Network-based strategies in metabolomics data analysis and interpretation: from molecular networking to biological interpretation.

abstract：INTRODUCTION:In several biomedical research fields, the cross-linking of peptides and proteins has an important impact on health and wellbeing. It is therefore of crucial importance to study this class of post-translational modifications in detail. The huge potential of mass spectrometric technologies in the mapping of...

journal_title：Expert review of proteomics

authors： Maes E,Dyer JM,McKerchar HJ,Deb-Choudhury S,Clerens S

更新日期：2017-10-01 00:00:00

abstract：:It is well known that chronic, excessive consumption of alcohol can cause brain damage/structural changes in the regions important for neurocognitive function. Some of the damages are permanent, while others are reversible. Molecular mechanisms underlying alcohol-induced and/or -related brain damage are largely unknow...

journal_title：Expert review of proteomics

authors： Matsumoto H,Matsumoto I

更新日期：2008-04-01 00:00:00

abstract：:The vascular endothelium lining the luminal surface of all blood vessels is constantly exposed to shear stress exerted by the flowing blood. Blood flow with high laminar shear stress confers protection by activation of antiatherogenic, antithrombotic and anti-inflammatory proteins, whereas low or oscillatory shear str...

journal_title：Expert review of proteomics

authors： Firasat S,Hecker M,Binder L,Asif AR

更新日期：2014-10-01 00:00:00

abstract：:Introduction: Duchenne muscular dystrophy is a neuromuscular disorder, which is caused by abnormalities in the DMD gene that encodes the membrane cytoskeletal protein dystrophin. Besides progressive skeletal muscle wasting, dystrophinopathy also affects non-skeletal muscle tissues, including cells in the cardio-respir...

journal_title：Expert review of proteomics

authors： Dowling P,Gargan S,Zweyer M,Swandulla D,Ohlendieck K

更新日期：2020-02-01 00:00:00

abstract：:Spermatozoa are unique cells that have highly compact DNA, motility (and hypermotility) patterns, a specific morphology, localized mitochondria and an apical acrosome. They are the end product of a dynamic process termed spermatogenesis. Sperm are therefore produced with specific proteins in order to effect different ...

journal_title：Expert review of proteomics

authors： Agarwal A,Bertolla RP,Samanta L

更新日期：2016-01-01 00:00:00

abstract：:Bile is a body fluid produced by the liver and drained by biliary ducts into the duodenum. It has two major functions: first, it contains bile acids, which are critical for the digestion of fats, and second, it is an excretory pathway for many endogenous and exogenous compounds. Proteomic analysis of bile is particula...

journal_title：Expert review of proteomics

authors： Farina A,Dumonceau JM,Lescuyer P

更新日期：2009-06-01 00:00:00

abstract：INTRODUCTION:Serum proteins are generally glycosylated and solubilized, and are thus present as glycoproteins. The glycan structure of glycoproteins reflects cell differentiation status; glycan structures generated by diseased cells are distinguishable from those produced by healthy cells. Proteins may therefore serve ...

journal_title：Expert review of proteomics

authors： Narimatsu H,Sato T

更新日期：2018-02-01 00:00:00

abstract：:Organellar proteomics aims to describe the full complement of proteins of subcellular structures and organelles. When compared with whole-cell or whole-tissue proteomes, the more focused results from subcellular proteomic studies have yielded relatively simpler datasets from which biologically relevant information can...

journal_title：Expert review of proteomics

authors： Gauthier DJ,Lazure C

更新日期：2008-08-01 00:00:00

abstract：:With the growing availability of mature systems and strategies in biotechnology and the continuously expanding knowledge of cellular processes and involved biomolecules, human sports drug testing has become a considerably complex field in the arena of analytical chemistry. Proving the exogenous origin of peptidic drug...

journal_title：Expert review of proteomics

authors： Thevis M,Thomas A,Schänzer W

更新日期：2014-12-01 00:00:00

abstract：INTRODUCTION:Pancreatic ductal adenocarcinoma (PDAC), which represents approximately 80% of all pancreatic cancers, is a highly aggressive malignant disease and one of the most lethal among all cancers. Overall, the 5-year survival rate among all pancreatic cancer patients is less than 9%; these rates have shown little...

