Hyperamylinemia as a risk factor for accelerated cognitive decline in diabetes.

abstract：:Although genomics techniques such as DNA microarrays have been widely used in virology, much more limited use has been made of proteomics. Although difficult, proteomics can greatly contribute to an understanding of virus-cell interactions, including the ternary structure of viral receptors at the cell surface, post-t...

journal_title：Expert review of proteomics

authors： Bernhard OK,Diefenbach RJ,Cunningham AL

更新日期：2005-08-01 00:00:00

abstract：INTRODUCTION:The lack of biomarkers indicating involved nociceptive and/or pain mechanisms makes diagnostic procedures problematic. Clinical pain research has begun to use proteomics. AREAS COVERED:This systematic review covers proteomic studies of chronic pain cohorts and in relation to clinical variables. Searches i...

journal_title：Expert review of proteomics

authors： Gerdle B,Ghafouri B

更新日期：2020-06-01 00:00:00

abstract：:Helicobacter pylori infection is linked to the development of gastric cancer. Atrophic body gastritis is considered the first important step in the histogenesis of such neoplasia. H. pylori infection is involved in the induction of atrophic body gastritis, but documentation of H. pylori infection is difficult because ...

journal_title：Expert review of proteomics

authors： Lahner E,Bernardini G,Santucci A,Annibale B

更新日期：2010-04-01 00:00:00

abstract：:It is well known that chronic, excessive consumption of alcohol can cause brain damage/structural changes in the regions important for neurocognitive function. Some of the damages are permanent, while others are reversible. Molecular mechanisms underlying alcohol-induced and/or -related brain damage are largely unknow...

journal_title：Expert review of proteomics

authors： Matsumoto H,Matsumoto I

更新日期：2008-04-01 00:00:00

abstract：:Introduction: Metaproteomics is an established method to obtain a comprehensive taxonomic and functional view of microbial communities. After more than a decade, we are now able to describe the promise, reality, and perspectives of metaproteomics and provide useful information about the choice of method, applications,...

journal_title：Expert review of proteomics

authors： Lohmann P,Schäpe SS,Haange SB,Oliphant K,Allen-Vercoe E,Jehmlich N,Von Bergen M

更新日期：2020-02-01 00:00:00

abstract：:Introduction: Atopic dermatitis (AD) is a multifactorial ailment associated with barrier breach and intense systemic inflammation. Several studies over the years have shown the complex interplay of a large number of factors in governing the progression and outcome of AD. In addition to the diverse types of AD resultin...

journal_title：Expert review of proteomics

authors： Bhattacharya N,Ganguli-Indra G,Indra AK

更新日期：2019-08-01 00:00:00

abstract：:Evaluation of: Di Girolamo F, Boschetti E, Chung MC, Guadagni F, Righetti PG. 'Proteomineering' or not? The debate on biomarker discovery in sera continues. J. Proteomics 74(5), 589-594 (2011). The combinatorial peptide ligand library in association with mass spectrometry can greatly enhance the dynamic range of the a...

journal_title：Expert review of proteomics

authors： Panfoli I,Bruschi M,Ravera S,Candiano G

更新日期：2011-08-01 00:00:00

abstract：:Osteoporosis is prevalent among the elderly and is a major cause of bone fracture in this population. Bone integrity is maintained by the dynamic processes of bone resorption and bone formation (bone remodeling). Osteoporosis results when there is an imbalance of the two counteracting processes. Bone mineral density, ...

journal_title：Expert review of proteomics

authors： Zhang H,Recker R,Lee WN,Xiao GG

更新日期：2010-02-01 00:00:00

abstract：INTRODUCTION:Ticks are obligate hematophagous arthropod ectoparasites that transmit pathogens responsible for a growing number of tick-borne diseases (TBDs) throughout the world. Vaccines have been shown to be the most efficient, cost-effective, and environmentally friendly approach for the control of ticks and the pre...

journal_title：Expert review of proteomics

authors： Artigas-Jerónimo S,De La Fuente J,Villar M

更新日期：2018-08-01 00:00:00

abstract：:With the growing availability of mature systems and strategies in biotechnology and the continuously expanding knowledge of cellular processes and involved biomolecules, human sports drug testing has become a considerably complex field in the arena of analytical chemistry. Proving the exogenous origin of peptidic drug...

