Abstract:
INTRODUCTION:The mission of the Chromosome-Centric Human Proteome Project (C-HPP), is to map and annotate the entire predicted human protein set (~20,000 proteins) encoded by each chromosome. The initial steps of the project are focused on 'missing proteins (MPs)', which lacked documented evidence for existence at protein level. In addition to remaining 2,579 MPs, we also target those annotated proteins having unknown functions, uPE1 proteins, alternative splice isoforms and post-translational modifications. We also consider how to investigate various protein functions involved in cis-regulatory phenomena, amplicons lncRNAs and smORFs. Areas covered: We will cover the scope, historic background, progress, challenges and future prospects of C-HPP. This review also addresses the question of how we can best improve the methodological approaches, select the optimal biological samples, and recommend stringent protocols for the identification and characterization of MPs. A new strategy for functional analysis of some of those annotated proteins having unknown function will also be discussed. Expert commentary: If the project moves well by reshaping the original goals, the current working modules and team work in the proposed extended planning period, it is anticipated that a progressively more detailed draft of an accurate chromosome-based proteome map will become available with functional information.
journal_name
Expert Rev Proteomicsjournal_title
Expert review of proteomicsauthors
Paik YK,Omenn GS,Hancock WS,Lane L,Overall CMdoi
10.1080/14789450.2017.1394189subject
Has Abstractpub_date
2017-12-01 00:00:00pages
1059-1071issue
12eissn
1478-9450issn
1744-8387journal_volume
14pub_type
杂志文章,评审abstract::It is well known that chronic, excessive consumption of alcohol can cause brain damage/structural changes in the regions important for neurocognitive function. Some of the damages are permanent, while others are reversible. Molecular mechanisms underlying alcohol-induced and/or -related brain damage are largely unknow...
journal_title:Expert review of proteomics
pub_type: 杂志文章,评审
doi:10.1586/14789450.5.2.321
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abstract::Polycystic ovary syndrome (PCOS) is the most common endocrine disorder in females of reproductive age, and its prevalence ranges between 6 and 8%. Associated problems include infertility, menstrual disorders, hirsutism and obesity. In addition, individuals with PCOS may be at increased risk of diabetes, endometrial ca...
journal_title:Expert review of proteomics
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journal_title:Expert review of proteomics
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journal_title:Expert review of proteomics
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journal_title:Expert review of proteomics
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journal_title:Expert review of proteomics
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journal_title:Expert review of proteomics
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abstract::Exosomes are nanovesicles, derived from the endocytic pathway, released by most cell types and found in many body fluids, including urine. A variety of exosomal functions have been reported, including transfer of RNA, cell communication, control of apoptosis and protein lifespan. Exosomes from mesenchymal stem cells c...
journal_title:Expert review of proteomics
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journal_title:Expert review of proteomics
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journal_title:Expert review of proteomics
pub_type: 杂志文章,评审
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abstract:INTRODUCTION:Breast cancer subtypes are currently defined by a combination of morphologic, genomic, and proteomic characteristics. These subtypes provide a molecular portrait of the tumor that aids diagnosis, prognosis, and treatment escalation/de-escalation options. Gene expression signatures describing intrinsic brea...
journal_title:Expert review of proteomics
pub_type: 杂志文章,评审
doi:10.1080/14789450.2018.1421071
更新日期:2018-02-01 00:00:00
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journal_title:Expert review of proteomics
pub_type: 杂志文章,评审
doi:10.1080/14789450.2017.1353912
更新日期:2017-08-01 00:00:00
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journal_title:Expert review of proteomics
pub_type: 杂志文章,评审
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更新日期:2017-10-01 00:00:00
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journal_title:Expert review of proteomics
pub_type: 杂志文章,评审
doi:10.1586/14789450.3.1.45
更新日期:2006-02-01 00:00:00
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journal_title:Expert review of proteomics
pub_type: 杂志文章,评审
doi:10.1586/epr.10.98
更新日期:2011-02-01 00:00:00
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journal_title:Expert review of proteomics
pub_type: 杂志文章,评审
doi:10.1586/epr.12.11
更新日期:2012-04-01 00:00:00
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journal_title:Expert review of proteomics
pub_type: 杂志文章,评审
doi:10.1586/14789450.3.3.271
更新日期:2006-06-01 00:00:00
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journal_title:Expert review of proteomics
pub_type: 杂志文章,评审
doi:10.1586/14789450.1.1.67
更新日期:2004-06-01 00:00:00
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pub_type: 杂志文章
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journal_title:Expert review of proteomics
pub_type: 杂志文章,评审
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journal_title:Expert review of proteomics
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journal_title:Expert review of proteomics
pub_type: 评论,杂志文章
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更新日期:2012-01-01 00:00:00
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pub_type: 杂志文章,评审
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journal_title:Expert review of proteomics
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