Proteomic analysis of cellular signaling.

abstract：:A major goal of proteomics is to develop methods that enable the systematic characterization of every protein within the cell or particular subcellular proteome using a single analytical platform. Although the equivalent has already been achieved in genomics, reaching this goal in proteomics represents a much greater ...

journal_title：Expert review of proteomics

authors： Blonder J,Conrads TP,Veenstra TD

更新日期：2004-08-01 00:00:00

abstract：:Introduction: Duchenne muscular dystrophy is a neuromuscular disorder, which is caused by abnormalities in the DMD gene that encodes the membrane cytoskeletal protein dystrophin. Besides progressive skeletal muscle wasting, dystrophinopathy also affects non-skeletal muscle tissues, including cells in the cardio-respir...

journal_title：Expert review of proteomics

authors： Dowling P,Gargan S,Zweyer M,Swandulla D,Ohlendieck K

更新日期：2020-02-01 00:00:00

abstract：:The advances in high-resolution mass spectrometry instrumentation, capable of accurate mass measurement and fast acquisition, have enabled new approaches for targeted quantitative proteomics. More specifically, analyses performed on quadrupole-orbitrap mass spectrometers operated in parallel reaction monitoring (PRM) ...

journal_title：Expert review of proteomics

authors： Gallien S,Domon B

更新日期：2015-01-01 00:00:00

abstract：:Macrophages, originating from the migration and differentiation of circulating monocytes into virtually all tissues, are extremely flexible and plastic cells that play vital homeostatic roles, but also contribute to the pathophysiology of many human diseases. For these reasons, they are intensively studied by differen...

journal_title：Expert review of proteomics

authors： Castagna A,Polati R,Bossi AM,Girelli D

更新日期：2012-04-01 00:00:00

abstract：:Huntington's disease (HD) is caused by expansion of a polyglutamine repeat in the N-terminal region of huntingtin (htt), a large protein that has been found to interact with a variety of proteins. It remains to be determined how the interactions of htt with other proteins are involved in the pathogenesis of HD. A rece...

journal_title：Expert review of proteomics

authors： Li S,Li XJ

更新日期：2012-01-01 00:00:00

abstract：INTRODUCTION:Metabolomics has become a crucial part of systems biology; however, data analysis is still often undertaken in a reductionist way focusing on changes in individual metabolites. Whilst such approaches indeed provide relevant insights into the metabolic phenotype of an organism, the intricate nature of metab...

journal_title：Expert review of proteomics

authors： Perez De Souza L,Alseekh S,Brotman Y,Fernie AR

更新日期：2020-04-01 00:00:00

abstract：:Tissue microarrays are a high-throughput method for the investigation of biomarkers in multiple tissue specimens at once. This technique allows for the analysis of up to 500 tissue samples in a single experiment using immunohistochemistry and in situ hybridization. Recently, cell lines and xenografts have been reduced...

journal_title：Expert review of proteomics

authors： Braunschweig T,Chung JY,Hewitt SM

更新日期：2005-06-01 00:00:00

abstract：INTRODUCTION:Frailty is consequent to age-dependent deregulation of several biological pathways and systems, encompassing namely sarcopenia, age-associated hormonal derangements, inflammation, and nutritional or metabolic deficiencies. Although the prevalence of frailty is usually between 10% and 20% in the general eld...

journal_title：Expert review of proteomics

authors： Danese E,Montagnana M,Lippi G

更新日期：2018-08-01 00:00:00

abstract：:In recent years, MALDI imaging mass spectrometry (MALDI-IMS) has developed as a promising tool to investigate the spatial distribution of biomolecules in intact tissue specimens. Ion densities of various molecules can be displayed as heat maps while preserving anatomical structures. In this short review, an overview o...

journal_title：Expert review of proteomics

authors： Chatterji B,Pich A

更新日期：2013-08-01 00:00:00

abstract：:This review addresses the challenges of neuroproteomics and recent progress in biomarkers and tests for neurodegenerative diseases, including Alzheimer's disease, Parkinson's disease and amyotrophic lateral sclerosis. The review will discuss how the application of quantitative 2D gel electrophoresis, combined with app...

