Helicobacter pylori immunoproteomics in gastric cancer and gastritis of the carcinoma phenotype.

abstract：:Mammalian sperm are differentiated germ cells that transfer genetic material from the male to the female. Owing to this essential role in the reproductive process, an understanding of the complex mechanisms that underlie sperm function has implications ranging from the development of novel contraceptives to the treatm...

journal_title：Expert review of proteomics

authors： Porambo JR,Salicioni AM,Visconti PE,Platt MD

更新日期：2012-10-01 00:00:00

abstract：:Normal multipotent tissue stem cells (SCs) are the driving force behind tissue turnover and repair. The cancer stem cell theory holds that tumors also contain stem-like cells that drive tumor growth and metastasis formation. However, very little is known about the regulation of SC maintenance pathways in cancer and ho...

journal_title：Expert review of proteomics

authors： Kranenburg O,Emmink BL,Knol J,van Houdt WJ,Rinkes IH,Jimenez CR

更新日期：2012-06-01 00:00:00

abstract：INTRODUCTION:The application of new proteomics methods may help to identify new diagnostic/predictive molecular markers in an attempt to improve the clinical management of atherosclerosis. Areas covered: Technological advances in proteomics have enhanced its sensitivity and multiplexing capacity, as well as the possibi...

journal_title：Expert review of proteomics

authors： Mourino-Alvarez L,Baldan-Martin M,Rincon R,Martin-Rojas T,Corbacho-Alonso N,Sastre-Oliva T,Barderas MG

更新日期：2017-08-01 00:00:00

abstract：INTRODUCTION:Pancreatic ductal adenocarcinoma (PDAC) is one of the deadliest cancers worldwide. However, there remain many unmet clinical needs, from diagnosis to treatment strategies. The inherent complexity of the molecular characteristics of PDAC has made it difficult to meet these challenges, rendering proteomic pr...

journal_title：Expert review of proteomics

authors： Kim H,Park J,Wang JI,Kim Y

更新日期：2017-11-01 00:00:00

abstract：INTRODUCTION:The lack of biomarkers indicating involved nociceptive and/or pain mechanisms makes diagnostic procedures problematic. Clinical pain research has begun to use proteomics. AREAS COVERED:This systematic review covers proteomic studies of chronic pain cohorts and in relation to clinical variables. Searches i...

journal_title：Expert review of proteomics

authors： Gerdle B,Ghafouri B

更新日期：2020-06-01 00:00:00

abstract：:Chronic physical inactivity is a major risk factor for a number of important lifestyle diseases, while inappropriate exposure to high physical demands is a risk factor for musculoskeletal injury and fatigue. Proteomic and metabolomic investigations of the physical activity continuum - extreme sedentariness to extremes...

journal_title：Expert review of proteomics

authors： Sampson DL,Broadbent JA,Parker AW,Upton Z,Parker TJ

更新日期：2014-02-01 00:00:00

abstract：:Prenatal diagnosis is now offered to high-risk pregnancies, including advanced maternal age, ultrasound anomalies and positive Down's syndrome screening, and karyotype on cultured fetal material is the test of choice to screen these pregnancies. However, microscope analysis can only detect gross chromosome abnormaliti...

journal_title：Expert review of proteomics

authors： Novelli A,Cavalli P,Bernardini L

更新日期：2013-04-01 00:00:00

abstract：INTRODUCTION:The skin protects the human body from external insults and regulates water and temperature homeostasis. A highly developed extracellular matrix (ECM) supports the skin and instructs its cell functions. Reduced functionality of the ECM is often associated with skin diseases that cause physical impairment an...

journal_title：Expert review of proteomics

authors： Dengjel J,Bruckner-Tuderman L,Nyström A

更新日期：2020-05-01 00:00:00

abstract：INTRODUCTION:Cell-free protein microarrays represent a special form of protein microarray which display proteins made fresh at the time of the experiment, avoiding storage and denaturation. They have been used increasingly in basic and translational research over the past decade to study protein-protein interactions, t...

journal_title：Expert review of proteomics

authors： Yu X,Petritis B,Duan H,Xu D,LaBaer J

更新日期：2018-01-01 00:00:00

abstract：:Introduction: Duchenne muscular dystrophy is a neuromuscular disorder, which is caused by abnormalities in the DMD gene that encodes the membrane cytoskeletal protein dystrophin. Besides progressive skeletal muscle wasting, dystrophinopathy also affects non-skeletal muscle tissues, including cells in the cardio-respir...

