Characterization and quantitation of membrane proteomes using multidimensional MS-based proteomic technologies.

abstract：:Proteomics and the study of protein-protein interactions are becoming increasingly important in our effort to understand human diseases on a system-wide level. Thanks to the development and curation of protein-interaction databases, up-to-date information on these interaction networks is accessible and publicly availa...

journal_title：Expert review of proteomics

authors： Pattin KA,Moore JH

更新日期：2009-12-01 00:00:00

abstract：:These are really exciting times in the field of Parkinson's disease research. Although the etiology of sporadic disease still remains a mystery, many of the proteins associated with hereditary disease (5-10% of all disease) have now been identified. Only time will tell whether proteins associated with hereditary disea...

journal_title：Expert review of proteomics

authors： Robinson PA

更新日期：2010-08-01 00:00:00

abstract：:Owing to its extensive use in the human diet, wheat is among the most common causes of food-related allergies and intolerances. Allergies to wheat are provoked by ingestion, inhalation or contact with either the soluble or the insoluble gluten proteins in wheat. Gluten proteins, and particularly the gliadin fraction, ...

journal_title：Expert review of proteomics

authors： Mamone G,Picariello G,Addeo F,Ferranti P

更新日期：2011-02-01 00:00:00

abstract：:Stroke is one of the most common causes of death worldwide and a major cause of acquired disability in adults. Despite advances in research during the last decade, prevention and treatment strategies still suffer from significant limitations, and therefore new theoretical and technical approaches are required. Technol...

journal_title：Expert review of proteomics

authors： Laborde CM,Mourino-Alvarez L,Akerstrom F,Padial LR,Vivanco F,Gil-Dones F,Barderas MG

更新日期：2012-08-01 00:00:00

abstract：:This article reviews the current state of systems biology approaches, including the experimental tools used to generate 'omic' data and computational frameworks to interpret this data. Through illustrative examples, systems biology approaches to understand gene expression and gene expression regulation are discussed. ...

journal_title：Expert review of proteomics

authors： Kuczenski RS,Aggarwal K,Lee KH

更新日期：2005-12-01 00:00:00

abstract：INTRODUCTION:Lung cancer and related diseases have been one of the most common causes of deaths worldwide. Genomic-based biomarkers may hardly reflect the underlying dynamic molecular mechanism of functional protein interactions, which is the center of a disease. Recent developments in mass spectrometry (MS) have made ...

journal_title：Expert review of proteomics

authors： Fujii K,Nakamura H,Nishimura T

更新日期：2017-04-01 00:00:00

abstract：:There are several lines of evidence that the modification of proteins by cytosolic- and nuclear-specific O-linked N-acetylglucosamine (O-GlcNAc) glycosylation is closely related to neuropathologies, particularly Alzheimer's disease. Several neuronal proteins have been identified as being modified with O-GlcNAc; these ...

journal_title：Expert review of proteomics

authors： Lefebvre T,Guinez C,Dehennaut V,Beseme-Dekeyser O,Morelle W,Michalski JC

更新日期：2005-04-01 00:00:00

abstract：:Chronic physical inactivity is a major risk factor for a number of important lifestyle diseases, while inappropriate exposure to high physical demands is a risk factor for musculoskeletal injury and fatigue. Proteomic and metabolomic investigations of the physical activity continuum - extreme sedentariness to extremes...

journal_title：Expert review of proteomics

authors： Sampson DL,Broadbent JA,Parker AW,Upton Z,Parker TJ

更新日期：2014-02-01 00:00:00

abstract：:A total of 40 years have already passed since the pioneering work of McCord and Fridovich on erythrocuprein superoxide dismutase (SOD) activity. This modern scientific 'Odyssey' has been accompanied by a series of successes in the fields of biochemistry, biomedicine and proteomics. In this article, we resume the main ...

journal_title：Expert review of proteomics

authors： D'Alessandro A,Zolla L

更新日期：2011-06-01 00:00:00

abstract：:Normal multipotent tissue stem cells (SCs) are the driving force behind tissue turnover and repair. The cancer stem cell theory holds that tumors also contain stem-like cells that drive tumor growth and metastasis formation. However, very little is known about the regulation of SC maintenance pathways in cancer and ho...

