Update on: proteome analysis in thyroid pathology - part II: overview of technical and clinical enhancement of proteomic investigation of the thyroid lesions.

abstract：INTRODUCTION:Frailty is consequent to age-dependent deregulation of several biological pathways and systems, encompassing namely sarcopenia, age-associated hormonal derangements, inflammation, and nutritional or metabolic deficiencies. Although the prevalence of frailty is usually between 10% and 20% in the general eld...

journal_title：Expert review of proteomics

authors： Danese E,Montagnana M,Lippi G

更新日期：2018-08-01 00:00:00

abstract：:In spite of the effective chronic myeloid leukemia (CML) therapy, a small percentage will fail on therapy and develop acute myeloid leukemia-like blast crisis. Understanding the underlying biology of therapy resistance is probably needed to develop better blood cancer therapy, and CML may be an ideal disease model for...

journal_title：Expert review of proteomics

authors： Gjertsen BT,Wiig H

更新日期：2012-12-01 00:00:00

abstract：INTRODUCTION:The skin protects the human body from external insults and regulates water and temperature homeostasis. A highly developed extracellular matrix (ECM) supports the skin and instructs its cell functions. Reduced functionality of the ECM is often associated with skin diseases that cause physical impairment an...

journal_title：Expert review of proteomics

authors： Dengjel J,Bruckner-Tuderman L,Nyström A

更新日期：2020-05-01 00:00:00

abstract：:Organellar proteomics aims to describe the full complement of proteins of subcellular structures and organelles. When compared with whole-cell or whole-tissue proteomes, the more focused results from subcellular proteomic studies have yielded relatively simpler datasets from which biologically relevant information can...

journal_title：Expert review of proteomics

authors： Gauthier DJ,Lazure C

更新日期：2008-08-01 00:00:00

abstract：:There is a wealth of knowledge in the field of in vitro diagnostics with regard to preanalytical variables and their impact on the determination of peptide and protein analytes in human serum and plasma. This information is applicable to clinical proteomics investigations, which utilize the same sample types. Studies ...

journal_title：Expert review of proteomics

authors： Rai AJ,Vitzthum F

更新日期：2006-08-01 00:00:00

abstract：:The concept of personalized medicine includes novel protein biomarkers that are expected to improve the early detection, diagnosis and therapy monitoring of malignant diseases. Tissues, biofluids, cell lines and xenograft models are the common sources of biomarker candidates that require verification of clinical value...

journal_title：Expert review of proteomics

authors： Pernikářová V,Bouchal P

更新日期：2015-01-01 00:00:00

abstract：:With the growing availability of mature systems and strategies in biotechnology and the continuously expanding knowledge of cellular processes and involved biomolecules, human sports drug testing has become a considerably complex field in the arena of analytical chemistry. Proving the exogenous origin of peptidic drug...

journal_title：Expert review of proteomics

authors： Thevis M,Thomas A,Schänzer W

更新日期：2014-12-01 00:00:00

abstract：:A total of 40 years have already passed since the pioneering work of McCord and Fridovich on erythrocuprein superoxide dismutase (SOD) activity. This modern scientific 'Odyssey' has been accompanied by a series of successes in the fields of biochemistry, biomedicine and proteomics. In this article, we resume the main ...

journal_title：Expert review of proteomics

authors： D'Alessandro A,Zolla L

更新日期：2011-06-01 00:00:00

abstract：:Human saliva is an attractive body fluid for disease diagnosis and prognosis because saliva testing is simple, safe, low-cost and noninvasive. Comprehensive analysis and identification of the proteomic content in human whole and ductal saliva will not only contribute to the understanding of oral health and disease pat...

journal_title：Expert review of proteomics

authors： Hu S,Loo JA,Wong DT

更新日期：2007-08-01 00:00:00

abstract：:Mammalian sperm are differentiated germ cells that transfer genetic material from the male to the female. Owing to this essential role in the reproductive process, an understanding of the complex mechanisms that underlie sperm function has implications ranging from the development of novel contraceptives to the treatm...

journal_title：Expert review of proteomics

authors： Porambo JR,Salicioni AM,Visconti PE,Platt MD

更新日期：2012-10-01 00:00:00

abstract：INTRODUCTION:Cutaneous leishmaniasis (CL), caused by different Leishmania parasite species, is associated with parasite-induced immune-mediated skin inflammation and ulceration. Whereas many CL studies focus on gene expression signatures in mouse models, the transcriptional response driving human patients in the field ...

