Plasma hepcidin in early-stage breast cancer patients: no relationship with interleukin-6, erythropoietin and erythroferrone.


OBJECTIVE:Hepcidin-25 production is stimulated by systemic inflammation, and it interferes with iron utilization, leading to anemia. This study aimed to investigate the relationships between the plasma levels of hepcidin, interleukin-6 (IL-6), erythropoietin (EPO) and erythroferrone (ERFE) in patients with benign breast disease or cancer. METHODS:Plasma samples from a cohort of 131 patients (47 with benign breast disease and 84 with breast cancer) were subjected to the evaluation of hepcidin, IL-6, EPO and ERFE using SELDI-TOF-MS or immunoassays. RESULTS:An elevated hepcidin was observed in malignant breast tumors compared to benign ones. No correlation was observed between hepcidin and IL-6, EPO or ERFE. CONCLUSION:Since the study included a cohort of patients (87%) with breast cancers smaller than 2 cm, these results may support our previous evidence about the potential role of hepcidin in breast cancer disease.


Expert Rev Proteomics


Ciniselli CM,De Bortoli M,Taverna E,Varinelli L,Pizzamiglio S,Veneroni S,Bonini C,Orlandi R,Verderio P,Bongarzone I




Has Abstract


2015-01-01 00:00:00












  • Advances in high-resolution quantitative proteomics: implications for clinical applications.

    abstract::The advances in high-resolution mass spectrometry instrumentation, capable of accurate mass measurement and fast acquisition, have enabled new approaches for targeted quantitative proteomics. More specifically, analyses performed on quadrupole-orbitrap mass spectrometers operated in parallel reaction monitoring (PRM) ...

    journal_title:Expert review of proteomics

    pub_type: 杂志文章,评审


    authors: Gallien S,Domon B

    更新日期:2015-01-01 00:00:00

  • New insights into viral structure and virus-cell interactions through proteomics.

    abstract::Although genomics techniques such as DNA microarrays have been widely used in virology, much more limited use has been made of proteomics. Although difficult, proteomics can greatly contribute to an understanding of virus-cell interactions, including the ternary structure of viral receptors at the cell surface, post-t...

    journal_title:Expert review of proteomics

    pub_type: 杂志文章,评审


    authors: Bernhard OK,Diefenbach RJ,Cunningham AL

    更新日期:2005-08-01 00:00:00

  • Proteomics advances for precision therapy in ovarian cancer.

    abstract::Introduction: Due to the relatively low mutation rate and high frequency of copy number variation, finding actionable genetic drivers of high-grade serous carcinoma (HGSC) is a challenging task. Furthermore, emerging studies show that genetic alterations are frequently poorly represented at the protein level adding a ...

    journal_title:Expert review of proteomics

    pub_type: 杂志文章,评审


    authors: Labrie M,Kendsersky ND,Ma H,Campbell L,Eng J,Chin K,Mills GB

    更新日期:2019-10-01 00:00:00

  • Top-down Proteomics: Technology Advancements and Applications to Heart Diseases.

    abstract:INTRODUCTION:Heart diseases are a leading cause of morbidity and mortality for both men and women worldwide, and impose significant economic burdens on the healthcare systems. Despite substantial effort over the last several decades, the molecular mechanisms underlying diseases of the heart remain poorly understood. A...

    journal_title:Expert review of proteomics

    pub_type: 杂志文章,评审


    authors: Cai W,Tucholski TM,Gregorich ZR,Ge Y

    更新日期:2016-08-01 00:00:00

  • 'Proteomineering': has the mine been excavated?

    abstract::Evaluation of: Di Girolamo F, Boschetti E, Chung MC, Guadagni F, Righetti PG. 'Proteomineering' or not? The debate on biomarker discovery in sera continues. J. Proteomics 74(5), 589-594 (2011). The combinatorial peptide ligand library in association with mass spectrometry can greatly enhance the dynamic range of the a...

    journal_title:Expert review of proteomics

    pub_type: 评论,杂志文章


    authors: Panfoli I,Bruschi M,Ravera S,Candiano G

    更新日期:2011-08-01 00:00:00

  • Proximity ligation assays: a recent addition to the proteomics toolbox.

    abstract::An essential skill for every researcher is to learn how to select and apply the most appropriate methods for the questions they are trying to answer. With the extensive variety of methods available, it is increasingly important to scrutinize the advantages and disadvantages of these techniques prior to making a decisi...

    journal_title:Expert review of proteomics

    pub_type: 杂志文章,评审


    authors: Weibrecht I,Leuchowius KJ,Clausson CM,Conze T,Jarvius M,Howell WM,Kamali-Moghaddam M,Söderberg O