journal_title：Expert review of proteomics

authors： Kranenburg O,Emmink BL,Knol J,van Houdt WJ,Rinkes IH,Jimenez CR

更新日期：2012-06-01 00:00:00

abstract：:Due to the enormous complexity of the proteome, focus in proteomics shifts more and more from the study of the complete proteome to the targeted analysis of part of the proteome. The isolation of this specific part of the proteome generally includes an affinity-based enrichment. Surface plasmon resonance (SPR), a labe...

journal_title：Expert review of proteomics

authors： Visser NF,Heck AJ

更新日期：2008-06-01 00:00:00

abstract：:Elucidating disulfide linkage patterns is a crucial part of protein characterization, for which mass spectrometry (MS) is now an indispensable analytical tool. In many cases, MS-based disulfide connectivity assignment is straightforwardly achieved using one-step protein fragmentation in the unreduced form followed by ...

journal_title：Expert review of proteomics

authors： Goyder MS,Rebeaud F,Pfeifer ME,Kálmán F

更新日期：2013-10-01 00:00:00

abstract：:Introduction: Atopic dermatitis (AD) is a multifactorial ailment associated with barrier breach and intense systemic inflammation. Several studies over the years have shown the complex interplay of a large number of factors in governing the progression and outcome of AD. In addition to the diverse types of AD resultin...

journal_title：Expert review of proteomics

authors： Bhattacharya N,Ganguli-Indra G,Indra AK

更新日期：2019-08-01 00:00:00

abstract：:Atherothrombosis is the primary cause of death in Western countries. The cellular and molecular mechanisms underlying atherosclerosis remain widely unknown. The complex nature of atherosclerotic cardiovascular diseases demands the development of novel technologies that enable discovery of new biomarkers for early dise...

journal_title：Expert review of proteomics

authors： Martín-Ventura JL,Blanco-Colio LM,Tunon J,Gomez-Guerrero C,Michel JB,Meilhac O,Egido J

更新日期：2007-04-01 00:00:00

abstract：INTRODUCTION:Cutaneous leishmaniasis (CL), caused by different Leishmania parasite species, is associated with parasite-induced immune-mediated skin inflammation and ulceration. Whereas many CL studies focus on gene expression signatures in mouse models, the transcriptional response driving human patients in the field ...

journal_title：Expert review of proteomics

authors： Masoudzadeh N,Mizbani A,Rafati S

更新日期：2020-01-01 00:00:00

abstract：:The rapid expansion of methods for measuring biological data ranging from DNA sequence variations to mRNA expression and protein abundance presents the opportunity to utilize multiple types of information jointly in the study of human health and disease. Organisms are complex systems that integrate inputs at myriad le...

journal_title：Expert review of proteomics

authors： Reif DM,White BC,Moore JH

更新日期：2004-06-01 00:00:00

abstract：INTRODUCTION:Frailty is consequent to age-dependent deregulation of several biological pathways and systems, encompassing namely sarcopenia, age-associated hormonal derangements, inflammation, and nutritional or metabolic deficiencies. Although the prevalence of frailty is usually between 10% and 20% in the general eld...

journal_title：Expert review of proteomics

authors： Danese E,Montagnana M,Lippi G

更新日期：2018-08-01 00:00:00

abstract：INTRODUCTION:Mass spectrometry (MS) is widely used in the characterization of biomolecules including peptide and protein therapeutics. These biotechnology products have seen rapid growth over the past few decades and continue to dominate the global pharmaceutical market. Advances in MS instrumentation and techniques ha...

journal_title：Expert review of proteomics

authors： Rathore D,Faustino A,Schiel J,Pang E,Boyne M,Rogstad S

更新日期：2018-05-01 00:00:00

abstract：:High-throughput proteomics technologies tend to provide highly sensitive information about living tissues and biological fluids. Analytes are characterized by intrinsic and extrinsic properties, the latter depending on each phase of their preparation, sometimes adding artifacts with crucial repercussions in result rel...

journal_title：Expert review of proteomics

authors： Barelli S,Crettaz D,Thadikkaran L,Rubin O,Tissot JD

更新日期：2007-06-01 00:00:00

abstract：:The advances in high-resolution mass spectrometry instrumentation, capable of accurate mass measurement and fast acquisition, have enabled new approaches for targeted quantitative proteomics. More specifically, analyses performed on quadrupole-orbitrap mass spectrometers operated in parallel reaction monitoring (PRM) ...

