Expression of both poly r(C) binding protein 1 (PCBP1) and miRNA-3978 is suppressed in peritoneal gastric cancer metastasis.

Abstract:

:The expression of legumain which has been shown overexpressed in patients with metastatic gastric cancer is positively correlated to both disease progression and outcome, and negatively correlated to microRNA (miR)-3978 expression. The RNA-binding protein, poly r(C) binding protein 1 (PCBP1) was the most downregulated protein in the metastatic tissue specimens. Quantitative real-time PCR showed that PCBP1 expression is transcriptionally downregulated in peritoneal metastasis tissues. RNA immunoprecipitation experiments showed that PCBP1 and miR-3978 are sequestered in normal peritoneal tissue, but the complex is disrupted following metastatic progression. PCBP1 expression mimicked miR-3978 expression across gastric cancer patients. Finally, replenishment of PCBP1 or miR-3978 expression in the peritoneal metastasis cell line MKN45 decreased legumain protein expression and chemosensitized the cells to treatment with docetaxel. However, replenishment of one and concomitant depletion of the other failed to induce chemosensitivity to docetaxel. Replenishment of miR-3978 also resulted in induction of PCBP1 protein expression, potentially indicating that miR-3978 expression might downregulate a negative regulator targeting PCBP1. Our current study reveals PCBP1 as an additional biomarker in peritoneal metastasis. PCBP1 and miR-3978 expression were correlated and suggests a potential interplay of differential miRNA biogenesis and RNA binding protein during metastatic progression.

journal_name

Sci Rep

journal_title

Scientific reports

authors

Ji FJ,Wu YY,An Z,Liu XS,Jiang JN,Chen FF,Fang XD

doi

10.1038/s41598-017-15448-9

subject

Has Abstract

pub_date

2017-11-14 00:00:00

pages

15488

issue

1

issn

2045-2322

pii

10.1038/s41598-017-15448-9

journal_volume

7

pub_type

杂志文章
  • Differential roles of caspase-1 and caspase-11 in infection and inflammation.

    abstract::Caspase-1, also known as interleukin-1β (IL-1β)-converting enzyme (ICE), regulates antimicrobial host defense, tissue repair, tumorigenesis, metabolism and membrane biogenesis. On activation within an inflammasome complex, caspase-1 induces pyroptosis and converts pro-IL-1β and pro-IL-18 into their biologically active...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep45126

    authors: Man SM,Karki R,Briard B,Burton A,Gingras S,Pelletier S,Kanneganti TD

    更新日期:2017-03-27 00:00:00

  • Observation of magnetic domains in graphene magnetized by controlling temperature, strain and magnetic field.

    abstract::Since the production of ferromagnetic graphene as an extremely important matter in spintronics has made a revolution in future technology, a great deal of efforts has recently been done to reach a simple and cost-effective method. Up to now, controlling the magnetic properties at extremely low temperature have been in...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-020-78262-w

    authors: Alimohammadian M,Sohrabi B

    更新日期:2020-12-07 00:00:00

  • Antiproton induced DNA damage: proton like in flight, carbon-ion like near rest.

    abstract::Biological validation of new radiotherapy modalities is essential to understand their therapeutic potential. Antiprotons have been proposed for cancer therapy due to enhanced dose deposition provided by antiproton-nucleon annihilation. We assessed cellular DNA damage and relative biological effectiveness (RBE) of a cl...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep01770

    authors: Kavanagh JN,Currell FJ,Timson DJ,Savage KI,Richard DJ,McMahon SJ,Hartley O,Cirrone GA,Romano F,Prise KM,Bassler N,Holzscheiter MH,Schettino G

    更新日期:2013-01-01 00:00:00

  • Analysis of genome-wide variants through bulked segregant RNA sequencing reveals a major gene for resistance to Plasmodiophora brassicae in Brassica oleracea.

