Proteomic profiling of fatty acid binding proteins in muscular dystrophy.


:Introduction: Duchenne muscular dystrophy is a neuromuscular disorder, which is caused by abnormalities in the DMD gene that encodes the membrane cytoskeletal protein dystrophin. Besides progressive skeletal muscle wasting, dystrophinopathy also affects non-skeletal muscle tissues, including cells in the cardio-respiratory system, the central nervous system, the liver and the kidney.Areas covered: This review summarizes the proteomic characterization of a key class of lipid chaperones, the large family of fatty acid binding proteins, and their potential role in muscular dystrophy. Recent proteomic surveys using animal models and patient specimens are reviewed. Pathobiochemical changes in specific proteoforms of fatty acid binding protein in the multi-system pathology of dystrophinopathy are discussed.Expert opinion: The mass spectrometric identification of distinct changes in fatty acid binding proteins in muscle, heart, liver, kidney and serum demonstrates that considerable alterations occur in key steps of metabolite transport and fat metabolism in muscular dystrophy. These new findings might be helpful to further develop a comprehensive biomarker signature of metabolic changes in X-linked muscular dystrophy, which should improve (i) our understanding of complex pathobiochemical changes due to dystrophin deficiency, (ii) the identification of novel therapeutic targets, and (iii) the design of differential diagnostic, prognostic and therapy-monitoring approaches.


Expert Rev Proteomics


Dowling P,Gargan S,Zweyer M,Swandulla D,Ohlendieck K




Has Abstract


2020-02-01 00:00:00












  • Urinary biomarkers of physical activity: candidates and clinical utility.

    abstract::Chronic physical inactivity is a major risk factor for a number of important lifestyle diseases, while inappropriate exposure to high physical demands is a risk factor for musculoskeletal injury and fatigue. Proteomic and metabolomic investigations of the physical activity continuum - extreme sedentariness to extremes...

    journal_title:Expert review of proteomics

    pub_type: 杂志文章,评审


    authors: Sampson DL,Broadbent JA,Parker AW,Upton Z,Parker TJ

    更新日期:2014-02-01 00:00:00

  • An update on the routine application of MALDI-TOF MS in clinical microbiology.

    abstract::Introduction: Matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS) has entered clinical diagnostics and is today a generally accepted and integral part of the workflow for microbial identification. MALDI-TOF MS identification systems received approval from national and internatio...

    journal_title:Expert review of proteomics

    pub_type: 杂志文章


    authors: Welker M,Van Belkum A,Girard V,Charrier JP,Pincus D

    更新日期:2019-08-01 00:00:00

  • Role for protein-protein interaction databases in human genetics.

    abstract::Proteomics and the study of protein-protein interactions are becoming increasingly important in our effort to understand human diseases on a system-wide level. Thanks to the development and curation of protein-interaction databases, up-to-date information on these interaction networks is accessible and publicly availa...

    journal_title:Expert review of proteomics

    pub_type: 杂志文章,评审


    authors: Pattin KA,Moore JH

    更新日期:2009-12-01 00:00:00

  • Best practice of identification and proteomic analysis of extracellular vesicles in human health and disease.

    abstract:INTRODUCTION:Extracellular vesicles are emerging sources of biomarkers for modern preventive and precision medicine. Extracellular vesicles in body fluids offer a unique opportunity for integrative biomarker approaches due to their complex biocargo that includes proteins, lipids, nucleic acids and metabolites. Mass spe...

    journal_title:Expert review of proteomics

    pub_type: 杂志文章,评审


    authors: Sódar BW,Kovács Á,Visnovitz T,Pállinger É,Vékey K,Pocsfalvi G,Turiák L,Buzás EI

    更新日期:2017-12-01 00:00:00

  • Advances in the Chromosome-Centric Human Proteome Project: looking to the future.

    abstract:INTRODUCTION:The mission of the Chromosome-Centric Human Proteome Project (C-HPP), is to map and annotate the entire predicted human protein set (~20,000 proteins) encoded by each chromosome. The initial steps of the project are focused on 'missing proteins (MPs)', which lacked documented evidence for existence at prot...

    journal_title:Expert review of proteomics

    pub_type: 杂志文章,评审


    authors: Paik YK,Omenn GS,Hancock WS,Lane L,Overall CM

    更新日期:2017-12-01 00:00:00

  • Advanced technologies for studying circulating tumor cells at the protein level.

    abstract::Metastasis is the main cause of cancer death. As the tumor progresses, cells from the primary tumor site are shed into the bloodstream as circulating tumor cells (CTCs). Eventually, these cells colonize other organs and form distant metastases. It is therefore imperative that we gain a better understanding of the biol...

