Oxide-ion conduction in the Dion-Jacobson phase CsBi2Ti2NbO10-δ.

abstract：:Most cancer vaccines are unsuccessful in eliciting clinically relevant effects. Without using exogenous antigens and adoptive cells, we show a concept of utilizing biologically reprogrammed cytomembranes of the fused cells (FCs) derived from dendritic cells (DCs) and cancer cells as tumor vaccines. The fusion of immun...

journal_title：Nature communications

authors： Liu WL,Zou MZ,Liu T,Zeng JY,Li X,Yu WY,Li CX,Ye JJ,Song W,Feng J,Zhang XZ

更新日期：2019-07-19 00:00:00

abstract：:DNA methylation maintenance by DNMT1 is an essential process in mammals but molecular mechanisms connecting DNA methylation patterns and enzyme activity remain elusive. Here, we systematically analyzed the specificity of DNMT1, revealing a pronounced influence of the DNA sequences flanking the target CpG site on DNMT1...

journal_title：Nature communications

authors： Adam S,Anteneh H,Hornisch M,Wagner V,Lu J,Radde NE,Bashtrykov P,Song J,Jeltsch A

更新日期：2020-07-24 00:00:00

abstract：:Imputing genotypes from reference panels created by whole-genome sequencing (WGS) provides a cost-effective strategy for augmenting the single-nucleotide polymorphism (SNP) content of genome-wide arrays. The UK10K Cohorts project has generated a data set of 3,781 whole genomes sequenced at low depth (average 7x), aimi...

journal_title：Nature communications

authors： Huang J,Howie B,McCarthy S,Memari Y,Walter K,Min JL,Danecek P,Malerba G,Trabetti E,Zheng HF,UK10K Consortium.,Gambaro G,Richards JB,Durbin R,Timpson NJ,Marchini J,Soranzo N

更新日期：2015-09-14 00:00:00

abstract：:Pachytene piRNAs are the most abundant piRNAs in mammalian adult testes. They are generated from long precursor transcripts by the primary piRNA biogenesis pathway but the factors involved in pachytene piRNA precursors processing are poorly understood. Here we show that the Tudor domain-containing 5 (TDRD5) protein is...

journal_title：Nature communications

authors： Ding D,Liu J,Midic U,Wu Y,Dong K,Melnick A,Latham KE,Chen C

更新日期：2018-01-09 00:00:00

abstract：:Because monoclonal antibodies (mAbs) have exceptional specificity and favorable pharmacology, substantial efforts have been made to functionalize them, either with potent cytotoxins, biologics, radionuclides, or fluorescent groups for therapeutic benefit and/or use as theranostic agents. To exploit our recently discov...

journal_title：Nature communications

authors： Bzymek KP,Puckett JW,Zer C,Xie J,Ma Y,King JD,Goodstein LH,Avery KN,Colcher D,Singh G,Horne DA,Williams JC

更新日期：2018-04-20 00:00:00

abstract：:The world's coastal zones are experiencing rapid development and an increase in storms and flooding. These hazards put coastal communities at heightened risk, which may increase with habitat loss. Here we analyse globally the role and cost effectiveness of coral reefs in risk reduction. Meta-analyses reveal that coral...

journal_title：Nature communications

authors： Ferrario F,Beck MW,Storlazzi CD,Micheli F,Shepard CC,Airoldi L

更新日期：2014-05-13 00:00:00

abstract：:With damage tolerance rivalling advanced engineering alloys and thermoplastic forming capabilities analogous to conventional plastics, metallic glasses are emerging as a modern engineering material. Here, we take advantage of their unique electrical and rheological properties along with the classic Lorentz force conce...

journal_title：Nature communications

authors： Kaltenboeck G,Demetriou MD,Roberts S,Johnson WL

更新日期：2016-02-08 00:00:00

abstract：:The amniote middle ear is a classical example of the evolutionary novelty. Although paleontological evidence supports the view that mammals and diapsids (modern reptiles and birds) independently acquired the middle ear after divergence from their common ancestor, the developmental bases of these transformations remain...

