Hyperamylinemia as a risk factor for accelerated cognitive decline in diabetes.


:Type II diabetes increases the risk for cognitive decline via multiple traits. Amylin is a pancreatic hormone that has amyloidogenic and cytotoxic properties similar to the amyloid-β peptide. The amylin hormone is overexpressed in individuals with pre-diabetic insulin resistance or obesity leading to amylin oligomerization and deposition in pancreatic islets. Amylin oligomerization was implicated in the apoptosis of the insulin-producing β-cells. Recent studies showed that brain tissue from diabetic patients with cerebrovascular dementia or Alzheimer's disease contains significant deposits of oligomerized amylin. It has also been reported that the brain amylin deposition reduced exploratory drive, recognition memory and vestibulomotor function in a rat model that overexpresses human amylin in the pancreas. These novel findings are reviewed here and the hypothesis that type II diabetes is linked with cognitive decline by amylin accumulation in the brain is proposed. Deciphering the impact of hyperamylinemia on the brain is critical for both etiology and treatment of dementia.


Expert Rev Proteomics


Ly H,Despa F




Has Abstract


2015-01-01 00:00:00












  • The role of mass spectrometry in the characterization of biologic protein products.

    abstract:INTRODUCTION:Mass spectrometry (MS) is widely used in the characterization of biomolecules including peptide and protein therapeutics. These biotechnology products have seen rapid growth over the past few decades and continue to dominate the global pharmaceutical market. Advances in MS instrumentation and techniques ha...

    journal_title:Expert review of proteomics

    pub_type: 杂志文章,评审


    authors: Rathore D,Faustino A,Schiel J,Pang E,Boyne M,Rogstad S

    更新日期:2018-05-01 00:00:00

  • Sperm phosphoproteomics: historical perspectives and current methodologies.

    abstract::Mammalian sperm are differentiated germ cells that transfer genetic material from the male to the female. Owing to this essential role in the reproductive process, an understanding of the complex mechanisms that underlie sperm function has implications ranging from the development of novel contraceptives to the treatm...

    journal_title:Expert review of proteomics

    pub_type: 杂志文章,评审


    authors: Porambo JR,Salicioni AM,Visconti PE,Platt MD

    更新日期:2012-10-01 00:00:00

  • Update on the pathobiology of neuropathic pain.

    abstract::Nerve injury or dysfunction in the peripheral and central nervous systems are the leading causes for the development of neuropathies, which are frequently associated with allodynia and hyperalgesia. Treatment of these disorders is often unsatisfactory due to side effects or insufficient analgesia of the currently avai...

    journal_title:Expert review of proteomics

    pub_type: 杂志文章,评审


    authors: Niederberger E,Kühlein H,Geisslinger G

    更新日期:2008-12-01 00:00:00

  • Recent insights into human bronchial proteomics - how are we progressing and what is next?

    abstract:INTRODUCTION:The human respiratory system is highly prone to diseases and complications. Many lung diseases, including lung cancer (LC), tuberculosis (TB), and chronic obstructive pulmonary disease (COPD) have been among the most common causes of death worldwide. Cystic fibrosis (CF), the most common genetic disease in...

    journal_title:Expert review of proteomics

    pub_type: 杂志文章,评审


    authors: Tan HW,Xu YM,Wu DD,Lau ATY

    更新日期:2018-02-01 00:00:00

  • Proteomics technologies in endometriosis.

    abstract::Endometriosis is a common disorder that is associated with infertility and pelvic pain. Diagnosis is based on the visualization of endometriotic lesions during surgery as no reliable serum marker is currently available. The etiology of endometriosis is largely unknown. Over the last 20 years, several proteomics techno...

    journal_title:Expert review of proteomics

    pub_type: 杂志文章,评审


    authors: Ferrero S,Gillott DJ,Remorgida V,Ragni N,Venturini PL,Grudzinskas JG

    更新日期:2008-10-01 00:00:00

  • Emerging protein array technologies for proteomics.

    abstract::Numerous efforts have been made to understand fundamental biology of diseases based on gene expression. However, the relationship between gene expression and onset of disease often remains obscure. The great advances in protein microarrays allow us to investigate this unclear question through protein profiles, which a...

    journal_title:Expert review of proteomics

    pub_type: 杂志文章,评审


    authors: Lee JR,Magee DM,Gaster RS,LaBaer J,Wang SX

    更新日期:2013-02-01 00:00:00

  • Recent advances in single-cell MALDI mass spectrometry imaging and potential clinical impact.