    journal_title:Expert review of proteomics

    pub_type: 杂志文章,评审


    authors: Chan CM,Au TC,Chan AT,Ma BB,Tsui NB,Ng SS,Hui EP,Chan LW,Ho WS,Yung BY,Wong SC

    更新日期:2013-12-01 00:00:00

  • 'Proteomineering': has the mine been excavated?

    abstract::Evaluation of: Di Girolamo F, Boschetti E, Chung MC, Guadagni F, Righetti PG. 'Proteomineering' or not? The debate on biomarker discovery in sera continues. J. Proteomics 74(5), 589-594 (2011). The combinatorial peptide ligand library in association with mass spectrometry can greatly enhance the dynamic range of the a...

    journal_title:Expert review of proteomics

    pub_type: 评论,杂志文章


    authors: Panfoli I,Bruschi M,Ravera S,Candiano G

    更新日期:2011-08-01 00:00:00

  • Update in research and methods in proteomics and bioinformatics.

    abstract::The 3rd International Conference on Proteomics & Bioinformatics (Proteomics 2013) Philadelphia, PA, USA, 15-17 July 2013 The Third International Conference on Proteomics & Bioinformatics (Proteomics 2013) was sponsored by the OMICS group and was organized in order to strengthen the future of proteomics science by brin...

    journal_title:Expert review of proteomics



    authors: Bencharit S,Border MB,Edelmann A,Byrd WC

    更新日期:2013-10-01 00:00:00

  • Advances in cell-free protein array methods.

    abstract:INTRODUCTION:Cell-free protein microarrays represent a special form of protein microarray which display proteins made fresh at the time of the experiment, avoiding storage and denaturation. They have been used increasingly in basic and translational research over the past decade to study protein-protein interactions, t...

    journal_title:Expert review of proteomics

    pub_type: 杂志文章


    authors: Yu X,Petritis B,Duan H,Xu D,LaBaer J

    更新日期:2018-01-01 00:00:00

  • The impact of microgravity-based proteomics research.

    abstract::Proteomics is performed in microgravity research in order to determine protein alterations occurring qualitatively and quantitatively, when single cells or whole organisms are exposed to real or simulated microgravity. To this purpose, antibody-dependent (Western blotting, flow cytometry, Luminex(®) technology) and an...

    journal_title:Expert review of proteomics

    pub_type: 杂志文章


    authors: Grimm D,Pietsch J,Wehland M,Richter P,Strauch SM,Lebert M,Magnusson NE,Wise P,Bauer J

    更新日期:2014-08-01 00:00:00

  • Recent technical strategies to identify diagnostic biomarkers for ovarian cancer.

    abstract::Ovarian cancer is the fifth leading cause of cancer deaths among North American women. Regrettably, there is currently no reliable circulating biomarker that can detect ovarian cancer in its early stages. The CA125 biomarker is very useful for treatment response monitoring, but its sensitivity is very low for early de...

    journal_title:Expert review of proteomics

    pub_type: 杂志文章,评审


    authors: Ye B,Gagnon A,Mok SC

    更新日期:2007-02-01 00:00:00

  • Platelet proteomics applied to the search for novel antiplatelet therapeutic targets.

    abstract:INTRODUCTION:Unwanted platelet activation is associated with numerous diseases, mainly thrombosis-related. In this context, proteomics has emerged as a novel tool with potential for drug target discovery and to scrutinize the effects of antiplatelet drugs. Areas covered: The present review presents the main findings of...

    journal_title:Expert review of proteomics

    pub_type: 杂志文章


    authors: Izquierdo I,García Á

    更新日期:2016-11-01 00:00:00

  • Proteomic analysis of human bile and potential applications for cancer diagnosis.

    abstract::Bile is a body fluid produced by the liver and drained by biliary ducts into the duodenum. It has two major functions: first, it contains bile acids, which are critical for the digestion of fats, and second, it is an excretory pathway for many endogenous and exogenous compounds. Proteomic analysis of bile is particula...

    journal_title:Expert review of proteomics

    pub_type: 杂志文章,评审


    authors: Farina A,Dumonceau JM,Lescuyer P

    更新日期:2009-06-01 00:00:00

  • Strategies in mass spectrometry for the assignment of Cys-Cys disulfide connectivities in proteins.

    abstract::Elucidating disulfide linkage patterns is a crucial part of protein characterization, for which mass spectrometry (MS) is now an indispensable analytical tool. In many cases, MS-based disulfide connectivity assignment is straightforwardly achieved using one-step protein fragmentation in the unreduced form followed by ...

