Plasma hepcidin in early-stage breast cancer patients: no relationship with interleukin-6, erythropoietin and erythroferrone.


OBJECTIVE:Hepcidin-25 production is stimulated by systemic inflammation, and it interferes with iron utilization, leading to anemia. This study aimed to investigate the relationships between the plasma levels of hepcidin, interleukin-6 (IL-6), erythropoietin (EPO) and erythroferrone (ERFE) in patients with benign breast disease or cancer. METHODS:Plasma samples from a cohort of 131 patients (47 with benign breast disease and 84 with breast cancer) were subjected to the evaluation of hepcidin, IL-6, EPO and ERFE using SELDI-TOF-MS or immunoassays. RESULTS:An elevated hepcidin was observed in malignant breast tumors compared to benign ones. No correlation was observed between hepcidin and IL-6, EPO or ERFE. CONCLUSION:Since the study included a cohort of patients (87%) with breast cancers smaller than 2 cm, these results may support our previous evidence about the potential role of hepcidin in breast cancer disease.


Expert Rev Proteomics


Ciniselli CM,De Bortoli M,Taverna E,Varinelli L,Pizzamiglio S,Veneroni S,Bonini C,Orlandi R,Verderio P,Bongarzone I




Has Abstract


2015-01-01 00:00:00












  • Recent insights into human bronchial proteomics - how are we progressing and what is next?

    abstract:INTRODUCTION:The human respiratory system is highly prone to diseases and complications. Many lung diseases, including lung cancer (LC), tuberculosis (TB), and chronic obstructive pulmonary disease (COPD) have been among the most common causes of death worldwide. Cystic fibrosis (CF), the most common genetic disease in...

    journal_title:Expert review of proteomics

    pub_type: 杂志文章,评审


    authors: Tan HW,Xu YM,Wu DD,Lau ATY

    更新日期:2018-02-01 00:00:00

  • Colorectal cancer biomarker discovery and validation using LC-MS/MS-based proteomics in blood: truth or dare?

    abstract::Globally, colorectal cancer (CRC) is the third most common malignant neoplasm. However, highly sensitive, specific, noninvasive tests that allow CRC diagnosis at an early stage are still needed. As circulatory blood reflects the physiological status of an individual and/or the disease status for several disorders, eff...

    journal_title:Expert review of proteomics

    pub_type: 杂志文章,评审


    authors: Reumer A,Maes E,Mertens I,Cho WC,Landuyt B,Valkenborg D,Schoofs L,Baggerman G

    更新日期:2014-08-01 00:00:00

  • Proteomics and frailty: a clinical overview.

    abstract:INTRODUCTION:Frailty is consequent to age-dependent deregulation of several biological pathways and systems, encompassing namely sarcopenia, age-associated hormonal derangements, inflammation, and nutritional or metabolic deficiencies. Although the prevalence of frailty is usually between 10% and 20% in the general eld...

    journal_title:Expert review of proteomics

    pub_type: 杂志文章,评审


    authors: Danese E,Montagnana M,Lippi G

    更新日期:2018-08-01 00:00:00

  • Advances in high-resolution quantitative proteomics: implications for clinical applications.

    abstract::The advances in high-resolution mass spectrometry instrumentation, capable of accurate mass measurement and fast acquisition, have enabled new approaches for targeted quantitative proteomics. More specifically, analyses performed on quadrupole-orbitrap mass spectrometers operated in parallel reaction monitoring (PRM) ...

    journal_title:Expert review of proteomics

    pub_type: 杂志文章,评审


    authors: Gallien S,Domon B

    更新日期:2015-01-01 00:00:00

  • Tissue and serum proteomic profiling for diagnostic and prognostic bladder cancer biomarkers.

    abstract::A panel of biomarkers for the early detection of bladder cancer has not yet been identified. Many different molecules, including DNA, RNA or proteins have been reported but none have provided adequate sensitivity for a single-tier screening test or a test to replace cystoscopy. Therefore, multimarker panels are discus...

    journal_title:Expert review of proteomics

    pub_type: 杂志文章,评审


    authors: Schwamborn K,Gaisa NT,Henkel C

    更新日期:2010-12-01 00:00:00

  • Update on: proteome analysis in thyroid pathology - part II: overview of technical and clinical enhancement of proteomic investigation of the thyroid lesions.

    abstract:INTRODUCTION:An accurate diagnostic classification of thyroid lesions remains an important clinical aspect that needs to be addressed in order to avoid 'diagnostic' thyroidectomies. Among the several 'omics' techniques, proteomics is playing a pivotal role in the search for diagnostic markers. In recent years, differen...

