Recent technical strategies to identify diagnostic biomarkers for ovarian cancer.

abstract：:Introduction: Type 1 diabetes (T1D) is characterized by autoimmune-induced dysfunction and destruction of the pancreatic beta cells. Unfortunately, this process is poorly understood, and the current best treatment for type 1 diabetes is the administration of exogenous insulin. To better understand these mechanisms and...

journal_title：Expert review of proteomics

authors： Nakayasu ES,Qian WJ,Evans-Molina C,Mirmira RG,Eizirik DL,Metz TO

更新日期：2019-07-01 00:00:00

abstract：:This review describes a new type of label-free optical biosensor that is inexpensively manufactured from continuous sheets of plastic film and incorporated into standard format microplates to enable highly sensitive, high-throughput detection of small molecules, proteins and cells. The biosensor and associated detecti...

journal_title：Expert review of proteomics

authors： Cunningham BT,Laing L

更新日期：2006-06-01 00:00:00

abstract：:Introduction: Due to the relatively low mutation rate and high frequency of copy number variation, finding actionable genetic drivers of high-grade serous carcinoma (HGSC) is a challenging task. Furthermore, emerging studies show that genetic alterations are frequently poorly represented at the protein level adding a ...

journal_title：Expert review of proteomics

authors： Labrie M,Kendsersky ND,Ma H,Campbell L,Eng J,Chin K,Mills GB

更新日期：2019-10-01 00:00:00

abstract：:Although genomics techniques such as DNA microarrays have been widely used in virology, much more limited use has been made of proteomics. Although difficult, proteomics can greatly contribute to an understanding of virus-cell interactions, including the ternary structure of viral receptors at the cell surface, post-t...

journal_title：Expert review of proteomics

authors： Bernhard OK,Diefenbach RJ,Cunningham AL

更新日期：2005-08-01 00:00:00

abstract：INTRODUCTION:Breast cancer subtypes are currently defined by a combination of morphologic, genomic, and proteomic characteristics. These subtypes provide a molecular portrait of the tumor that aids diagnosis, prognosis, and treatment escalation/de-escalation options. Gene expression signatures describing intrinsic brea...

journal_title：Expert review of proteomics

authors： Mueller C,Haymond A,Davis JB,Williams A,Espina V

更新日期：2018-02-01 00:00:00

abstract：:A panel of biomarkers for the early detection of bladder cancer has not yet been identified. Many different molecules, including DNA, RNA or proteins have been reported but none have provided adequate sensitivity for a single-tier screening test or a test to replace cystoscopy. Therefore, multimarker panels are discus...

journal_title：Expert review of proteomics

authors： Schwamborn K,Gaisa NT,Henkel C

更新日期：2010-12-01 00:00:00

abstract：INTRODUCTION:Heart diseases are a leading cause of morbidity and mortality for both men and women worldwide, and impose significant economic burdens on the healthcare systems. Despite substantial effort over the last several decades, the molecular mechanisms underlying diseases of the heart remain poorly understood. A...

journal_title：Expert review of proteomics

authors： Cai W,Tucholski TM,Gregorich ZR,Ge Y

更新日期：2016-08-01 00:00:00

abstract：:Introduction: Degradation of proteins by cellular proteasomes is critical for the fidelity of protein homeostasis and proper cell function. Indeed, perturbations in proteasome function, as well as the degradation of specific substrates, are associated with a variety of human diseases. Yet, monitoring and analyzing pro...

journal_title：Expert review of proteomics

authors： Javitt A,Merbl Y

更新日期：2019-07-19 00:00:00

abstract：:Stroke is one of the most common causes of death worldwide and a major cause of acquired disability in adults. Despite advances in research during the last decade, prevention and treatment strategies still suffer from significant limitations, and therefore new theoretical and technical approaches are required. Technol...

journal_title：Expert review of proteomics

authors： Laborde CM,Mourino-Alvarez L,Akerstrom F,Padial LR,Vivanco F,Gil-Dones F,Barderas MG

更新日期：2012-08-01 00:00:00

abstract：:Polycystic ovary syndrome (PCOS) is the most common endocrine disorder in females of reproductive age, and its prevalence ranges between 6 and 8%. Associated problems include infertility, menstrual disorders, hirsutism and obesity. In addition, individuals with PCOS may be at increased risk of diabetes, endometrial ca...

journal_title：Expert review of proteomics

authors： Atiomo WU,Khalid S,Ziauddin A,Tooth D,Layfield R

更新日期：2009-10-01 00:00:00

abstract：:Introduction: Autophagy is one of the most conserved clearance systems through which eukaryotes manage to handle dysfunctional and excess organelles and macromolecules. This catabolic process has not only a role in the maintenance of basal turnover of cellular components, but it is also essential in cells adaptation t...