journal_title：Expert review of proteomics

authors： Masoudzadeh N,Mizbani A,Rafati S

更新日期：2020-01-01 00:00:00

abstract：:The emergence of advanced liquid chromatography mass spectrometry technologies for characterizing very complex mixtures of proteins has greatly propelled the field of proteomics, the goal of which is the simultaneous examination of all the proteins expressed by an organism. This research area represents a paradigm shi...

journal_title：Expert review of proteomics

authors： VerBerkmoes NC,Connelly HM,Pan C,Hettich RL

更新日期：2004-12-01 00:00:00

abstract：:Introduction: Autophagy is one of the most conserved clearance systems through which eukaryotes manage to handle dysfunctional and excess organelles and macromolecules. This catabolic process has not only a role in the maintenance of basal turnover of cellular components, but it is also essential in cells adaptation t...

journal_title：Expert review of proteomics

authors： Di Domenico F,Zuliani I,Tramutola A

更新日期：2019-01-01 00:00:00

abstract：:Endometriosis is a common disorder that is associated with infertility and pelvic pain. Diagnosis is based on the visualization of endometriotic lesions during surgery as no reliable serum marker is currently available. The etiology of endometriosis is largely unknown. Over the last 20 years, several proteomics techno...

journal_title：Expert review of proteomics

authors： Ferrero S,Gillott DJ,Remorgida V,Ragni N,Venturini PL,Grudzinskas JG

更新日期：2008-10-01 00:00:00

abstract：:Chronic physical inactivity is a major risk factor for a number of important lifestyle diseases, while inappropriate exposure to high physical demands is a risk factor for musculoskeletal injury and fatigue. Proteomic and metabolomic investigations of the physical activity continuum - extreme sedentariness to extremes...

journal_title：Expert review of proteomics

authors： Sampson DL,Broadbent JA,Parker AW,Upton Z,Parker TJ

更新日期：2014-02-01 00:00:00

abstract：INTRODUCTION:Leptomeningeal metastases (LM) from lymphoma remain a difficult complication for oncologist due to the high incidence in morbidity and mortality. Early diagnostic and initiation of treatment are essential to prevent neurological deterioration. Areas covered: In this review, several proteomic approaches are...

journal_title：Expert review of proteomics

authors： Galicia N,Dégano R,Díez P,González-González M,Góngora R,Ibarrola N,Fuentes M

更新日期：2017-04-01 00:00:00

abstract：:The advances in high-resolution mass spectrometry instrumentation, capable of accurate mass measurement and fast acquisition, have enabled new approaches for targeted quantitative proteomics. More specifically, analyses performed on quadrupole-orbitrap mass spectrometers operated in parallel reaction monitoring (PRM) ...

journal_title：Expert review of proteomics

authors： Gallien S,Domon B

更新日期：2015-01-01 00:00:00

abstract：:Helicobacter pylori infection is linked to the development of gastric cancer. Atrophic body gastritis is considered the first important step in the histogenesis of such neoplasia. H. pylori infection is involved in the induction of atrophic body gastritis, but documentation of H. pylori infection is difficult because ...

journal_title：Expert review of proteomics

authors： Lahner E,Bernardini G,Santucci A,Annibale B

更新日期：2010-04-01 00:00:00

abstract：:Clinical proteomics has been applied to the identification of biomarkers of obstetric and neonatal disease. We will discuss a number of encouraging studies that have led to potentially valid biomarkers in the context of Down's syndrome, preterm birth, amniotic infections, preeclampsia, intrauterine growth restriction ...

journal_title：Expert review of proteomics

authors： Klein J,Buffin-Meyer B,Mullen W,Carty DM,Delles C,Vlahou A,Mischak H,Decramer S,Bascands JL,Schanstra JP

更新日期：2014-02-01 00:00:00

abstract：:Stroke is one of the most common causes of death worldwide and a major cause of acquired disability in adults. Despite advances in research during the last decade, prevention and treatment strategies still suffer from significant limitations, and therefore new theoretical and technical approaches are required. Technol...

journal_title：Expert review of proteomics

authors： Laborde CM,Mourino-Alvarez L,Akerstrom F,Padial LR,Vivanco F,Gil-Dones F,Barderas MG

更新日期：2012-08-01 00:00:00

abstract：INTRODUCTION:Ticks are obligate hematophagous arthropod ectoparasites that transmit pathogens responsible for a growing number of tick-borne diseases (TBDs) throughout the world. Vaccines have been shown to be the most efficient, cost-effective, and environmentally friendly approach for the control of ticks and the pre...

