Hyperamylinemia as a risk factor for accelerated cognitive decline in diabetes.


:Type II diabetes increases the risk for cognitive decline via multiple traits. Amylin is a pancreatic hormone that has amyloidogenic and cytotoxic properties similar to the amyloid-β peptide. The amylin hormone is overexpressed in individuals with pre-diabetic insulin resistance or obesity leading to amylin oligomerization and deposition in pancreatic islets. Amylin oligomerization was implicated in the apoptosis of the insulin-producing β-cells. Recent studies showed that brain tissue from diabetic patients with cerebrovascular dementia or Alzheimer's disease contains significant deposits of oligomerized amylin. It has also been reported that the brain amylin deposition reduced exploratory drive, recognition memory and vestibulomotor function in a rat model that overexpresses human amylin in the pancreas. These novel findings are reviewed here and the hypothesis that type II diabetes is linked with cognitive decline by amylin accumulation in the brain is proposed. Deciphering the impact of hyperamylinemia on the brain is critical for both etiology and treatment of dementia.


Expert Rev Proteomics


Ly H,Despa F




Has Abstract


2015-01-01 00:00:00












  • Concepts and strategies of soybean seed proteomics using the shotgun proteomics approach.

    abstract::Introduction: The last decade has yielded significant developments in the field of proteomics, especially in mass spectrometry (MS) and data analysis tools. In particular, a shift from gel-based to MS-based proteomics has been observed, thereby providing a platform with which to construct proteome atlases for all life...

    journal_title:Expert review of proteomics

    pub_type: 杂志文章,评审


    authors: Min CW,Gupta R,Agrawal GK,Rakwal R,Kim ST

    更新日期:2019-09-01 00:00:00

  • Transcriptomic profiling in Cutaneous Leishmaniasis patients.

    abstract:INTRODUCTION:Cutaneous leishmaniasis (CL), caused by different Leishmania parasite species, is associated with parasite-induced immune-mediated skin inflammation and ulceration. Whereas many CL studies focus on gene expression signatures in mouse models, the transcriptional response driving human patients in the field ...

    journal_title:Expert review of proteomics

    pub_type: 杂志文章


    authors: Masoudzadeh N,Mizbani A,Rafati S

    更新日期:2020-01-01 00:00:00

  • Advances in endothelial shear stress proteomics.

    abstract::The vascular endothelium lining the luminal surface of all blood vessels is constantly exposed to shear stress exerted by the flowing blood. Blood flow with high laminar shear stress confers protection by activation of antiatherogenic, antithrombotic and anti-inflammatory proteins, whereas low or oscillatory shear str...

    journal_title:Expert review of proteomics

    pub_type: 杂志文章,评审


    authors: Firasat S,Hecker M,Binder L,Asif AR

    更新日期:2014-10-01 00:00:00

  • Plasma/serum proteomics: pre-analytical issues.

    abstract::High-throughput proteomics technologies tend to provide highly sensitive information about living tissues and biological fluids. Analytes are characterized by intrinsic and extrinsic properties, the latter depending on each phase of their preparation, sometimes adding artifacts with crucial repercussions in result rel...

    journal_title:Expert review of proteomics

    pub_type: 杂志文章,评审


    authors: Barelli S,Crettaz D,Thadikkaran L,Rubin O,Tissot JD

    更新日期:2007-06-01 00:00:00

  • Proteomics in atherothrombosis: a future perspective.

    abstract::Atherothrombosis is the primary cause of death in Western countries. The cellular and molecular mechanisms underlying atherosclerosis remain widely unknown. The complex nature of atherosclerotic cardiovascular diseases demands the development of novel technologies that enable discovery of new biomarkers for early dise...

    journal_title:Expert review of proteomics

    pub_type: 杂志文章,评审


    authors: Martín-Ventura JL,Blanco-Colio LM,Tunon J,Gomez-Guerrero C,Michel JB,Meilhac O,Egido J

    更新日期:2007-04-01 00:00:00

  • The SODyssey: superoxide dismutases from biochemistry, through proteomics, to oxidative stress, aging and nutraceuticals.

    abstract::A total of 40 years have already passed since the pioneering work of McCord and Fridovich on erythrocuprein superoxide dismutase (SOD) activity. This modern scientific 'Odyssey' has been accompanied by a series of successes in the fields of biochemistry, biomedicine and proteomics. In this article, we resume the main ...

    journal_title:Expert review of proteomics

    pub_type: 杂志文章,评审


    authors: D'Alessandro A,Zolla L

    更新日期:2011-06-01 00:00:00

  • Human saliva proteome analysis and disease biomarker discovery.