journal_title：Expert review of proteomics

authors： Dowling P,Gargan S,Zweyer M,Swandulla D,Ohlendieck K

更新日期：2020-02-01 00:00:00

abstract：INTRODUCTION:Pancreatic ductal adenocarcinoma (PDAC), which represents approximately 80% of all pancreatic cancers, is a highly aggressive malignant disease and one of the most lethal among all cancers. Overall, the 5-year survival rate among all pancreatic cancer patients is less than 9%; these rates have shown little...

journal_title：Expert review of proteomics

authors： Meleady P,Abdul Rahman R,Henry M,Moriarty M,Clynes M

更新日期：2020-06-01 00:00:00

abstract：INTRODUCTION:Metabolomics has become a crucial part of systems biology; however, data analysis is still often undertaken in a reductionist way focusing on changes in individual metabolites. Whilst such approaches indeed provide relevant insights into the metabolic phenotype of an organism, the intricate nature of metab...

journal_title：Expert review of proteomics

authors： Perez De Souza L,Alseekh S,Brotman Y,Fernie AR

更新日期：2020-04-01 00:00:00

abstract：INTRODUCTION:Leptomeningeal metastases (LM) from lymphoma remain a difficult complication for oncologist due to the high incidence in morbidity and mortality. Early diagnostic and initiation of treatment are essential to prevent neurological deterioration. Areas covered: In this review, several proteomic approaches are...

journal_title：Expert review of proteomics

authors： Galicia N,Dégano R,Díez P,González-González M,Góngora R,Ibarrola N,Fuentes M

更新日期：2017-04-01 00:00:00

abstract：INTRODUCTION:Ticks are obligate hematophagous arthropod ectoparasites that transmit pathogens responsible for a growing number of tick-borne diseases (TBDs) throughout the world. Vaccines have been shown to be the most efficient, cost-effective, and environmentally friendly approach for the control of ticks and the pre...

journal_title：Expert review of proteomics

authors： Artigas-Jerónimo S,De La Fuente J,Villar M

更新日期：2018-08-01 00:00:00

abstract：:The emergence of advanced liquid chromatography mass spectrometry technologies for characterizing very complex mixtures of proteins has greatly propelled the field of proteomics, the goal of which is the simultaneous examination of all the proteins expressed by an organism. This research area represents a paradigm shi...

journal_title：Expert review of proteomics

authors： VerBerkmoes NC,Connelly HM,Pan C,Hettich RL

更新日期：2004-12-01 00:00:00

abstract：:Introduction: Matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS) has entered clinical diagnostics and is today a generally accepted and integral part of the workflow for microbial identification. MALDI-TOF MS identification systems received approval from national and internatio...

journal_title：Expert review of proteomics

authors： Welker M,Van Belkum A,Girard V,Charrier JP,Pincus D

更新日期：2019-08-01 00:00:00

abstract：:Ubiquitin-proteasome-mediated protein degradation is central to the regulation of many important biological processes, including cell cycle progression, apoptosis and DNA repair. Recognition and degradation of ubiquitinated substrates by the 26S proteasome is tightly regulated to maintain normal cell growth. Disruptio...

journal_title：Expert review of proteomics

authors： Wang X,Guerrero C,Kaiser P,Huang L

更新日期：2007-10-01 00:00:00

abstract：:Atherothrombosis is the primary cause of death in Western countries. The cellular and molecular mechanisms underlying atherosclerosis remain widely unknown. The complex nature of atherosclerotic cardiovascular diseases demands the development of novel technologies that enable discovery of new biomarkers for early dise...

journal_title：Expert review of proteomics

authors： Martín-Ventura JL,Blanco-Colio LM,Tunon J,Gomez-Guerrero C,Michel JB,Meilhac O,Egido J

更新日期：2007-04-01 00:00:00

abstract：:Organellar proteomics aims to describe the full complement of proteins of subcellular structures and organelles. When compared with whole-cell or whole-tissue proteomes, the more focused results from subcellular proteomic studies have yielded relatively simpler datasets from which biologically relevant information can...

journal_title：Expert review of proteomics

authors： Gauthier DJ,Lazure C

更新日期：2008-08-01 00:00:00

abstract：:Globally, colorectal cancer (CRC) is the third most common malignant neoplasm. However, highly sensitive, specific, noninvasive tests that allow CRC diagnosis at an early stage are still needed. As circulatory blood reflects the physiological status of an individual and/or the disease status for several disorders, eff...