journal_title：Nature communications

authors： Kitazawa T,Takechi M,Hirasawa T,Adachi N,Narboux-Nême N,Kume H,Maeda K,Hirai T,Miyagawa-Tomita S,Kurihara Y,Hitomi J,Levi G,Kuratani S,Kurihara H

更新日期：2015-04-22 00:00:00

abstract：:Performance for skills such as a sequence of finger movements improves during sleep. This has widely been interpreted as evidence for a role of sleep in strengthening skill learning. Here we propose a different interpretation. We propose that practice and sleep form different aspects of skill. To show this, we train 8...

journal_title：Nature communications

authors： Song S,Cohen LG

更新日期：2014-03-19 00:00:00

abstract：:Discharge from sliding outlet glaciers controls uncertainty in projections for future sea level. Remarkably, over 90% of glacial area is subject to gravitational driving stresses below 150 kPa (median ∼70 kPa). Longstanding explanations that appeal to the shear-thinning rheology of ice tend to overpredict driving stre...

journal_title：Nature communications

authors： Meyer CR,Downey AS,Rempel AW

更新日期：2018-08-13 00:00:00

abstract：:To cope with the global bacterial multidrug resistance, scientific communities have devoted significant efforts to develop novel antibiotics, particularly those with new modes of actions. Teixobactin, recently isolated from uncultured bacteria, is considered as a promising first-in-class drug candidate for clinical de...

journal_title：Nature communications

authors： Jin K,Sam IH,Po KHL,Lin D,Ghazvini Zadeh EH,Chen S,Yuan Y,Li X

更新日期：2016-08-03 00:00:00

abstract：:Single-cell analysis reveals aspects of cellular physiology not evident from population-based studies, particularly in the case of highly multiplexed methods such as mass cytometry (CyTOF) able to correlate the levels of multiple signalling, differentiation and cell fate markers. Immunofluorescence (IF) microscopy add...

journal_title：Nature communications

authors： Lin JR,Fallahi-Sichani M,Sorger PK

更新日期：2015-09-24 00:00:00

abstract：:Chronic kidney disease (CKD) is defined by reduced estimated glomerular filtration rate (eGFR). Previous genetic studies have implicated regulatory mechanisms contributing to CKD. Here we present epigenome-wide association studies of eGFR and CKD using whole-blood DNA methylation of 2264 ARIC Study and 2595 Framingham...

journal_title：Nature communications

authors： Chu AY,Tin A,Schlosser P,Ko YA,Qiu C,Yao C,Joehanes R,Grams ME,Liang L,Gluck CA,Liu C,Coresh J,Hwang SJ,Levy D,Boerwinkle E,Pankow JS,Yang Q,Fornage M,Fox CS,Susztak K,Köttgen A

更新日期：2017-11-03 00:00:00

abstract：:Collective cell migration mediates multiple tissue morphogenesis processes. Yet how multi-dimensional mesenchymal cell movements are coordinated remains mostly unknown. Here we report that coordinated mesenchymal cell migration during chicken feather elongation is accompanied by dynamic changes of bioelectric currents...

journal_title：Nature communications

authors： Li A,Cho JH,Reid B,Tseng CC,He L,Tan P,Yeh CY,Wu P,Li Y,Widelitz RB,Zhou Y,Zhao M,Chow RH,Chuong CM

更新日期：2018-12-18 00:00:00

abstract：:Bacterial vaginosis is a condition associated with adverse reproductive outcomes and characterized by a shift from a Lactobacillus-dominant vaginal microbiota to a polymicrobial microbiota, consistently colonized by strains of Gardnerella vaginalis. Metronidazole is the first-line treatment; however, treatment failure...