    abstract::Single-cell analysis is gaining popularity in the field of mass spectrometry as a method for analyzing protein and peptide content in cells. The spatial resolution of MALDI mass spectrometry (MS) imaging is by a large extent limited by the laser focal diameter and the displacement of analytes during matrix deposition....

    journal_title:Expert review of proteomics

    pub_type: 杂志文章,评审


    authors: Boggio KJ,Obasuyi E,Sugino K,Nelson SB,Agar NY,Agar JN

    更新日期:2011-10-01 00:00:00

  • Role for protein-protein interaction databases in human genetics.

    abstract::Proteomics and the study of protein-protein interactions are becoming increasingly important in our effort to understand human diseases on a system-wide level. Thanks to the development and curation of protein-interaction databases, up-to-date information on these interaction networks is accessible and publicly availa...

    journal_title:Expert review of proteomics

    pub_type: 杂志文章,评审


    authors: Pattin KA,Moore JH

    更新日期:2009-12-01 00:00:00

  • Proteomics in atherothrombosis: a future perspective.

    abstract::Atherothrombosis is the primary cause of death in Western countries. The cellular and molecular mechanisms underlying atherosclerosis remain widely unknown. The complex nature of atherosclerotic cardiovascular diseases demands the development of novel technologies that enable discovery of new biomarkers for early dise...

    journal_title:Expert review of proteomics

    pub_type: 杂志文章,评审


    authors: Martín-Ventura JL,Blanco-Colio LM,Tunon J,Gomez-Guerrero C,Michel JB,Meilhac O,Egido J

    更新日期:2007-04-01 00:00:00

  • Proteomic profiling of fatty acid binding proteins in muscular dystrophy.

    abstract::Introduction: Duchenne muscular dystrophy is a neuromuscular disorder, which is caused by abnormalities in the DMD gene that encodes the membrane cytoskeletal protein dystrophin. Besides progressive skeletal muscle wasting, dystrophinopathy also affects non-skeletal muscle tissues, including cells in the cardio-respir...

    journal_title:Expert review of proteomics

    pub_type: 杂志文章


    authors: Dowling P,Gargan S,Zweyer M,Swandulla D,Ohlendieck K

    更新日期:2020-02-01 00:00:00

  • Proteomic studies of common chronic pain conditions - a systematic review and associated network analyses.

    abstract:INTRODUCTION:The lack of biomarkers indicating involved nociceptive and/or pain mechanisms makes diagnostic procedures problematic. Clinical pain research has begun to use proteomics. AREAS COVERED:This systematic review covers proteomic studies of chronic pain cohorts and in relation to clinical variables. Searches i...

    journal_title:Expert review of proteomics

    pub_type: 杂志文章


    authors: Gerdle B,Ghafouri B

    更新日期:2020-06-01 00:00:00

  • 'Proteomineering': has the mine been excavated?

    abstract::Evaluation of: Di Girolamo F, Boschetti E, Chung MC, Guadagni F, Righetti PG. 'Proteomineering' or not? The debate on biomarker discovery in sera continues. J. Proteomics 74(5), 589-594 (2011). The combinatorial peptide ligand library in association with mass spectrometry can greatly enhance the dynamic range of the a...

    journal_title:Expert review of proteomics

    pub_type: 评论,杂志文章


    authors: Panfoli I,Bruschi M,Ravera S,Candiano G

    更新日期:2011-08-01 00:00:00

  • Proteomic study of skeletal muscle in obesity and type 2 diabetes: progress and potential.

    abstract:INTRODUCTION:Skeletal muscle is the major site of insulin-stimulated glucose uptake and imparts the beneficial effects of exercise, and hence is an important site of insulin resistance in obesity and type 2 diabetes (T2D). Despite extensive molecular biology-oriented research the molecular mechanisms underlying insulin...

    journal_title:Expert review of proteomics

    pub_type: 杂志文章,评审


    authors: Kruse R,Højlund K

    更新日期:2018-10-01 00:00:00

  • Nutrition proteomics and biomarker discovery.

    abstract::Baukje de Roos is a principal investigator at the University of Aberdeen, Rowett Institute of Nutrition and Health. She investigates mechanisms through which dietary fats and fatty acids, and also polyphenols, affect parameters involved in the development of heart disease in vivo. This is achieved not only by measurin...

    journal_title:Expert review of proteomics

    pub_type: 面试


    authors: de Roos B

    更新日期:2009-08-01 00:00:00

  • Advances in high-resolution quantitative proteomics: implications for clinical applications.