journal_title：Expert review of proteomics

authors： Reumer A,Maes E,Mertens I,Cho WC,Landuyt B,Valkenborg D,Schoofs L,Baggerman G

更新日期：2014-08-01 00:00:00

abstract：:The advances in high-resolution mass spectrometry instrumentation, capable of accurate mass measurement and fast acquisition, have enabled new approaches for targeted quantitative proteomics. More specifically, analyses performed on quadrupole-orbitrap mass spectrometers operated in parallel reaction monitoring (PRM) ...

journal_title：Expert review of proteomics

authors： Gallien S,Domon B

更新日期：2015-01-01 00:00:00

abstract：INTRODUCTION:Breast cancer subtypes are currently defined by a combination of morphologic, genomic, and proteomic characteristics. These subtypes provide a molecular portrait of the tumor that aids diagnosis, prognosis, and treatment escalation/de-escalation options. Gene expression signatures describing intrinsic brea...

journal_title：Expert review of proteomics

authors： Mueller C,Haymond A,Davis JB,Williams A,Espina V

更新日期：2018-02-01 00:00:00

abstract：INTRODUCTION:High-content protein microarrays in principle enable the functional interrogation of the human proteome in a broad range of applications, including biomarker discovery, profiling of immune responses, identification of enzyme substrates, and quantifying protein-small molecule, protein-protein and protein-DN...

journal_title：Expert review of proteomics

authors： Duarte JG,Blackburn JM

更新日期：2017-07-01 00:00:00

abstract：:Protein phosphorylation events are key regulators of cellular signaling processes. In the era of functional genomics, rational drug design programs demand large-scale high-throughput analysis of signal transduction cascades. Significant improvements in the area of mass spectrometry-based proteomics have provided excit...

journal_title：Expert review of proteomics

authors： Chen WG,White FM

更新日期：2004-10-01 00:00:00

abstract：OBJECTIVE:Hepcidin-25 production is stimulated by systemic inflammation, and it interferes with iron utilization, leading to anemia. This study aimed to investigate the relationships between the plasma levels of hepcidin, interleukin-6 (IL-6), erythropoietin (EPO) and erythroferrone (ERFE) in patients with benign breas...

journal_title：Expert review of proteomics

authors： Ciniselli CM,De Bortoli M,Taverna E,Varinelli L,Pizzamiglio S,Veneroni S,Bonini C,Orlandi R,Verderio P,Bongarzone I

更新日期：2015-01-01 00:00:00

abstract：:Macrophages, originating from the migration and differentiation of circulating monocytes into virtually all tissues, are extremely flexible and plastic cells that play vital homeostatic roles, but also contribute to the pathophysiology of many human diseases. For these reasons, they are intensively studied by differen...

journal_title：Expert review of proteomics

authors： Castagna A,Polati R,Bossi AM,Girelli D

更新日期：2012-04-01 00:00:00

abstract：:Type II diabetes increases the risk for cognitive decline via multiple traits. Amylin is a pancreatic hormone that has amyloidogenic and cytotoxic properties similar to the amyloid-β peptide. The amylin hormone is overexpressed in individuals with pre-diabetic insulin resistance or obesity leading to amylin oligomeriz...

journal_title：Expert review of proteomics

authors： Ly H,Despa F

更新日期：2015-01-01 00:00:00

abstract：:Tremendous efforts have been put together over the last several years to complete the entire sequencing of the human genome. As we enter the proteomic era, when the major aim is understanding which gene encodes which protein, the time has also come to identify their precise function inside the astonishing signaling ne...

journal_title：Expert review of proteomics

authors： Vigneault F,Guérin SL

更新日期：2005-10-01 00:00:00

abstract：:With the growing availability of mature systems and strategies in biotechnology and the continuously expanding knowledge of cellular processes and involved biomolecules, human sports drug testing has become a considerably complex field in the arena of analytical chemistry. Proving the exogenous origin of peptidic drug...

journal_title：Expert review of proteomics

authors： Thevis M,Thomas A,Schänzer W

更新日期：2014-12-01 00:00:00

abstract：:Viruses have coevolved with their hosts, acquiring strategies to subvert host cellular pathways for effective viral replication and spread. Human cytomegalovirus (HCMV), a widely-spread β-herpesvirus, is a major cause of birth defects and opportunistic infections in HIV-1/AIDS patients. HCMV displays an intricate syst...

journal_title：Expert review of proteomics

authors： Jean Beltran PM,Cristea IM

更新日期：2014-12-01 00:00:00