Investigation of therapy resistance mechanisms in myeloid leukemia by protein profiling of bone marrow extracellular fluid.

abstract：:Endometriosis is a common disorder that is associated with infertility and pelvic pain. Diagnosis is based on the visualization of endometriotic lesions during surgery as no reliable serum marker is currently available. The etiology of endometriosis is largely unknown. Over the last 20 years, several proteomics techno...

journal_title：Expert review of proteomics

authors： Ferrero S,Gillott DJ,Remorgida V,Ragni N,Venturini PL,Grudzinskas JG

更新日期：2008-10-01 00:00:00

abstract：:Owing to its extensive use in the human diet, wheat is among the most common causes of food-related allergies and intolerances. Allergies to wheat are provoked by ingestion, inhalation or contact with either the soluble or the insoluble gluten proteins in wheat. Gluten proteins, and particularly the gliadin fraction, ...

journal_title：Expert review of proteomics

authors： Mamone G,Picariello G,Addeo F,Ferranti P

更新日期：2011-02-01 00:00:00

abstract：:Protein phosphorylation continues to be regarded as one of the most important post-translational modifications found in eukaryotes and has been implicated in key roles in the development of a number of human diseases. In order to elucidate roles for the 518 human kinases, phosphorylation has routinely been studied usi...

journal_title：Expert review of proteomics

authors： Mok J,Zhu X,Snyder M

更新日期：2011-12-01 00:00:00

abstract：INTRODUCTION:Heart diseases are a leading cause of morbidity and mortality for both men and women worldwide, and impose significant economic burdens on the healthcare systems. Despite substantial effort over the last several decades, the molecular mechanisms underlying diseases of the heart remain poorly understood. A...

journal_title：Expert review of proteomics

authors： Cai W,Tucholski TM,Gregorich ZR,Ge Y

更新日期：2016-08-01 00:00:00

abstract：:Protein profiling using high-throughput tandem mass spectrometry has become a powerful method for analyzing changes in global protein expression patterns in cells and tissues as a function of developmental, physiologic and disease processes. This review summarizes the utility and practical application of multidimensio...

journal_title：Expert review of proteomics

authors： Kislinger T,Emili A

更新日期：2005-01-01 00:00:00

abstract：OBJECTIVE:Hepcidin-25 production is stimulated by systemic inflammation, and it interferes with iron utilization, leading to anemia. This study aimed to investigate the relationships between the plasma levels of hepcidin, interleukin-6 (IL-6), erythropoietin (EPO) and erythroferrone (ERFE) in patients with benign breas...

journal_title：Expert review of proteomics

authors： Ciniselli CM,De Bortoli M,Taverna E,Varinelli L,Pizzamiglio S,Veneroni S,Bonini C,Orlandi R,Verderio P,Bongarzone I

更新日期：2015-01-01 00:00:00

abstract：:Normal multipotent tissue stem cells (SCs) are the driving force behind tissue turnover and repair. The cancer stem cell theory holds that tumors also contain stem-like cells that drive tumor growth and metastasis formation. However, very little is known about the regulation of SC maintenance pathways in cancer and ho...

journal_title：Expert review of proteomics

authors： Kranenburg O,Emmink BL,Knol J,van Houdt WJ,Rinkes IH,Jimenez CR

更新日期：2012-06-01 00:00:00

abstract：:The challenges encountered by proteomic researchers seeking diagnostic, prognostic and mechanistic markers were the subject of the 1-day meeting, Proteomics: Advances in Biomarker Discovery hosted by EuroSciCon. The speakers had a broad range of clinical and basic science interests, and presented data using a number o...

journal_title：Expert review of proteomics

authors： Cowan ML,Vera J

更新日期：2008-02-01 00:00:00

abstract：:A total of 40 years have already passed since the pioneering work of McCord and Fridovich on erythrocuprein superoxide dismutase (SOD) activity. This modern scientific 'Odyssey' has been accompanied by a series of successes in the fields of biochemistry, biomedicine and proteomics. In this article, we resume the main ...

journal_title：Expert review of proteomics

authors： D'Alessandro A,Zolla L

更新日期：2011-06-01 00:00:00

abstract：:Proteomics is performed in microgravity research in order to determine protein alterations occurring qualitatively and quantitatively, when single cells or whole organisms are exposed to real or simulated microgravity. To this purpose, antibody-dependent (Western blotting, flow cytometry, Luminex(®) technology) and an...