journal_title：Expert review of proteomics

authors： Artigas-Jerónimo S,De La Fuente J,Villar M

更新日期：2018-08-01 00:00:00

abstract：:The Central and Eastern European Proteomic Conference (CEEPC) proudly celebrated its 10th Anniversary with an exciting scientific program inclusive of proteome, proteomics and systems biology in Budapest, Hungary. Since 2007, CEEPC has represented 'state-of the-art' proteomics in and around Central and Eastern Europe ...

journal_title：Expert review of proteomics

authors： Gadher SJ,Drahos L,Vékey K,Kovarova H

更新日期：2017-07-01 00:00:00

abstract：:It is well known that chronic, excessive consumption of alcohol can cause brain damage/structural changes in the regions important for neurocognitive function. Some of the damages are permanent, while others are reversible. Molecular mechanisms underlying alcohol-induced and/or -related brain damage are largely unknow...

journal_title：Expert review of proteomics

authors： Matsumoto H,Matsumoto I

更新日期：2008-04-01 00:00:00

abstract：:As a complementary approach to 2D-PAGE, multidimensional liquid chromatography (MDLC) separation methods have been widely applied in all kinds of biological sample investigations. MDLC coupled with mass spectrometry is playing an important role in proteome research owing to its high speed, high resolution and high sen...

journal_title：Expert review of proteomics

authors： Gao M,Qi D,Zhang P,Deng C,Zhang X

更新日期：2010-10-01 00:00:00

abstract：:Exosomes are nanovesicles, derived from the endocytic pathway, released by most cell types and found in many body fluids, including urine. A variety of exosomal functions have been reported, including transfer of RNA, cell communication, control of apoptosis and protein lifespan. Exosomes from mesenchymal stem cells c...

journal_title：Expert review of proteomics

authors： Bruschi M,Ravera S,Santucci L,Candiano G,Bartolucci M,Calzia D,Lavarello C,Inglese E,Petretto A,Ghiggeri G,Panfoli I

更新日期：2015-08-01 00:00:00

abstract：:Introduction: Degradation of proteins by cellular proteasomes is critical for the fidelity of protein homeostasis and proper cell function. Indeed, perturbations in proteasome function, as well as the degradation of specific substrates, are associated with a variety of human diseases. Yet, monitoring and analyzing pro...

journal_title：Expert review of proteomics

authors： Javitt A,Merbl Y

更新日期：2019-07-19 00:00:00

abstract：:The isolation of neural stem cells from fetal and adult mammalian CNS and the demonstration of functional neurogenesis in adult CNS have offered perspectives for treatment of many devastating hereditary and acquired neurological diseases. Due to this enormous potential, neural stem cells are a subject of extensive mol...

journal_title：Expert review of proteomics

authors： Skalnikova H,Vodicka P,Gadher SJ,Kovarova H

更新日期：2008-04-01 00:00:00

abstract：:Normal multipotent tissue stem cells (SCs) are the driving force behind tissue turnover and repair. The cancer stem cell theory holds that tumors also contain stem-like cells that drive tumor growth and metastasis formation. However, very little is known about the regulation of SC maintenance pathways in cancer and ho...

journal_title：Expert review of proteomics

authors： Kranenburg O,Emmink BL,Knol J,van Houdt WJ,Rinkes IH,Jimenez CR

更新日期：2012-06-01 00:00:00

abstract：:Single-cell analysis is gaining popularity in the field of mass spectrometry as a method for analyzing protein and peptide content in cells. The spatial resolution of MALDI mass spectrometry (MS) imaging is by a large extent limited by the laser focal diameter and the displacement of analytes during matrix deposition....

journal_title：Expert review of proteomics

authors： Boggio KJ,Obasuyi E,Sugino K,Nelson SB,Agar NY,Agar JN

更新日期：2011-10-01 00:00:00

abstract：INTRODUCTION:Mass spectrometry (MS) is widely used in the characterization of biomolecules including peptide and protein therapeutics. These biotechnology products have seen rapid growth over the past few decades and continue to dominate the global pharmaceutical market. Advances in MS instrumentation and techniques ha...

journal_title：Expert review of proteomics

authors： Rathore D,Faustino A,Schiel J,Pang E,Boyne M,Rogstad S

更新日期：2018-05-01 00:00:00