Hyperamylinemia as a risk factor for accelerated cognitive decline in diabetes.

Abstract:

:Type II diabetes increases the risk for cognitive decline via multiple traits. Amylin is a pancreatic hormone that has amyloidogenic and cytotoxic properties similar to the amyloid-β peptide. The amylin hormone is overexpressed in individuals with pre-diabetic insulin resistance or obesity leading to amylin oligomerization and deposition in pancreatic islets. Amylin oligomerization was implicated in the apoptosis of the insulin-producing β-cells. Recent studies showed that brain tissue from diabetic patients with cerebrovascular dementia or Alzheimer's disease contains significant deposits of oligomerized amylin. It has also been reported that the brain amylin deposition reduced exploratory drive, recognition memory and vestibulomotor function in a rat model that overexpresses human amylin in the pancreas. These novel findings are reviewed here and the hypothesis that type II diabetes is linked with cognitive decline by amylin accumulation in the brain is proposed. Deciphering the impact of hyperamylinemia on the brain is critical for both etiology and treatment of dementia.

journal_name

Expert Rev Proteomics

authors

Ly H,Despa F

doi

10.1586/14789450.2015.1104251

subject

Has Abstract

pub_date

2015-01-01 00:00:00

pages

575-7

issue

6

eissn

1478-9450

issn

1744-8387

journal_volume

12

pub_type

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