    journal_title:Expert review of proteomics

    pub_type: 杂志文章,评审


    authors: Piga I,Casano S,Smith A,Tettamanti S,Leni D,Capitoli G,Pincelli AI,Scardilli M,Galimberti S,Magni F,Pagni F

    更新日期:2018-11-01 00:00:00

  • Proteomics technologies in endometriosis.

    abstract::Endometriosis is a common disorder that is associated with infertility and pelvic pain. Diagnosis is based on the visualization of endometriotic lesions during surgery as no reliable serum marker is currently available. The etiology of endometriosis is largely unknown. Over the last 20 years, several proteomics techno...

    journal_title:Expert review of proteomics

    pub_type: 杂志文章,评审


    authors: Ferrero S,Gillott DJ,Remorgida V,Ragni N,Venturini PL,Grudzinskas JG

    更新日期:2008-10-01 00:00:00

  • Skin proteomics - analysis of the extracellular matrix in health and disease.

    abstract:INTRODUCTION:The skin protects the human body from external insults and regulates water and temperature homeostasis. A highly developed extracellular matrix (ECM) supports the skin and instructs its cell functions. Reduced functionality of the ECM is often associated with skin diseases that cause physical impairment an...

    journal_title:Expert review of proteomics

    pub_type: 杂志文章


    authors: Dengjel J,Bruckner-Tuderman L,Nyström A

    更新日期:2020-05-01 00:00:00

  • Proteomic analysis in allergy and intolerance to wheat products.

    abstract::Owing to its extensive use in the human diet, wheat is among the most common causes of food-related allergies and intolerances. Allergies to wheat are provoked by ingestion, inhalation or contact with either the soluble or the insoluble gluten proteins in wheat. Gluten proteins, and particularly the gliadin fraction, ...

    journal_title:Expert review of proteomics

    pub_type: 杂志文章,评审


    authors: Mamone G,Picariello G,Addeo F,Ferranti P

    更新日期:2011-02-01 00:00:00

  • Development of multidimensional liquid chromatography and application in proteomic analysis.

    abstract::As a complementary approach to 2D-PAGE, multidimensional liquid chromatography (MDLC) separation methods have been widely applied in all kinds of biological sample investigations. MDLC coupled with mass spectrometry is playing an important role in proteome research owing to its high speed, high resolution and high sen...

    journal_title:Expert review of proteomics

    pub_type: 杂志文章,评审


    authors: Gao M,Qi D,Zhang P,Deng C,Zhang X

    更新日期:2010-10-01 00:00:00

  • Plasma/serum proteomics: pre-analytical issues.

    abstract::High-throughput proteomics technologies tend to provide highly sensitive information about living tissues and biological fluids. Analytes are characterized by intrinsic and extrinsic properties, the latter depending on each phase of their preparation, sometimes adding artifacts with crucial repercussions in result rel...

    journal_title:Expert review of proteomics

    pub_type: 杂志文章,评审


    authors: Barelli S,Crettaz D,Thadikkaran L,Rubin O,Tissot JD

    更新日期:2007-06-01 00:00:00

  • The life cycle and pathogenesis of human cytomegalovirus infection: lessons from proteomics.

    abstract::Viruses have coevolved with their hosts, acquiring strategies to subvert host cellular pathways for effective viral replication and spread. Human cytomegalovirus (HCMV), a widely-spread β-herpesvirus, is a major cause of birth defects and opportunistic infections in HIV-1/AIDS patients. HCMV displays an intricate syst...

    journal_title:Expert review of proteomics

    pub_type: 杂志文章


    authors: Jean Beltran PM,Cristea IM

    更新日期:2014-12-01 00:00:00

  • Understanding the molecular basis of Parkinson's disease, identification of biomarkers and routes to therapy.

    abstract::These are really exciting times in the field of Parkinson's disease research. Although the etiology of sporadic disease still remains a mystery, many of the proteins associated with hereditary disease (5-10% of all disease) have now been identified. Only time will tell whether proteins associated with hereditary disea...

    journal_title:Expert review of proteomics

    pub_type: 杂志文章,评审


    authors: Robinson PA

    更新日期:2010-08-01 00:00:00

  • Sperm proteomics: potential impact on male infertility treatment.

    abstract::Spermatozoa are unique cells that have highly compact DNA, motility (and hypermotility) patterns, a specific morphology, localized mitochondria and an apical acrosome. They are the end product of a dynamic process termed spermatogenesis. Sperm are therefore produced with specific proteins in order to effect different ...