journal_title：Expert review of proteomics

authors： Thevis M,Thomas A,Schänzer W

更新日期：2014-12-01 00:00:00

abstract：:Antigen processing forwards various information about the cellular status and the proteome to the cell surface for scrutiny by the cellular immune system. Thus the repertoire of major histocompatibility complex (MHC)-bound peptides and the MHC ligandome, indirectly mirrors the proteome in order to make alterations ins...

journal_title：Expert review of proteomics

authors： Hillen N,Stevanovic S

更新日期：2006-12-01 00:00:00

abstract：INTRODUCTION:The human respiratory system is highly prone to diseases and complications. Many lung diseases, including lung cancer (LC), tuberculosis (TB), and chronic obstructive pulmonary disease (COPD) have been among the most common causes of death worldwide. Cystic fibrosis (CF), the most common genetic disease in...

journal_title：Expert review of proteomics

authors： Tan HW,Xu YM,Wu DD,Lau ATY

更新日期：2018-02-01 00:00:00

abstract：INTRODUCTION:Unwanted platelet activation is associated with numerous diseases, mainly thrombosis-related. In this context, proteomics has emerged as a novel tool with potential for drug target discovery and to scrutinize the effects of antiplatelet drugs. Areas covered: The present review presents the main findings of...

journal_title：Expert review of proteomics

authors： Izquierdo I,García Á

更新日期：2016-11-01 00:00:00

abstract：:Tremendous efforts have been put together over the last several years to complete the entire sequencing of the human genome. As we enter the proteomic era, when the major aim is understanding which gene encodes which protein, the time has also come to identify their precise function inside the astonishing signaling ne...

journal_title：Expert review of proteomics

authors： Vigneault F,Guérin SL

更新日期：2005-10-01 00:00:00

abstract：:The vascular endothelium lining the luminal surface of all blood vessels is constantly exposed to shear stress exerted by the flowing blood. Blood flow with high laminar shear stress confers protection by activation of antiatherogenic, antithrombotic and anti-inflammatory proteins, whereas low or oscillatory shear str...

journal_title：Expert review of proteomics

authors： Firasat S,Hecker M,Binder L,Asif AR

更新日期：2014-10-01 00:00:00

abstract：INTRODUCTION:The application of new proteomics methods may help to identify new diagnostic/predictive molecular markers in an attempt to improve the clinical management of atherosclerosis. Areas covered: Technological advances in proteomics have enhanced its sensitivity and multiplexing capacity, as well as the possibi...

journal_title：Expert review of proteomics

authors： Mourino-Alvarez L,Baldan-Martin M,Rincon R,Martin-Rojas T,Corbacho-Alonso N,Sastre-Oliva T,Barderas MG

更新日期：2017-08-01 00:00:00

abstract：:Introduction: Degradation of proteins by cellular proteasomes is critical for the fidelity of protein homeostasis and proper cell function. Indeed, perturbations in proteasome function, as well as the degradation of specific substrates, are associated with a variety of human diseases. Yet, monitoring and analyzing pro...

journal_title：Expert review of proteomics

authors： Javitt A,Merbl Y

更新日期：2019-07-19 00:00:00

abstract：:Introduction: Glycomics, which aims to define the glycome of a biological system to better assess the biological attributes of the glycans, has attracted increasing interest. However, the complexity and diversity of glycans present challenging barriers to glycome definition. Technological advances are major drivers in...

journal_title：Expert review of proteomics

authors： Cao WQ,Liu MQ,Kong SY,Wu MX,Huang ZZ,Yang PY

更新日期：2020-01-01 00:00:00

abstract：INTRODUCTION:Pancreatic ductal adenocarcinoma (PDAC) is one of the deadliest cancers worldwide. However, there remain many unmet clinical needs, from diagnosis to treatment strategies. The inherent complexity of the molecular characteristics of PDAC has made it difficult to meet these challenges, rendering proteomic pr...

journal_title：Expert review of proteomics

authors： Kim H,Park J,Wang JI,Kim Y

更新日期：2017-11-01 00:00:00

abstract：:These are really exciting times in the field of Parkinson's disease research. Although the etiology of sporadic disease still remains a mystery, many of the proteins associated with hereditary disease (5-10% of all disease) have now been identified. Only time will tell whether proteins associated with hereditary disea...

