Proteomic profiling of fatty acid binding proteins in muscular dystrophy.


:Introduction: Duchenne muscular dystrophy is a neuromuscular disorder, which is caused by abnormalities in the DMD gene that encodes the membrane cytoskeletal protein dystrophin. Besides progressive skeletal muscle wasting, dystrophinopathy also affects non-skeletal muscle tissues, including cells in the cardio-respiratory system, the central nervous system, the liver and the kidney.Areas covered: This review summarizes the proteomic characterization of a key class of lipid chaperones, the large family of fatty acid binding proteins, and their potential role in muscular dystrophy. Recent proteomic surveys using animal models and patient specimens are reviewed. Pathobiochemical changes in specific proteoforms of fatty acid binding protein in the multi-system pathology of dystrophinopathy are discussed.Expert opinion: The mass spectrometric identification of distinct changes in fatty acid binding proteins in muscle, heart, liver, kidney and serum demonstrates that considerable alterations occur in key steps of metabolite transport and fat metabolism in muscular dystrophy. These new findings might be helpful to further develop a comprehensive biomarker signature of metabolic changes in X-linked muscular dystrophy, which should improve (i) our understanding of complex pathobiochemical changes due to dystrophin deficiency, (ii) the identification of novel therapeutic targets, and (iii) the design of differential diagnostic, prognostic and therapy-monitoring approaches.


Expert Rev Proteomics


Dowling P,Gargan S,Zweyer M,Swandulla D,Ohlendieck K




Has Abstract


2020-02-01 00:00:00












  • Characterization and quantitation of membrane proteomes using multidimensional MS-based proteomic technologies.

    abstract::A major goal of proteomics is to develop methods that enable the systematic characterization of every protein within the cell or particular subcellular proteome using a single analytical platform. Although the equivalent has already been achieved in genomics, reaching this goal in proteomics represents a much greater ...

    journal_title:Expert review of proteomics

    pub_type: 杂志文章,评审


    authors: Blonder J,Conrads TP,Veenstra TD

    更新日期:2004-08-01 00:00:00

  • Proximity ligation assays: a recent addition to the proteomics toolbox.

    abstract::An essential skill for every researcher is to learn how to select and apply the most appropriate methods for the questions they are trying to answer. With the extensive variety of methods available, it is increasingly important to scrutinize the advantages and disadvantages of these techniques prior to making a decisi...

    journal_title:Expert review of proteomics

    pub_type: 杂志文章,评审


    authors: Weibrecht I,Leuchowius KJ,Clausson CM,Conze T,Jarvius M,Howell WM,Kamali-Moghaddam M,Söderberg O

    更新日期:2010-06-01 00:00:00

  • Proteomics in studying cancer stem cell biology.

    abstract::Normal multipotent tissue stem cells (SCs) are the driving force behind tissue turnover and repair. The cancer stem cell theory holds that tumors also contain stem-like cells that drive tumor growth and metastasis formation. However, very little is known about the regulation of SC maintenance pathways in cancer and ho...

    journal_title:Expert review of proteomics

    pub_type: 杂志文章,评审


    authors: Kranenburg O,Emmink BL,Knol J,van Houdt WJ,Rinkes IH,Jimenez CR

    更新日期:2012-06-01 00:00:00

  • Advances in high-resolution quantitative proteomics: implications for clinical applications.

    abstract::The advances in high-resolution mass spectrometry instrumentation, capable of accurate mass measurement and fast acquisition, have enabled new approaches for targeted quantitative proteomics. More specifically, analyses performed on quadrupole-orbitrap mass spectrometers operated in parallel reaction monitoring (PRM) ...

    journal_title:Expert review of proteomics

    pub_type: 杂志文章,评审


    authors: Gallien S,Domon B

    更新日期:2015-01-01 00:00:00

  • Detecting peptidic drugs, drug candidates and analogs in sports doping: current status and future directions.

    abstract::With the growing availability of mature systems and strategies in biotechnology and the continuously expanding knowledge of cellular processes and involved biomolecules, human sports drug testing has become a considerably complex field in the arena of analytical chemistry. Proving the exogenous origin of peptidic drug...

    journal_title:Expert review of proteomics

    pub_type: 杂志文章


    authors: Thevis M,Thomas A,Schänzer W

    更新日期:2014-12-01 00:00:00

  • Multidimensional protein identification technology: current status and future prospects.

    abstract::Protein profiling using high-throughput tandem mass spectrometry has become a powerful method for analyzing changes in global protein expression patterns in cells and tissues as a function of developmental, physiologic and disease processes. This review summarizes the utility and practical application of multidimensio...