    journal_title:Expert review of proteomics

    pub_type: 杂志文章,评审


    authors: Agarwal A,Bertolla RP,Samanta L

    更新日期:2016-01-01 00:00:00

  • Top-down Proteomics: Technology Advancements and Applications to Heart Diseases.

    abstract:INTRODUCTION:Heart diseases are a leading cause of morbidity and mortality for both men and women worldwide, and impose significant economic burdens on the healthcare systems. Despite substantial effort over the last several decades, the molecular mechanisms underlying diseases of the heart remain poorly understood. A...

    journal_title:Expert review of proteomics

    pub_type: 杂志文章,评审


    authors: Cai W,Tucholski TM,Gregorich ZR,Ge Y

    更新日期:2016-08-01 00:00:00

  • Framework for a systems approach to proteomic biomarker profiling in polycystic ovary syndrome.

    abstract::Polycystic ovary syndrome (PCOS) is the most common endocrine disorder in females of reproductive age, and its prevalence ranges between 6 and 8%. Associated problems include infertility, menstrual disorders, hirsutism and obesity. In addition, individuals with PCOS may be at increased risk of diabetes, endometrial ca...

    journal_title:Expert review of proteomics

    pub_type: 杂志文章,评审


    authors: Atiomo WU,Khalid S,Ziauddin A,Tooth D,Layfield R

    更新日期:2009-10-01 00:00:00

  • Applying selected reaction monitoring to targeted proteomics.

    abstract::Selected reaction monitoring (SRM) is a highly selective and sensitive mass spectrometric methodology for precise and accurate quantification of low-abundant proteins in complex mixtures and for characterization of modified peptides, and constitutes the method of choice in targeted proteomics. Owing to its outstanding...

    journal_title:Expert review of proteomics

    pub_type: 杂志文章,评审


    authors: Calvo E,Camafeita E,Fernández-Gutiérrez B,López JA

    更新日期:2011-04-01 00:00:00

  • Update in research and methods in proteomics and bioinformatics.

    abstract::The 3rd International Conference on Proteomics & Bioinformatics (Proteomics 2013) Philadelphia, PA, USA, 15-17 July 2013 The Third International Conference on Proteomics & Bioinformatics (Proteomics 2013) was sponsored by the OMICS group and was organized in order to strengthen the future of proteomics science by brin...

    journal_title:Expert review of proteomics



    authors: Bencharit S,Border MB,Edelmann A,Byrd WC

    更新日期:2013-10-01 00:00:00

  • Proteomic analysis of human bile and potential applications for cancer diagnosis.

    abstract::Bile is a body fluid produced by the liver and drained by biliary ducts into the duodenum. It has two major functions: first, it contains bile acids, which are critical for the digestion of fats, and second, it is an excretory pathway for many endogenous and exogenous compounds. Proteomic analysis of bile is particula...

    journal_title:Expert review of proteomics

    pub_type: 杂志文章,评审


    authors: Farina A,Dumonceau JM,Lescuyer P

    更新日期:2009-06-01 00:00:00

  • The future of prenatal diagnosis: karyotype, microarray or both? Technical and ethical considerations.

    abstract::Prenatal diagnosis is now offered to high-risk pregnancies, including advanced maternal age, ultrasound anomalies and positive Down's syndrome screening, and karyotype on cultured fetal material is the test of choice to screen these pregnancies. However, microscope analysis can only detect gross chromosome abnormaliti...

    journal_title:Expert review of proteomics

    pub_type: 评论,杂志文章


    authors: Novelli A,Cavalli P,Bernardini L

    更新日期:2013-04-01 00:00:00

  • Network-based strategies in metabolomics data analysis and interpretation: from molecular networking to biological interpretation.

    abstract:INTRODUCTION:Metabolomics has become a crucial part of systems biology; however, data analysis is still often undertaken in a reductionist way focusing on changes in individual metabolites. Whilst such approaches indeed provide relevant insights into the metabolic phenotype of an organism, the intricate nature of metab...

    journal_title:Expert review of proteomics

    pub_type: 杂志文章


    authors: Perez De Souza L,Alseekh S,Brotman Y,Fernie AR

    更新日期:2020-04-01 00:00:00

  • The role of mass spectrometry in the characterization of biologic protein products.

    abstract:INTRODUCTION:Mass spectrometry (MS) is widely used in the characterization of biomolecules including peptide and protein therapeutics. These biotechnology products have seen rapid growth over the past few decades and continue to dominate the global pharmaceutical market. Advances in MS instrumentation and techniques ha...

