Hyperamylinemia as a risk factor for accelerated cognitive decline in diabetes.


:Type II diabetes increases the risk for cognitive decline via multiple traits. Amylin is a pancreatic hormone that has amyloidogenic and cytotoxic properties similar to the amyloid-β peptide. The amylin hormone is overexpressed in individuals with pre-diabetic insulin resistance or obesity leading to amylin oligomerization and deposition in pancreatic islets. Amylin oligomerization was implicated in the apoptosis of the insulin-producing β-cells. Recent studies showed that brain tissue from diabetic patients with cerebrovascular dementia or Alzheimer's disease contains significant deposits of oligomerized amylin. It has also been reported that the brain amylin deposition reduced exploratory drive, recognition memory and vestibulomotor function in a rat model that overexpresses human amylin in the pancreas. These novel findings are reviewed here and the hypothesis that type II diabetes is linked with cognitive decline by amylin accumulation in the brain is proposed. Deciphering the impact of hyperamylinemia on the brain is critical for both etiology and treatment of dementia.


Expert Rev Proteomics


Ly H,Despa F




Has Abstract


2015-01-01 00:00:00












  • Targeted proteomics of solid cancers: from quantification of known biomarkers towards reading the digital proteome maps.

    abstract::The concept of personalized medicine includes novel protein biomarkers that are expected to improve the early detection, diagnosis and therapy monitoring of malignant diseases. Tissues, biofluids, cell lines and xenograft models are the common sources of biomarker candidates that require verification of clinical value...

    journal_title:Expert review of proteomics

    pub_type: 杂志文章,评审


    authors: Pernikářová V,Bouchal P

    更新日期:2015-01-01 00:00:00

  • Proteomic analysis in allergy and intolerance to wheat products.

    abstract::Owing to its extensive use in the human diet, wheat is among the most common causes of food-related allergies and intolerances. Allergies to wheat are provoked by ingestion, inhalation or contact with either the soluble or the insoluble gluten proteins in wheat. Gluten proteins, and particularly the gliadin fraction, ...

    journal_title:Expert review of proteomics

    pub_type: 杂志文章,评审


    authors: Mamone G,Picariello G,Addeo F,Ferranti P

    更新日期:2011-02-01 00:00:00

  • Update on: proteome analysis in thyroid pathology - part II: overview of technical and clinical enhancement of proteomic investigation of the thyroid lesions.

    abstract:INTRODUCTION:An accurate diagnostic classification of thyroid lesions remains an important clinical aspect that needs to be addressed in order to avoid 'diagnostic' thyroidectomies. Among the several 'omics' techniques, proteomics is playing a pivotal role in the search for diagnostic markers. In recent years, differen...

    journal_title:Expert review of proteomics

    pub_type: 杂志文章,评审


    authors: Piga I,Casano S,Smith A,Tettamanti S,Leni D,Capitoli G,Pincelli AI,Scardilli M,Galimberti S,Magni F,Pagni F

    更新日期:2018-11-01 00:00:00

  • Sperm proteomics: potential impact on male infertility treatment.

    abstract::Spermatozoa are unique cells that have highly compact DNA, motility (and hypermotility) patterns, a specific morphology, localized mitochondria and an apical acrosome. They are the end product of a dynamic process termed spermatogenesis. Sperm are therefore produced with specific proteins in order to effect different ...

    journal_title:Expert review of proteomics

    pub_type: 杂志文章,评审


    authors: Agarwal A,Bertolla RP,Samanta L

    更新日期:2016-01-01 00:00:00

  • Advanced proteomic technologies for cancer biomarker discovery.

    abstract::Proteomic technologies have experienced major improvements in recent years. Such advances have facilitated the discovery of potential tumor markers with improved sensitivities and specificities for the diagnosis, prognosis and treatment monitoring of cancer patients. This review will focus on four state-of-the-art pro...

    journal_title:Expert review of proteomics

    pub_type: 杂志文章,评审


    authors: Wong SC,Chan CM,Ma BB,Lam MY,Choi GC,Au TC,Chan AS,Chan AT

    更新日期:2009-04-01 00:00:00

  • Global views of proteasome-mediated degradation by mass spectrometry.

    abstract::Introduction: Degradation of proteins by cellular proteasomes is critical for the fidelity of protein homeostasis and proper cell function. Indeed, perturbations in proteasome function, as well as the degradation of specific substrates, are associated with a variety of human diseases. Yet, monitoring and analyzing pro...

    journal_title:Expert review of proteomics

    pub_type: 杂志文章


    authors: Javitt A,Merbl Y

    更新日期:2019-07-19 00:00:00

  • Framework for a systems approach to proteomic biomarker profiling in polycystic ovary syndrome.

