Human saliva proteome analysis and disease biomarker discovery.

abstract：:The concept of personalized medicine includes novel protein biomarkers that are expected to improve the early detection, diagnosis and therapy monitoring of malignant diseases. Tissues, biofluids, cell lines and xenograft models are the common sources of biomarker candidates that require verification of clinical value...

journal_title：Expert review of proteomics

authors： Pernikářová V,Bouchal P

更新日期：2015-01-01 00:00:00

abstract：:Baukje de Roos is a principal investigator at the University of Aberdeen, Rowett Institute of Nutrition and Health. She investigates mechanisms through which dietary fats and fatty acids, and also polyphenols, affect parameters involved in the development of heart disease in vivo. This is achieved not only by measurin...

journal_title：Expert review of proteomics

authors： de Roos B

更新日期：2009-08-01 00:00:00

abstract：INTRODUCTION:Pancreatic ductal adenocarcinoma (PDAC) is one of the deadliest cancers worldwide. However, there remain many unmet clinical needs, from diagnosis to treatment strategies. The inherent complexity of the molecular characteristics of PDAC has made it difficult to meet these challenges, rendering proteomic pr...

journal_title：Expert review of proteomics

authors： Kim H,Park J,Wang JI,Kim Y

更新日期：2017-11-01 00:00:00

abstract：:Introduction: Metaproteomics is an established method to obtain a comprehensive taxonomic and functional view of microbial communities. After more than a decade, we are now able to describe the promise, reality, and perspectives of metaproteomics and provide useful information about the choice of method, applications,...

journal_title：Expert review of proteomics

authors： Lohmann P,Schäpe SS,Haange SB,Oliphant K,Allen-Vercoe E,Jehmlich N,Von Bergen M

更新日期：2020-02-01 00:00:00

abstract：:Introduction: Atopic dermatitis (AD) is a multifactorial ailment associated with barrier breach and intense systemic inflammation. Several studies over the years have shown the complex interplay of a large number of factors in governing the progression and outcome of AD. In addition to the diverse types of AD resultin...

journal_title：Expert review of proteomics

authors： Bhattacharya N,Ganguli-Indra G,Indra AK

更新日期：2019-08-01 00:00:00

abstract：INTRODUCTION:Chromatin remodeling complexes play important roles in the control of genome regulation in both normal and diseased states, and are therefore critical components for the regulation of epigenetic states in cells. Given the role epigenetics plays in cancer, for example, chromatin remodeling complexes are rou...

journal_title：Expert review of proteomics

authors： Eubanks CG,Dayebgadoh G,Liu X,Washburn MP

更新日期：2017-10-01 00:00:00

abstract：:Normal multipotent tissue stem cells (SCs) are the driving force behind tissue turnover and repair. The cancer stem cell theory holds that tumors also contain stem-like cells that drive tumor growth and metastasis formation. However, very little is known about the regulation of SC maintenance pathways in cancer and ho...

journal_title：Expert review of proteomics

authors： Kranenburg O,Emmink BL,Knol J,van Houdt WJ,Rinkes IH,Jimenez CR

更新日期：2012-06-01 00:00:00

abstract：:Protein profiling using high-throughput tandem mass spectrometry has become a powerful method for analyzing changes in global protein expression patterns in cells and tissues as a function of developmental, physiologic and disease processes. This review summarizes the utility and practical application of multidimensio...

journal_title：Expert review of proteomics

authors： Kislinger T,Emili A

更新日期：2005-01-01 00:00:00

abstract：INTRODUCTION:The application of new proteomics methods may help to identify new diagnostic/predictive molecular markers in an attempt to improve the clinical management of atherosclerosis. Areas covered: Technological advances in proteomics have enhanced its sensitivity and multiplexing capacity, as well as the possibi...

journal_title：Expert review of proteomics

authors： Mourino-Alvarez L,Baldan-Martin M,Rincon R,Martin-Rojas T,Corbacho-Alonso N,Sastre-Oliva T,Barderas MG

更新日期：2017-08-01 00:00:00

abstract：INTRODUCTION:Cell-free protein microarrays represent a special form of protein microarray which display proteins made fresh at the time of the experiment, avoiding storage and denaturation. They have been used increasingly in basic and translational research over the past decade to study protein-protein interactions, t...

journal_title：Expert review of proteomics

authors： Yu X,Petritis B,Duan H,Xu D,LaBaer J

更新日期：2018-01-01 00:00:00

abstract：INTRODUCTION:In several biomedical research fields, the cross-linking of peptides and proteins has an important impact on health and wellbeing. It is therefore of crucial importance to study this class of post-translational modifications in detail. The huge potential of mass spectrometric technologies in the mapping of...