    journal_title:Expert review of proteomics

    pub_type: 杂志文章,评审


    authors: Kislinger T,Emili A

    更新日期:2005-01-01 00:00:00

  • Proteomic analysis of human bile and potential applications for cancer diagnosis.

    abstract::Bile is a body fluid produced by the liver and drained by biliary ducts into the duodenum. It has two major functions: first, it contains bile acids, which are critical for the digestion of fats, and second, it is an excretory pathway for many endogenous and exogenous compounds. Proteomic analysis of bile is particula...

    journal_title:Expert review of proteomics

    pub_type: 杂志文章,评审


    authors: Farina A,Dumonceau JM,Lescuyer P

    更新日期:2009-06-01 00:00:00

  • Transcriptomic profiling in Cutaneous Leishmaniasis patients.

    abstract:INTRODUCTION:Cutaneous leishmaniasis (CL), caused by different Leishmania parasite species, is associated with parasite-induced immune-mediated skin inflammation and ulceration. Whereas many CL studies focus on gene expression signatures in mouse models, the transcriptional response driving human patients in the field ...

    journal_title:Expert review of proteomics

    pub_type: 杂志文章


    authors: Masoudzadeh N,Mizbani A,Rafati S

    更新日期:2020-01-01 00:00:00

  • Proteomics in atherothrombosis: a future perspective.

    abstract::Atherothrombosis is the primary cause of death in Western countries. The cellular and molecular mechanisms underlying atherosclerosis remain widely unknown. The complex nature of atherosclerotic cardiovascular diseases demands the development of novel technologies that enable discovery of new biomarkers for early dise...

    journal_title:Expert review of proteomics

    pub_type: 杂志文章,评审


    authors: Martín-Ventura JL,Blanco-Colio LM,Tunon J,Gomez-Guerrero C,Michel JB,Meilhac O,Egido J

    更新日期:2007-04-01 00:00:00

  • Proteomics advances for precision therapy in ovarian cancer.

    abstract::Introduction: Due to the relatively low mutation rate and high frequency of copy number variation, finding actionable genetic drivers of high-grade serous carcinoma (HGSC) is a challenging task. Furthermore, emerging studies show that genetic alterations are frequently poorly represented at the protein level adding a ...

    journal_title:Expert review of proteomics

    pub_type: 杂志文章,评审


    authors: Labrie M,Kendsersky ND,Ma H,Campbell L,Eng J,Chin K,Mills GB

    更新日期:2019-10-01 00:00:00

  • Recent advances in proteomic profiling of pancreatic ductal adenocarcinoma and the road ahead.

    abstract:INTRODUCTION:Pancreatic ductal adenocarcinoma (PDAC) is one of the deadliest cancers worldwide. However, there remain many unmet clinical needs, from diagnosis to treatment strategies. The inherent complexity of the molecular characteristics of PDAC has made it difficult to meet these challenges, rendering proteomic pr...

    journal_title:Expert review of proteomics

    pub_type: 杂志文章,评审


    authors: Kim H,Park J,Wang JI,Kim Y

    更新日期:2017-11-01 00:00:00

  • Integrated analysis of genetic, genomic and proteomic data.

    abstract::The rapid expansion of methods for measuring biological data ranging from DNA sequence variations to mRNA expression and protein abundance presents the opportunity to utilize multiple types of information jointly in the study of human health and disease. Organisms are complex systems that integrate inputs at myriad le...

    journal_title:Expert review of proteomics

    pub_type: 杂志文章,评审


    authors: Reif DM,White BC,Moore JH

    更新日期:2004-06-01 00:00:00

  • The role of proteomics in assessing beta-cell dysfunction and death in type 1 diabetes.

    abstract::Introduction: Type 1 diabetes (T1D) is characterized by autoimmune-induced dysfunction and destruction of the pancreatic beta cells. Unfortunately, this process is poorly understood, and the current best treatment for type 1 diabetes is the administration of exogenous insulin. To better understand these mechanisms and...

    journal_title:Expert review of proteomics

    pub_type: 杂志文章


    authors: Nakayasu ES,Qian WJ,Evans-Molina C,Mirmira RG,Eizirik DL,Metz TO

    更新日期:2019-07-01 00:00:00

  • Recent technical strategies to identify diagnostic biomarkers for ovarian cancer.

    abstract::Ovarian cancer is the fifth leading cause of cancer deaths among North American women. Regrettably, there is currently no reliable circulating biomarker that can detect ovarian cancer in its early stages. The CA125 biomarker is very useful for treatment response monitoring, but its sensitivity is very low for early de...