    abstract::Polycystic ovary syndrome (PCOS) is the most common endocrine disorder in females of reproductive age, and its prevalence ranges between 6 and 8%. Associated problems include infertility, menstrual disorders, hirsutism and obesity. In addition, individuals with PCOS may be at increased risk of diabetes, endometrial ca...

    journal_title:Expert review of proteomics

    pub_type: 杂志文章,评审


    authors: Atiomo WU,Khalid S,Ziauddin A,Tooth D,Layfield R

    更新日期:2009-10-01 00:00:00

  • Proteomics: advances in biomarker discovery.

    abstract::The challenges encountered by proteomic researchers seeking diagnostic, prognostic and mechanistic markers were the subject of the 1-day meeting, Proteomics: Advances in Biomarker Discovery hosted by EuroSciCon. The speakers had a broad range of clinical and basic science interests, and presented data using a number o...

    journal_title:Expert review of proteomics



    authors: Cowan ML,Vera J

    更新日期:2008-02-01 00:00:00

  • Colorectal cancer biomarker discovery and validation using LC-MS/MS-based proteomics in blood: truth or dare?

    abstract::Globally, colorectal cancer (CRC) is the third most common malignant neoplasm. However, highly sensitive, specific, noninvasive tests that allow CRC diagnosis at an early stage are still needed. As circulatory blood reflects the physiological status of an individual and/or the disease status for several disorders, eff...

    journal_title:Expert review of proteomics

    pub_type: 杂志文章,评审


    authors: Reumer A,Maes E,Mertens I,Cho WC,Landuyt B,Valkenborg D,Schoofs L,Baggerman G

    更新日期:2014-08-01 00:00:00

  • Proteomics in atherothrombosis: a future perspective.

    abstract::Atherothrombosis is the primary cause of death in Western countries. The cellular and molecular mechanisms underlying atherosclerosis remain widely unknown. The complex nature of atherosclerotic cardiovascular diseases demands the development of novel technologies that enable discovery of new biomarkers for early dise...

    journal_title:Expert review of proteomics

    pub_type: 杂志文章,评审


    authors: Martín-Ventura JL,Blanco-Colio LM,Tunon J,Gomez-Guerrero C,Michel JB,Meilhac O,Egido J

    更新日期:2007-04-01 00:00:00

  • Proteomics and frailty: a clinical overview.

    abstract:INTRODUCTION:Frailty is consequent to age-dependent deregulation of several biological pathways and systems, encompassing namely sarcopenia, age-associated hormonal derangements, inflammation, and nutritional or metabolic deficiencies. Although the prevalence of frailty is usually between 10% and 20% in the general eld...

    journal_title:Expert review of proteomics

    pub_type: 杂志文章,评审


    authors: Danese E,Montagnana M,Lippi G

    更新日期:2018-08-01 00:00:00

  • Wisteria floribunda agglutinin positive glycobiomarkers: a unique lectin as a serum biomarker probe in various diseases.

    abstract:INTRODUCTION:Serum proteins are generally glycosylated and solubilized, and are thus present as glycoproteins. The glycan structure of glycoproteins reflects cell differentiation status; glycan structures generated by diseased cells are distinguishable from those produced by healthy cells. Proteins may therefore serve ...

    journal_title:Expert review of proteomics

    pub_type: 杂志文章,评审


    authors: Narimatsu H,Sato T

    更新日期:2018-02-01 00:00:00

  • A huntingtin-HAP1-PCM1 pathway in ciliogenesis.

    abstract::Huntington's disease (HD) is caused by expansion of a polyglutamine repeat in the N-terminal region of huntingtin (htt), a large protein that has been found to interact with a variety of proteins. It remains to be determined how the interactions of htt with other proteins are involved in the pathogenesis of HD. A rece...

    journal_title:Expert review of proteomics

    pub_type: 评论,杂志文章


    authors: Li S,Li XJ

    更新日期:2012-01-01 00:00:00

  • Advances in high-resolution quantitative proteomics: implications for clinical applications.

    abstract::The advances in high-resolution mass spectrometry instrumentation, capable of accurate mass measurement and fast acquisition, have enabled new approaches for targeted quantitative proteomics. More specifically, analyses performed on quadrupole-orbitrap mass spectrometers operated in parallel reaction monitoring (PRM) ...

    journal_title:Expert review of proteomics

    pub_type: 杂志文章,评审


    authors: Gallien S,Domon B

    更新日期:2015-01-01 00:00:00

  • New insights into viral structure and virus-cell interactions through proteomics.