    abstract::Human saliva is an attractive body fluid for disease diagnosis and prognosis because saliva testing is simple, safe, low-cost and noninvasive. Comprehensive analysis and identification of the proteomic content in human whole and ductal saliva will not only contribute to the understanding of oral health and disease pat...

    journal_title:Expert review of proteomics

    pub_type: 杂志文章,评审


    authors: Hu S,Loo JA,Wong DT

    更新日期:2007-08-01 00:00:00

  • Proteomic analysis of human bile and potential applications for cancer diagnosis.

    abstract::Bile is a body fluid produced by the liver and drained by biliary ducts into the duodenum. It has two major functions: first, it contains bile acids, which are critical for the digestion of fats, and second, it is an excretory pathway for many endogenous and exogenous compounds. Proteomic analysis of bile is particula...

    journal_title:Expert review of proteomics

    pub_type: 杂志文章,评审


    authors: Farina A,Dumonceau JM,Lescuyer P

    更新日期:2009-06-01 00:00:00

  • Proteomics and frailty: a clinical overview.

    abstract:INTRODUCTION:Frailty is consequent to age-dependent deregulation of several biological pathways and systems, encompassing namely sarcopenia, age-associated hormonal derangements, inflammation, and nutritional or metabolic deficiencies. Although the prevalence of frailty is usually between 10% and 20% in the general eld...

    journal_title:Expert review of proteomics

    pub_type: 杂志文章,评审


    authors: Danese E,Montagnana M,Lippi G

    更新日期:2018-08-01 00:00:00

  • Urinary biomarkers of physical activity: candidates and clinical utility.

    abstract::Chronic physical inactivity is a major risk factor for a number of important lifestyle diseases, while inappropriate exposure to high physical demands is a risk factor for musculoskeletal injury and fatigue. Proteomic and metabolomic investigations of the physical activity continuum - extreme sedentariness to extremes...

    journal_title:Expert review of proteomics

    pub_type: 杂志文章,评审


    authors: Sampson DL,Broadbent JA,Parker AW,Upton Z,Parker TJ

    更新日期:2014-02-01 00:00:00

  • Regulation of gene expression: probing DNA-protein interactions in vivo and in vitro.

    abstract::Tremendous efforts have been put together over the last several years to complete the entire sequencing of the human genome. As we enter the proteomic era, when the major aim is understanding which gene encodes which protein, the time has also come to identify their precise function inside the astonishing signaling ne...

    journal_title:Expert review of proteomics

    pub_type: 杂志文章,评审


    authors: Vigneault F,Guérin SL

    更新日期:2005-10-01 00:00:00

  • Advanced technologies for studying circulating tumor cells at the protein level.

    abstract::Metastasis is the main cause of cancer death. As the tumor progresses, cells from the primary tumor site are shed into the bloodstream as circulating tumor cells (CTCs). Eventually, these cells colonize other organs and form distant metastases. It is therefore imperative that we gain a better understanding of the biol...

    journal_title:Expert review of proteomics

    pub_type: 杂志文章,评审


    authors: Chan CM,Au TC,Chan AT,Ma BB,Tsui NB,Ng SS,Hui EP,Chan LW,Ho WS,Yung BY,Wong SC

    更新日期:2013-12-01 00:00:00

  • Network-based strategies in metabolomics data analysis and interpretation: from molecular networking to biological interpretation.

    abstract:INTRODUCTION:Metabolomics has become a crucial part of systems biology; however, data analysis is still often undertaken in a reductionist way focusing on changes in individual metabolites. Whilst such approaches indeed provide relevant insights into the metabolic phenotype of an organism, the intricate nature of metab...

    journal_title:Expert review of proteomics

    pub_type: 杂志文章


    authors: Perez De Souza L,Alseekh S,Brotman Y,Fernie AR

    更新日期:2020-04-01 00:00:00

  • Protein-protein cross-linking and human health: the challenge of elucidating with mass spectrometry.

    abstract:INTRODUCTION:In several biomedical research fields, the cross-linking of peptides and proteins has an important impact on health and wellbeing. It is therefore of crucial importance to study this class of post-translational modifications in detail. The huge potential of mass spectrometric technologies in the mapping of...

    journal_title:Expert review of proteomics

    pub_type: 杂志文章,评审


    authors: Maes E,Dyer JM,McKerchar HJ,Deb-Choudhury S,Clerens S

    更新日期:2017-10-01 00:00:00

  • The future of prenatal diagnosis: karyotype, microarray or both? Technical and ethical considerations.