    journal_title:Expert review of proteomics

    pub_type: 杂志文章,评审


    authors: Ye B,Gagnon A,Mok SC

    更新日期:2007-02-01 00:00:00

  • Complementary methods to assist subcellular fractionation in organellar proteomics.

    abstract::Organellar proteomics aims to describe the full complement of proteins of subcellular structures and organelles. When compared with whole-cell or whole-tissue proteomes, the more focused results from subcellular proteomic studies have yielded relatively simpler datasets from which biologically relevant information can...

    journal_title:Expert review of proteomics

    pub_type: 杂志文章,评审


    authors: Gauthier DJ,Lazure C

    更新日期:2008-08-01 00:00:00

  • The impact of microgravity-based proteomics research.

    abstract::Proteomics is performed in microgravity research in order to determine protein alterations occurring qualitatively and quantitatively, when single cells or whole organisms are exposed to real or simulated microgravity. To this purpose, antibody-dependent (Western blotting, flow cytometry, Luminex(®) technology) and an...

    journal_title:Expert review of proteomics

    pub_type: 杂志文章


    authors: Grimm D,Pietsch J,Wehland M,Richter P,Strauch SM,Lebert M,Magnusson NE,Wise P,Bauer J

    更新日期:2014-08-01 00:00:00

  • Surface plasmon resonance mass spectrometry in proteomics.

    abstract::Due to the enormous complexity of the proteome, focus in proteomics shifts more and more from the study of the complete proteome to the targeted analysis of part of the proteome. The isolation of this specific part of the proteome generally includes an affinity-based enrichment. Surface plasmon resonance (SPR), a labe...

    journal_title:Expert review of proteomics

    pub_type: 杂志文章,评审


    authors: Visser NF,Heck AJ

    更新日期:2008-06-01 00:00:00

  • Clinical proteomics in obstetrics and neonatology.

    abstract::Clinical proteomics has been applied to the identification of biomarkers of obstetric and neonatal disease. We will discuss a number of encouraging studies that have led to potentially valid biomarkers in the context of Down's syndrome, preterm birth, amniotic infections, preeclampsia, intrauterine growth restriction ...

    journal_title:Expert review of proteomics

    pub_type: 杂志文章,评审


    authors: Klein J,Buffin-Meyer B,Mullen W,Carty DM,Delles C,Vlahou A,Mischak H,Decramer S,Bascands JL,Schanstra JP

    更新日期:2014-02-01 00:00:00

  • Investigation of therapy resistance mechanisms in myeloid leukemia by protein profiling of bone marrow extracellular fluid.

    abstract::In spite of the effective chronic myeloid leukemia (CML) therapy, a small percentage will fail on therapy and develop acute myeloid leukemia-like blast crisis. Understanding the underlying biology of therapy resistance is probably needed to develop better blood cancer therapy, and CML may be an ideal disease model for...

    journal_title:Expert review of proteomics

    pub_type: 评论,杂志文章


    authors: Gjertsen BT,Wiig H

    更新日期:2012-12-01 00:00:00

  • Potential blood biomarkers for stroke.

    abstract::Stroke is one of the most common causes of death worldwide and a major cause of acquired disability in adults. Despite advances in research during the last decade, prevention and treatment strategies still suffer from significant limitations, and therefore new theoretical and technical approaches are required. Technol...

    journal_title:Expert review of proteomics

    pub_type: 杂志文章,评审


    authors: Laborde CM,Mourino-Alvarez L,Akerstrom F,Padial LR,Vivanco F,Gil-Dones F,Barderas MG

    更新日期:2012-08-01 00:00:00

  • Proteomics in bone research.

    abstract::Osteoporosis is prevalent among the elderly and is a major cause of bone fracture in this population. Bone integrity is maintained by the dynamic processes of bone resorption and bone formation (bone remodeling). Osteoporosis results when there is an imbalance of the two counteracting processes. Bone mineral density, ...

    journal_title:Expert review of proteomics

    pub_type: 杂志文章


    authors: Zhang H,Recker R,Lee WN,Xiao GG

    更新日期:2010-02-01 00:00:00

  • Improved understanding of gene expression regulation using systems biology.

    abstract::This article reviews the current state of systems biology approaches, including the experimental tools used to generate 'omic' data and computational frameworks to interpret this data. Through illustrative examples, systems biology approaches to understand gene expression and gene expression regulation are discussed. ...