journal_title：Expert review of proteomics

authors： Grimm D,Pietsch J,Wehland M,Richter P,Strauch SM,Lebert M,Magnusson NE,Wise P,Bauer J

更新日期：2014-08-01 00:00:00

abstract：:Atherothrombosis is the primary cause of death in Western countries. The cellular and molecular mechanisms underlying atherosclerosis remain widely unknown. The complex nature of atherosclerotic cardiovascular diseases demands the development of novel technologies that enable discovery of new biomarkers for early dise...

journal_title：Expert review of proteomics

authors： Martín-Ventura JL,Blanco-Colio LM,Tunon J,Gomez-Guerrero C,Michel JB,Meilhac O,Egido J

更新日期：2007-04-01 00:00:00

abstract：INTRODUCTION:The lack of biomarkers indicating involved nociceptive and/or pain mechanisms makes diagnostic procedures problematic. Clinical pain research has begun to use proteomics. AREAS COVERED:This systematic review covers proteomic studies of chronic pain cohorts and in relation to clinical variables. Searches i...

journal_title：Expert review of proteomics

authors： Gerdle B,Ghafouri B

更新日期：2020-06-01 00:00:00

abstract：:Viruses have coevolved with their hosts, acquiring strategies to subvert host cellular pathways for effective viral replication and spread. Human cytomegalovirus (HCMV), a widely-spread β-herpesvirus, is a major cause of birth defects and opportunistic infections in HIV-1/AIDS patients. HCMV displays an intricate syst...

journal_title：Expert review of proteomics

authors： Jean Beltran PM,Cristea IM

更新日期：2014-12-01 00:00:00

abstract：:Introduction: Autophagy is one of the most conserved clearance systems through which eukaryotes manage to handle dysfunctional and excess organelles and macromolecules. This catabolic process has not only a role in the maintenance of basal turnover of cellular components, but it is also essential in cells adaptation t...

journal_title：Expert review of proteomics

authors： Di Domenico F,Zuliani I,Tramutola A

更新日期：2019-01-01 00:00:00

abstract：INTRODUCTION:The mission of the Chromosome-Centric Human Proteome Project (C-HPP), is to map and annotate the entire predicted human protein set (~20,000 proteins) encoded by each chromosome. The initial steps of the project are focused on 'missing proteins (MPs)', which lacked documented evidence for existence at prot...

journal_title：Expert review of proteomics

authors： Paik YK,Omenn GS,Hancock WS,Lane L,Overall CM

更新日期：2017-12-01 00:00:00

abstract：INTRODUCTION:Breast cancer subtypes are currently defined by a combination of morphologic, genomic, and proteomic characteristics. These subtypes provide a molecular portrait of the tumor that aids diagnosis, prognosis, and treatment escalation/de-escalation options. Gene expression signatures describing intrinsic brea...

journal_title：Expert review of proteomics

authors： Mueller C,Haymond A,Davis JB,Williams A,Espina V

更新日期：2018-02-01 00:00:00

abstract：:Osteoporosis is prevalent among the elderly and is a major cause of bone fracture in this population. Bone integrity is maintained by the dynamic processes of bone resorption and bone formation (bone remodeling). Osteoporosis results when there is an imbalance of the two counteracting processes. Bone mineral density, ...

journal_title：Expert review of proteomics

authors： Zhang H,Recker R,Lee WN,Xiao GG

更新日期：2010-02-01 00:00:00

abstract：:Introduction: The last decade has yielded significant developments in the field of proteomics, especially in mass spectrometry (MS) and data analysis tools. In particular, a shift from gel-based to MS-based proteomics has been observed, thereby providing a platform with which to construct proteome atlases for all life...

journal_title：Expert review of proteomics

authors： Min CW,Gupta R,Agrawal GK,Rakwal R,Kim ST

更新日期：2019-09-01 00:00:00

abstract：INTRODUCTION:Ticks are obligate hematophagous arthropod ectoparasites that transmit pathogens responsible for a growing number of tick-borne diseases (TBDs) throughout the world. Vaccines have been shown to be the most efficient, cost-effective, and environmentally friendly approach for the control of ticks and the pre...

journal_title：Expert review of proteomics

authors： Artigas-Jerónimo S,De La Fuente J,Villar M

更新日期：2018-08-01 00:00:00

abstract：INTRODUCTION:Mass spectrometry (MS)-based proteomics has become an indispensable tool for the characterization of the proteome and its post-translational modifications (PTM). In addition to standard protein sequence databases, proteogenomics strategies search the spectral data against the theoretical spectra obtained f...