    journal_title:Expert review of proteomics

    pub_type: 杂志文章,评审


    authors: Goyder MS,Rebeaud F,Pfeifer ME,Kálmán F

    更新日期:2013-10-01 00:00:00

  • Targeted proteomics of solid cancers: from quantification of known biomarkers towards reading the digital proteome maps.

    abstract::The concept of personalized medicine includes novel protein biomarkers that are expected to improve the early detection, diagnosis and therapy monitoring of malignant diseases. Tissues, biofluids, cell lines and xenograft models are the common sources of biomarker candidates that require verification of clinical value...

    journal_title:Expert review of proteomics

    pub_type: 杂志文章,评审


    authors: Pernikářová V,Bouchal P

    更新日期:2015-01-01 00:00:00

  • Urinary proteomics for the study of genetic kidney diseases.

    abstract::Despite their low prevalence, genetic kidney diseases (GKD) still represent a serious health problem. They often lead to kidney failure and to the consequent need of dialysis or kidney transplant. To date, reliable diagnosis requires laborious genetic tests and/or a renal biopsy. Moreover, only scant and non-specific ...

    journal_title:Expert review of proteomics

    pub_type: 杂志文章,评审


    authors: Raimondo F,Cerra D,Magni F,Pitto M

    更新日期:2016-01-01 00:00:00

  • Proteomics in bone research.

    abstract::Osteoporosis is prevalent among the elderly and is a major cause of bone fracture in this population. Bone integrity is maintained by the dynamic processes of bone resorption and bone formation (bone remodeling). Osteoporosis results when there is an imbalance of the two counteracting processes. Bone mineral density, ...

    journal_title:Expert review of proteomics

    pub_type: 杂志文章


    authors: Zhang H,Recker R,Lee WN,Xiao GG

    更新日期:2010-02-01 00:00:00

  • The role of mass spectrometry in the characterization of biologic protein products.

    abstract:INTRODUCTION:Mass spectrometry (MS) is widely used in the characterization of biomolecules including peptide and protein therapeutics. These biotechnology products have seen rapid growth over the past few decades and continue to dominate the global pharmaceutical market. Advances in MS instrumentation and techniques ha...

    journal_title:Expert review of proteomics

    pub_type: 杂志文章,评审


    authors: Rathore D,Faustino A,Schiel J,Pang E,Boyne M,Rogstad S

    更新日期:2018-05-01 00:00:00

  • Emerging protein array technologies for proteomics.

    abstract::Numerous efforts have been made to understand fundamental biology of diseases based on gene expression. However, the relationship between gene expression and onset of disease often remains obscure. The great advances in protein microarrays allow us to investigate this unclear question through protein profiles, which a...

    journal_title:Expert review of proteomics

    pub_type: 杂志文章,评审


    authors: Lee JR,Magee DM,Gaster RS,LaBaer J,Wang SX

    更新日期:2013-02-01 00:00:00

  • The SODyssey: superoxide dismutases from biochemistry, through proteomics, to oxidative stress, aging and nutraceuticals.

    abstract::A total of 40 years have already passed since the pioneering work of McCord and Fridovich on erythrocuprein superoxide dismutase (SOD) activity. This modern scientific 'Odyssey' has been accompanied by a series of successes in the fields of biochemistry, biomedicine and proteomics. In this article, we resume the main ...

    journal_title:Expert review of proteomics

    pub_type: 杂志文章,评审


    authors: D'Alessandro A,Zolla L

    更新日期:2011-06-01 00:00:00

  • Multidimensional protein identification technology: current status and future prospects.

    abstract::Protein profiling using high-throughput tandem mass spectrometry has become a powerful method for analyzing changes in global protein expression patterns in cells and tissues as a function of developmental, physiologic and disease processes. This review summarizes the utility and practical application of multidimensio...

    journal_title:Expert review of proteomics

    pub_type: 杂志文章,评审


    authors: Kislinger T,Emili A

    更新日期:2005-01-01 00:00:00

  • Proteomic studies of common chronic pain conditions - a systematic review and associated network analyses.

    abstract:INTRODUCTION:The lack of biomarkers indicating involved nociceptive and/or pain mechanisms makes diagnostic procedures problematic. Clinical pain research has begun to use proteomics. AREAS COVERED:This systematic review covers proteomic studies of chronic pain cohorts and in relation to clinical variables. Searches i...

    journal_title:Expert review of proteomics

    pub_type: 杂志文章


    authors: Gerdle B,Ghafouri B

    更新日期:2020-06-01 00:00:00

  • Proteomics technologies in endometriosis.