    更新日期:2010-06-01 00:00:00

  • Clinical proteomics in obstetrics and neonatology.

    abstract::Clinical proteomics has been applied to the identification of biomarkers of obstetric and neonatal disease. We will discuss a number of encouraging studies that have led to potentially valid biomarkers in the context of Down's syndrome, preterm birth, amniotic infections, preeclampsia, intrauterine growth restriction ...

    journal_title:Expert review of proteomics

    pub_type: 杂志文章,评审


    authors: Klein J,Buffin-Meyer B,Mullen W,Carty DM,Delles C,Vlahou A,Mischak H,Decramer S,Bascands JL,Schanstra JP

    更新日期:2014-02-01 00:00:00

  • Microplate-based, label-free detection of biomolecular interactions: applications in proteomics.

    abstract::This review describes a new type of label-free optical biosensor that is inexpensively manufactured from continuous sheets of plastic film and incorporated into standard format microplates to enable highly sensitive, high-throughput detection of small molecules, proteins and cells. The biosensor and associated detecti...

    journal_title:Expert review of proteomics

    pub_type: 杂志文章,评审


    authors: Cunningham BT,Laing L

    更新日期:2006-06-01 00:00:00

  • Proteomic studies of common chronic pain conditions - a systematic review and associated network analyses.

    abstract:INTRODUCTION:The lack of biomarkers indicating involved nociceptive and/or pain mechanisms makes diagnostic procedures problematic. Clinical pain research has begun to use proteomics. AREAS COVERED:This systematic review covers proteomic studies of chronic pain cohorts and in relation to clinical variables. Searches i...

    journal_title:Expert review of proteomics

    pub_type: 杂志文章


    authors: Gerdle B,Ghafouri B

    更新日期:2020-06-01 00:00:00

  • Regulation of gene expression: probing DNA-protein interactions in vivo and in vitro.

    abstract::Tremendous efforts have been put together over the last several years to complete the entire sequencing of the human genome. As we enter the proteomic era, when the major aim is understanding which gene encodes which protein, the time has also come to identify their precise function inside the astonishing signaling ne...

    journal_title:Expert review of proteomics

    pub_type: 杂志文章,评审


    authors: Vigneault F,Guérin SL

    更新日期:2005-10-01 00:00:00

  • Advances in endothelial shear stress proteomics.

    abstract::The vascular endothelium lining the luminal surface of all blood vessels is constantly exposed to shear stress exerted by the flowing blood. Blood flow with high laminar shear stress confers protection by activation of antiatherogenic, antithrombotic and anti-inflammatory proteins, whereas low or oscillatory shear str...

    journal_title:Expert review of proteomics

    pub_type: 杂志文章,评审


    authors: Firasat S,Hecker M,Binder L,Asif AR

    更新日期:2014-10-01 00:00:00

  • Understanding type 1 diabetes through proteomics.

    abstract:INTRODUCTION:Auto-immunity against pancreatic beta-cells leads to an absolute shortage of the hormone insulin, resulting in hyperglycemia and the onset of type 1 diabetes (T1D). Proteomic approaches have been used to elucidate the mechanisms of beta-cell dysfunction and death. Areas covered: In the present review, we d...

    journal_title:Expert review of proteomics

    pub_type: 杂志文章,评审


    authors: Crèvecoeur I,Vig S,Mathieu C,Overbergh L

    更新日期:2017-07-01 00:00:00

  • Network-based strategies in metabolomics data analysis and interpretation: from molecular networking to biological interpretation.

    abstract:INTRODUCTION:Metabolomics has become a crucial part of systems biology; however, data analysis is still often undertaken in a reductionist way focusing on changes in individual metabolites. Whilst such approaches indeed provide relevant insights into the metabolic phenotype of an organism, the intricate nature of metab...

    journal_title:Expert review of proteomics

    pub_type: 杂志文章


    authors: Perez De Souza L,Alseekh S,Brotman Y,Fernie AR

    更新日期:2020-04-01 00:00:00

  • Unravelling the biology of chromatin in health and cancer using proteomic approaches.

    abstract:INTRODUCTION:Chromatin remodeling complexes play important roles in the control of genome regulation in both normal and diseased states, and are therefore critical components for the regulation of epigenetic states in cells. Given the role epigenetics plays in cancer, for example, chromatin remodeling complexes are rou...

    journal_title:Expert review of proteomics

    pub_type: 杂志文章,评审


    authors: Eubanks CG,Dayebgadoh G,Liu X,Washburn MP

    更新日期:2017-10-01 00:00:00

  • Novel methods in glycomics: a 2019 update.