    journal_title:Expert review of proteomics

    pub_type: 杂志文章,评审


    authors: Kuczenski RS,Aggarwal K,Lee KH

    更新日期:2005-12-01 00:00:00

  • Alcoholism: protein expression profiles in a human hippocampal model.

    abstract::It is well known that chronic, excessive consumption of alcohol can cause brain damage/structural changes in the regions important for neurocognitive function. Some of the damages are permanent, while others are reversible. Molecular mechanisms underlying alcohol-induced and/or -related brain damage are largely unknow...

    journal_title:Expert review of proteomics

    pub_type: 杂志文章,评审


    authors: Matsumoto H,Matsumoto I

    更新日期:2008-04-01 00:00:00

  • Proteomics technologies in endometriosis.

    abstract::Endometriosis is a common disorder that is associated with infertility and pelvic pain. Diagnosis is based on the visualization of endometriotic lesions during surgery as no reliable serum marker is currently available. The etiology of endometriosis is largely unknown. Over the last 20 years, several proteomics techno...

    journal_title:Expert review of proteomics

    pub_type: 杂志文章,评审


    authors: Ferrero S,Gillott DJ,Remorgida V,Ragni N,Venturini PL,Grudzinskas JG

    更新日期:2008-10-01 00:00:00

  • Concepts and strategies of soybean seed proteomics using the shotgun proteomics approach.

    abstract::Introduction: The last decade has yielded significant developments in the field of proteomics, especially in mass spectrometry (MS) and data analysis tools. In particular, a shift from gel-based to MS-based proteomics has been observed, thereby providing a platform with which to construct proteome atlases for all life...

    journal_title:Expert review of proteomics

    pub_type: 杂志文章,评审


    authors: Min CW,Gupta R,Agrawal GK,Rakwal R,Kim ST

    更新日期:2019-09-01 00:00:00

  • Urinary proteomics for the study of genetic kidney diseases.

    abstract::Despite their low prevalence, genetic kidney diseases (GKD) still represent a serious health problem. They often lead to kidney failure and to the consequent need of dialysis or kidney transplant. To date, reliable diagnosis requires laborious genetic tests and/or a renal biopsy. Moreover, only scant and non-specific ...

    journal_title:Expert review of proteomics

    pub_type: 杂志文章,评审


    authors: Raimondo F,Cerra D,Magni F,Pitto M

    更新日期:2016-01-01 00:00:00

  • Framework for a systems approach to proteomic biomarker profiling in polycystic ovary syndrome.

    abstract::Polycystic ovary syndrome (PCOS) is the most common endocrine disorder in females of reproductive age, and its prevalence ranges between 6 and 8%. Associated problems include infertility, menstrual disorders, hirsutism and obesity. In addition, individuals with PCOS may be at increased risk of diabetes, endometrial ca...

    journal_title:Expert review of proteomics

    pub_type: 杂志文章,评审


    authors: Atiomo WU,Khalid S,Ziauddin A,Tooth D,Layfield R

    更新日期:2009-10-01 00:00:00

  • Proteomic study of skeletal muscle in obesity and type 2 diabetes: progress and potential.

    abstract:INTRODUCTION:Skeletal muscle is the major site of insulin-stimulated glucose uptake and imparts the beneficial effects of exercise, and hence is an important site of insulin resistance in obesity and type 2 diabetes (T2D). Despite extensive molecular biology-oriented research the molecular mechanisms underlying insulin...

    journal_title:Expert review of proteomics

    pub_type: 杂志文章,评审


    authors: Kruse R,Højlund K

    更新日期:2018-10-01 00:00:00

  • Protein-protein cross-linking and human health: the challenge of elucidating with mass spectrometry.

    abstract:INTRODUCTION:In several biomedical research fields, the cross-linking of peptides and proteins has an important impact on health and wellbeing. It is therefore of crucial importance to study this class of post-translational modifications in detail. The huge potential of mass spectrometric technologies in the mapping of...

    journal_title:Expert review of proteomics

    pub_type: 杂志文章,评审


    authors: Maes E,Dyer JM,McKerchar HJ,Deb-Choudhury S,Clerens S

    更新日期:2017-10-01 00:00:00

  • Advances in the development of human protein microarrays.

    abstract:INTRODUCTION:High-content protein microarrays in principle enable the functional interrogation of the human proteome in a broad range of applications, including biomarker discovery, profiling of immune responses, identification of enzyme substrates, and quantifying protein-small molecule, protein-protein and protein-DN...

    journal_title:Expert review of proteomics

    pub_type: 杂志文章,评审


    authors: Duarte JG,Blackburn JM

    更新日期:2017-07-01 00:00:00