journal_title：Expert review of proteomics

authors： Robinson PA

更新日期：2010-08-01 00:00:00

abstract：:Chronic physical inactivity is a major risk factor for a number of important lifestyle diseases, while inappropriate exposure to high physical demands is a risk factor for musculoskeletal injury and fatigue. Proteomic and metabolomic investigations of the physical activity continuum - extreme sedentariness to extremes...

journal_title：Expert review of proteomics

authors： Sampson DL,Broadbent JA,Parker AW,Upton Z,Parker TJ

更新日期：2014-02-01 00:00:00

abstract：:Clinical proteomics has been applied to the identification of biomarkers of obstetric and neonatal disease. We will discuss a number of encouraging studies that have led to potentially valid biomarkers in the context of Down's syndrome, preterm birth, amniotic infections, preeclampsia, intrauterine growth restriction ...

journal_title：Expert review of proteomics

authors： Klein J,Buffin-Meyer B,Mullen W,Carty DM,Delles C,Vlahou A,Mischak H,Decramer S,Bascands JL,Schanstra JP

更新日期：2014-02-01 00:00:00

abstract：:Huntington's disease (HD) is caused by expansion of a polyglutamine repeat in the N-terminal region of huntingtin (htt), a large protein that has been found to interact with a variety of proteins. It remains to be determined how the interactions of htt with other proteins are involved in the pathogenesis of HD. A rece...

journal_title：Expert review of proteomics

authors： Li S,Li XJ

更新日期：2012-01-01 00:00:00

abstract：:A major goal of proteomics is to develop methods that enable the systematic characterization of every protein within the cell or particular subcellular proteome using a single analytical platform. Although the equivalent has already been achieved in genomics, reaching this goal in proteomics represents a much greater ...

journal_title：Expert review of proteomics

authors： Blonder J,Conrads TP,Veenstra TD

更新日期：2004-08-01 00:00:00

abstract：:Introduction: Matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS) has entered clinical diagnostics and is today a generally accepted and integral part of the workflow for microbial identification. MALDI-TOF MS identification systems received approval from national and internatio...

journal_title：Expert review of proteomics

authors： Welker M,Van Belkum A,Girard V,Charrier JP,Pincus D

更新日期：2019-08-01 00:00:00

abstract：:Proteins have several measurable features in biological fluids that may change under pathological conditions. The current disease biomarker discovery is mostly based on protein concentration in the sample as the measurable feature. Changes in protein structures, such as post-translational modifications and in protein-...

journal_title：Expert review of proteomics

authors： Zaslavsky BY,Uversky VN,Chait A

更新日期：2016-01-01 00:00:00

abstract：:The advances in high-resolution mass spectrometry instrumentation, capable of accurate mass measurement and fast acquisition, have enabled new approaches for targeted quantitative proteomics. More specifically, analyses performed on quadrupole-orbitrap mass spectrometers operated in parallel reaction monitoring (PRM) ...

journal_title：Expert review of proteomics

authors： Gallien S,Domon B

更新日期：2015-01-01 00:00:00

abstract：INTRODUCTION:Serum proteins are generally glycosylated and solubilized, and are thus present as glycoproteins. The glycan structure of glycoproteins reflects cell differentiation status; glycan structures generated by diseased cells are distinguishable from those produced by healthy cells. Proteins may therefore serve ...

journal_title：Expert review of proteomics

authors： Narimatsu H,Sato T

更新日期：2018-02-01 00:00:00

abstract：:Selected reaction monitoring (SRM) is a highly selective and sensitive mass spectrometric methodology for precise and accurate quantification of low-abundant proteins in complex mixtures and for characterization of modified peptides, and constitutes the method of choice in targeted proteomics. Owing to its outstanding...

journal_title：Expert review of proteomics

authors： Calvo E,Camafeita E,Fernández-Gutiérrez B,López JA

更新日期：2011-04-01 00:00:00

abstract：:Due to the enormous complexity of the proteome, focus in proteomics shifts more and more from the study of the complete proteome to the targeted analysis of part of the proteome. The isolation of this specific part of the proteome generally includes an affinity-based enrichment. Surface plasmon resonance (SPR), a labe...

journal_title：Expert review of proteomics

authors： Visser NF,Heck AJ

更新日期：2008-06-01 00:00:00