Abstract:
:Despite their low prevalence, genetic kidney diseases (GKD) still represent a serious health problem. They often lead to kidney failure and to the consequent need of dialysis or kidney transplant. To date, reliable diagnosis requires laborious genetic tests and/or a renal biopsy. Moreover, only scant and non-specific markers exist for prognostic purposes. Biomarkers assayed in an easily available and low-cost sample, such as urine, would be highly valuable. Urinary proteomics can provide clues related to their development through the identification of differentially expressed proteins codified by the affected genes, or other dis-regulated species, in total or fractionated urine, providing novel mechanistic insights. In this review, the authors summarize and discuss the results of the main proteomic investigations on GKD urine samples and in urinary extracellular vesicles.
journal_name
Expert Rev Proteomicsjournal_title
Expert review of proteomicsauthors
Raimondo F,Cerra D,Magni F,Pitto Mdoi
10.1586/14789450.2016.1136218subject
Has Abstractpub_date
2016-01-01 00:00:00pages
309-24issue
3eissn
1478-9450issn
1744-8387journal_volume
13pub_type
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