journal_title：Nature communications

authors： Lee CY,Cheu RK,Lemke MM,Gustin AT,France MT,Hampel B,Thurman AR,Doncel GF,Ravel J,Klatt NR,Arnold KB

更新日期：2020-12-01 00:00:00

abstract：:The original version of this article contained an error in the spelling of the author Christian A.M. Wilson, which was incorrectly given as Christian M.A. Wilson. This has now been corrected in both the PDF and HTML versions of the article. ...

journal_title：Nature communications

authors： Bustamante A,Sotelo-Campos J,Guerra DG,Floor M,Wilson CAM,Bustamante C,Báez M

更新日期：2017-12-14 00:00:00

abstract：:In vitro fabrication of functional vascularized three-dimensional tissues has been a long-standing objective in the field of tissue engineering. Here we report a technique to engineer cardiac tissues with perfusable blood vessels in vitro. Using resected tissue with a connectable artery and vein as a vascular bed, we ...

journal_title：Nature communications

authors： Sekine H,Shimizu T,Sakaguchi K,Dobashi I,Wada M,Yamato M,Kobayashi E,Umezu M,Okano T

更新日期：2013-01-01 00:00:00

abstract：:Transition metal catalyzed Sonogashira cross-coupling of terminal alkynes with aryl(vinyl) (pseudo)halides has been successfully extended to alkyl halides for the synthesis of functionalized internal alkynes. The direct alkynylation of remote unfunctionalized sp3 carbon by terminal alkynes remains difficult to realize...

journal_title：Nature communications

authors： Li Z,Torres-Ochoa RO,Wang Q,Zhu J

更新日期：2020-01-21 00:00:00

abstract：:Clustered regularly-interspaced palindromic repeats (CRISPR)-based genetic screens using single-guide-RNA (sgRNA) libraries have proven powerful to identify genetic regulators. Applying CRISPR screens to interrogate functional elements in noncoding regions requires generating sgRNA libraries that are densely covering,...

journal_title：Nature communications

authors： Cheng J,Roden CA,Pan W,Zhu S,Baccei A,Pan X,Jiang T,Kluger Y,Weissman SM,Guo S,Flavell RA,Ding Y,Lu J

更新日期：2016-03-30 00:00:00

abstract：:The dynamical properties and mechanical functions of amorphous materials are governed by their microscopic structures, particularly the elasticity of the interaction networks, which is generally complicated by structural heterogeneity. This ubiquitous heterogeneous nature of amorphous materials is intriguingly attribu...

journal_title：Nature communications

authors： Yan L

更新日期：2018-04-10 00:00:00

abstract：:Xylanolytic enzymes from glycoside hydrolase family 43 (GH43) are involved in the breakdown of hemicellulose, the second most abundant carbohydrate in plants. Here, we kinetically and mechanistically describe the non-reducing-end xylose-releasing exo-oligoxylanase activity and report the crystal structure of a native ...

journal_title：Nature communications

authors： Morais MAB,Coines J,Domingues MN,Pirolla RAS,Tonoli CCC,Santos CR,Correa JBL,Gozzo FC,Rovira C,Murakami MT

更新日期：2021-01-14 00:00:00

abstract：:FinO-domain proteins are a widespread family of bacterial RNA-binding proteins with regulatory functions. Their target spectrum ranges from a single RNA pair, in the case of plasmid-encoded FinO, to global RNA regulons, as with enterobacterial ProQ. To assess whether the FinO domain itself is intrinsically selective o...

journal_title：Nature communications

authors： Bauriedl S,Gerovac M,Heidrich N,Bischler T,Barquist L,Vogel J,Schoen C

更新日期：2020-06-04 00:00:00

abstract：:The ever-increasing demand for flexible electronics calls for the development of low-voltage and high-mobility organic thin-film transistors (OTFTs) that can be integrated into emerging display and labeling technologies. Polymer dielectrics with comprehensive and balanced dielectric properties (i.e., a good balance be...