journal_title：Expert review of proteomics

authors： Di Domenico F,Zuliani I,Tramutola A

更新日期：2019-01-01 00:00:00

abstract：:Small heat shock proteins (sHsps) are ubiquitous molecular chaperones that are implicated in a variety of diseases. Upon stress, they stabilize unfolding proteins and prevent them from aggregating. However, under physiological conditions without severe stress, some sHsps interact with other proteins. In a perspective ...

journal_title：Expert review of proteomics

authors： Mymrikov EV,Haslbeck M

更新日期：2015-06-01 00:00:00

abstract：:Introduction: Duchenne muscular dystrophy is a neuromuscular disorder, which is caused by abnormalities in the DMD gene that encodes the membrane cytoskeletal protein dystrophin. Besides progressive skeletal muscle wasting, dystrophinopathy also affects non-skeletal muscle tissues, including cells in the cardio-respir...

journal_title：Expert review of proteomics

authors： Dowling P,Gargan S,Zweyer M,Swandulla D,Ohlendieck K

更新日期：2020-02-01 00:00:00

abstract：:Chronic physical inactivity is a major risk factor for a number of important lifestyle diseases, while inappropriate exposure to high physical demands is a risk factor for musculoskeletal injury and fatigue. Proteomic and metabolomic investigations of the physical activity continuum - extreme sedentariness to extremes...

journal_title：Expert review of proteomics

authors： Sampson DL,Broadbent JA,Parker AW,Upton Z,Parker TJ

更新日期：2014-02-01 00:00:00

abstract：INTRODUCTION:Auto-immunity against pancreatic beta-cells leads to an absolute shortage of the hormone insulin, resulting in hyperglycemia and the onset of type 1 diabetes (T1D). Proteomic approaches have been used to elucidate the mechanisms of beta-cell dysfunction and death. Areas covered: In the present review, we d...

journal_title：Expert review of proteomics

authors： Crèvecoeur I,Vig S,Mathieu C,Overbergh L

更新日期：2017-07-01 00:00:00

abstract：:An essential skill for every researcher is to learn how to select and apply the most appropriate methods for the questions they are trying to answer. With the extensive variety of methods available, it is increasingly important to scrutinize the advantages and disadvantages of these techniques prior to making a decisi...

journal_title：Expert review of proteomics

authors： Weibrecht I,Leuchowius KJ,Clausson CM,Conze T,Jarvius M,Howell WM,Kamali-Moghaddam M,Söderberg O

更新日期：2010-06-01 00:00:00

abstract：:Introduction: Metaproteomics is an established method to obtain a comprehensive taxonomic and functional view of microbial communities. After more than a decade, we are now able to describe the promise, reality, and perspectives of metaproteomics and provide useful information about the choice of method, applications,...

journal_title：Expert review of proteomics

authors： Lohmann P,Schäpe SS,Haange SB,Oliphant K,Allen-Vercoe E,Jehmlich N,Von Bergen M

更新日期：2020-02-01 00:00:00

abstract：:The challenges encountered by proteomic researchers seeking diagnostic, prognostic and mechanistic markers were the subject of the 1-day meeting, Proteomics: Advances in Biomarker Discovery hosted by EuroSciCon. The speakers had a broad range of clinical and basic science interests, and presented data using a number o...

journal_title：Expert review of proteomics

authors： Cowan ML,Vera J

更新日期：2008-02-01 00:00:00

abstract：INTRODUCTION:The lack of biomarkers indicating involved nociceptive and/or pain mechanisms makes diagnostic procedures problematic. Clinical pain research has begun to use proteomics. AREAS COVERED:This systematic review covers proteomic studies of chronic pain cohorts and in relation to clinical variables. Searches i...

journal_title：Expert review of proteomics

authors： Gerdle B,Ghafouri B

更新日期：2020-06-01 00:00:00

abstract：:Selected reaction monitoring (SRM) is a highly selective and sensitive mass spectrometric methodology for precise and accurate quantification of low-abundant proteins in complex mixtures and for characterization of modified peptides, and constitutes the method of choice in targeted proteomics. Owing to its outstanding...

journal_title：Expert review of proteomics

authors： Calvo E,Camafeita E,Fernández-Gutiérrez B,López JA

更新日期：2011-04-01 00:00:00

abstract：:High-throughput proteomics technologies tend to provide highly sensitive information about living tissues and biological fluids. Analytes are characterized by intrinsic and extrinsic properties, the latter depending on each phase of their preparation, sometimes adding artifacts with crucial repercussions in result rel...