journal_title：Expert review of proteomics

authors： Sheta EA,Appel SH,Goldknopf IL

更新日期：2006-02-01 00:00:00

abstract：:Normal multipotent tissue stem cells (SCs) are the driving force behind tissue turnover and repair. The cancer stem cell theory holds that tumors also contain stem-like cells that drive tumor growth and metastasis formation. However, very little is known about the regulation of SC maintenance pathways in cancer and ho...

journal_title：Expert review of proteomics

authors： Kranenburg O,Emmink BL,Knol J,van Houdt WJ,Rinkes IH,Jimenez CR

更新日期：2012-06-01 00:00:00

abstract：:Proteomic technologies have experienced major improvements in recent years. Such advances have facilitated the discovery of potential tumor markers with improved sensitivities and specificities for the diagnosis, prognosis and treatment monitoring of cancer patients. This review will focus on four state-of-the-art pro...

journal_title：Expert review of proteomics

authors： Wong SC,Chan CM,Ma BB,Lam MY,Choi GC,Au TC,Chan AS,Chan AT

更新日期：2009-04-01 00:00:00

abstract：:A panel of biomarkers for the early detection of bladder cancer has not yet been identified. Many different molecules, including DNA, RNA or proteins have been reported but none have provided adequate sensitivity for a single-tier screening test or a test to replace cystoscopy. Therefore, multimarker panels are discus...

journal_title：Expert review of proteomics

authors： Schwamborn K,Gaisa NT,Henkel C

更新日期：2010-12-01 00:00:00

abstract：:Protein profiling using high-throughput tandem mass spectrometry has become a powerful method for analyzing changes in global protein expression patterns in cells and tissues as a function of developmental, physiologic and disease processes. This review summarizes the utility and practical application of multidimensio...

journal_title：Expert review of proteomics

authors： Kislinger T,Emili A

更新日期：2005-01-01 00:00:00

abstract：:Prenatal diagnosis is now offered to high-risk pregnancies, including advanced maternal age, ultrasound anomalies and positive Down's syndrome screening, and karyotype on cultured fetal material is the test of choice to screen these pregnancies. However, microscope analysis can only detect gross chromosome abnormaliti...

journal_title：Expert review of proteomics

authors： Novelli A,Cavalli P,Bernardini L

更新日期：2013-04-01 00:00:00

abstract：:Evaluation of: Di Girolamo F, Boschetti E, Chung MC, Guadagni F, Righetti PG. 'Proteomineering' or not? The debate on biomarker discovery in sera continues. J. Proteomics 74(5), 589-594 (2011). The combinatorial peptide ligand library in association with mass spectrometry can greatly enhance the dynamic range of the a...

journal_title：Expert review of proteomics

authors： Panfoli I,Bruschi M,Ravera S,Candiano G

更新日期：2011-08-01 00:00:00

abstract：:Introduction: Type 1 diabetes (T1D) is characterized by autoimmune-induced dysfunction and destruction of the pancreatic beta cells. Unfortunately, this process is poorly understood, and the current best treatment for type 1 diabetes is the administration of exogenous insulin. To better understand these mechanisms and...

journal_title：Expert review of proteomics

authors： Nakayasu ES,Qian WJ,Evans-Molina C,Mirmira RG,Eizirik DL,Metz TO

更新日期：2019-07-01 00:00:00

abstract：:Tremendous efforts have been put together over the last several years to complete the entire sequencing of the human genome. As we enter the proteomic era, when the major aim is understanding which gene encodes which protein, the time has also come to identify their precise function inside the astonishing signaling ne...

journal_title：Expert review of proteomics

authors： Vigneault F,Guérin SL

更新日期：2005-10-01 00:00:00

abstract：:Human saliva is an attractive body fluid for disease diagnosis and prognosis because saliva testing is simple, safe, low-cost and noninvasive. Comprehensive analysis and identification of the proteomic content in human whole and ductal saliva will not only contribute to the understanding of oral health and disease pat...

journal_title：Expert review of proteomics

authors： Hu S,Loo JA,Wong DT

更新日期：2007-08-01 00:00:00

abstract：:Helicobacter pylori infection is linked to the development of gastric cancer. Atrophic body gastritis is considered the first important step in the histogenesis of such neoplasia. H. pylori infection is involved in the induction of atrophic body gastritis, but documentation of H. pylori infection is difficult because ...

