New insights into viral structure and virus-cell interactions through proteomics.

abstract：INTRODUCTION:The skin protects the human body from external insults and regulates water and temperature homeostasis. A highly developed extracellular matrix (ECM) supports the skin and instructs its cell functions. Reduced functionality of the ECM is often associated with skin diseases that cause physical impairment an...

journal_title：Expert review of proteomics

authors： Dengjel J,Bruckner-Tuderman L,Nyström A

更新日期：2020-05-01 00:00:00

abstract：:It is well known that chronic, excessive consumption of alcohol can cause brain damage/structural changes in the regions important for neurocognitive function. Some of the damages are permanent, while others are reversible. Molecular mechanisms underlying alcohol-induced and/or -related brain damage are largely unknow...

journal_title：Expert review of proteomics

authors： Matsumoto H,Matsumoto I

更新日期：2008-04-01 00:00:00

abstract：:Ovarian cancer is the fifth leading cause of cancer deaths among North American women. Regrettably, there is currently no reliable circulating biomarker that can detect ovarian cancer in its early stages. The CA125 biomarker is very useful for treatment response monitoring, but its sensitivity is very low for early de...

journal_title：Expert review of proteomics

authors： Ye B,Gagnon A,Mok SC

更新日期：2007-02-01 00:00:00

abstract：:These are really exciting times in the field of Parkinson's disease research. Although the etiology of sporadic disease still remains a mystery, many of the proteins associated with hereditary disease (5-10% of all disease) have now been identified. Only time will tell whether proteins associated with hereditary disea...

journal_title：Expert review of proteomics

authors： Robinson PA

更新日期：2010-08-01 00:00:00

abstract：INTRODUCTION:Metabolomics has become a crucial part of systems biology; however, data analysis is still often undertaken in a reductionist way focusing on changes in individual metabolites. Whilst such approaches indeed provide relevant insights into the metabolic phenotype of an organism, the intricate nature of metab...

journal_title：Expert review of proteomics

authors： Perez De Souza L,Alseekh S,Brotman Y,Fernie AR

更新日期：2020-04-01 00:00:00

abstract：:With the growing availability of mature systems and strategies in biotechnology and the continuously expanding knowledge of cellular processes and involved biomolecules, human sports drug testing has become a considerably complex field in the arena of analytical chemistry. Proving the exogenous origin of peptidic drug...

journal_title：Expert review of proteomics

authors： Thevis M,Thomas A,Schänzer W

更新日期：2014-12-01 00:00:00

abstract：:The isolation of neural stem cells from fetal and adult mammalian CNS and the demonstration of functional neurogenesis in adult CNS have offered perspectives for treatment of many devastating hereditary and acquired neurological diseases. Due to this enormous potential, neural stem cells are a subject of extensive mol...

journal_title：Expert review of proteomics

authors： Skalnikova H,Vodicka P,Gadher SJ,Kovarova H

更新日期：2008-04-01 00:00:00

abstract：INTRODUCTION:Mass spectrometry (MS) is widely used in the characterization of biomolecules including peptide and protein therapeutics. These biotechnology products have seen rapid growth over the past few decades and continue to dominate the global pharmaceutical market. Advances in MS instrumentation and techniques ha...

journal_title：Expert review of proteomics

authors： Rathore D,Faustino A,Schiel J,Pang E,Boyne M,Rogstad S

更新日期：2018-05-01 00:00:00

abstract：INTRODUCTION:Breast cancer subtypes are currently defined by a combination of morphologic, genomic, and proteomic characteristics. These subtypes provide a molecular portrait of the tumor that aids diagnosis, prognosis, and treatment escalation/de-escalation options. Gene expression signatures describing intrinsic brea...

journal_title：Expert review of proteomics

authors： Mueller C,Haymond A,Davis JB,Williams A,Espina V

更新日期：2018-02-01 00:00:00

abstract：:Viruses have coevolved with their hosts, acquiring strategies to subvert host cellular pathways for effective viral replication and spread. Human cytomegalovirus (HCMV), a widely-spread β-herpesvirus, is a major cause of birth defects and opportunistic infections in HIV-1/AIDS patients. HCMV displays an intricate syst...

journal_title：Expert review of proteomics

authors： Jean Beltran PM,Cristea IM

更新日期：2014-12-01 00:00:00

abstract：:Proteins have several measurable features in biological fluids that may change under pathological conditions. The current disease biomarker discovery is mostly based on protein concentration in the sample as the measurable feature. Changes in protein structures, such as post-translational modifications and in protein-...

