NG,Nathanson L

更新日期：2019-06-01 00:00:00

abstract：:Fibulin-5 (FBLN-5) is a widely expressed, integrin-binding extracellular matrix protein that mediates endothelial cell adhesion and scaffolds cells to elastic fibers. It is also a gene target of TGF-beta in fibroblasts and endothelial cells that regulates cell proliferation and motility in a context-specific manner. W...

journal_title：DNA and cell biology

authors： Albig AR,Schiemann WP

更新日期：2004-06-01 00:00:00

abstract：:Head and neck squamous cell carcinoma (HNSCC) is a malignancy with relatively high incidence and poor prognosis. RNA-binding proteins (RBPs) were reported to be dysregulated in multiple cancers and were closely associated with tumor initiation and progression. However, an integrated analysis of the roles of RBPs in HN...

journal_title：DNA and cell biology

authors： Jin Y,Qin X

更新日期：2020-10-01 00:00:00

abstract：:At supramolecular resolution, DNA synthesis begins at preferred replication origins in the chromosomes of metazoan cells. To characterize one of these origins in detail, the initiation of replication was examined in the HeLa c-myc origin. Polymerase chain reaction (PCR) amplification of size-fractionated nascent chrom...

journal_title：DNA and cell biology

authors： Trivedi A,Waltz SE,Kamath S,Leffak M

更新日期：1998-10-01 00:00:00

abstract：:The major surface promoter of human hepatitis B virus can produce three distinct groups of S transcripts. The initiation sites of these transcripts are in close proximity. Encompassing the ATG for the middle surface protein, the largest S transcript (+1) encodes the middle surface protein whereas the other two (+20 an...

journal_title：DNA and cell biology

authors： Kuo YL,Ting LP

更新日期：1997-05-01 00:00:00

abstract：:The incidence of premature ovarian failure (POF), a condition causing amenorrhea and hypergonadotropic hypoestrogenism in women before the age of 40, has been increasing in recent years. As an irreversible pathological change, improved treatment strategies for this disease are urgently needed. In this study, a type of...

journal_title：DNA and cell biology

authors： Liu T,Qin W,Huang Y,Zhao Y,Wang J

更新日期：2013-12-01 00:00:00

abstract：:CONSTANS (CO)/CONSTANS-like (COL) genes that have been studied in annual model plants such as Arabidopsis thaliana and Oryza sativa play key roles in the photoperiodic flowering pathway. Moso bamboo is a perennial plant characterized by a long vegetative stage and flowers synchronously followed by widespread death. Ho...

journal_title：DNA and cell biology

authors： Liu J,Cheng Z,Li X,Xie L,Bai Y,Peng L,Li J,Gao J

更新日期：2019-07-01 00:00:00

abstract：:Sestrin2 is involved in a different cellular response to stress conditions. However, the function of Sestrin2 in the cardiovascular system remains unknown. In the present study, we tested whether Sestrin2 has a beneficial effect on macrophage cell apoptosis induced by oxidized low-density lipoprotein (oxLDL). We found...

journal_title：DNA and cell biology

authors： Hu HJ,Shi ZY,Lin XL,Chen SM,Wang QY,Tang SY

更新日期：2015-04-01 00:00:00

abstract：:Endogenous phytohormones auxin (indole-3-acetic acid [IAA]), abscisic acid (ABA), gibberellin (GA3), and brassinosteroid (BR) play a role in responses to drought stress in higher plants. Tea plant is one of the major economic corps worldwide. The tender shoots of tea plants are the main source for tea production. The ...

journal_title：DNA and cell biology

authors： Li H,Teng RM,Liu JX,Yang RY,Yang YZ,Lin SJ,Han MH,Liu JY,Zhuang J

更新日期：2019-11-01 00:00:00

abstract：:In the rat, the growth hormone receptor (GH-R) gene generates two transcripts, one encoding the transmembrane GH-R, and a shorter one encoding the GH-binding protein (GH-BP). These transcripts exhibit a high degree of heterogeneity in their 5'-untranslated regions (5'-UTRs). Some of the exons encoding these 5'-UTR var...

journal_title：DNA and cell biology

authors： Domené HM,Cassorla F,Werner H,Roberts CT Jr,Leroith D

更新日期：1995-03-01 00:00:00

abstract：:Previous studies showed that when growth hormone-releasing hormone (GHRH) was administered to either pregnant rats or pigs as a plasmid-mediated therapy, pituitary weight, somatotroph and lactotroph numbers, and postnatal growth rate of the offspring increased. To determine if these responses resulted from direct effe...

