Proteomic study of skeletal muscle in obesity and type 2 diabetes: progress and potential.

abstract：:Introduction: Duchenne muscular dystrophy is a neuromuscular disorder, which is caused by abnormalities in the DMD gene that encodes the membrane cytoskeletal protein dystrophin. Besides progressive skeletal muscle wasting, dystrophinopathy also affects non-skeletal muscle tissues, including cells in the cardio-respir...

journal_title：Expert review of proteomics

authors： Dowling P,Gargan S,Zweyer M,Swandulla D,Ohlendieck K

更新日期：2020-02-01 00:00:00

abstract：INTRODUCTION:Mass spectrometry (MS) is widely used in the characterization of biomolecules including peptide and protein therapeutics. These biotechnology products have seen rapid growth over the past few decades and continue to dominate the global pharmaceutical market. Advances in MS instrumentation and techniques ha...

journal_title：Expert review of proteomics

authors： Rathore D,Faustino A,Schiel J,Pang E,Boyne M,Rogstad S

更新日期：2018-05-01 00:00:00

abstract：:Proteomics is performed in microgravity research in order to determine protein alterations occurring qualitatively and quantitatively, when single cells or whole organisms are exposed to real or simulated microgravity. To this purpose, antibody-dependent (Western blotting, flow cytometry, Luminex(®) technology) and an...

journal_title：Expert review of proteomics

authors： Grimm D,Pietsch J,Wehland M,Richter P,Strauch SM,Lebert M,Magnusson NE,Wise P,Bauer J

更新日期：2014-08-01 00:00:00

abstract：:Spermatozoa are unique cells that have highly compact DNA, motility (and hypermotility) patterns, a specific morphology, localized mitochondria and an apical acrosome. They are the end product of a dynamic process termed spermatogenesis. Sperm are therefore produced with specific proteins in order to effect different ...

journal_title：Expert review of proteomics

authors： Agarwal A,Bertolla RP,Samanta L

更新日期：2016-01-01 00:00:00

abstract：:Although genomics techniques such as DNA microarrays have been widely used in virology, much more limited use has been made of proteomics. Although difficult, proteomics can greatly contribute to an understanding of virus-cell interactions, including the ternary structure of viral receptors at the cell surface, post-t...

journal_title：Expert review of proteomics

authors： Bernhard OK,Diefenbach RJ,Cunningham AL

更新日期：2005-08-01 00:00:00

abstract：INTRODUCTION:Pancreatic ductal adenocarcinoma (PDAC), which represents approximately 80% of all pancreatic cancers, is a highly aggressive malignant disease and one of the most lethal among all cancers. Overall, the 5-year survival rate among all pancreatic cancer patients is less than 9%; these rates have shown little...

journal_title：Expert review of proteomics

authors： Meleady P,Abdul Rahman R,Henry M,Moriarty M,Clynes M

更新日期：2020-06-01 00:00:00

abstract：:Antigen processing forwards various information about the cellular status and the proteome to the cell surface for scrutiny by the cellular immune system. Thus the repertoire of major histocompatibility complex (MHC)-bound peptides and the MHC ligandome, indirectly mirrors the proteome in order to make alterations ins...

journal_title：Expert review of proteomics

authors： Hillen N,Stevanovic S

更新日期：2006-12-01 00:00:00

abstract：INTRODUCTION:Unwanted platelet activation is associated with numerous diseases, mainly thrombosis-related. In this context, proteomics has emerged as a novel tool with potential for drug target discovery and to scrutinize the effects of antiplatelet drugs. Areas covered: The present review presents the main findings of...

journal_title：Expert review of proteomics

authors： Izquierdo I,García Á

更新日期：2016-11-01 00:00:00

abstract：:Introduction: Autophagy is one of the most conserved clearance systems through which eukaryotes manage to handle dysfunctional and excess organelles and macromolecules. This catabolic process has not only a role in the maintenance of basal turnover of cellular components, but it is also essential in cells adaptation t...

journal_title：Expert review of proteomics

authors： Di Domenico F,Zuliani I,Tramutola A

更新日期：2019-01-01 00:00:00

abstract：:Due to the enormous complexity of the proteome, focus in proteomics shifts more and more from the study of the complete proteome to the targeted analysis of part of the proteome. The isolation of this specific part of the proteome generally includes an affinity-based enrichment. Surface plasmon resonance (SPR), a labe...