    abstract::Although genomics techniques such as DNA microarrays have been widely used in virology, much more limited use has been made of proteomics. Although difficult, proteomics can greatly contribute to an understanding of virus-cell interactions, including the ternary structure of viral receptors at the cell surface, post-t...

    journal_title:Expert review of proteomics

    pub_type: 杂志文章,评审


    authors: Bernhard OK,Diefenbach RJ,Cunningham AL

    更新日期:2005-08-01 00:00:00

  • MALDI imaging mass spectrometry and analysis of endogenous peptides.

    abstract::In recent years, MALDI imaging mass spectrometry (MALDI-IMS) has developed as a promising tool to investigate the spatial distribution of biomolecules in intact tissue specimens. Ion densities of various molecules can be displayed as heat maps while preserving anatomical structures. In this short review, an overview o...

    journal_title:Expert review of proteomics

    pub_type: 杂志文章,评审


    authors: Chatterji B,Pich A

    更新日期:2013-08-01 00:00:00

  • Monocyte/macrophage proteomics: recent findings and biomedical applications.

    abstract::Macrophages, originating from the migration and differentiation of circulating monocytes into virtually all tissues, are extremely flexible and plastic cells that play vital homeostatic roles, but also contribute to the pathophysiology of many human diseases. For these reasons, they are intensively studied by differen...

    journal_title:Expert review of proteomics

    pub_type: 杂志文章,评审


    authors: Castagna A,Polati R,Bossi AM,Girelli D

    更新日期:2012-04-01 00:00:00

  • Protein-protein cross-linking and human health: the challenge of elucidating with mass spectrometry.

    abstract:INTRODUCTION:In several biomedical research fields, the cross-linking of peptides and proteins has an important impact on health and wellbeing. It is therefore of crucial importance to study this class of post-translational modifications in detail. The huge potential of mass spectrometric technologies in the mapping of...

    journal_title:Expert review of proteomics

    pub_type: 杂志文章,评审


    authors: Maes E,Dyer JM,McKerchar HJ,Deb-Choudhury S,Clerens S

    更新日期:2017-10-01 00:00:00

  • Dissecting phosphorylation networks: lessons learned from yeast.

    abstract::Protein phosphorylation continues to be regarded as one of the most important post-translational modifications found in eukaryotes and has been implicated in key roles in the development of a number of human diseases. In order to elucidate roles for the 518 human kinases, phosphorylation has routinely been studied usi...

    journal_title:Expert review of proteomics

    pub_type: 杂志文章,评审


    authors: Mok J,Zhu X,Snyder M

    更新日期:2011-12-01 00:00:00

  • Strategies in mass spectrometry for the assignment of Cys-Cys disulfide connectivities in proteins.

    abstract::Elucidating disulfide linkage patterns is a crucial part of protein characterization, for which mass spectrometry (MS) is now an indispensable analytical tool. In many cases, MS-based disulfide connectivity assignment is straightforwardly achieved using one-step protein fragmentation in the unreduced form followed by ...

    journal_title:Expert review of proteomics

    pub_type: 杂志文章,评审


    authors: Goyder MS,Rebeaud F,Pfeifer ME,Kálmán F

    更新日期:2013-10-01 00:00:00

  • Contribution of mass spectrometry-based proteomics to immunology.

    abstract::Antigen processing forwards various information about the cellular status and the proteome to the cell surface for scrutiny by the cellular immune system. Thus the repertoire of major histocompatibility complex (MHC)-bound peptides and the MHC ligandome, indirectly mirrors the proteome in order to make alterations ins...

    journal_title:Expert review of proteomics

    pub_type: 杂志文章,评审


    authors: Hillen N,Stevanovic S

    更新日期:2006-12-01 00:00:00

  • A decade of proteomics accomplished! Central and Eastern European Proteomic Conference (CEEPC) celebrates its 10th Anniversary in Budapest, Hungary.

    abstract::The Central and Eastern European Proteomic Conference (CEEPC) proudly celebrated its 10th Anniversary with an exciting scientific program inclusive of proteome, proteomics and systems biology in Budapest, Hungary. Since 2007, CEEPC has represented 'state-of the-art' proteomics in and around Central and Eastern Europe ...

    journal_title:Expert review of proteomics

    pub_type: 杂志文章


    authors: Gadher SJ,Drahos L,Vékey K,Kovarova H

    更新日期:2017-07-01 00:00:00

  • Proximity ligation assays: a recent addition to the proteomics toolbox.

    abstract::An essential skill for every researcher is to learn how to select and apply the most appropriate methods for the questions they are trying to answer. With the extensive variety of methods available, it is increasingly important to scrutinize the advantages and disadvantages of these techniques prior to making a decisi...

