Proteomic study of skeletal muscle in obesity and type 2 diabetes: progress and potential.


INTRODUCTION:Skeletal muscle is the major site of insulin-stimulated glucose uptake and imparts the beneficial effects of exercise, and hence is an important site of insulin resistance in obesity and type 2 diabetes (T2D). Despite extensive molecular biology-oriented research the molecular mechanisms underlying insulin resistance in skeletal muscle remain to be established. Areas covered: The proteomic capabilities have greatly improved over the last decades. This review summarizes the technical challenges in skeletal muscle proteomics studies as well as the results of quantitative proteomic studies of skeletal muscle in relation to obesity, T2D, and exercise. Expert commentary: Current available proteomic studies contribute to the view that insulin resistance in obesity and T2D is associated with increased glycolysis and reduced mitochondrial oxidative metabolism in skeletal muscle, and that the latter can be improved by exercise. Future proteomics studies should be designed to markedly intensify the identification of abnormalities in metabolic and signaling pathways in skeletal muscle of insulin-resistant individuals to increase the understanding of the pathogenesis of T2D, but more importantly to identify multiple novel targets of treatment of which at least some can be safely targeted by novel drugs to treat and prevent T2D and reduce risk of cardiovascular disease.


Expert Rev Proteomics


Kruse R,Højlund K




Has Abstract


2018-10-01 00:00:00












  • Proteomic profiling of fatty acid binding proteins in muscular dystrophy.

    abstract::Introduction: Duchenne muscular dystrophy is a neuromuscular disorder, which is caused by abnormalities in the DMD gene that encodes the membrane cytoskeletal protein dystrophin. Besides progressive skeletal muscle wasting, dystrophinopathy also affects non-skeletal muscle tissues, including cells in the cardio-respir...

    journal_title:Expert review of proteomics

    pub_type: 杂志文章


    authors: Dowling P,Gargan S,Zweyer M,Swandulla D,Ohlendieck K

    更新日期:2020-02-01 00:00:00

  • The role of mass spectrometry in the characterization of biologic protein products.

    abstract:INTRODUCTION:Mass spectrometry (MS) is widely used in the characterization of biomolecules including peptide and protein therapeutics. These biotechnology products have seen rapid growth over the past few decades and continue to dominate the global pharmaceutical market. Advances in MS instrumentation and techniques ha...

    journal_title:Expert review of proteomics

    pub_type: 杂志文章,评审


    authors: Rathore D,Faustino A,Schiel J,Pang E,Boyne M,Rogstad S

    更新日期:2018-05-01 00:00:00

  • The impact of microgravity-based proteomics research.

    abstract::Proteomics is performed in microgravity research in order to determine protein alterations occurring qualitatively and quantitatively, when single cells or whole organisms are exposed to real or simulated microgravity. To this purpose, antibody-dependent (Western blotting, flow cytometry, Luminex(®) technology) and an...

    journal_title:Expert review of proteomics

    pub_type: 杂志文章


    authors: Grimm D,Pietsch J,Wehland M,Richter P,Strauch SM,Lebert M,Magnusson NE,Wise P,Bauer J

    更新日期:2014-08-01 00:00:00

  • Sperm proteomics: potential impact on male infertility treatment.

    abstract::Spermatozoa are unique cells that have highly compact DNA, motility (and hypermotility) patterns, a specific morphology, localized mitochondria and an apical acrosome. They are the end product of a dynamic process termed spermatogenesis. Sperm are therefore produced with specific proteins in order to effect different ...

    journal_title:Expert review of proteomics

    pub_type: 杂志文章,评审


    authors: Agarwal A,Bertolla RP,Samanta L

    更新日期:2016-01-01 00:00:00

  • New insights into viral structure and virus-cell interactions through proteomics.

    abstract::Although genomics techniques such as DNA microarrays have been widely used in virology, much more limited use has been made of proteomics. Although difficult, proteomics can greatly contribute to an understanding of virus-cell interactions, including the ternary structure of viral receptors at the cell surface, post-t...

    journal_title:Expert review of proteomics

    pub_type: 杂志文章,评审


    authors: Bernhard OK,Diefenbach RJ,Cunningham AL

    更新日期:2005-08-01 00:00:00

  • Proteomic analysis of pancreatic ductal adenocarcinoma.

    abstract:INTRODUCTION:Pancreatic ductal adenocarcinoma (PDAC), which represents approximately 80% of all pancreatic cancers, is a highly aggressive malignant disease and one of the most lethal among all cancers. Overall, the 5-year survival rate among all pancreatic cancer patients is less than 9%; these rates have shown little...