journal_title：DNA and cell biology

authors： Fiorotto ML,Lopez R,Oliver WT,Khan AS,Draghia-Akli R

更新日期：2006-08-01 00:00:00

abstract：:The aromatic hydrocarbon receptor (AHR) is a ligand-activated transcription factor that regulates the expression of several drug-metabolizing enzymes and has been implicated in immunosuppression, teratogenesis, cell-specific hyperplasia, and certain types of malignancies and toxicities. The mouse Ahr gene 5' proximal ...

journal_title：DNA and cell biology

authors： Fitzgerald CT,Nebert DW,Puga A

更新日期：1998-09-01 00:00:00

abstract：:Matrix metalloproteinase-7 (MMP-7) is a small secreted proteolytic enzyme with broad substrate specificity. Its expression is associated with tumor invasion, metastasis, and survival for a number of cancers. However, data from published studies with individually low statistical power are conflicting. Here, we performe...

journal_title：DNA and cell biology

authors： Yuan-Yuan M,Li-Feng Z,Li-Jie Z

更新日期：2012-05-01 00:00:00

abstract：:Cytochrome P450c17 catalyzes the 17alpha-hydroxylase/17,20 lyase activity needed for sex steroid synthesis. We recently characterized the nuclear phosphoprotein SET as a novel transcriptional regulator that binds to the -447/-399 region of the rat P450c17 gene, along with the transcription factors COUP-TF II, NGF-IB, ...

journal_title：DNA and cell biology

authors： Zhang P,Compagnone NA,Fiore C,Vigne JL,Culp P,Musci TJ,Mellon SH

更新日期：2001-10-01 00:00:00

abstract：:We have cloned a putative yeast homolog of the gene encoding the human Tat-binding protein, TBP-1. The gene termed TBPY encodes a 45,243-dalton protein displaying a heptad repeat of hydrophobic amino acids reminiscent of a leucine zipper. Secondary structure predictions suggest the possibility of formation of an amphi...

journal_title：DNA and cell biology

authors： Goyer C,Lee HS,Malo D,Sonenberg N

更新日期：1992-10-01 00:00:00

abstract：:We have shown previously that rat hepatoma FTO-2B cells express two mRNAs, called F (fetal) and L (liver), from distinct promoters of the same gene coding for 6-phosphofructo-2-kinase (PFK-2). This enzyme catalyzes the synthesis of fructose 2,6-bisphosphate, an allosteric stimulator of glycolysis. We have now found th...

journal_title：DNA and cell biology

authors： Dupriez VJ,Rousseau GG

更新日期：1997-09-01 00:00:00

abstract：:Long noncoding RNA host gene 16 (SNHG16) has a key role in a variety of cancer progression. However, the role and mechanism of SNHG16 in osteosarcoma (OS) remain unknown. In this study, we examined the functional role of SNHG16 in OS cells through knocked-down SNHG16 by using siRNA. We found that SNHG16 is overexpress...

journal_title：DNA and cell biology

authors： Su P,Mu S,Wang Z

更新日期：2019-02-01 00:00:00

abstract：:FOXO3 is a member of the Forkhead box class O (FOXO) transcription factor family that modulates the transcription of target genes in a variety of cellular functions in lower animals to mammals. It has been implicated in the attenuation of insulin-signaling pathways, including having a potential role in lifespan contro...

journal_title：DNA and cell biology

authors： Byun SO,Zhou H,Hickford JG

更新日期：2011-07-01 00:00:00

abstract：:The CAT gene is widely used as a reporter in eukaryotic systems because of the efficient translation of its mRNA. We report here that a sequence occurring in the CAT mRNA at +15 nucleotides from CAT AUG is essential for translation. This sequence includes a stem-loop structure, which, however, exhibits a calculated st...

journal_title：DNA and cell biology

authors： Ciullo M,Del Pozzo G,Autiero M,Guardiola J

更新日期：2000-01-01 00:00:00

abstract：:The linkage of rheumatoid arthritis (RA) to HLA-DR haplotypes, high levels of HLA-DR expression, and T-cell infiltration in the joints, indicate a central role for the interaction of T-cell receptors (TCR) with antigen (Ag) + major histocompatibility complex (MHC) complexes in pathogenesis. Receptor analysis in RA has...