    abstract::Two cabbage (Brassica oleracea) cultivars 'Tekila' and 'Kilaherb' were identified as resistant to several pathotypes of Plasmodiophora brassicae. In this study, we identified a clubroot resistance gene (Rcr7) in 'Tekila' for resistance to pathotype 3 of P. brassicae from a segregating population derived from 'Tekila' ...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-018-36187-5

    authors: Dakouri A,Zhang X,Peng G,Falk KC,Gossen BD,Strelkov SE,Yu F

    更新日期:2018-12-05 00:00:00

  • Fast spectrally encoded Mueller optical scanning microscopy.

    abstract::Mueller microscopes enable imaging of the optical anisotropic properties of biological or non-biological samples, in phase and amplitude, at sub-micrometre scale. However, the development of Mueller microscopes poses an instrumental challenge: the production of polarimetric parameters must be sufficiently quick to ens...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-019-40467-z

    authors: Rivet S,Dubreuil M,Bradu A,Le Grand Y

    更新日期:2019-03-08 00:00:00

  • Minority and Majority Charge Carrier Mobility in Cu2ZnSnSe4 revealed by Terahertz Spectroscopy.

    abstract::The mobilities of electrons and holes determine the applicability of any semiconductor, but their individual measurement remains a major challenge. Here, we show that time-resolved terahertz spectroscopy (TRTS) can distinguish the mobilities of minority and majority charge carriers independently of the doping-type and...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-018-32695-6

    authors: Hempel H,Hages CJ,Eichberger R,Repins I,Unold T

    更新日期:2018-09-27 00:00:00

  • Electronic system with memristive synapses for pattern recognition.

    abstract::Memristive synapses, the most promising passive devices for synaptic interconnections in artificial neural networks, are the driving force behind recent research on hardware neural networks. Despite significant efforts to utilize memristive synapses, progress to date has only shown the possibility of building a neural...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep10123

    authors: Park S,Chu M,Kim J,Noh J,Jeon M,Hun Lee B,Hwang H,Lee B,Lee BG

    更新日期:2015-05-05 00:00:00

  • HDAC4 degradation by combined TRAIL and valproic acid treatment induces apoptotic cell death of TRAIL-resistant head and neck cancer cells.

    abstract::Although TRAIL can directly induce cell death in some cancer cells, it appears that TRAIL resistance exists in many cancers. This study focuses on anti-cancer drugs for TRAIL-resistant head and neck cancer (HNC) to provide further progress toward effective cancer therapy. Results indicate in TRAIL-resistant HNC cells,...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-018-31039-8

    authors: Lee BS,Kim YS,Kim HJ,Kim DH,Won HR,Kim YS,Kim CH

    更新日期:2018-08-21 00:00:00

  • A lower dose of intravitreal conbercept effectively treats retinopathy of prematurity.

    abstract::Intravitreal Conbercept (IVC) is the latest applied and effective treatment for the management of retinopathy of prematurity (ROP). However, conbercept escapes from the vitreous into the general circulation and reduce systemic VEGF concentrations. Thus, there are concerns about systemic complications, in these prematu...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-018-28987-6

    authors: Cheng Y,Meng Q,Linghu D,Zhao M,Liang J

    更新日期:2018-07-16 00:00:00

  • Proteomic Changes Associated with Successive Reproductive Periods in Male Polychaetous Neanthes arenaceodentata.

    abstract::The polychaetous annelid Neanthes acuminata complex has a widespread distribution, with the California population referred to as N. arenaceodentata. The reproductive pattern in this complex is unique, in that the female reproduces once and then dies, whereas the male can reproduce up to nine times. The male incubates ...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep13561

    authors: Chandramouli KH,Reish D,Zhang H,Qian PY,Ravasi T

    更新日期:2015-09-04 00:00:00

  • YqfB protein from Escherichia coli: an atypical amidohydrolase active towards N4-acylcytosine derivatives.