journal_title：Expert review of proteomics

authors： Lahner E,Bernardini G,Santucci A,Annibale B

更新日期：2010-04-01 00:00:00

abstract：:Globally, colorectal cancer (CRC) is the third most common malignant neoplasm. However, highly sensitive, specific, noninvasive tests that allow CRC diagnosis at an early stage are still needed. As circulatory blood reflects the physiological status of an individual and/or the disease status for several disorders, eff...

journal_title：Expert review of proteomics

authors： Reumer A,Maes E,Mertens I,Cho WC,Landuyt B,Valkenborg D,Schoofs L,Baggerman G

更新日期：2014-08-01 00:00:00

abstract：:The emergence of advanced liquid chromatography mass spectrometry technologies for characterizing very complex mixtures of proteins has greatly propelled the field of proteomics, the goal of which is the simultaneous examination of all the proteins expressed by an organism. This research area represents a paradigm shi...

journal_title：Expert review of proteomics

authors： VerBerkmoes NC,Connelly HM,Pan C,Hettich RL

更新日期：2004-12-01 00:00:00

abstract：:Introduction: Due to the relatively low mutation rate and high frequency of copy number variation, finding actionable genetic drivers of high-grade serous carcinoma (HGSC) is a challenging task. Furthermore, emerging studies show that genetic alterations are frequently poorly represented at the protein level adding a ...

journal_title：Expert review of proteomics

authors： Labrie M,Kendsersky ND,Ma H,Campbell L,Eng J,Chin K,Mills GB

更新日期：2019-10-01 00:00:00

abstract：:Baukje de Roos is a principal investigator at the University of Aberdeen, Rowett Institute of Nutrition and Health. She investigates mechanisms through which dietary fats and fatty acids, and also polyphenols, affect parameters involved in the development of heart disease in vivo. This is achieved not only by measurin...

journal_title：Expert review of proteomics

authors： de Roos B

更新日期：2009-08-01 00:00:00

abstract：INTRODUCTION:Skeletal muscle is the major site of insulin-stimulated glucose uptake and imparts the beneficial effects of exercise, and hence is an important site of insulin resistance in obesity and type 2 diabetes (T2D). Despite extensive molecular biology-oriented research the molecular mechanisms underlying insulin...

journal_title：Expert review of proteomics

authors： Kruse R,Højlund K

更新日期：2018-10-01 00:00:00

abstract：:As a complementary approach to 2D-PAGE, multidimensional liquid chromatography (MDLC) separation methods have been widely applied in all kinds of biological sample investigations. MDLC coupled with mass spectrometry is playing an important role in proteome research owing to its high speed, high resolution and high sen...

journal_title：Expert review of proteomics

authors： Gao M,Qi D,Zhang P,Deng C,Zhang X

更新日期：2010-10-01 00:00:00

abstract：INTRODUCTION:Chromatin remodeling complexes play important roles in the control of genome regulation in both normal and diseased states, and are therefore critical components for the regulation of epigenetic states in cells. Given the role epigenetics plays in cancer, for example, chromatin remodeling complexes are rou...

journal_title：Expert review of proteomics

authors： Eubanks CG,Dayebgadoh G,Liu X,Washburn MP

更新日期：2017-10-01 00:00:00

abstract：:The rapid expansion of methods for measuring biological data ranging from DNA sequence variations to mRNA expression and protein abundance presents the opportunity to utilize multiple types of information jointly in the study of human health and disease. Organisms are complex systems that integrate inputs at myriad le...

journal_title：Expert review of proteomics

authors： Reif DM,White BC,Moore JH

更新日期：2004-06-01 00:00:00

abstract：:A total of 40 years have already passed since the pioneering work of McCord and Fridovich on erythrocuprein superoxide dismutase (SOD) activity. This modern scientific 'Odyssey' has been accompanied by a series of successes in the fields of biochemistry, biomedicine and proteomics. In this article, we resume the main ...

journal_title：Expert review of proteomics

authors： D'Alessandro A,Zolla L

更新日期：2011-06-01 00:00:00

abstract：:Type II diabetes increases the risk for cognitive decline via multiple traits. Amylin is a pancreatic hormone that has amyloidogenic and cytotoxic properties similar to the amyloid-β peptide. The amylin hormone is overexpressed in individuals with pre-diabetic insulin resistance or obesity leading to amylin oligomeriz...

journal_title：Expert review of proteomics

authors： Ly H,Despa F

更新日期：2015-01-01 00:00:00