    journal_title:Expert review of proteomics

    pub_type: 杂志文章


    authors: Meleady P,Abdul Rahman R,Henry M,Moriarty M,Clynes M

    更新日期:2020-06-01 00:00:00

  • Contribution of mass spectrometry-based proteomics to immunology.

    abstract::Antigen processing forwards various information about the cellular status and the proteome to the cell surface for scrutiny by the cellular immune system. Thus the repertoire of major histocompatibility complex (MHC)-bound peptides and the MHC ligandome, indirectly mirrors the proteome in order to make alterations ins...

    journal_title:Expert review of proteomics

    pub_type: 杂志文章,评审


    authors: Hillen N,Stevanovic S

    更新日期:2006-12-01 00:00:00

  • Platelet proteomics applied to the search for novel antiplatelet therapeutic targets.

    abstract:INTRODUCTION:Unwanted platelet activation is associated with numerous diseases, mainly thrombosis-related. In this context, proteomics has emerged as a novel tool with potential for drug target discovery and to scrutinize the effects of antiplatelet drugs. Areas covered: The present review presents the main findings of...

    journal_title:Expert review of proteomics

    pub_type: 杂志文章


    authors: Izquierdo I,García Á

    更新日期:2016-11-01 00:00:00

  • Shining a light on defective autophagy by proteomics approaches: implications for neurodegenerative illnesses.

    abstract::Introduction: Autophagy is one of the most conserved clearance systems through which eukaryotes manage to handle dysfunctional and excess organelles and macromolecules. This catabolic process has not only a role in the maintenance of basal turnover of cellular components, but it is also essential in cells adaptation t...

    journal_title:Expert review of proteomics

    pub_type: 杂志文章,评审


    authors: Di Domenico F,Zuliani I,Tramutola A

    更新日期:2019-01-01 00:00:00

  • Surface plasmon resonance mass spectrometry in proteomics.

    abstract::Due to the enormous complexity of the proteome, focus in proteomics shifts more and more from the study of the complete proteome to the targeted analysis of part of the proteome. The isolation of this specific part of the proteome generally includes an affinity-based enrichment. Surface plasmon resonance (SPR), a labe...

    journal_title:Expert review of proteomics

    pub_type: 杂志文章,评审


    authors: Visser NF,Heck AJ

    更新日期:2008-06-01 00:00:00

  • Monocyte/macrophage proteomics: recent findings and biomedical applications.

    abstract::Macrophages, originating from the migration and differentiation of circulating monocytes into virtually all tissues, are extremely flexible and plastic cells that play vital homeostatic roles, but also contribute to the pathophysiology of many human diseases. For these reasons, they are intensively studied by differen...

    journal_title:Expert review of proteomics

    pub_type: 杂志文章,评审


    authors: Castagna A,Polati R,Bossi AM,Girelli D

    更新日期:2012-04-01 00:00:00

  • A decade of proteomics accomplished! Central and Eastern European Proteomic Conference (CEEPC) celebrates its 10th Anniversary in Budapest, Hungary.

    abstract::The Central and Eastern European Proteomic Conference (CEEPC) proudly celebrated its 10th Anniversary with an exciting scientific program inclusive of proteome, proteomics and systems biology in Budapest, Hungary. Since 2007, CEEPC has represented 'state-of the-art' proteomics in and around Central and Eastern Europe ...

    journal_title:Expert review of proteomics

    pub_type: 杂志文章


    authors: Gadher SJ,Drahos L,Vékey K,Kovarova H

    更新日期:2017-07-01 00:00:00

  • Framework for a systems approach to proteomic biomarker profiling in polycystic ovary syndrome.

    abstract::Polycystic ovary syndrome (PCOS) is the most common endocrine disorder in females of reproductive age, and its prevalence ranges between 6 and 8%. Associated problems include infertility, menstrual disorders, hirsutism and obesity. In addition, individuals with PCOS may be at increased risk of diabetes, endometrial ca...

    journal_title:Expert review of proteomics

    pub_type: 杂志文章,评审


    authors: Atiomo WU,Khalid S,Ziauddin A,Tooth D,Layfield R

    更新日期:2009-10-01 00:00:00

  • Skin proteomics - analysis of the extracellular matrix in health and disease.

    abstract:INTRODUCTION:The skin protects the human body from external insults and regulates water and temperature homeostasis. A highly developed extracellular matrix (ECM) supports the skin and instructs its cell functions. Reduced functionality of the ECM is often associated with skin diseases that cause physical impairment an...