journal_title：Expert review of proteomics

authors： Meleady P,Abdul Rahman R,Henry M,Moriarty M,Clynes M

更新日期：2020-06-01 00:00:00

abstract：:This review addresses the challenges of neuroproteomics and recent progress in biomarkers and tests for neurodegenerative diseases, including Alzheimer's disease, Parkinson's disease and amyotrophic lateral sclerosis. The review will discuss how the application of quantitative 2D gel electrophoresis, combined with app...

journal_title：Expert review of proteomics

authors： Sheta EA,Appel SH,Goldknopf IL

更新日期：2006-02-01 00:00:00

abstract：INTRODUCTION:Skeletal muscle is the major site of insulin-stimulated glucose uptake and imparts the beneficial effects of exercise, and hence is an important site of insulin resistance in obesity and type 2 diabetes (T2D). Despite extensive molecular biology-oriented research the molecular mechanisms underlying insulin...

journal_title：Expert review of proteomics

authors： Kruse R,Højlund K

更新日期：2018-10-01 00:00:00

abstract：:In spite of the effective chronic myeloid leukemia (CML) therapy, a small percentage will fail on therapy and develop acute myeloid leukemia-like blast crisis. Understanding the underlying biology of therapy resistance is probably needed to develop better blood cancer therapy, and CML may be an ideal disease model for...

journal_title：Expert review of proteomics

authors： Gjertsen BT,Wiig H

更新日期：2012-12-01 00:00:00

abstract：:Owing to its extensive use in the human diet, wheat is among the most common causes of food-related allergies and intolerances. Allergies to wheat are provoked by ingestion, inhalation or contact with either the soluble or the insoluble gluten proteins in wheat. Gluten proteins, and particularly the gliadin fraction, ...

journal_title：Expert review of proteomics

authors： Mamone G,Picariello G,Addeo F,Ferranti P

更新日期：2011-02-01 00:00:00

abstract：:Protein phosphorylation events are key regulators of cellular signaling processes. In the era of functional genomics, rational drug design programs demand large-scale high-throughput analysis of signal transduction cascades. Significant improvements in the area of mass spectrometry-based proteomics have provided excit...

journal_title：Expert review of proteomics

authors： Chen WG,White FM

更新日期：2004-10-01 00:00:00

abstract：:Protein profiling using high-throughput tandem mass spectrometry has become a powerful method for analyzing changes in global protein expression patterns in cells and tissues as a function of developmental, physiologic and disease processes. This review summarizes the utility and practical application of multidimensio...

journal_title：Expert review of proteomics

authors： Kislinger T,Emili A

更新日期：2005-01-01 00:00:00

abstract：INTRODUCTION:The human respiratory system is highly prone to diseases and complications. Many lung diseases, including lung cancer (LC), tuberculosis (TB), and chronic obstructive pulmonary disease (COPD) have been among the most common causes of death worldwide. Cystic fibrosis (CF), the most common genetic disease in...

journal_title：Expert review of proteomics

authors： Tan HW,Xu YM,Wu DD,Lau ATY

更新日期：2018-02-01 00:00:00

abstract：:Neurodegenerative diseases are devastating disorders and the demands on their treatment are set to rise in connection with higher disease incidence. Knowledge of the spatiotemporal profile of cellular protein expression during neural differentiation and definition of a set of markers highly specific for targeted neura...

journal_title：Expert review of proteomics

authors： Zizkova M,Sucha R,Tyleckova J,Jarkovska K,Mairychova K,Kotrcova E,Marsala M,Gadher SJ,Kovarova H

更新日期：2015-02-01 00:00:00

abstract：:Helicobacter pylori infection is linked to the development of gastric cancer. Atrophic body gastritis is considered the first important step in the histogenesis of such neoplasia. H. pylori infection is involved in the induction of atrophic body gastritis, but documentation of H. pylori infection is difficult because ...

journal_title：Expert review of proteomics

authors： Lahner E,Bernardini G,Santucci A,Annibale B

更新日期：2010-04-01 00:00:00

abstract：:Numerous efforts have been made to understand fundamental biology of diseases based on gene expression. However, the relationship between gene expression and onset of disease often remains obscure. The great advances in protein microarrays allow us to investigate this unclear question through protein profiles, which a...

journal_title：Expert review of proteomics

authors： Lee JR,Magee DM,Gaster RS,LaBaer J,Wang SX

更新日期：2013-02-01 00:00:00

abstract：:This article reviews the current state of systems biology approaches, including the experimental tools used to generate 'omic' data and computational frameworks to interpret this data. Through illustrative examples, systems biology approaches to understand gene expression and gene expression regulation are discussed. ...