journal_title：Expert review of proteomics

authors： Maes E,Dyer JM,McKerchar HJ,Deb-Choudhury S,Clerens S

更新日期：2017-10-01 00:00:00

abstract：:Prenatal diagnosis is now offered to high-risk pregnancies, including advanced maternal age, ultrasound anomalies and positive Down's syndrome screening, and karyotype on cultured fetal material is the test of choice to screen these pregnancies. However, microscope analysis can only detect gross chromosome abnormaliti...

journal_title：Expert review of proteomics

authors： Novelli A,Cavalli P,Bernardini L

更新日期：2013-04-01 00:00:00

abstract：:Single-cell analysis is gaining popularity in the field of mass spectrometry as a method for analyzing protein and peptide content in cells. The spatial resolution of MALDI mass spectrometry (MS) imaging is by a large extent limited by the laser focal diameter and the displacement of analytes during matrix deposition....

journal_title：Expert review of proteomics

authors： Boggio KJ,Obasuyi E,Sugino K,Nelson SB,Agar NY,Agar JN

更新日期：2011-10-01 00:00:00

abstract：OBJECTIVE:Hepcidin-25 production is stimulated by systemic inflammation, and it interferes with iron utilization, leading to anemia. This study aimed to investigate the relationships between the plasma levels of hepcidin, interleukin-6 (IL-6), erythropoietin (EPO) and erythroferrone (ERFE) in patients with benign breas...

journal_title：Expert review of proteomics

authors： Ciniselli CM,De Bortoli M,Taverna E,Varinelli L,Pizzamiglio S,Veneroni S,Bonini C,Orlandi R,Verderio P,Bongarzone I

更新日期：2015-01-01 00:00:00

abstract：:The challenges encountered by proteomic researchers seeking diagnostic, prognostic and mechanistic markers were the subject of the 1-day meeting, Proteomics: Advances in Biomarker Discovery hosted by EuroSciCon. The speakers had a broad range of clinical and basic science interests, and presented data using a number o...

journal_title：Expert review of proteomics

authors： Cowan ML,Vera J

更新日期：2008-02-01 00:00:00

abstract：:Protein phosphorylation events are key regulators of cellular signaling processes. In the era of functional genomics, rational drug design programs demand large-scale high-throughput analysis of signal transduction cascades. Significant improvements in the area of mass spectrometry-based proteomics have provided excit...

journal_title：Expert review of proteomics

authors： Chen WG,White FM

更新日期：2004-10-01 00:00:00

abstract：:Stroke is one of the most common causes of death worldwide and a major cause of acquired disability in adults. Despite advances in research during the last decade, prevention and treatment strategies still suffer from significant limitations, and therefore new theoretical and technical approaches are required. Technol...

journal_title：Expert review of proteomics

authors： Laborde CM,Mourino-Alvarez L,Akerstrom F,Padial LR,Vivanco F,Gil-Dones F,Barderas MG

更新日期：2012-08-01 00:00:00

abstract：INTRODUCTION:Skeletal muscle is the major site of insulin-stimulated glucose uptake and imparts the beneficial effects of exercise, and hence is an important site of insulin resistance in obesity and type 2 diabetes (T2D). Despite extensive molecular biology-oriented research the molecular mechanisms underlying insulin...

journal_title：Expert review of proteomics

authors： Kruse R,Højlund K

更新日期：2018-10-01 00:00:00

abstract：:Spermatozoa are unique cells that have highly compact DNA, motility (and hypermotility) patterns, a specific morphology, localized mitochondria and an apical acrosome. They are the end product of a dynamic process termed spermatogenesis. Sperm are therefore produced with specific proteins in order to effect different ...

journal_title：Expert review of proteomics

authors： Agarwal A,Bertolla RP,Samanta L

更新日期：2016-01-01 00:00:00

abstract：:Elucidating disulfide linkage patterns is a crucial part of protein characterization, for which mass spectrometry (MS) is now an indispensable analytical tool. In many cases, MS-based disulfide connectivity assignment is straightforwardly achieved using one-step protein fragmentation in the unreduced form followed by ...

journal_title：Expert review of proteomics

authors： Goyder MS,Rebeaud F,Pfeifer ME,Kálmán F

更新日期：2013-10-01 00:00:00

abstract：:Exosomes are nanovesicles, derived from the endocytic pathway, released by most cell types and found in many body fluids, including urine. A variety of exosomal functions have been reported, including transfer of RNA, cell communication, control of apoptosis and protein lifespan. Exosomes from mesenchymal stem cells c...