journal_title：Expert review of proteomics

authors： Gallien S,Domon B

更新日期：2015-01-01 00:00:00

abstract：:Baukje de Roos is a principal investigator at the University of Aberdeen, Rowett Institute of Nutrition and Health. She investigates mechanisms through which dietary fats and fatty acids, and also polyphenols, affect parameters involved in the development of heart disease in vivo. This is achieved not only by measurin...

journal_title：Expert review of proteomics

authors： de Roos B

更新日期：2009-08-01 00:00:00

abstract：:Introduction: The last decade has yielded significant developments in the field of proteomics, especially in mass spectrometry (MS) and data analysis tools. In particular, a shift from gel-based to MS-based proteomics has been observed, thereby providing a platform with which to construct proteome atlases for all life...

journal_title：Expert review of proteomics

authors： Min CW,Gupta R,Agrawal GK,Rakwal R,Kim ST

更新日期：2019-09-01 00:00:00

abstract：:The emergence of advanced liquid chromatography mass spectrometry technologies for characterizing very complex mixtures of proteins has greatly propelled the field of proteomics, the goal of which is the simultaneous examination of all the proteins expressed by an organism. This research area represents a paradigm shi...

journal_title：Expert review of proteomics

authors： VerBerkmoes NC,Connelly HM,Pan C,Hettich RL

更新日期：2004-12-01 00:00:00

abstract：:Globally, colorectal cancer (CRC) is the third most common malignant neoplasm. However, highly sensitive, specific, noninvasive tests that allow CRC diagnosis at an early stage are still needed. As circulatory blood reflects the physiological status of an individual and/or the disease status for several disorders, eff...

journal_title：Expert review of proteomics

authors： Reumer A,Maes E,Mertens I,Cho WC,Landuyt B,Valkenborg D,Schoofs L,Baggerman G

更新日期：2014-08-01 00:00:00

abstract：:Endometriosis is a common disorder that is associated with infertility and pelvic pain. Diagnosis is based on the visualization of endometriotic lesions during surgery as no reliable serum marker is currently available. The etiology of endometriosis is largely unknown. Over the last 20 years, several proteomics techno...

journal_title：Expert review of proteomics

authors： Ferrero S,Gillott DJ,Remorgida V,Ragni N,Venturini PL,Grudzinskas JG

更新日期：2008-10-01 00:00:00

abstract：INTRODUCTION:Metabolomics has become a crucial part of systems biology; however, data analysis is still often undertaken in a reductionist way focusing on changes in individual metabolites. Whilst such approaches indeed provide relevant insights into the metabolic phenotype of an organism, the intricate nature of metab...

journal_title：Expert review of proteomics

authors： Perez De Souza L,Alseekh S,Brotman Y,Fernie AR

更新日期：2020-04-01 00:00:00

abstract：:The Central and Eastern European Proteomic Conference (CEEPC) proudly celebrated its 10th Anniversary with an exciting scientific program inclusive of proteome, proteomics and systems biology in Budapest, Hungary. Since 2007, CEEPC has represented 'state-of the-art' proteomics in and around Central and Eastern Europe ...

journal_title：Expert review of proteomics

authors： Gadher SJ,Drahos L,Vékey K,Kovarova H

更新日期：2017-07-01 00:00:00

abstract：:Neurodegenerative diseases are devastating disorders and the demands on their treatment are set to rise in connection with higher disease incidence. Knowledge of the spatiotemporal profile of cellular protein expression during neural differentiation and definition of a set of markers highly specific for targeted neura...

journal_title：Expert review of proteomics

authors： Zizkova M,Sucha R,Tyleckova J,Jarkovska K,Mairychova K,Kotrcova E,Marsala M,Gadher SJ,Kovarova H

更新日期：2015-02-01 00:00:00

abstract：INTRODUCTION:Chromatin remodeling complexes play important roles in the control of genome regulation in both normal and diseased states, and are therefore critical components for the regulation of epigenetic states in cells. Given the role epigenetics plays in cancer, for example, chromatin remodeling complexes are rou...

journal_title：Expert review of proteomics

authors： Eubanks CG,Dayebgadoh G,Liu X,Washburn MP

更新日期：2017-10-01 00:00:00

abstract：:This review describes a new type of label-free optical biosensor that is inexpensively manufactured from continuous sheets of plastic film and incorporated into standard format microplates to enable highly sensitive, high-throughput detection of small molecules, proteins and cells. The biosensor and associated detecti...

journal_title：Expert review of proteomics

authors： Cunningham BT,Laing L

更新日期：2006-06-01 00:00:00