    journal_title:Expert review of proteomics

    pub_type: 杂志文章,评审


    authors: Weibrecht I,Leuchowius KJ,Clausson CM,Conze T,Jarvius M,Howell WM,Kamali-Moghaddam M,Söderberg O

    更新日期:2010-06-01 00:00:00

  • The human urinary exosome as a potential metabolic effector cargo.

    abstract::Exosomes are nanovesicles, derived from the endocytic pathway, released by most cell types and found in many body fluids, including urine. A variety of exosomal functions have been reported, including transfer of RNA, cell communication, control of apoptosis and protein lifespan. Exosomes from mesenchymal stem cells c...

    journal_title:Expert review of proteomics

    pub_type: 杂志文章,评审


    authors: Bruschi M,Ravera S,Santucci L,Candiano G,Bartolucci M,Calzia D,Lavarello C,Inglese E,Petretto A,Ghiggeri G,Panfoli I

    更新日期:2015-08-01 00:00:00

  • The role of proteomics in assessing beta-cell dysfunction and death in type 1 diabetes.

    abstract::Introduction: Type 1 diabetes (T1D) is characterized by autoimmune-induced dysfunction and destruction of the pancreatic beta cells. Unfortunately, this process is poorly understood, and the current best treatment for type 1 diabetes is the administration of exogenous insulin. To better understand these mechanisms and...

    journal_title:Expert review of proteomics

    pub_type: 杂志文章


    authors: Nakayasu ES,Qian WJ,Evans-Molina C,Mirmira RG,Eizirik DL,Metz TO

    更新日期:2019-07-01 00:00:00

  • Recent advances in single-cell MALDI mass spectrometry imaging and potential clinical impact.

    abstract::Single-cell analysis is gaining popularity in the field of mass spectrometry as a method for analyzing protein and peptide content in cells. The spatial resolution of MALDI mass spectrometry (MS) imaging is by a large extent limited by the laser focal diameter and the displacement of analytes during matrix deposition....

    journal_title:Expert review of proteomics

    pub_type: 杂志文章,评审


    authors: Boggio KJ,Obasuyi E,Sugino K,Nelson SB,Agar NY,Agar JN

    更新日期:2011-10-01 00:00:00

  • Helicobacter pylori immunoproteomics in gastric cancer and gastritis of the carcinoma phenotype.

    abstract::Helicobacter pylori infection is linked to the development of gastric cancer. Atrophic body gastritis is considered the first important step in the histogenesis of such neoplasia. H. pylori infection is involved in the induction of atrophic body gastritis, but documentation of H. pylori infection is difficult because ...

    journal_title:Expert review of proteomics

    pub_type: 杂志文章,评审


    authors: Lahner E,Bernardini G,Santucci A,Annibale B

    更新日期:2010-04-01 00:00:00

  • Concepts and strategies of soybean seed proteomics using the shotgun proteomics approach.

    abstract::Introduction: The last decade has yielded significant developments in the field of proteomics, especially in mass spectrometry (MS) and data analysis tools. In particular, a shift from gel-based to MS-based proteomics has been observed, thereby providing a platform with which to construct proteome atlases for all life...

    journal_title:Expert review of proteomics

    pub_type: 杂志文章,评审


    authors: Min CW,Gupta R,Agrawal GK,Rakwal R,Kim ST

    更新日期:2019-09-01 00:00:00

  • Recent advances and clinical insights into the use of proteomics in the study of atherosclerosis.

    abstract:INTRODUCTION:The application of new proteomics methods may help to identify new diagnostic/predictive molecular markers in an attempt to improve the clinical management of atherosclerosis. Areas covered: Technological advances in proteomics have enhanced its sensitivity and multiplexing capacity, as well as the possibi...

    journal_title:Expert review of proteomics

    pub_type: 杂志文章,评审


    authors: Mourino-Alvarez L,Baldan-Martin M,Rincon R,Martin-Rojas T,Corbacho-Alonso N,Sastre-Oliva T,Barderas MG

    更新日期:2017-08-01 00:00:00

  • Regulation of gene expression: probing DNA-protein interactions in vivo and in vitro.

    abstract::Tremendous efforts have been put together over the last several years to complete the entire sequencing of the human genome. As we enter the proteomic era, when the major aim is understanding which gene encodes which protein, the time has also come to identify their precise function inside the astonishing signaling ne...

    journal_title:Expert review of proteomics

    pub_type: 杂志文章,评审


    authors: Vigneault F,Guérin SL

    更新日期:2005-10-01 00:00:00