    journal_title:Expert review of proteomics

    pub_type: 杂志文章


    authors: Dengjel J,Bruckner-Tuderman L,Nyström A

    更新日期:2020-05-01 00:00:00

  • Transcriptional control and transcriptomic analysis of lipid metabolism in skin barrier formation and atopic dermatitis (AD).

    abstract::Introduction: Atopic dermatitis (AD) is a multifactorial ailment associated with barrier breach and intense systemic inflammation. Several studies over the years have shown the complex interplay of a large number of factors in governing the progression and outcome of AD. In addition to the diverse types of AD resultin...

    journal_title:Expert review of proteomics

    pub_type: 杂志文章


    authors: Bhattacharya N,Ganguli-Indra G,Indra AK

    更新日期:2019-08-01 00:00:00

  • Advances in cell-free protein array methods.

    abstract:INTRODUCTION:Cell-free protein microarrays represent a special form of protein microarray which display proteins made fresh at the time of the experiment, avoiding storage and denaturation. They have been used increasingly in basic and translational research over the past decade to study protein-protein interactions, t...

    journal_title:Expert review of proteomics

    pub_type: 杂志文章


    authors: Yu X,Petritis B,Duan H,Xu D,LaBaer J

    更新日期:2018-01-01 00:00:00

  • Update on: proteome analysis in thyroid pathology - part II: overview of technical and clinical enhancement of proteomic investigation of the thyroid lesions.

    abstract:INTRODUCTION:An accurate diagnostic classification of thyroid lesions remains an important clinical aspect that needs to be addressed in order to avoid 'diagnostic' thyroidectomies. Among the several 'omics' techniques, proteomics is playing a pivotal role in the search for diagnostic markers. In recent years, differen...

    journal_title:Expert review of proteomics

    pub_type: 杂志文章,评审


    authors: Piga I,Casano S,Smith A,Tettamanti S,Leni D,Capitoli G,Pincelli AI,Scardilli M,Galimberti S,Magni F,Pagni F

    更新日期:2018-11-01 00:00:00

  • Protein biomarkers for subtyping breast cancer and implications for future research.

    abstract:INTRODUCTION:Breast cancer subtypes are currently defined by a combination of morphologic, genomic, and proteomic characteristics. These subtypes provide a molecular portrait of the tumor that aids diagnosis, prognosis, and treatment escalation/de-escalation options. Gene expression signatures describing intrinsic brea...

    journal_title:Expert review of proteomics

    pub_type: 杂志文章,评审


    authors: Mueller C,Haymond A,Davis JB,Williams A,Espina V

    更新日期:2018-02-01 00:00:00

  • Transcriptomic profiling in Cutaneous Leishmaniasis patients.

    abstract:INTRODUCTION:Cutaneous leishmaniasis (CL), caused by different Leishmania parasite species, is associated with parasite-induced immune-mediated skin inflammation and ulceration. Whereas many CL studies focus on gene expression signatures in mouse models, the transcriptional response driving human patients in the field ...

    journal_title:Expert review of proteomics

    pub_type: 杂志文章


    authors: Masoudzadeh N,Mizbani A,Rafati S

    更新日期:2020-01-01 00:00:00

  • Novel methods in glycomics: a 2019 update.

    abstract::Introduction: Glycomics, which aims to define the glycome of a biological system to better assess the biological attributes of the glycans, has attracted increasing interest. However, the complexity and diversity of glycans present challenging barriers to glycome definition. Technological advances are major drivers in...

    journal_title:Expert review of proteomics

    pub_type: 杂志文章


    authors: Cao WQ,Liu MQ,Kong SY,Wu MX,Huang ZZ,Yang PY

    更新日期:2020-01-01 00:00:00

  • Unravelling the biology of chromatin in health and cancer using proteomic approaches.

    abstract:INTRODUCTION:Chromatin remodeling complexes play important roles in the control of genome regulation in both normal and diseased states, and are therefore critical components for the regulation of epigenetic states in cells. Given the role epigenetics plays in cancer, for example, chromatin remodeling complexes are rou...

    journal_title:Expert review of proteomics

    pub_type: 杂志文章,评审


    authors: Eubanks CG,Dayebgadoh G,Liu X,Washburn MP

    更新日期:2017-10-01 00:00:00

  • Recent advances in proteomic profiling of pancreatic ductal adenocarcinoma and the road ahead.

    abstract:INTRODUCTION:Pancreatic ductal adenocarcinoma (PDAC) is one of the deadliest cancers worldwide. However, there remain many unmet clinical needs, from diagnosis to treatment strategies. The inherent complexity of the molecular characteristics of PDAC has made it difficult to meet these challenges, rendering proteomic pr...