    abstract::Human activating signal cointegrator homology (ASCH) domain-containing proteins are widespread and diverse but, at present, the vast majority of those proteins have no function assigned to them. This study demonstrates that the 103-amino acid Escherichia coli protein YqfB, previously identified as hypothetical, is a u...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-020-57664-w

    authors: Stanislauskienė R,Laurynėnas A,Rutkienė R,Aučynaitė A,Tauraitė D,Meškienė R,Urbelienė N,Kaupinis A,Valius M,Kaliniene L,Meškys R

    更新日期:2020-01-21 00:00:00

  • Using remote sensing environmental data to forecast malaria incidence at a rural district hospital in Western Kenya.

    abstract::Malaria surveillance data provide opportunity to develop forecasting models. Seasonal variability in environmental factors correlate with malaria transmission, thus the identification of transmission patterns is useful in developing prediction models. However, with changing seasonal transmission patterns, either due t...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-017-02560-z

    authors: Sewe MO,Tozan Y,Ahlm C,Rocklöv J

    更新日期:2017-06-01 00:00:00

  • Improved drought stress tolerance in Arabidopsis by CRISPR/dCas9 fusion with a Histone AcetylTransferase.

    abstract::Drought episodes decrease plant growth and productivity, which in turn cause high economic losses. Plants naturally sense and respond to water stress by activating specific signalling pathways leading to physiological and developmental adaptations. Genetically engineering genes that belong to these pathways might impr...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-019-44571-y

    authors: Roca Paixão JF,Gillet FX,Ribeiro TP,Bournaud C,Lourenço-Tessutti IT,Noriega DD,Melo BP,de Almeida-Engler J,Grossi-de-Sa MF

    更新日期:2019-05-30 00:00:00

  • Adipose-derived Stem Cell Conditioned Media Extends Survival time of a mouse model of Amyotrophic Lateral Sclerosis.

    abstract::Adipose stromal cells (ASC) secrete various trophic factors that assist in the protection of neurons in a variety of neuronal death models. In this study, we tested the effects of human ASC conditional medium (ASC-CM) in human amyotrophic lateral sclerosis (ALS) transgenic mouse model expressing mutant superoxide dism...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep16953

    authors: Fontanilla CV,Gu H,Liu Q,Zhu TZ,Zhou C,Johnstone BH,March KL,Pascuzzi RM,Farlow MR,Du Y

    更新日期:2015-11-20 00:00:00

  • Overexpression of LINC00152 correlates with poor patient survival and knockdown impairs cell proliferation in lung cancer.

    abstract::We employed RNA sequencing analysis to reveal dysregulated lncRNAs in lung cancer utilizing 461 lung adenocarcinomas and 156 normal lung tissues from 3 separate cohorts. We found that LINC00152 was highly overexpressed in lung tumors as compared to their adjacent normal tissues. Patients with high LINC00152 expression...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-017-03043-x

    authors: Feng S,Zhang J,Su W,Bai S,Xiao L,Chen X,Lin J,Reddy RM,Chang AC,Beer DG,Chen G

    更新日期:2017-06-07 00:00:00

  • Publisher Correction: Truels and strategies for survival.

    abstract::An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

    journal_title:Scientific reports

    pub_type: 已发布勘误

    doi:10.1038/s41598-020-62013-y

    authors: Dorraki M,Allison A,Abbott D

    更新日期:2020-03-17 00:00:00

  • Delayed discharge is associated with higher complement C3 levels and a longer nucleic acid-negative conversion time in patients with COVID-19.

    abstract::To determine factors associated with delayed discharge of hospitalized patients with coronavirus disease (COVID-19). This retrospective cohort study included 47 patients with COVID-19 admitted to three hospitals in Quanzhou City, Fujian Province, China, between January 21, 2020 and March 6, 2020. Univariate and multiv...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-021-81010-3

    authors: Lin P,Chen W,Huang H,Lin Y,Cai M,Lin D,Cai H,Su Z,Zhuang X,Yu X

    更新日期:2021-01-13 00:00:00

  • Osthole inhibits histamine-dependent itch via modulating TRPV1 activity.

