Proteomic analysis of pancreatic ductal adenocarcinoma.

Abstract:

INTRODUCTION:Pancreatic ductal adenocarcinoma (PDAC), which represents approximately 80% of all pancreatic cancers, is a highly aggressive malignant disease and one of the most lethal among all cancers. Overall, the 5-year survival rate among all pancreatic cancer patients is less than 9%; these rates have shown little change over the past 30 years. A more comprehensive understanding of the molecular mechanisms underlying this complex disease is crucial to the development of new diagnostic tools for early detection and disease monitoring, as well as to identify new and more effective therapeutics to improve patient outcomes. AREA COVERED:We summarize recent advances in proteomic strategies and mass spectrometry to identify new biomarkers for early detection and monitoring of disease progression, predict response to therapy, and to identify novel proteins that have the potential to be 'druggable' therapeutic targets. An overview of proteomic studies that have been conducted to further our mechanistic understanding of metastasis and chemotherapy resistance in PDAC disease progression will also be discussed. EXPERT COMMENTARY:The results from these PDAC proteomic studies on a variety of PDAC sample types (e.g., blood, tissue, cell lines, exosomes, etc.) provide great promise of having a significant clinical impact and improving patient outcomes.

journal_name

Expert Rev Proteomics

authors

Meleady P,Abdul Rahman R,Henry M,Moriarty M,Clynes M

doi

10.1080/14789450.2020.1803743

subject

Has Abstract

pub_date

2020-06-01 00:00:00

pages

453-467

issue

6

eissn

1478-9450

issn

1744-8387

journal_volume

17

pub_type

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