Protein-protein cross-linking and human health: the challenge of elucidating with mass spectrometry.

Abstract:

INTRODUCTION:In several biomedical research fields, the cross-linking of peptides and proteins has an important impact on health and wellbeing. It is therefore of crucial importance to study this class of post-translational modifications in detail. The huge potential of mass spectrometric technologies in the mapping of these protein-protein cross-links is however overshadowed by the challenges that the field has to overcome. Areas covered: In this review, we summarize the different pitfalls and challenges that the protein-protein cross-linking field is confronted with when using mass spectrometry approaches. We additionally focus on native disulfide bridges as an example and provide some examples of cross-links that are important in the biomedical field. Expert commentary: The current flow of methodological improvements, mainly from the chemical cross-linking field, has delivered a significant contribution to deciphering native and insult-induced cross-links. Although an automated data analysis of proteome-wide peptide cross-linking is currently only possible in chemical cross-linking experiments, the field is well on the way towards a more automated analysis of native and insult-induced cross-links in raw mass spectrometry data that will boost its potential in biomedical applications.

journal_name

Expert Rev Proteomics

authors

Maes E,Dyer JM,McKerchar HJ,Deb-Choudhury S,Clerens S

doi

10.1080/14789450.2017.1362336

subject

Has Abstract

pub_date

2017-10-01 00:00:00

pages

917-929

issue

10

eissn

1478-9450

issn

1744-8387

journal_volume

14

pub_type

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