    abstract::Osthole, an active coumarin isolated from Cnidium monnieri (L.) Cusson, has long been used in China as an antipruritic herbal medicine; however, the antipruitic mechanism of osthole is unknown. We studied the molecular mechanism of osthole in histamine-dependent itch by behavioral test, Ca(2+) imaging, and electrophys...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep25657

    authors: Yang NN,Shi H,Yu G,Wang CM,Zhu C,Yang Y,Yuan XL,Tang M,Wang ZL,Gegen T,He Q,Tang K,Lan L,Wu GY,Tang ZX

    更新日期:2016-05-10 00:00:00

  • Correlative nonlinear optical microscopy and infrared nanoscopy reveals collagen degradation in altered parchments.

    abstract::This paper presents the correlative imaging of collagen denaturation by nonlinear optical microscopy (NLO) and nanoscale infrared (IR) spectroscopy to obtain morphological and chemical information at different length scales. Such multiscale correlated measurements are applied to the investigation of ancient parchments...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep26344

    authors: Latour G,Robinet L,Dazzi A,Portier F,Deniset-Besseau A,Schanne-Klein MC

    更新日期:2016-05-19 00:00:00

  • Fluorescence spectroscopy as an efficient tool for staging the degree of liver fibrosis: an in vivo comparison with MRI.

    abstract::The study utilizes autofluorescence spectroscopy (AFS) along with multivariate spectral analysis for differentiating various stages of hepatic fibrosis. AFS has recently emerged as an efficient tool for evaluating the variations in different endogenous flurophores. In this study, the potential of AFS for differentiati...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-018-29370-1

    authors: Nazeer SS,Saraswathy A,Shenoy SJ,Jayasree RS

    更新日期:2018-07-20 00:00:00

  • Shared somatosensory and motor functions in musicians.

    abstract::Skilled individuals are characterized by fine-tuned perceptual and motor functions. Here, we tested the idea that the sensory and motor functions of highly-trained individuals are coupled. We assessed the relationships among multifaceted somatosensory and motor functions of expert pianists. The results demonstrated a ...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep37632

    authors: Hosoda M,Furuya S

    更新日期:2016-11-25 00:00:00

  • Organic-Silica Interactions in Saline: Elucidating the Structural Influence of Calcium in Low-Salinity Enhanced Oil Recovery.

    abstract::Enhanced oil recovery using low-salinity solutions to sweep sandstone reservoirs is a widely-practiced strategy. The mechanisms governing this remain unresolved. Here, we elucidate the role of Ca2+ by combining chemical force microscopy (CFM) and molecular dynamics (MD) simulations. We probe the influence of electroly...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-017-10327-9

    authors: Desmond JL,Juhl K,Hassenkam T,Stipp SLS,Walsh TR,Rodger PM

    更新日期:2017-09-08 00:00:00

  • Yeast two-hybrid screening for proteins that interact with PFT in wheat.

    abstract::Fusarium head blight (FHB) is a devastating disease of wheat worldwide. Fhb1 is the most consistently reported quantitative trait locus (QTL) for FHB resistance breeding. A pore-forming toxin-like (PFT) gene at Fhb1 was first cloned by map-based cloning and found to confer FHB resistance in wheat. Proteins often inter...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-019-52030-x

    authors: He Y,Wu L,Liu X,Zhang X,Jiang P,Ma H

    更新日期:2019-10-29 00:00:00

  • Measuring molecular frequencies in the 1-10 μm range at 11-digits accuracy.

    abstract::High-resolution spectroscopy in the 1-10 μm region has never been fully tackled for the lack of widely-tunable and practical light sources. Indeed, all solutions proposed thus far suffer from at least one of three issues: they are feasible only in a narrow spectral range; the power available for spectroscopy is limite...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-017-12891-6

    authors: Insero G,Borri S,Calonico D,Pastor PC,Clivati C,D'Ambrosio D,De Natale P,Inguscio M,Levi F,Santambrogio G