journal_title：Nature communications

authors： Ji D,Li T,Zou Y,Chu M,Zhou K,Liu J,Tian G,Zhang Z,Zhang X,Li L,Wu D,Dong H,Miao Q,Fuchs H,Hu W

更新日期：2018-06-14 00:00:00

abstract：:DNA damage and secondary structures can stall the replication machinery. Cells possess numerous tolerance mechanisms to complete genome duplication in the presence of such impediments. In addition to translesion synthesis (TLS) polymerases, most eukaryotic cells contain a multifunctional replicative enzyme called prim...

journal_title：Nature communications

authors： Guilliam TA,Brissett NC,Ehlinger A,Keen BA,Kolesar P,Taylor EM,Bailey LJ,Lindsay HD,Chazin WJ,Doherty AJ

更新日期：2017-05-23 00:00:00

abstract：:Room-temperature infrared sub-band gap photoresponse in silicon is of interest for telecommunications, imaging and solid-state energy conversion. Attempts to induce infrared response in silicon largely centred on combining the modification of its electronic structure via controlled defect formation (for example, vacan...

journal_title：Nature communications

authors： Mailoa JP,Akey AJ,Simmons CB,Hutchinson D,Mathews J,Sullivan JT,Recht D,Winkler MT,Williams JS,Warrender JM,Persans PD,Aziz MJ,Buonassisi T

更新日期：2014-01-01 00:00:00

abstract：:Iminium catalysis, involving the transformation of iminium ions to enamines, has been extensively studied in the context of a number of organic processes. However, the reverse of this process involving conversion of enamines to iminium species has not been realized. Here, we describe a new transformation-'oxidative en...

journal_title：Nature communications

authors： Zhang SL,Xie HX,Zhu J,Li H,Zhang XS,Li J,Wang W

更新日期：2011-01-01 00:00:00

abstract：:Integrin αVβ8, which like αVβ6 functions to activate TGF-βs, is atypical. Its β8 subunit binds to a distinctive cytoskeleton adaptor and does not exhibit large changes in conformation upon binding to ligand. Here, crystal structures, hydrogen-deuterium exchange dynamics, and affinity measurements on mutants are used t...

journal_title：Nature communications

authors： Wang J,Su Y,Iacob RE,Engen JR,Springer TA

更新日期：2019-12-02 00:00:00

abstract：:Androgen-ablation therapies, which are the standard treatment for metastatic prostate cancer, invariably lead to acquired resistance. Hence, a systematic identification of additional drivers may provide useful insights into the development of effective therapies. Numerous microRNAs that are critical for metastasis are...

journal_title：Nature communications

authors： Xue M,Liu H,Zhang L,Chang H,Liu Y,Du S,Yang Y,Wang P

更新日期：2017-04-11 00:00:00

abstract：:Imaging of nuclear structures within intact eukaryotic nuclei is imperative to understand the effect of chromatin folding on genome function. Recent developments of super-resolution fluorescence microscopy techniques combine high specificity, sensitivity, and less-invasive sample preparation procedures with the sub-di...

journal_title：Nature communications

authors： Sarmento MJ,Oneto M,Pelicci S,Pesce L,Scipioni L,Faretta M,Furia L,Dellino GI,Pelicci PG,Bianchini P,Diaspro A,Lanzanò L

更新日期：2018-08-24 00:00:00

abstract：:PET hydrolase (PETase), which hydrolyzes polyethylene terephthalate (PET) into soluble building blocks, provides an attractive avenue for the bioconversion of plastics. Here we present the structures of a novel PETase from the PET-consuming microbe Ideonella sakaiensis in complex with substrate and product analogs. Th...

journal_title：Nature communications

authors： Han X,Liu W,Huang JW,Ma J,Zheng Y,Ko TP,Xu L,Cheng YS,Chen CC,Guo RT

更新日期：2017-12-13 00:00:00