Abstract：
:Pediococcus pentosaceus LBM 18 has shown potential as producer of an antibacterial and antifungal bacteriocin-like inhibitory substance (BLIS). BLIS inhibited the growth of spoilage bacteria belonging to Lactobacillus, Enterococcus and Listeria genera with higher activity than Nisaplin used as control. It gave rise to inhibition halos with diameters from 9.70 to 20.00 mm, with Lactobacillus sakei being the most sensitive strain (13.50-20.00 mm). It also effectively suppressed the growth of fungi isolated from corn grain silage for up to 25 days and impaired morphology of colonies by likely affecting fungal membranes. These results point out that P. pentosaceus BLIS may be used as a new promising alternative to conventional antibacterial and antifungal substances, with potential applications in agriculture and food industry as a natural bio-controlling agent. Moreover, cytotoxicity and cell death induction tests demonstrated cytotoxicity and toxicity of BLIS to human colon adenocarcinoma Caco-2cells but not to peripheral blood mononuclear cells, with suggests possible applications of BLIS also in medical-pharmaceutical applications.
journal_name
Sci Repjournal_title
Scientific reportsauthors
de Souza de Azevedo PO,Mendonça CMN,Moreno ACR,Bueno AVI,de Almeida SRY,Seibert L,Converti A,Watanabe IS,Gierus M,de Souza Oliveira RPdoi
10.1038/s41598-020-68922-2subject
Has Abstractpub_date
2020-07-23 00:00:00pages
12291issue
1issn
2045-2322pii
10.1038/s41598-020-68922-2journal_volume
10pub_type
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