journal_title：Expert review of proteomics

authors： Barelli S,Crettaz D,Thadikkaran L,Rubin O,Tissot JD

更新日期：2007-06-01 00:00:00

abstract：:In recent years, MALDI imaging mass spectrometry (MALDI-IMS) has developed as a promising tool to investigate the spatial distribution of biomolecules in intact tissue specimens. Ion densities of various molecules can be displayed as heat maps while preserving anatomical structures. In this short review, an overview o...

journal_title：Expert review of proteomics

authors： Chatterji B,Pich A

更新日期：2013-08-01 00:00:00

abstract：:The concept of personalized medicine includes novel protein biomarkers that are expected to improve the early detection, diagnosis and therapy monitoring of malignant diseases. Tissues, biofluids, cell lines and xenograft models are the common sources of biomarker candidates that require verification of clinical value...

journal_title：Expert review of proteomics

authors： Pernikářová V,Bouchal P

更新日期：2015-01-01 00:00:00

abstract：INTRODUCTION:Extracellular vesicles are emerging sources of biomarkers for modern preventive and precision medicine. Extracellular vesicles in body fluids offer a unique opportunity for integrative biomarker approaches due to their complex biocargo that includes proteins, lipids, nucleic acids and metabolites. Mass spe...

journal_title：Expert review of proteomics

authors： Sódar BW,Kovács Á,Visnovitz T,Pállinger É,Vékey K,Pocsfalvi G,Turiák L,Buzás EI

更新日期：2017-12-01 00:00:00

abstract：:Elucidating disulfide linkage patterns is a crucial part of protein characterization, for which mass spectrometry (MS) is now an indispensable analytical tool. In many cases, MS-based disulfide connectivity assignment is straightforwardly achieved using one-step protein fragmentation in the unreduced form followed by ...

journal_title：Expert review of proteomics

authors： Goyder MS,Rebeaud F,Pfeifer ME,Kálmán F

更新日期：2013-10-01 00:00:00

abstract：OBJECTIVE:Hepcidin-25 production is stimulated by systemic inflammation, and it interferes with iron utilization, leading to anemia. This study aimed to investigate the relationships between the plasma levels of hepcidin, interleukin-6 (IL-6), erythropoietin (EPO) and erythroferrone (ERFE) in patients with benign breas...

journal_title：Expert review of proteomics

authors： Ciniselli CM,De Bortoli M,Taverna E,Varinelli L,Pizzamiglio S,Veneroni S,Bonini C,Orlandi R,Verderio P,Bongarzone I

更新日期：2015-01-01 00:00:00

abstract：:As a complementary approach to 2D-PAGE, multidimensional liquid chromatography (MDLC) separation methods have been widely applied in all kinds of biological sample investigations. MDLC coupled with mass spectrometry is playing an important role in proteome research owing to its high speed, high resolution and high sen...

journal_title：Expert review of proteomics

authors： Gao M,Qi D,Zhang P,Deng C,Zhang X

更新日期：2010-10-01 00:00:00

abstract：:The Central and Eastern European Proteomic Conference (CEEPC) proudly celebrated its 10th Anniversary with an exciting scientific program inclusive of proteome, proteomics and systems biology in Budapest, Hungary. Since 2007, CEEPC has represented 'state-of the-art' proteomics in and around Central and Eastern Europe ...

journal_title：Expert review of proteomics

authors： Gadher SJ,Drahos L,Vékey K,Kovarova H

更新日期：2017-07-01 00:00:00

abstract：:Prenatal diagnosis is now offered to high-risk pregnancies, including advanced maternal age, ultrasound anomalies and positive Down's syndrome screening, and karyotype on cultured fetal material is the test of choice to screen these pregnancies. However, microscope analysis can only detect gross chromosome abnormaliti...

journal_title：Expert review of proteomics

authors： Novelli A,Cavalli P,Bernardini L

更新日期：2013-04-01 00:00:00

abstract：INTRODUCTION:Leptomeningeal metastases (LM) from lymphoma remain a difficult complication for oncologist due to the high incidence in morbidity and mortality. Early diagnostic and initiation of treatment are essential to prevent neurological deterioration. Areas covered: In this review, several proteomic approaches are...

journal_title：Expert review of proteomics

authors： Galicia N,Dégano R,Díez P,González-González M,Góngora R,Ibarrola N,Fuentes M

更新日期：2017-04-01 00:00:00