Abstract:
INTRODUCTION:Pancreatic ductal adenocarcinoma (PDAC) is one of the deadliest cancers worldwide. However, there remain many unmet clinical needs, from diagnosis to treatment strategies. The inherent complexity of the molecular characteristics of PDAC has made it difficult to meet these challenges, rendering proteomic profiling of PDAC a critical area of research. Area covered: In this review, we present recent advances in mass spectrometry (MS) and its current application in proteomic studies on PDAC. In addition, we discuss future directions for research that can efficiently incorporate current MS-based technologies that address key issues of PDAC proteomics. Expert commentary: Compared with other cancer studies, little progress has been made in PDAC proteomics, perhaps attributed to the difficulty in performing in-depth and large-scale clinical studies on PDAC. However, recent advances in mass spectrometry can advance PDAC proteomics past the fundamental research stage.
journal_name
Expert Rev Proteomicsjournal_title
Expert review of proteomicsauthors
Kim H,Park J,Wang JI,Kim Ydoi
10.1080/14789450.2017.1382356subject
Has Abstractpub_date
2017-11-01 00:00:00pages
963-971issue
11eissn
1478-9450issn
1744-8387journal_volume
14pub_type
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