journal_title：Expert review of proteomics

authors： Visser NF,Heck AJ

更新日期：2008-06-01 00:00:00

abstract：:Macrophages, originating from the migration and differentiation of circulating monocytes into virtually all tissues, are extremely flexible and plastic cells that play vital homeostatic roles, but also contribute to the pathophysiology of many human diseases. For these reasons, they are intensively studied by differen...

journal_title：Expert review of proteomics

authors： Castagna A,Polati R,Bossi AM,Girelli D

更新日期：2012-04-01 00:00:00

abstract：:The Central and Eastern European Proteomic Conference (CEEPC) proudly celebrated its 10th Anniversary with an exciting scientific program inclusive of proteome, proteomics and systems biology in Budapest, Hungary. Since 2007, CEEPC has represented 'state-of the-art' proteomics in and around Central and Eastern Europe ...

journal_title：Expert review of proteomics

authors： Gadher SJ,Drahos L,Vékey K,Kovarova H

更新日期：2017-07-01 00:00:00

abstract：:Polycystic ovary syndrome (PCOS) is the most common endocrine disorder in females of reproductive age, and its prevalence ranges between 6 and 8%. Associated problems include infertility, menstrual disorders, hirsutism and obesity. In addition, individuals with PCOS may be at increased risk of diabetes, endometrial ca...

journal_title：Expert review of proteomics

authors： Atiomo WU,Khalid S,Ziauddin A,Tooth D,Layfield R

更新日期：2009-10-01 00:00:00

abstract：INTRODUCTION:The skin protects the human body from external insults and regulates water and temperature homeostasis. A highly developed extracellular matrix (ECM) supports the skin and instructs its cell functions. Reduced functionality of the ECM is often associated with skin diseases that cause physical impairment an...

journal_title：Expert review of proteomics

authors： Dengjel J,Bruckner-Tuderman L,Nyström A

更新日期：2020-05-01 00:00:00

abstract：:Introduction: Atopic dermatitis (AD) is a multifactorial ailment associated with barrier breach and intense systemic inflammation. Several studies over the years have shown the complex interplay of a large number of factors in governing the progression and outcome of AD. In addition to the diverse types of AD resultin...

journal_title：Expert review of proteomics

authors： Bhattacharya N,Ganguli-Indra G,Indra AK

更新日期：2019-08-01 00:00:00

abstract：INTRODUCTION:Cell-free protein microarrays represent a special form of protein microarray which display proteins made fresh at the time of the experiment, avoiding storage and denaturation. They have been used increasingly in basic and translational research over the past decade to study protein-protein interactions, t...

journal_title：Expert review of proteomics

authors： Yu X,Petritis B,Duan H,Xu D,LaBaer J

更新日期：2018-01-01 00:00:00

abstract：INTRODUCTION:An accurate diagnostic classification of thyroid lesions remains an important clinical aspect that needs to be addressed in order to avoid 'diagnostic' thyroidectomies. Among the several 'omics' techniques, proteomics is playing a pivotal role in the search for diagnostic markers. In recent years, differen...

journal_title：Expert review of proteomics

authors： Piga I,Casano S,Smith A,Tettamanti S,Leni D,Capitoli G,Pincelli AI,Scardilli M,Galimberti S,Magni F,Pagni F

更新日期：2018-11-01 00:00:00

abstract：INTRODUCTION:Breast cancer subtypes are currently defined by a combination of morphologic, genomic, and proteomic characteristics. These subtypes provide a molecular portrait of the tumor that aids diagnosis, prognosis, and treatment escalation/de-escalation options. Gene expression signatures describing intrinsic brea...

journal_title：Expert review of proteomics

authors： Mueller C,Haymond A,Davis JB,Williams A,Espina V

更新日期：2018-02-01 00:00:00

abstract：INTRODUCTION:Cutaneous leishmaniasis (CL), caused by different Leishmania parasite species, is associated with parasite-induced immune-mediated skin inflammation and ulceration. Whereas many CL studies focus on gene expression signatures in mouse models, the transcriptional response driving human patients in the field ...

journal_title：Expert review of proteomics

authors： Masoudzadeh N,Mizbani A,Rafati S

更新日期：2020-01-01 00:00:00

abstract：:Introduction: Glycomics, which aims to define the glycome of a biological system to better assess the biological attributes of the glycans, has attracted increasing interest. However, the complexity and diversity of glycans present challenging barriers to glycome definition. Technological advances are major drivers in...