journal_title：Expert review of proteomics

authors： Hernandez-Valladares M,Vaudel M,Selheim F,Berven F,Bruserud Ø

更新日期：2017-08-01 00:00:00

abstract：INTRODUCTION:In several biomedical research fields, the cross-linking of peptides and proteins has an important impact on health and wellbeing. It is therefore of crucial importance to study this class of post-translational modifications in detail. The huge potential of mass spectrometric technologies in the mapping of...

journal_title：Expert review of proteomics

authors： Maes E,Dyer JM,McKerchar HJ,Deb-Choudhury S,Clerens S

更新日期：2017-10-01 00:00:00

abstract：:The concept of personalized medicine includes novel protein biomarkers that are expected to improve the early detection, diagnosis and therapy monitoring of malignant diseases. Tissues, biofluids, cell lines and xenograft models are the common sources of biomarker candidates that require verification of clinical value...

journal_title：Expert review of proteomics

authors： Pernikářová V,Bouchal P

更新日期：2015-01-01 00:00:00

abstract：:Metastasis is the main cause of cancer death. As the tumor progresses, cells from the primary tumor site are shed into the bloodstream as circulating tumor cells (CTCs). Eventually, these cells colonize other organs and form distant metastases. It is therefore imperative that we gain a better understanding of the biol...

journal_title：Expert review of proteomics

authors： Chan CM,Au TC,Chan AT,Ma BB,Tsui NB,Ng SS,Hui EP,Chan LW,Ho WS,Yung BY,Wong SC

更新日期：2013-12-01 00:00:00

abstract：INTRODUCTION:Pancreatic ductal adenocarcinoma (PDAC) is one of the deadliest cancers worldwide. However, there remain many unmet clinical needs, from diagnosis to treatment strategies. The inherent complexity of the molecular characteristics of PDAC has made it difficult to meet these challenges, rendering proteomic pr...

journal_title：Expert review of proteomics

authors： Kim H,Park J,Wang JI,Kim Y

更新日期：2017-11-01 00:00:00

abstract：:Introduction: Degradation of proteins by cellular proteasomes is critical for the fidelity of protein homeostasis and proper cell function. Indeed, perturbations in proteasome function, as well as the degradation of specific substrates, are associated with a variety of human diseases. Yet, monitoring and analyzing pro...

journal_title：Expert review of proteomics

authors： Javitt A,Merbl Y

更新日期：2019-07-19 00:00:00

abstract：:The rapid expansion of methods for measuring biological data ranging from DNA sequence variations to mRNA expression and protein abundance presents the opportunity to utilize multiple types of information jointly in the study of human health and disease. Organisms are complex systems that integrate inputs at myriad le...

journal_title：Expert review of proteomics

authors： Reif DM,White BC,Moore JH

更新日期：2004-06-01 00:00:00

abstract：:Introduction: Matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS) has entered clinical diagnostics and is today a generally accepted and integral part of the workflow for microbial identification. MALDI-TOF MS identification systems received approval from national and internatio...

journal_title：Expert review of proteomics

authors： Welker M,Van Belkum A,Girard V,Charrier JP,Pincus D

更新日期：2019-08-01 00:00:00

abstract：INTRODUCTION:Pancreatic ductal adenocarcinoma (PDAC), which represents approximately 80% of all pancreatic cancers, is a highly aggressive malignant disease and one of the most lethal among all cancers. Overall, the 5-year survival rate among all pancreatic cancer patients is less than 9%; these rates have shown little...

journal_title：Expert review of proteomics

authors： Meleady P,Abdul Rahman R,Henry M,Moriarty M,Clynes M

更新日期：2020-06-01 00:00:00

abstract：:Protein phosphorylation events are key regulators of cellular signaling processes. In the era of functional genomics, rational drug design programs demand large-scale high-throughput analysis of signal transduction cascades. Significant improvements in the area of mass spectrometry-based proteomics have provided excit...

journal_title：Expert review of proteomics

authors： Chen WG,White FM

更新日期：2004-10-01 00:00:00

abstract：INTRODUCTION:Serum proteins are generally glycosylated and solubilized, and are thus present as glycoproteins. The glycan structure of glycoproteins reflects cell differentiation status; glycan structures generated by diseased cells are distinguishable from those produced by healthy cells. Proteins may therefore serve ...

journal_title：Expert review of proteomics

authors： Narimatsu H,Sato T

更新日期：2018-02-01 00:00:00