journal_title：Expert review of proteomics

authors： Zaslavsky BY,Uversky VN,Chait A

更新日期：2016-01-01 00:00:00

abstract：:A panel of biomarkers for the early detection of bladder cancer has not yet been identified. Many different molecules, including DNA, RNA or proteins have been reported but none have provided adequate sensitivity for a single-tier screening test or a test to replace cystoscopy. Therefore, multimarker panels are discus...

journal_title：Expert review of proteomics

authors： Schwamborn K,Gaisa NT,Henkel C

更新日期：2010-12-01 00:00:00

abstract：:Clinical proteomics has been applied to the identification of biomarkers of obstetric and neonatal disease. We will discuss a number of encouraging studies that have led to potentially valid biomarkers in the context of Down's syndrome, preterm birth, amniotic infections, preeclampsia, intrauterine growth restriction ...

journal_title：Expert review of proteomics

authors： Klein J,Buffin-Meyer B,Mullen W,Carty DM,Delles C,Vlahou A,Mischak H,Decramer S,Bascands JL,Schanstra JP

更新日期：2014-02-01 00:00:00

abstract：INTRODUCTION:Heart diseases are a leading cause of morbidity and mortality for both men and women worldwide, and impose significant economic burdens on the healthcare systems. Despite substantial effort over the last several decades, the molecular mechanisms underlying diseases of the heart remain poorly understood. A...

journal_title：Expert review of proteomics

authors： Cai W,Tucholski TM,Gregorich ZR,Ge Y

更新日期：2016-08-01 00:00:00

abstract：INTRODUCTION:Frailty is consequent to age-dependent deregulation of several biological pathways and systems, encompassing namely sarcopenia, age-associated hormonal derangements, inflammation, and nutritional or metabolic deficiencies. Although the prevalence of frailty is usually between 10% and 20% in the general eld...

journal_title：Expert review of proteomics

authors： Danese E,Montagnana M,Lippi G

更新日期：2018-08-01 00:00:00

abstract：:An essential skill for every researcher is to learn how to select and apply the most appropriate methods for the questions they are trying to answer. With the extensive variety of methods available, it is increasingly important to scrutinize the advantages and disadvantages of these techniques prior to making a decisi...

journal_title：Expert review of proteomics

authors： Weibrecht I,Leuchowius KJ,Clausson CM,Conze T,Jarvius M,Howell WM,Kamali-Moghaddam M,Söderberg O

更新日期：2010-06-01 00:00:00

abstract：:Introduction: Type 1 diabetes (T1D) is characterized by autoimmune-induced dysfunction and destruction of the pancreatic beta cells. Unfortunately, this process is poorly understood, and the current best treatment for type 1 diabetes is the administration of exogenous insulin. To better understand these mechanisms and...

journal_title：Expert review of proteomics

authors： Nakayasu ES,Qian WJ,Evans-Molina C,Mirmira RG,Eizirik DL,Metz TO

更新日期：2019-07-01 00:00:00

abstract：:Introduction: The last decade has yielded significant developments in the field of proteomics, especially in mass spectrometry (MS) and data analysis tools. In particular, a shift from gel-based to MS-based proteomics has been observed, thereby providing a platform with which to construct proteome atlases for all life...

journal_title：Expert review of proteomics

authors： Min CW,Gupta R,Agrawal GK,Rakwal R,Kim ST

更新日期：2019-09-01 00:00:00

abstract：INTRODUCTION:Extracellular vesicles are emerging sources of biomarkers for modern preventive and precision medicine. Extracellular vesicles in body fluids offer a unique opportunity for integrative biomarker approaches due to their complex biocargo that includes proteins, lipids, nucleic acids and metabolites. Mass spe...

journal_title：Expert review of proteomics

authors： Sódar BW,Kovács Á,Visnovitz T,Pállinger É,Vékey K,Pocsfalvi G,Turiák L,Buzás EI

更新日期：2017-12-01 00:00:00

abstract：:Bile is a body fluid produced by the liver and drained by biliary ducts into the duodenum. It has two major functions: first, it contains bile acids, which are critical for the digestion of fats, and second, it is an excretory pathway for many endogenous and exogenous compounds. Proteomic analysis of bile is particula...