    abstract::Introduction: Glycomics, which aims to define the glycome of a biological system to better assess the biological attributes of the glycans, has attracted increasing interest. However, the complexity and diversity of glycans present challenging barriers to glycome definition. Technological advances are major drivers in...

    journal_title:Expert review of proteomics

    pub_type: 杂志文章


    authors: Cao WQ,Liu MQ,Kong SY,Wu MX,Huang ZZ,Yang PY

    更新日期:2020-01-01 00:00:00

  • Transcriptional control and transcriptomic analysis of lipid metabolism in skin barrier formation and atopic dermatitis (AD).

    abstract::Introduction: Atopic dermatitis (AD) is a multifactorial ailment associated with barrier breach and intense systemic inflammation. Several studies over the years have shown the complex interplay of a large number of factors in governing the progression and outcome of AD. In addition to the diverse types of AD resultin...

    journal_title:Expert review of proteomics

    pub_type: 杂志文章


    authors: Bhattacharya N,Ganguli-Indra G,Indra AK

    更新日期:2019-08-01 00:00:00

  • Proteomics in atherothrombosis: a future perspective.

    abstract::Atherothrombosis is the primary cause of death in Western countries. The cellular and molecular mechanisms underlying atherosclerosis remain widely unknown. The complex nature of atherosclerotic cardiovascular diseases demands the development of novel technologies that enable discovery of new biomarkers for early dise...

    journal_title:Expert review of proteomics

    pub_type: 杂志文章,评审


    authors: Martín-Ventura JL,Blanco-Colio LM,Tunon J,Gomez-Guerrero C,Michel JB,Meilhac O,Egido J

    更新日期:2007-04-01 00:00:00

  • Sperm phosphoproteomics: historical perspectives and current methodologies.

    abstract::Mammalian sperm are differentiated germ cells that transfer genetic material from the male to the female. Owing to this essential role in the reproductive process, an understanding of the complex mechanisms that underlie sperm function has implications ranging from the development of novel contraceptives to the treatm...

    journal_title:Expert review of proteomics

    pub_type: 杂志文章,评审


    authors: Porambo JR,Salicioni AM,Visconti PE,Platt MD

    更新日期:2012-10-01 00:00:00

  • Proteomic study of skeletal muscle in obesity and type 2 diabetes: progress and potential.

    abstract:INTRODUCTION:Skeletal muscle is the major site of insulin-stimulated glucose uptake and imparts the beneficial effects of exercise, and hence is an important site of insulin resistance in obesity and type 2 diabetes (T2D). Despite extensive molecular biology-oriented research the molecular mechanisms underlying insulin...

    journal_title:Expert review of proteomics

    pub_type: 杂志文章,评审


    authors: Kruse R,Højlund K

    更新日期:2018-10-01 00:00:00

  • Medical implications of understanding the functions of human small heat shock proteins.

    abstract::Small heat shock proteins (sHsps) are ubiquitous molecular chaperones that are implicated in a variety of diseases. Upon stress, they stabilize unfolding proteins and prevent them from aggregating. However, under physiological conditions without severe stress, some sHsps interact with other proteins. In a perspective ...

    journal_title:Expert review of proteomics

    pub_type: 杂志文章,评审


    authors: Mymrikov EV,Haslbeck M

    更新日期:2015-06-01 00:00:00

  • Urinary proteomics for the study of genetic kidney diseases.

    abstract::Despite their low prevalence, genetic kidney diseases (GKD) still represent a serious health problem. They often lead to kidney failure and to the consequent need of dialysis or kidney transplant. To date, reliable diagnosis requires laborious genetic tests and/or a renal biopsy. Moreover, only scant and non-specific ...

    journal_title:Expert review of proteomics

    pub_type: 杂志文章,评审


    authors: Raimondo F,Cerra D,Magni F,Pitto M

    更新日期:2016-01-01 00:00:00

  • An update on the routine application of MALDI-TOF MS in clinical microbiology.

    abstract::Introduction: Matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS) has entered clinical diagnostics and is today a generally accepted and integral part of the workflow for microbial identification. MALDI-TOF MS identification systems received approval from national and internatio...

    journal_title:Expert review of proteomics

    pub_type: 杂志文章


    authors: Welker M,Van Belkum A,Girard V,Charrier JP,Pincus D

    更新日期:2019-08-01 00:00:00

  • Advances in cell-free protein array methods.