    journal_title:Expert review of proteomics

    pub_type: 杂志文章,评审


    authors: Kim H,Park J,Wang JI,Kim Y

    更新日期:2017-11-01 00:00:00

  • Multidimensional protein identification technology: current status and future prospects.

    abstract::Protein profiling using high-throughput tandem mass spectrometry has become a powerful method for analyzing changes in global protein expression patterns in cells and tissues as a function of developmental, physiologic and disease processes. This review summarizes the utility and practical application of multidimensio...

    journal_title:Expert review of proteomics

    pub_type: 杂志文章,评审


    authors: Kislinger T,Emili A

    更新日期:2005-01-01 00:00:00

  • Advances in endothelial shear stress proteomics.

    abstract::The vascular endothelium lining the luminal surface of all blood vessels is constantly exposed to shear stress exerted by the flowing blood. Blood flow with high laminar shear stress confers protection by activation of antiatherogenic, antithrombotic and anti-inflammatory proteins, whereas low or oscillatory shear str...

    journal_title:Expert review of proteomics

    pub_type: 杂志文章,评审


    authors: Firasat S,Hecker M,Binder L,Asif AR

    更新日期:2014-10-01 00:00:00

  • Urinary biomarkers of physical activity: candidates and clinical utility.

    abstract::Chronic physical inactivity is a major risk factor for a number of important lifestyle diseases, while inappropriate exposure to high physical demands is a risk factor for musculoskeletal injury and fatigue. Proteomic and metabolomic investigations of the physical activity continuum - extreme sedentariness to extremes...

    journal_title:Expert review of proteomics

    pub_type: 杂志文章,评审


    authors: Sampson DL,Broadbent JA,Parker AW,Upton Z,Parker TJ

    更新日期:2014-02-01 00:00:00

  • Proteomics in atherothrombosis: a future perspective.

    abstract::Atherothrombosis is the primary cause of death in Western countries. The cellular and molecular mechanisms underlying atherosclerosis remain widely unknown. The complex nature of atherosclerotic cardiovascular diseases demands the development of novel technologies that enable discovery of new biomarkers for early dise...

    journal_title:Expert review of proteomics

    pub_type: 杂志文章,评审


    authors: Martín-Ventura JL,Blanco-Colio LM,Tunon J,Gomez-Guerrero C,Michel JB,Meilhac O,Egido J

    更新日期:2007-04-01 00:00:00

  • Regulation of gene expression: probing DNA-protein interactions in vivo and in vitro.

    abstract::Tremendous efforts have been put together over the last several years to complete the entire sequencing of the human genome. As we enter the proteomic era, when the major aim is understanding which gene encodes which protein, the time has also come to identify their precise function inside the astonishing signaling ne...

    journal_title:Expert review of proteomics

    pub_type: 杂志文章,评审


    authors: Vigneault F,Guérin SL

    更新日期:2005-10-01 00:00:00

  • The life cycle and pathogenesis of human cytomegalovirus infection: lessons from proteomics.

    abstract::Viruses have coevolved with their hosts, acquiring strategies to subvert host cellular pathways for effective viral replication and spread. Human cytomegalovirus (HCMV), a widely-spread β-herpesvirus, is a major cause of birth defects and opportunistic infections in HIV-1/AIDS patients. HCMV displays an intricate syst...

    journal_title:Expert review of proteomics

    pub_type: 杂志文章


    authors: Jean Beltran PM,Cristea IM

    更新日期:2014-12-01 00:00:00

  • Proteomics: advances in biomarker discovery.

    abstract::The challenges encountered by proteomic researchers seeking diagnostic, prognostic and mechanistic markers were the subject of the 1-day meeting, Proteomics: Advances in Biomarker Discovery hosted by EuroSciCon. The speakers had a broad range of clinical and basic science interests, and presented data using a number o...

    journal_title:Expert review of proteomics



    authors: Cowan ML,Vera J

    更新日期:2008-02-01 00:00:00

  • Detecting peptidic drugs, drug candidates and analogs in sports doping: current status and future directions.

    abstract::With the growing availability of mature systems and strategies in biotechnology and the continuously expanding knowledge of cellular processes and involved biomolecules, human sports drug testing has become a considerably complex field in the arena of analytical chemistry. Proving the exogenous origin of peptidic drug...

    journal_title:Expert review of proteomics

    pub_type: 杂志文章


    authors: Thevis M,Thomas A,Schänzer W

    更新日期:2014-12-01 00:00:00