    更新日期:2017-10-06 00:00:00

  • Genome-wide mapping of DNase I hypersensitive sites reveals chromatin accessibility changes in Arabidopsis euchromatin and heterochromatin regions under extended darkness.

    abstract::Light, as the energy source in photosynthesis, is essential for plant growth and development. Extended darkness causes dramatic gene expression changes. In this study, we applied DNase-seq (DNase I hypersensitive site sequencing) to study changes of chromatin accessibility in euchromatic and heterochromatic regions un...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-017-04524-9

    authors: Liu Y,Zhang W,Zhang K,You Q,Yan H,Jiao Y,Jiang J,Xu W,Su Z

    更新日期:2017-06-22 00:00:00

  • Myh11+ microvascular mural cells and derived mesenchymal stem cells promote retinal fibrosis.

    abstract::Retinal diseases are frequently characterized by the accumulation of excessive scar tissue found throughout the neural retina. However, the pathophysiology of retinal fibrosis remains poorly understood, and the cell types that contribute to the fibrotic response are incompletely defined. Here, we show that myofibrobla...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-020-72875-x

    authors: Ray HC,Corliss BA,Bruce AC,Kesting S,Dey P,Mansour J,Seaman SA,Smolko CM,Mathews C,Dey BK,Owens GK,Peirce SM,Yates PA

    更新日期:2020-09-25 00:00:00

  • Clinical implications of intrinsic molecular subtypes of breast cancer for sentinel node status.

    abstract::Axillary lymph node status is an important prognostic factor for breast cancer patients and sentinel lymph node biopsy (SLNB) is a less invasive surgical proxy. We examined if consecutively derived molecular subtypes from primary breast cancers provide additional predictive value for SLNB status. 1556 patients with a ...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-021-81538-4

    authors: Rossing M,Pedersen CB,Tvedskov T,Vejborg I,Talman ML,Olsen LR,Kroman N,Nielsen FC,Jensen MB,Ejlertsen B

    更新日期:2021-01-26 00:00:00

  • Potential of in vivo real-time gastric gas profiling: a pilot evaluation of heat-stress and modulating dietary cinnamon effect in an animal model.

    abstract::Gastroenterologists are still unable to differentiate between some of the most ordinary disorders of the gut and consequently patients are misdiagnosed. We have developed a swallowable gas sensor capsule for addressing this. The gases of the gut are the by-product of the fermentation processes during digestion, affect...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep33387

    authors: Ou JZ,Cottrell JJ,Ha N,Pillai N,Yao CK,Berean KJ,Ward SA,Grando D,Muir JG,Harrison CJ,Wijesiriwardana U,Dunshea FR,Gibson PR,Kalantar-Zadeh K

    更新日期:2016-09-16 00:00:00

  • A variant of the castor zinc finger 1 (CASZ1) gene is differentially associated with the clinical classification of chronic venous disease.

    abstract::Recent reports have suggested a reproducible association between the rs11121615 SNP, located within an intron of the castor zinc finger 1 (CASZ1) gene, and varicose veins. This study aimed to determine if this variant is also differentially associated with the various clinical classifications of chronic venous disease...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-019-50586-2

    authors: Jones GT,Marsman J,Pardo LM,Nijsten T,De Maeseneer M,Phillips V,Lynch-Sutherland C,Horsfield J,Krysa J,van Rij AM

    更新日期:2019-09-30 00:00:00

  • Red coral extinction risk enhanced by ocean acidification.

    abstract::The red coral Corallium rubrum is a habitat-forming species with a prominent and structural role in mesophotic habitats, which sustains biodiversity hotspots. This precious coral is threatened by both over-exploitation and temperature driven mass mortality events. We report here that biocalcification, growth rates and...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep01457

    authors: Cerrano C,Cardini U,Bianchelli S,Corinaldesi C,Pusceddu A,Danovaro R

    更新日期:2013-01-01 00:00:00