    abstract::Prenatal diagnosis is now offered to high-risk pregnancies, including advanced maternal age, ultrasound anomalies and positive Down's syndrome screening, and karyotype on cultured fetal material is the test of choice to screen these pregnancies. However, microscope analysis can only detect gross chromosome abnormaliti...

    journal_title:Expert review of proteomics

    pub_type: 评论,杂志文章


    authors: Novelli A,Cavalli P,Bernardini L

    更新日期:2013-04-01 00:00:00

  • Proteomic study of skeletal muscle in obesity and type 2 diabetes: progress and potential.

    abstract:INTRODUCTION:Skeletal muscle is the major site of insulin-stimulated glucose uptake and imparts the beneficial effects of exercise, and hence is an important site of insulin resistance in obesity and type 2 diabetes (T2D). Despite extensive molecular biology-oriented research the molecular mechanisms underlying insulin...

    journal_title:Expert review of proteomics

    pub_type: 杂志文章,评审


    authors: Kruse R,Højlund K

    更新日期:2018-10-01 00:00:00

  • Clinical proteomics in obstetrics and neonatology.

    abstract::Clinical proteomics has been applied to the identification of biomarkers of obstetric and neonatal disease. We will discuss a number of encouraging studies that have led to potentially valid biomarkers in the context of Down's syndrome, preterm birth, amniotic infections, preeclampsia, intrauterine growth restriction ...

    journal_title:Expert review of proteomics

    pub_type: 杂志文章,评审


    authors: Klein J,Buffin-Meyer B,Mullen W,Carty DM,Delles C,Vlahou A,Mischak H,Decramer S,Bascands JL,Schanstra JP

    更新日期:2014-02-01 00:00:00

  • Monocyte/macrophage proteomics: recent findings and biomedical applications.

    abstract::Macrophages, originating from the migration and differentiation of circulating monocytes into virtually all tissues, are extremely flexible and plastic cells that play vital homeostatic roles, but also contribute to the pathophysiology of many human diseases. For these reasons, they are intensively studied by differen...

    journal_title:Expert review of proteomics

    pub_type: 杂志文章,评审


    authors: Castagna A,Polati R,Bossi AM,Girelli D

    更新日期:2012-04-01 00:00:00

  • MALDI imaging mass spectrometry and analysis of endogenous peptides.

    abstract::In recent years, MALDI imaging mass spectrometry (MALDI-IMS) has developed as a promising tool to investigate the spatial distribution of biomolecules in intact tissue specimens. Ion densities of various molecules can be displayed as heat maps while preserving anatomical structures. In this short review, an overview o...

    journal_title:Expert review of proteomics

    pub_type: 杂志文章,评审


    authors: Chatterji B,Pich A

    更新日期:2013-08-01 00:00:00

  • Dissecting phosphorylation networks: lessons learned from yeast.

    abstract::Protein phosphorylation continues to be regarded as one of the most important post-translational modifications found in eukaryotes and has been implicated in key roles in the development of a number of human diseases. In order to elucidate roles for the 518 human kinases, phosphorylation has routinely been studied usi...

    journal_title:Expert review of proteomics

    pub_type: 杂志文章,评审


    authors: Mok J,Zhu X,Snyder M

    更新日期:2011-12-01 00:00:00

  • Proteomic analysis in allergy and intolerance to wheat products.

    abstract::Owing to its extensive use in the human diet, wheat is among the most common causes of food-related allergies and intolerances. Allergies to wheat are provoked by ingestion, inhalation or contact with either the soluble or the insoluble gluten proteins in wheat. Gluten proteins, and particularly the gliadin fraction, ...

    journal_title:Expert review of proteomics

    pub_type: 杂志文章,评审


    authors: Mamone G,Picariello G,Addeo F,Ferranti P

    更新日期:2011-02-01 00:00:00

  • The role of mass spectrometry in the characterization of biologic protein products.

    abstract:INTRODUCTION:Mass spectrometry (MS) is widely used in the characterization of biomolecules including peptide and protein therapeutics. These biotechnology products have seen rapid growth over the past few decades and continue to dominate the global pharmaceutical market. Advances in MS instrumentation and techniques ha...

    journal_title:Expert review of proteomics

    pub_type: 杂志文章,评审


    authors: Rathore D,Faustino A,Schiel J,Pang E,Boyne M,Rogstad S

    更新日期:2018-05-01 00:00:00

  • Proteome-wide analysis of neural stem cell differentiation to facilitate transition to cell replacement therapies.

    abstract::Neurodegenerative diseases are devastating disorders and the demands on their treatment are set to rise in connection with higher disease incidence. Knowledge of the spatiotemporal profile of cellular protein expression during neural differentiation and definition of a set of markers highly specific for targeted neura...