    abstract:INTRODUCTION:Cell-free protein microarrays represent a special form of protein microarray which display proteins made fresh at the time of the experiment, avoiding storage and denaturation. They have been used increasingly in basic and translational research over the past decade to study protein-protein interactions, t...

    journal_title:Expert review of proteomics

    pub_type: 杂志文章


    authors: Yu X,Petritis B,Duan H,Xu D,LaBaer J

    更新日期:2018-01-01 00:00:00

  • Targeted proteomics of solid cancers: from quantification of known biomarkers towards reading the digital proteome maps.

    abstract::The concept of personalized medicine includes novel protein biomarkers that are expected to improve the early detection, diagnosis and therapy monitoring of malignant diseases. Tissues, biofluids, cell lines and xenograft models are the common sources of biomarker candidates that require verification of clinical value...

    journal_title:Expert review of proteomics

    pub_type: 杂志文章,评审


    authors: Pernikářová V,Bouchal P

    更新日期:2015-01-01 00:00:00

  • Does O-GlcNAc play a role in neurodegenerative diseases?

    abstract::There are several lines of evidence that the modification of proteins by cytosolic- and nuclear-specific O-linked N-acetylglucosamine (O-GlcNAc) glycosylation is closely related to neuropathologies, particularly Alzheimer's disease. Several neuronal proteins have been identified as being modified with O-GlcNAc; these ...

    journal_title:Expert review of proteomics

    pub_type: 杂志文章,评审


    authors: Lefebvre T,Guinez C,Dehennaut V,Beseme-Dekeyser O,Morelle W,Michalski JC

    更新日期:2005-04-01 00:00:00

  • Recent advances in proteomic profiling of pancreatic ductal adenocarcinoma and the road ahead.

    abstract:INTRODUCTION:Pancreatic ductal adenocarcinoma (PDAC) is one of the deadliest cancers worldwide. However, there remain many unmet clinical needs, from diagnosis to treatment strategies. The inherent complexity of the molecular characteristics of PDAC has made it difficult to meet these challenges, rendering proteomic pr...

    journal_title:Expert review of proteomics

    pub_type: 杂志文章,评审


    authors: Kim H,Park J,Wang JI,Kim Y

    更新日期:2017-11-01 00:00:00

  • Update in research and methods in proteomics and bioinformatics.

    abstract::The 3rd International Conference on Proteomics & Bioinformatics (Proteomics 2013) Philadelphia, PA, USA, 15-17 July 2013 The Third International Conference on Proteomics & Bioinformatics (Proteomics 2013) was sponsored by the OMICS group and was organized in order to strengthen the future of proteomics science by brin...

    journal_title:Expert review of proteomics



    authors: Bencharit S,Border MB,Edelmann A,Byrd WC

    更新日期:2013-10-01 00:00:00

  • The SODyssey: superoxide dismutases from biochemistry, through proteomics, to oxidative stress, aging and nutraceuticals.

    abstract::A total of 40 years have already passed since the pioneering work of McCord and Fridovich on erythrocuprein superoxide dismutase (SOD) activity. This modern scientific 'Odyssey' has been accompanied by a series of successes in the fields of biochemistry, biomedicine and proteomics. In this article, we resume the main ...

    journal_title:Expert review of proteomics

    pub_type: 杂志文章,评审


    authors: D'Alessandro A,Zolla L

    更新日期:2011-06-01 00:00:00

  • Advanced technologies for studying circulating tumor cells at the protein level.

    abstract::Metastasis is the main cause of cancer death. As the tumor progresses, cells from the primary tumor site are shed into the bloodstream as circulating tumor cells (CTCs). Eventually, these cells colonize other organs and form distant metastases. It is therefore imperative that we gain a better understanding of the biol...

    journal_title:Expert review of proteomics

    pub_type: 杂志文章,评审


    authors: Chan CM,Au TC,Chan AT,Ma BB,Tsui NB,Ng SS,Hui EP,Chan LW,Ho WS,Yung BY,Wong SC

    更新日期:2013-12-01 00:00:00

  • Function is what counts: how microbial community complexity affects species, proteome and pathway coverage in metaproteomics.

    abstract::Introduction: Metaproteomics is an established method to obtain a comprehensive taxonomic and functional view of microbial communities. After more than a decade, we are now able to describe the promise, reality, and perspectives of metaproteomics and provide useful information about the choice of method, applications,...

    journal_title:Expert review of proteomics

    pub_type: 杂志文章


    authors: Lohmann P,Schäpe SS,Haange SB,Oliphant K,Allen-Vercoe E,Jehmlich N,Von Bergen M

    更新日期:2020-02-01 00:00:00