journal_title：Expert review of proteomics

authors： Kuczenski RS,Aggarwal K,Lee KH

更新日期：2005-12-01 00:00:00

abstract：INTRODUCTION:Unwanted platelet activation is associated with numerous diseases, mainly thrombosis-related. In this context, proteomics has emerged as a novel tool with potential for drug target discovery and to scrutinize the effects of antiplatelet drugs. Areas covered: The present review presents the main findings of...

journal_title：Expert review of proteomics

authors： Izquierdo I,García Á

更新日期：2016-11-01 00:00:00

abstract：:Clinical proteomics has been applied to the identification of biomarkers of obstetric and neonatal disease. We will discuss a number of encouraging studies that have led to potentially valid biomarkers in the context of Down's syndrome, preterm birth, amniotic infections, preeclampsia, intrauterine growth restriction ...

journal_title：Expert review of proteomics

authors： Klein J,Buffin-Meyer B,Mullen W,Carty DM,Delles C,Vlahou A,Mischak H,Decramer S,Bascands JL,Schanstra JP

更新日期：2014-02-01 00:00:00

abstract：:Polycystic ovary syndrome (PCOS) is the most common endocrine disorder in females of reproductive age, and its prevalence ranges between 6 and 8%. Associated problems include infertility, menstrual disorders, hirsutism and obesity. In addition, individuals with PCOS may be at increased risk of diabetes, endometrial ca...

journal_title：Expert review of proteomics

authors： Atiomo WU,Khalid S,Ziauddin A,Tooth D,Layfield R

更新日期：2009-10-01 00:00:00

abstract：:Osteoporosis is prevalent among the elderly and is a major cause of bone fracture in this population. Bone integrity is maintained by the dynamic processes of bone resorption and bone formation (bone remodeling). Osteoporosis results when there is an imbalance of the two counteracting processes. Bone mineral density, ...

journal_title：Expert review of proteomics

authors： Zhang H,Recker R,Lee WN,Xiao GG

更新日期：2010-02-01 00:00:00

abstract：:As a complementary approach to 2D-PAGE, multidimensional liquid chromatography (MDLC) separation methods have been widely applied in all kinds of biological sample investigations. MDLC coupled with mass spectrometry is playing an important role in proteome research owing to its high speed, high resolution and high sen...

journal_title：Expert review of proteomics

authors： Gao M,Qi D,Zhang P,Deng C,Zhang X

更新日期：2010-10-01 00:00:00

abstract：:An essential skill for every researcher is to learn how to select and apply the most appropriate methods for the questions they are trying to answer. With the extensive variety of methods available, it is increasingly important to scrutinize the advantages and disadvantages of these techniques prior to making a decisi...

journal_title：Expert review of proteomics

authors： Weibrecht I,Leuchowius KJ,Clausson CM,Conze T,Jarvius M,Howell WM,Kamali-Moghaddam M,Söderberg O

更新日期：2010-06-01 00:00:00

abstract：:Due to the enormous complexity of the proteome, focus in proteomics shifts more and more from the study of the complete proteome to the targeted analysis of part of the proteome. The isolation of this specific part of the proteome generally includes an affinity-based enrichment. Surface plasmon resonance (SPR), a labe...

journal_title：Expert review of proteomics

authors： Visser NF,Heck AJ

更新日期：2008-06-01 00:00:00

abstract：INTRODUCTION:Cell-free protein microarrays represent a special form of protein microarray which display proteins made fresh at the time of the experiment, avoiding storage and denaturation. They have been used increasingly in basic and translational research over the past decade to study protein-protein interactions, t...

journal_title：Expert review of proteomics

authors： Yu X,Petritis B,Duan H,Xu D,LaBaer J

更新日期：2018-01-01 00:00:00

abstract：:Viruses have coevolved with their hosts, acquiring strategies to subvert host cellular pathways for effective viral replication and spread. Human cytomegalovirus (HCMV), a widely-spread β-herpesvirus, is a major cause of birth defects and opportunistic infections in HIV-1/AIDS patients. HCMV displays an intricate syst...

journal_title：Expert review of proteomics

authors： Jean Beltran PM,Cristea IM

更新日期：2014-12-01 00:00:00