    journal_title:Expert review of proteomics

    pub_type: 杂志文章,评审


    authors: Zizkova M,Sucha R,Tyleckova J,Jarkovska K,Mairychova K,Kotrcova E,Marsala M,Gadher SJ,Kovarova H

    更新日期:2015-02-01 00:00:00

  • Integrated analysis of genetic, genomic and proteomic data.

    abstract::The rapid expansion of methods for measuring biological data ranging from DNA sequence variations to mRNA expression and protein abundance presents the opportunity to utilize multiple types of information jointly in the study of human health and disease. Organisms are complex systems that integrate inputs at myriad le...

    journal_title:Expert review of proteomics

    pub_type: 杂志文章,评审


    authors: Reif DM,White BC,Moore JH

    更新日期:2004-06-01 00:00:00

  • Proteomics of proteasome complexes and ubiquitinated proteins.

    abstract::Ubiquitin-proteasome-mediated protein degradation is central to the regulation of many important biological processes, including cell cycle progression, apoptosis and DNA repair. Recognition and degradation of ubiquitinated substrates by the 26S proteasome is tightly regulated to maintain normal cell growth. Disruptio...

    journal_title:Expert review of proteomics

    pub_type: 杂志文章,评审


    authors: Wang X,Guerrero C,Kaiser P,Huang L

    更新日期:2007-10-01 00:00:00

  • Potential blood biomarkers for stroke.

    abstract::Stroke is one of the most common causes of death worldwide and a major cause of acquired disability in adults. Despite advances in research during the last decade, prevention and treatment strategies still suffer from significant limitations, and therefore new theoretical and technical approaches are required. Technol...

    journal_title:Expert review of proteomics

    pub_type: 杂志文章,评审


    authors: Laborde CM,Mourino-Alvarez L,Akerstrom F,Padial LR,Vivanco F,Gil-Dones F,Barderas MG

    更新日期:2012-08-01 00:00:00

  • Best practice of identification and proteomic analysis of extracellular vesicles in human health and disease.

    abstract:INTRODUCTION:Extracellular vesicles are emerging sources of biomarkers for modern preventive and precision medicine. Extracellular vesicles in body fluids offer a unique opportunity for integrative biomarker approaches due to their complex biocargo that includes proteins, lipids, nucleic acids and metabolites. Mass spe...

    journal_title:Expert review of proteomics

    pub_type: 杂志文章,评审


    authors: Sódar BW,Kovács Á,Visnovitz T,Pállinger É,Vékey K,Pocsfalvi G,Turiák L,Buzás EI

    更新日期:2017-12-01 00:00:00

  • Plasma hepcidin in early-stage breast cancer patients: no relationship with interleukin-6, erythropoietin and erythroferrone.

    abstract:OBJECTIVE:Hepcidin-25 production is stimulated by systemic inflammation, and it interferes with iron utilization, leading to anemia. This study aimed to investigate the relationships between the plasma levels of hepcidin, interleukin-6 (IL-6), erythropoietin (EPO) and erythroferrone (ERFE) in patients with benign breas...

    journal_title:Expert review of proteomics

    pub_type: 杂志文章


    authors: Ciniselli CM,De Bortoli M,Taverna E,Varinelli L,Pizzamiglio S,Veneroni S,Bonini C,Orlandi R,Verderio P,Bongarzone I

    更新日期:2015-01-01 00:00:00

  • Proximity ligation assays: a recent addition to the proteomics toolbox.

    abstract::An essential skill for every researcher is to learn how to select and apply the most appropriate methods for the questions they are trying to answer. With the extensive variety of methods available, it is increasingly important to scrutinize the advantages and disadvantages of these techniques prior to making a decisi...

    journal_title:Expert review of proteomics

    pub_type: 杂志文章,评审


    authors: Weibrecht I,Leuchowius KJ,Clausson CM,Conze T,Jarvius M,Howell WM,Kamali-Moghaddam M,Söderberg O

    更新日期:2010-06-01 00:00:00

  • The human urinary exosome as a potential metabolic effector cargo.

    abstract::Exosomes are nanovesicles, derived from the endocytic pathway, released by most cell types and found in many body fluids, including urine. A variety of exosomal functions have been reported, including transfer of RNA, cell communication, control of apoptosis and protein lifespan. Exosomes from mesenchymal stem cells c...

    journal_title:Expert review of proteomics

    pub_type: 杂志文章,评审


    authors: Bruschi M,Ravera S,Santucci L,Candiano G,Bartolucci M,Calzia D,Lavarello C,Inglese E,Petretto A,Ghiggeri G,Panfoli I

    更新日期:2015-08-01 00:00:00