    abstract::The advances in high-resolution mass spectrometry instrumentation, capable of accurate mass measurement and fast acquisition, have enabled new approaches for targeted quantitative proteomics. More specifically, analyses performed on quadrupole-orbitrap mass spectrometers operated in parallel reaction monitoring (PRM) ...

    journal_title:Expert review of proteomics

    pub_type: 杂志文章,评审


    authors: Gallien S,Domon B

    更新日期:2015-01-01 00:00:00

  • The role of proteomics in assessing beta-cell dysfunction and death in type 1 diabetes.

    abstract::Introduction: Type 1 diabetes (T1D) is characterized by autoimmune-induced dysfunction and destruction of the pancreatic beta cells. Unfortunately, this process is poorly understood, and the current best treatment for type 1 diabetes is the administration of exogenous insulin. To better understand these mechanisms and...

    journal_title:Expert review of proteomics

    pub_type: 杂志文章


    authors: Nakayasu ES,Qian WJ,Evans-Molina C,Mirmira RG,Eizirik DL,Metz TO

    更新日期:2019-07-01 00:00:00

  • Recent technical strategies to identify diagnostic biomarkers for ovarian cancer.

    abstract::Ovarian cancer is the fifth leading cause of cancer deaths among North American women. Regrettably, there is currently no reliable circulating biomarker that can detect ovarian cancer in its early stages. The CA125 biomarker is very useful for treatment response monitoring, but its sensitivity is very low for early de...

    journal_title:Expert review of proteomics

    pub_type: 杂志文章,评审


    authors: Ye B,Gagnon A,Mok SC

    更新日期:2007-02-01 00:00:00

  • An update on the routine application of MALDI-TOF MS in clinical microbiology.

    abstract::Introduction: Matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS) has entered clinical diagnostics and is today a generally accepted and integral part of the workflow for microbial identification. MALDI-TOF MS identification systems received approval from national and internatio...

    journal_title:Expert review of proteomics

    pub_type: 杂志文章


    authors: Welker M,Van Belkum A,Girard V,Charrier JP,Pincus D

    更新日期:2019-08-01 00:00:00

  • Unravelling the biology of chromatin in health and cancer using proteomic approaches.

    abstract:INTRODUCTION:Chromatin remodeling complexes play important roles in the control of genome regulation in both normal and diseased states, and are therefore critical components for the regulation of epigenetic states in cells. Given the role epigenetics plays in cancer, for example, chromatin remodeling complexes are rou...

    journal_title:Expert review of proteomics

    pub_type: 杂志文章,评审


    authors: Eubanks CG,Dayebgadoh G,Liu X,Washburn MP

    更新日期:2017-10-01 00:00:00

  • A huntingtin-HAP1-PCM1 pathway in ciliogenesis.

    abstract::Huntington's disease (HD) is caused by expansion of a polyglutamine repeat in the N-terminal region of huntingtin (htt), a large protein that has been found to interact with a variety of proteins. It remains to be determined how the interactions of htt with other proteins are involved in the pathogenesis of HD. A rece...

    journal_title:Expert review of proteomics

    pub_type: 评论,杂志文章


    authors: Li S,Li XJ

    更新日期:2012-01-01 00:00:00

  • Mass spectrometric approaches for characterizing bacterial proteomes.

    abstract::The emergence of advanced liquid chromatography mass spectrometry technologies for characterizing very complex mixtures of proteins has greatly propelled the field of proteomics, the goal of which is the simultaneous examination of all the proteins expressed by an organism. This research area represents a paradigm shi...

    journal_title:Expert review of proteomics

    pub_type: 杂志文章,评审


    authors: VerBerkmoes NC,Connelly HM,Pan C,Hettich RL

    更新日期:2004-12-01 00:00:00

  • Effects of preanalytical variables on peptide and protein measurements in human serum and plasma: implications for clinical proteomics.

    abstract::There is a wealth of knowledge in the field of in vitro diagnostics with regard to preanalytical variables and their impact on the determination of peptide and protein analytes in human serum and plasma. This information is applicable to clinical proteomics investigations, which utilize the same sample types. Studies ...

    journal_title:Expert review of proteomics

    pub_type: 杂志文章,评审


    authors: Rai AJ,Vitzthum F

    更新日期:2006-08-01 00:00:00

  • Colorectal cancer biomarker discovery and validation using LC-MS/MS-based proteomics in blood: truth or dare?