journal_title：Expert review of proteomics

authors： Farina A,Dumonceau JM,Lescuyer P

更新日期：2009-06-01 00:00:00

abstract：:Exosomes are nanovesicles, derived from the endocytic pathway, released by most cell types and found in many body fluids, including urine. A variety of exosomal functions have been reported, including transfer of RNA, cell communication, control of apoptosis and protein lifespan. Exosomes from mesenchymal stem cells c...

journal_title：Expert review of proteomics

authors： Bruschi M,Ravera S,Santucci L,Candiano G,Bartolucci M,Calzia D,Lavarello C,Inglese E,Petretto A,Ghiggeri G,Panfoli I

更新日期：2015-08-01 00:00:00

abstract：:In recent years, MALDI imaging mass spectrometry (MALDI-IMS) has developed as a promising tool to investigate the spatial distribution of biomolecules in intact tissue specimens. Ion densities of various molecules can be displayed as heat maps while preserving anatomical structures. In this short review, an overview o...

journal_title：Expert review of proteomics

authors： Chatterji B,Pich A

更新日期：2013-08-01 00:00:00

abstract：:The vascular endothelium lining the luminal surface of all blood vessels is constantly exposed to shear stress exerted by the flowing blood. Blood flow with high laminar shear stress confers protection by activation of antiatherogenic, antithrombotic and anti-inflammatory proteins, whereas low or oscillatory shear str...

journal_title：Expert review of proteomics

authors： Firasat S,Hecker M,Binder L,Asif AR

更新日期：2014-10-01 00:00:00

abstract：:Baukje de Roos is a principal investigator at the University of Aberdeen, Rowett Institute of Nutrition and Health. She investigates mechanisms through which dietary fats and fatty acids, and also polyphenols, affect parameters involved in the development of heart disease in vivo. This is achieved not only by measurin...

journal_title：Expert review of proteomics

authors： de Roos B

更新日期：2009-08-01 00:00:00

abstract：:Spermatozoa are unique cells that have highly compact DNA, motility (and hypermotility) patterns, a specific morphology, localized mitochondria and an apical acrosome. They are the end product of a dynamic process termed spermatogenesis. Sperm are therefore produced with specific proteins in order to effect different ...

journal_title：Expert review of proteomics

authors： Agarwal A,Bertolla RP,Samanta L

更新日期：2016-01-01 00:00:00

abstract：:Huntington's disease (HD) is caused by expansion of a polyglutamine repeat in the N-terminal region of huntingtin (htt), a large protein that has been found to interact with a variety of proteins. It remains to be determined how the interactions of htt with other proteins are involved in the pathogenesis of HD. A rece...

journal_title：Expert review of proteomics

authors： Li S,Li XJ

更新日期：2012-01-01 00:00:00

abstract：:Single-cell analysis is gaining popularity in the field of mass spectrometry as a method for analyzing protein and peptide content in cells. The spatial resolution of MALDI mass spectrometry (MS) imaging is by a large extent limited by the laser focal diameter and the displacement of analytes during matrix deposition....

journal_title：Expert review of proteomics

authors： Boggio KJ,Obasuyi E,Sugino K,Nelson SB,Agar NY,Agar JN

更新日期：2011-10-01 00:00:00

abstract：:Protein phosphorylation events are key regulators of cellular signaling processes. In the era of functional genomics, rational drug design programs demand large-scale high-throughput analysis of signal transduction cascades. Significant improvements in the area of mass spectrometry-based proteomics have provided excit...

journal_title：Expert review of proteomics

authors： Chen WG,White FM

更新日期：2004-10-01 00:00:00

abstract：INTRODUCTION:Lung cancer and related diseases have been one of the most common causes of deaths worldwide. Genomic-based biomarkers may hardly reflect the underlying dynamic molecular mechanism of functional protein interactions, which is the center of a disease. Recent developments in mass spectrometry (MS) have made ...

journal_title：Expert review of proteomics

authors： Fujii K,Nakamura H,Nishimura T

更新日期：2017-04-01 00:00:00

abstract：INTRODUCTION:The human respiratory system is highly prone to diseases and complications. Many lung diseases, including lung cancer (LC), tuberculosis (TB), and chronic obstructive pulmonary disease (COPD) have been among the most common causes of death worldwide. Cystic fibrosis (CF), the most common genetic disease in...

journal_title：Expert review of proteomics

authors： Tan HW,Xu YM,Wu DD,Lau ATY

更新日期：2018-02-01 00:00:00