    abstract::Endometriosis is a common disorder that is associated with infertility and pelvic pain. Diagnosis is based on the visualization of endometriotic lesions during surgery as no reliable serum marker is currently available. The etiology of endometriosis is largely unknown. Over the last 20 years, several proteomics techno...

    journal_title:Expert review of proteomics

    pub_type: 杂志文章,评审


    authors: Ferrero S,Gillott DJ,Remorgida V,Ragni N,Venturini PL,Grudzinskas JG

    更新日期:2008-10-01 00:00:00

  • Recent insights into human bronchial proteomics - how are we progressing and what is next?

    abstract:INTRODUCTION:The human respiratory system is highly prone to diseases and complications. Many lung diseases, including lung cancer (LC), tuberculosis (TB), and chronic obstructive pulmonary disease (COPD) have been among the most common causes of death worldwide. Cystic fibrosis (CF), the most common genetic disease in...

    journal_title:Expert review of proteomics

    pub_type: 杂志文章,评审


    authors: Tan HW,Xu YM,Wu DD,Lau ATY

    更新日期:2018-02-01 00:00:00

  • Plasma/serum proteomics: pre-analytical issues.

    abstract::High-throughput proteomics technologies tend to provide highly sensitive information about living tissues and biological fluids. Analytes are characterized by intrinsic and extrinsic properties, the latter depending on each phase of their preparation, sometimes adding artifacts with crucial repercussions in result rel...

    journal_title:Expert review of proteomics

    pub_type: 杂志文章,评审


    authors: Barelli S,Crettaz D,Thadikkaran L,Rubin O,Tissot JD

    更新日期:2007-06-01 00:00:00

  • Advanced proteomic technologies for cancer biomarker discovery.

    abstract::Proteomic technologies have experienced major improvements in recent years. Such advances have facilitated the discovery of potential tumor markers with improved sensitivities and specificities for the diagnosis, prognosis and treatment monitoring of cancer patients. This review will focus on four state-of-the-art pro...

    journal_title:Expert review of proteomics

    pub_type: 杂志文章,评审


    authors: Wong SC,Chan CM,Ma BB,Lam MY,Choi GC,Au TC,Chan AS,Chan AT

    更新日期:2009-04-01 00:00:00

  • Function is what counts: how microbial community complexity affects species, proteome and pathway coverage in metaproteomics.

    abstract::Introduction: Metaproteomics is an established method to obtain a comprehensive taxonomic and functional view of microbial communities. After more than a decade, we are now able to describe the promise, reality, and perspectives of metaproteomics and provide useful information about the choice of method, applications,...

    journal_title:Expert review of proteomics

    pub_type: 杂志文章


    authors: Lohmann P,Schäpe SS,Haange SB,Oliphant K,Allen-Vercoe E,Jehmlich N,Von Bergen M

    更新日期:2020-02-01 00:00:00

  • The life cycle and pathogenesis of human cytomegalovirus infection: lessons from proteomics.

    abstract::Viruses have coevolved with their hosts, acquiring strategies to subvert host cellular pathways for effective viral replication and spread. Human cytomegalovirus (HCMV), a widely-spread β-herpesvirus, is a major cause of birth defects and opportunistic infections in HIV-1/AIDS patients. HCMV displays an intricate syst...

    journal_title:Expert review of proteomics

    pub_type: 杂志文章


    authors: Jean Beltran PM,Cristea IM

    更新日期:2014-12-01 00:00:00

  • Effects of preanalytical variables on peptide and protein measurements in human serum and plasma: implications for clinical proteomics.

    abstract::There is a wealth of knowledge in the field of in vitro diagnostics with regard to preanalytical variables and their impact on the determination of peptide and protein analytes in human serum and plasma. This information is applicable to clinical proteomics investigations, which utilize the same sample types. Studies ...

    journal_title:Expert review of proteomics

    pub_type: 杂志文章,评审


    authors: Rai AJ,Vitzthum F

    更新日期:2006-08-01 00:00:00

  • Hyperamylinemia as a risk factor for accelerated cognitive decline in diabetes.

    abstract::Type II diabetes increases the risk for cognitive decline via multiple traits. Amylin is a pancreatic hormone that has amyloidogenic and cytotoxic properties similar to the amyloid-β peptide. The amylin hormone is overexpressed in individuals with pre-diabetic insulin resistance or obesity leading to amylin oligomeriz...

    journal_title:Expert review of proteomics

    pub_type: 社论,评审


    authors: Ly H,Despa F

    更新日期:2015-01-01 00:00:00