journal_title：Expert review of proteomics

authors： Cao WQ,Liu MQ,Kong SY,Wu MX,Huang ZZ,Yang PY

更新日期：2020-01-01 00:00:00

abstract：INTRODUCTION:Chromatin remodeling complexes play important roles in the control of genome regulation in both normal and diseased states, and are therefore critical components for the regulation of epigenetic states in cells. Given the role epigenetics plays in cancer, for example, chromatin remodeling complexes are rou...

journal_title：Expert review of proteomics

authors： Eubanks CG,Dayebgadoh G,Liu X,Washburn MP

更新日期：2017-10-01 00:00:00

abstract：INTRODUCTION:Pancreatic ductal adenocarcinoma (PDAC) is one of the deadliest cancers worldwide. However, there remain many unmet clinical needs, from diagnosis to treatment strategies. The inherent complexity of the molecular characteristics of PDAC has made it difficult to meet these challenges, rendering proteomic pr...

journal_title：Expert review of proteomics

authors： Kim H,Park J,Wang JI,Kim Y

更新日期：2017-11-01 00:00:00

abstract：:Protein profiling using high-throughput tandem mass spectrometry has become a powerful method for analyzing changes in global protein expression patterns in cells and tissues as a function of developmental, physiologic and disease processes. This review summarizes the utility and practical application of multidimensio...

journal_title：Expert review of proteomics

authors： Kislinger T,Emili A

更新日期：2005-01-01 00:00:00

abstract：:The vascular endothelium lining the luminal surface of all blood vessels is constantly exposed to shear stress exerted by the flowing blood. Blood flow with high laminar shear stress confers protection by activation of antiatherogenic, antithrombotic and anti-inflammatory proteins, whereas low or oscillatory shear str...

journal_title：Expert review of proteomics

authors： Firasat S,Hecker M,Binder L,Asif AR

更新日期：2014-10-01 00:00:00

abstract：:Chronic physical inactivity is a major risk factor for a number of important lifestyle diseases, while inappropriate exposure to high physical demands is a risk factor for musculoskeletal injury and fatigue. Proteomic and metabolomic investigations of the physical activity continuum - extreme sedentariness to extremes...

journal_title：Expert review of proteomics

authors： Sampson DL,Broadbent JA,Parker AW,Upton Z,Parker TJ

更新日期：2014-02-01 00:00:00

abstract：:Atherothrombosis is the primary cause of death in Western countries. The cellular and molecular mechanisms underlying atherosclerosis remain widely unknown. The complex nature of atherosclerotic cardiovascular diseases demands the development of novel technologies that enable discovery of new biomarkers for early dise...

journal_title：Expert review of proteomics

authors： Martín-Ventura JL,Blanco-Colio LM,Tunon J,Gomez-Guerrero C,Michel JB,Meilhac O,Egido J

更新日期：2007-04-01 00:00:00

abstract：:Tremendous efforts have been put together over the last several years to complete the entire sequencing of the human genome. As we enter the proteomic era, when the major aim is understanding which gene encodes which protein, the time has also come to identify their precise function inside the astonishing signaling ne...

journal_title：Expert review of proteomics

authors： Vigneault F,Guérin SL

更新日期：2005-10-01 00:00:00

abstract：:Viruses have coevolved with their hosts, acquiring strategies to subvert host cellular pathways for effective viral replication and spread. Human cytomegalovirus (HCMV), a widely-spread β-herpesvirus, is a major cause of birth defects and opportunistic infections in HIV-1/AIDS patients. HCMV displays an intricate syst...

journal_title：Expert review of proteomics

authors： Jean Beltran PM,Cristea IM

更新日期：2014-12-01 00:00:00

abstract：:The challenges encountered by proteomic researchers seeking diagnostic, prognostic and mechanistic markers were the subject of the 1-day meeting, Proteomics: Advances in Biomarker Discovery hosted by EuroSciCon. The speakers had a broad range of clinical and basic science interests, and presented data using a number o...

journal_title：Expert review of proteomics

authors： Cowan ML,Vera J

更新日期：2008-02-01 00:00:00

abstract：:With the growing availability of mature systems and strategies in biotechnology and the continuously expanding knowledge of cellular processes and involved biomolecules, human sports drug testing has become a considerably complex field in the arena of analytical chemistry. Proving the exogenous origin of peptidic drug...

journal_title：Expert review of proteomics

authors： Thevis M,Thomas A,Schänzer W

更新日期：2014-12-01 00:00:00