journal_title：DNA and cell biology

authors： Keiber-Emmons T,Fang Q,Cai W,Friedman SM,Crow MK,Lotke P,Williams WV

更新日期：1998-02-01 00:00:00

abstract：:Apoptotic endonuclease G (EndoG) is responsible for DNA fragmentation both during and after cell death. Previous studies demonstrated that genetic inactivation of EndoG is cytoprotective against various pro-apoptotic stimuli; however, specific inhibitors for EndoG are not available. In this study, we have developed a ...

journal_title：DNA and cell biology

authors： Jang DS,Penthala NR,Apostolov EO,Wang X,Crooks PA,Basnakian AG

更新日期：2015-02-01 00:00:00

abstract：:Adipose-derived stem cells/adipose-derived progenitor cells (ADPCs) are multipotent stem cells that can differentiate in vitro into many cell types. However, the vast majority of experimental materials were obtained from human, mouse, rabbit, and other mammals but rarely from poultry. In this study, ADPCs were isolate...

journal_title：DNA and cell biology

authors： Gong X,Hou L,Bai C,Jin D,He X,Guan W,Ma Y

更新日期：2011-07-01 00:00:00

abstract：:The promoter of the human urokinase plasminogen activator (uPA) gene contains a sequence identical with the retinoblastoma control element (RCE) of the murine c-fos gene, as well as several Sp1 binding sites. In a number of cell lines, the uPA promoter is activated during enforced expression of the retinoblastoma prot...

journal_title：DNA and cell biology

authors： Novak U,Paradiso L,Hamilton JA

更新日期：1994-11-01 00:00:00

abstract：:Defective T cell receptor (TCR) signaling resulting in lower T cell function plays a crucial role in the pathogenesis of T cell immunodeficiency in leukemia. Previous studies have indicated that lower TCRζ levels are a common characteristic of patients with leukemia, and upregulating TCRζ could partially recover T cel...

journal_title：DNA and cell biology

authors： Shi L,Chen S,Zha X,Xu Y,Xu L,Yang L,Lu Y,Zhu K,Li Y

更新日期：2015-07-01 00:00:00

abstract：:There is strong evidence for the presence of a functional renin-angiotensin system in human adipose tissue. The aim of our study was to investigate the association of polymorphic variants of angiotensin-converting enzyme gene (ACE I/D) and angiotensin II type I receptor gene (AGTR1 A1166C) with extreme obesity and obe...

journal_title：DNA and cell biology

authors： Pacholczyk M,Ferenc T,Kowalski J,Adamczyk P,Chojnowski J,Ponikowska I

更新日期：2013-08-01 00:00:00

abstract：:Oxysterols are oxygenated derivatives of cholesterol. They have been shown to influence a variety of biological functions including sterol metabolism, lipid trafficking, and apoptosis. Recently, 12 human OSBP-related genes have been identified. In this study, we have identified a family of 12 oxysterol-binding protein...

journal_title：DNA and cell biology

authors： Anniss AM,Apostolopoulos J,Dworkin S,Purton LE,Sparrow RL

更新日期：2002-08-01 00:00:00

abstract：:The potential association of variant surface glycoprotein (VSG) gene expression with clonal expression of virulence in African trypanosomes was addressed. Two populations of clonally related trypanosomes, which differ dramatically in virulence for the infected host, but display the same apparent VSG surface coat pheno...

journal_title：DNA and cell biology

authors： Inverso JA,Uphoff TS,Johnson SC,Paulnock DM,Mansfield JM

更新日期：2010-05-01 00:00:00

abstract：:Proopiomelanocortin (POMC) is expressed predominantly in the corticotrophic cells of the pituitary. Regulatory sequences required for the expression of the human (h) POMC gene were investigated using transient expression of hPOMC-CAT fusion genes in pituitary and nonpituitary cells in combination with DNase I footprin...

journal_title：DNA and cell biology

authors： Kraus J,Buchfelder M,Höllt V

更新日期：1993-07-01 00:00:00

abstract：:Triple-negative breast cancer (TNBC) refers to breast cancer without significant expression of estrogen receptor (ER), progesterone receptor (PR), or human epidermal growth factor receptor 2. We sought to identify the hub genes and find the potential progression mechanism of TNBC as well as immunotherapeutic targets. ...

journal_title：DNA and cell biology

authors： Wang F,Cao X,Yin L,Wang Q,He Z

更新日期：2020-10-01 00:00:00