journal_title：Expert review of proteomics

authors： Bruschi M,Ravera S,Santucci L,Candiano G,Bartolucci M,Calzia D,Lavarello C,Inglese E,Petretto A,Ghiggeri G,Panfoli I

更新日期：2015-08-01 00:00:00

abstract：INTRODUCTION:Lung cancer and related diseases have been one of the most common causes of deaths worldwide. Genomic-based biomarkers may hardly reflect the underlying dynamic molecular mechanism of functional protein interactions, which is the center of a disease. Recent developments in mass spectrometry (MS) have made ...

journal_title：Expert review of proteomics

authors： Fujii K,Nakamura H,Nishimura T

更新日期：2017-04-01 00:00:00

abstract：:This article reviews the current state of systems biology approaches, including the experimental tools used to generate 'omic' data and computational frameworks to interpret this data. Through illustrative examples, systems biology approaches to understand gene expression and gene expression regulation are discussed. ...

journal_title：Expert review of proteomics

authors： Kuczenski RS,Aggarwal K,Lee KH

更新日期：2005-12-01 00:00:00

abstract：INTRODUCTION:Unwanted platelet activation is associated with numerous diseases, mainly thrombosis-related. In this context, proteomics has emerged as a novel tool with potential for drug target discovery and to scrutinize the effects of antiplatelet drugs. Areas covered: The present review presents the main findings of...

journal_title：Expert review of proteomics

authors： Izquierdo I,García Á

更新日期：2016-11-01 00:00:00

abstract：:Introduction: Autophagy is one of the most conserved clearance systems through which eukaryotes manage to handle dysfunctional and excess organelles and macromolecules. This catabolic process has not only a role in the maintenance of basal turnover of cellular components, but it is also essential in cells adaptation t...

journal_title：Expert review of proteomics

authors： Di Domenico F,Zuliani I,Tramutola A

更新日期：2019-01-01 00:00:00

abstract：:There are several lines of evidence that the modification of proteins by cytosolic- and nuclear-specific O-linked N-acetylglucosamine (O-GlcNAc) glycosylation is closely related to neuropathologies, particularly Alzheimer's disease. Several neuronal proteins have been identified as being modified with O-GlcNAc; these ...

journal_title：Expert review of proteomics

authors： Lefebvre T,Guinez C,Dehennaut V,Beseme-Dekeyser O,Morelle W,Michalski JC

更新日期：2005-04-01 00:00:00

abstract：:A total of 40 years have already passed since the pioneering work of McCord and Fridovich on erythrocuprein superoxide dismutase (SOD) activity. This modern scientific 'Odyssey' has been accompanied by a series of successes in the fields of biochemistry, biomedicine and proteomics. In this article, we resume the main ...

journal_title：Expert review of proteomics

authors： D'Alessandro A,Zolla L

更新日期：2011-06-01 00:00:00

abstract：:Introduction: Type 1 diabetes (T1D) is characterized by autoimmune-induced dysfunction and destruction of the pancreatic beta cells. Unfortunately, this process is poorly understood, and the current best treatment for type 1 diabetes is the administration of exogenous insulin. To better understand these mechanisms and...

journal_title：Expert review of proteomics

authors： Nakayasu ES,Qian WJ,Evans-Molina C,Mirmira RG,Eizirik DL,Metz TO

更新日期：2019-07-01 00:00:00

abstract：:Metastasis is the main cause of cancer death. As the tumor progresses, cells from the primary tumor site are shed into the bloodstream as circulating tumor cells (CTCs). Eventually, these cells colonize other organs and form distant metastases. It is therefore imperative that we gain a better understanding of the biol...

journal_title：Expert review of proteomics

authors： Chan CM,Au TC,Chan AT,Ma BB,Tsui NB,Ng SS,Hui EP,Chan LW,Ho WS,Yung BY,Wong SC

更新日期：2013-12-01 00:00:00

abstract：:Chronic physical inactivity is a major risk factor for a number of important lifestyle diseases, while inappropriate exposure to high physical demands is a risk factor for musculoskeletal injury and fatigue. Proteomic and metabolomic investigations of the physical activity continuum - extreme sedentariness to extremes...

journal_title：Expert review of proteomics

authors： Sampson DL,Broadbent JA,Parker AW,Upton Z,Parker TJ

更新日期：2014-02-01 00:00:00