    abstract::Globally, colorectal cancer (CRC) is the third most common malignant neoplasm. However, highly sensitive, specific, noninvasive tests that allow CRC diagnosis at an early stage are still needed. As circulatory blood reflects the physiological status of an individual and/or the disease status for several disorders, eff...

    journal_title:Expert review of proteomics

    pub_type: 杂志文章,评审


    authors: Reumer A,Maes E,Mertens I,Cho WC,Landuyt B,Valkenborg D,Schoofs L,Baggerman G

    更新日期:2014-08-01 00:00:00

  • Tissue microarrays: bridging the gap between research and the clinic.

    abstract::Tissue microarrays are a high-throughput method for the investigation of biomarkers in multiple tissue specimens at once. This technique allows for the analysis of up to 500 tissue samples in a single experiment using immunohistochemistry and in situ hybridization. Recently, cell lines and xenografts have been reduced...

    journal_title:Expert review of proteomics

    pub_type: 杂志文章,评审


    authors: Braunschweig T,Chung JY,Hewitt SM

    更新日期:2005-06-01 00:00:00

  • Understanding type 1 diabetes through proteomics.

    abstract:INTRODUCTION:Auto-immunity against pancreatic beta-cells leads to an absolute shortage of the hormone insulin, resulting in hyperglycemia and the onset of type 1 diabetes (T1D). Proteomic approaches have been used to elucidate the mechanisms of beta-cell dysfunction and death. Areas covered: In the present review, we d...

    journal_title:Expert review of proteomics

    pub_type: 杂志文章,评审


    authors: Crèvecoeur I,Vig S,Mathieu C,Overbergh L

    更新日期:2017-07-01 00:00:00

  • Wisteria floribunda agglutinin positive glycobiomarkers: a unique lectin as a serum biomarker probe in various diseases.

    abstract:INTRODUCTION:Serum proteins are generally glycosylated and solubilized, and are thus present as glycoproteins. The glycan structure of glycoproteins reflects cell differentiation status; glycan structures generated by diseased cells are distinguishable from those produced by healthy cells. Proteins may therefore serve ...

    journal_title:Expert review of proteomics

    pub_type: 杂志文章,评审


    authors: Narimatsu H,Sato T

    更新日期:2018-02-01 00:00:00

  • Top-down Proteomics: Technology Advancements and Applications to Heart Diseases.

    abstract:INTRODUCTION:Heart diseases are a leading cause of morbidity and mortality for both men and women worldwide, and impose significant economic burdens on the healthcare systems. Despite substantial effort over the last several decades, the molecular mechanisms underlying diseases of the heart remain poorly understood. A...

    journal_title:Expert review of proteomics

    pub_type: 杂志文章,评审


    authors: Cai W,Tucholski TM,Gregorich ZR,Ge Y

    更新日期:2016-08-01 00:00:00

  • Strategies in mass spectrometry for the assignment of Cys-Cys disulfide connectivities in proteins.

    abstract::Elucidating disulfide linkage patterns is a crucial part of protein characterization, for which mass spectrometry (MS) is now an indispensable analytical tool. In many cases, MS-based disulfide connectivity assignment is straightforwardly achieved using one-step protein fragmentation in the unreduced form followed by ...

    journal_title:Expert review of proteomics

    pub_type: 杂志文章,评审


    authors: Goyder MS,Rebeaud F,Pfeifer ME,Kálmán F

    更新日期:2013-10-01 00:00:00

  • Framework for a systems approach to proteomic biomarker profiling in polycystic ovary syndrome.

    abstract::Polycystic ovary syndrome (PCOS) is the most common endocrine disorder in females of reproductive age, and its prevalence ranges between 6 and 8%. Associated problems include infertility, menstrual disorders, hirsutism and obesity. In addition, individuals with PCOS may be at increased risk of diabetes, endometrial ca...

    journal_title:Expert review of proteomics

    pub_type: 杂志文章,评审


    authors: Atiomo WU,Khalid S,Ziauddin A,Tooth D,Layfield R

    更新日期:2009-10-01 00:00:00

  • Surface plasmon resonance mass spectrometry in proteomics.

    abstract::Due to the enormous complexity of the proteome, focus in proteomics shifts more and more from the study of the complete proteome to the targeted analysis of part of the proteome. The isolation of this specific part of the proteome generally includes an affinity-based enrichment. Surface plasmon resonance (SPR), a labe...

    journal_title:Expert review of proteomics

    pub_type: 杂志文章,评审


    authors: Visser NF,Heck AJ

    更新日期:2008-06-01 00:00:00