    journal_title:Expert review of proteomics

    pub_type: 杂志文章,评审


    authors: Rathore D,Faustino A,Schiel J,Pang E,Boyne M,Rogstad S

    更新日期:2018-05-01 00:00:00

  • Integrated analysis of genetic, genomic and proteomic data.

    abstract::The rapid expansion of methods for measuring biological data ranging from DNA sequence variations to mRNA expression and protein abundance presents the opportunity to utilize multiple types of information jointly in the study of human health and disease. Organisms are complex systems that integrate inputs at myriad le...

    journal_title:Expert review of proteomics

    pub_type: 杂志文章,评审


    authors: Reif DM,White BC,Moore JH

    更新日期:2004-06-01 00:00:00

  • Detecting peptidic drugs, drug candidates and analogs in sports doping: current status and future directions.

    abstract::With the growing availability of mature systems and strategies in biotechnology and the continuously expanding knowledge of cellular processes and involved biomolecules, human sports drug testing has become a considerably complex field in the arena of analytical chemistry. Proving the exogenous origin of peptidic drug...

    journal_title:Expert review of proteomics

    pub_type: 杂志文章


    authors: Thevis M,Thomas A,Schänzer W

    更新日期:2014-12-01 00:00:00

  • Contribution of mass spectrometry-based proteomics to immunology.

    abstract::Antigen processing forwards various information about the cellular status and the proteome to the cell surface for scrutiny by the cellular immune system. Thus the repertoire of major histocompatibility complex (MHC)-bound peptides and the MHC ligandome, indirectly mirrors the proteome in order to make alterations ins...

    journal_title:Expert review of proteomics

    pub_type: 杂志文章,评审


    authors: Hillen N,Stevanovic S

    更新日期:2006-12-01 00:00:00

  • Does O-GlcNAc play a role in neurodegenerative diseases?

    abstract::There are several lines of evidence that the modification of proteins by cytosolic- and nuclear-specific O-linked N-acetylglucosamine (O-GlcNAc) glycosylation is closely related to neuropathologies, particularly Alzheimer's disease. Several neuronal proteins have been identified as being modified with O-GlcNAc; these ...

    journal_title:Expert review of proteomics

    pub_type: 杂志文章,评审


    authors: Lefebvre T,Guinez C,Dehennaut V,Beseme-Dekeyser O,Morelle W,Michalski JC

    更新日期:2005-04-01 00:00:00

  • Recent mass spectrometry-based proteomics for biomarker discovery in lung cancer, COPD, and asthma.

    abstract:INTRODUCTION:Lung cancer and related diseases have been one of the most common causes of deaths worldwide. Genomic-based biomarkers may hardly reflect the underlying dynamic molecular mechanism of functional protein interactions, which is the center of a disease. Recent developments in mass spectrometry (MS) have made ...

    journal_title:Expert review of proteomics

    pub_type: 杂志文章,评审


    authors: Fujii K,Nakamura H,Nishimura T

    更新日期:2017-04-01 00:00:00

  • Multidimensional protein identification technology: current status and future prospects.

    abstract::Protein profiling using high-throughput tandem mass spectrometry has become a powerful method for analyzing changes in global protein expression patterns in cells and tissues as a function of developmental, physiologic and disease processes. This review summarizes the utility and practical application of multidimensio...

    journal_title:Expert review of proteomics

    pub_type: 杂志文章,评审


    authors: Kislinger T,Emili A

    更新日期:2005-01-01 00:00:00

  • The impact of microgravity-based proteomics research.

    abstract::Proteomics is performed in microgravity research in order to determine protein alterations occurring qualitatively and quantitatively, when single cells or whole organisms are exposed to real or simulated microgravity. To this purpose, antibody-dependent (Western blotting, flow cytometry, Luminex(®) technology) and an...

    journal_title:Expert review of proteomics

    pub_type: 杂志文章


    authors: Grimm D,Pietsch J,Wehland M,Richter P,Strauch SM,Lebert M,Magnusson NE,Wise P,Bauer J

    更新日期:2014-08-01 00:00:00

  • Proteomic study of skeletal muscle in obesity and type 2 diabetes: progress and potential.

    abstract:INTRODUCTION:Skeletal muscle is the major site of insulin-stimulated glucose uptake and imparts the beneficial effects of exercise, and hence is an important site of insulin resistance in obesity and type 2 diabetes (T2D). Despite extensive molecular biology-oriented research the molecular mechanisms underlying insulin...

    journal_title:Expert review of proteomics

    pub_type: 杂志文章,评审


    authors: Kruse R,Højlund K

    更新日期:2018-10-01 00:00:00