Abstract:
INTRODUCTION:The application of new proteomics methods may help to identify new diagnostic/predictive molecular markers in an attempt to improve the clinical management of atherosclerosis. Areas covered: Technological advances in proteomics have enhanced its sensitivity and multiplexing capacity, as well as the possibility of studying protein interactions and tissue structure. These advances will help us better understand the molecular mechanisms at play in atherosclerosis as a biological system. Moreover, this should help identify new predictive/diagnostic biomarkers and therapeutic targets that may facilitate effective risk stratification and early diagnosis, with the ensuing rapid implementation of treatment. This review provides a comprehensive overview of the novel methods in proteomics, including state-of-the-art techniques, novel biological samples and applications for the study of atherosclerosis. Expert commentary: Collaboration between clinicians and researchers is crucial to further validate and introduce new molecular markers to manage atherosclerosis that are identified using the most up to date proteomic approaches.
journal_name
Expert Rev Proteomicsjournal_title
Expert review of proteomicsauthors
Mourino-Alvarez L,Baldan-Martin M,Rincon R,Martin-Rojas T,Corbacho-Alonso N,Sastre-Oliva T,Barderas MGdoi
10.1080/14789450.2017.1353912subject
Has Abstractpub_date
2017-08-01 00:00:00pages
701-713issue
8eissn
1478-9450issn
1744-8387journal_volume
14pub_type
杂志文章,评审abstract::With the growing availability of mature systems and strategies in biotechnology and the continuously expanding knowledge of cellular processes and involved biomolecules, human sports drug testing has become a considerably complex field in the arena of analytical chemistry. Proving the exogenous origin of peptidic drug...
journal_title:Expert review of proteomics
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doi:10.1586/14789450.2014.965159
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abstract::Ubiquitin-proteasome-mediated protein degradation is central to the regulation of many important biological processes, including cell cycle progression, apoptosis and DNA repair. Recognition and degradation of ubiquitinated substrates by the 26S proteasome is tightly regulated to maintain normal cell growth. Disruptio...
journal_title:Expert review of proteomics
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journal_title:Expert review of proteomics
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doi:10.1586/14789450.2013.858021
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journal_title:Expert review of proteomics
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journal_title:Expert review of proteomics
pub_type: 杂志文章,评审
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journal_title:Expert review of proteomics
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journal_title:Expert review of proteomics
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journal_title:Expert review of proteomics
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journal_title:Expert review of proteomics
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journal_title:Expert review of proteomics
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journal_title:Expert review of proteomics
pub_type: 杂志文章,评审
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journal_title:Expert review of proteomics
pub_type: 杂志文章
doi:10.1080/14789450.2016.1246188
更新日期:2016-11-01 00:00:00
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journal_title:Expert review of proteomics
pub_type: 杂志文章,评审
doi:10.1586/14789450.3.6.653
更新日期:2006-12-01 00:00:00
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journal_title:Expert review of proteomics
pub_type: 杂志文章
doi:10.1586/14789450.2014.971116
更新日期:2014-12-01 00:00:00
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journal_title:Expert review of proteomics
pub_type: 杂志文章,评审
doi:10.1080/14789450.2018.1469982
更新日期:2018-05-01 00:00:00
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journal_title:Expert review of proteomics
pub_type: 评论,杂志文章
doi:10.1586/epr.12.55
更新日期:2012-12-01 00:00:00
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journal_title:Expert review of proteomics
pub_type: 杂志文章
doi:10.1080/14789450.2020.1773261
更新日期:2020-05-01 00:00:00
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journal_title:Expert review of proteomics
pub_type: 杂志文章,评审
doi:10.1080/14789450.2018.1528147
更新日期:2018-10-01 00:00:00
abstract::The rapid expansion of methods for measuring biological data ranging from DNA sequence variations to mRNA expression and protein abundance presents the opportunity to utilize multiple types of information jointly in the study of human health and disease. Organisms are complex systems that integrate inputs at myriad le...
journal_title:Expert review of proteomics
pub_type: 杂志文章,评审
doi:10.1586/14789450.1.1.67
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journal_title:Expert review of proteomics
pub_type: 杂志文章,评审
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journal_title:Expert review of proteomics
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journal_title:Expert review of proteomics
pub_type: 杂志文章,评审
doi:10.1586/14789450.4.4.531
更新日期:2007-08-01 00:00:00
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journal_title:Expert review of proteomics
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abstract::Introduction: The last decade has yielded significant developments in the field of proteomics, especially in mass spectrometry (MS) and data analysis tools. In particular, a shift from gel-based to MS-based proteomics has been observed, thereby providing a platform with which to construct proteome atlases for all life...
journal_title:Expert review of proteomics
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abstract::Evaluation of: Di Girolamo F, Boschetti E, Chung MC, Guadagni F, Righetti PG. 'Proteomineering' or not? The debate on biomarker discovery in sera continues. J. Proteomics 74(5), 589-594 (2011). The combinatorial peptide ligand library in association with mass spectrometry can greatly enhance the dynamic range of the a...
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