Abstract:
:Since extracellular vesicles (EVs) were discovered in 1983 in sheep reticulocytes samples, they have gradually attracted scientific attention and become a topic of great interest in the life sciences field. EVs are small membrane particles, released by virtually every cell that carries a variety of functional molecules. Their main function is to deliver messages to the surrounding area in both physiological and pathological conditions. Initially, they were thought to be either cell debris, signs of cell death, or unspecific structures. However, accumulating evidence support a theory that EVs are a universal mechanism of communication. Thanks to their biological characteristics and functions, EVs are likely to represent a promising strategy for obtaining pathogen information, identifying therapeutic targets and selecting specific biomarkers for a variety of diseases, such as autoimmune diseases. In this review, we provide a brief overview of recent progress in the study of the biology and functions of EVs. We also discuss their roles in diagnosis and therapy, with particular emphasis on autoimmune diseases.
journal_name
Int J Biol Scijournal_title
International journal of biological sciencesauthors
Tian J,Casella G,Zhang Y,Rostami A,Li Xdoi
10.7150/ijbs.39629subject
Has Abstractpub_date
2020-01-01 00:00:00pages
620-632issue
4issn
1449-2288pii
ijbsv16p0620journal_volume
16pub_type
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journal_title:International journal of biological sciences
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journal_title:International journal of biological sciences
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journal_title:International journal of biological sciences
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journal_title:International journal of biological sciences
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abstract::Prostate cancer (PCa) remains the most prevalent malignancy among males in the western world. Though hormonal therapies through chemical or surgical castration have been proposed many years ago, heretofore, such mainstay for the treatment on advanced PCa has not fundamentally changed. These therapeutic responses are t...
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journal_title:International journal of biological sciences
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journal_title:International journal of biological sciences
pub_type: 杂志文章,评审
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更新日期:2007-10-25 00:00:00
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journal_title:International journal of biological sciences
pub_type: 杂志文章,随机对照试验
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更新日期:2008-02-18 00:00:00
abstract::The genetic landscape of pancreatic cancer shows nearly ubiquitous mutations of K-RAS. However, oncogenic K-Ras(mt) alone is not sufficient to lead to pancreatic ductal adenocarcinoma (PDAC) in either human or in genetically modified adult mouse models. Many stimulants, such as high fat diet, CCK, LPS, PGE2 and others...
journal_title:International journal of biological sciences
pub_type: 杂志文章,评审
doi:10.7150/ijbs.15020
更新日期:2016-01-28 00:00:00
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journal_title:International journal of biological sciences
pub_type: 杂志文章,评审
doi:10.7150/ijbs.7823
更新日期:2014-01-10 00:00:00
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journal_title:International journal of biological sciences
pub_type: 杂志文章
doi:10.7150/ijbs.46822
更新日期:2020-07-19 00:00:00
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journal_title:International journal of biological sciences
pub_type: 杂志文章
doi:10.7150/ijbs.24548
更新日期:2018-05-22 00:00:00
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journal_title:International journal of biological sciences
pub_type: 杂志文章
doi:10.7150/ijbs.39098
更新日期:2020-02-17 00:00:00
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journal_title:International journal of biological sciences
pub_type: 杂志文章
doi:10.7150/ijbs.18472
更新日期:2017-05-16 00:00:00
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journal_title:International journal of biological sciences
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doi:10.7150/ijbs.18976
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journal_title:International journal of biological sciences
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更新日期:2007-03-02 00:00:00
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journal_title:International journal of biological sciences
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更新日期:2020-04-15 00:00:00
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journal_title:International journal of biological sciences
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更新日期:2019-01-01 00:00:00
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journal_title:International journal of biological sciences
pub_type: 杂志文章
doi:10.7150/ijbs.8.1
更新日期:2012-01-01 00:00:00
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journal_title:International journal of biological sciences
pub_type: 杂志文章
doi:10.7150/ijbs.4.48
更新日期:2008-02-06 00:00:00
abstract::The Zucker diabetic fatty (ZDF) rat is a model of type II diabetes and metabolic syndrome based on impaired glucose tolerance caused by the inherited insulin-resistance gene. The ZDF rat exhibits progressive nephropathy; however, the detailed mechanisms have remained unclear. This study was performed to examine the po...
journal_title:International journal of biological sciences
pub_type: 杂志文章
doi:10.7150/ijbs.3.40
更新日期:2006-11-01 00:00:00
abstract::Sirtuins are highly conserved NAD+-dependent protein deacetylases and/or ADP-ribosyltransferases that can extend the lifespan of several lower model organisms including yeast, worms and flies. The seven mammalian sirtuins, SIRT1 to SIRT7, have emerged as key metabolic sensors that directly link environmental signals t...
journal_title:International journal of biological sciences
pub_type: 杂志文章,评审
doi:10.7150/ijbs.7.575
更新日期:2011-01-01 00:00:00
abstract::The terminal loop region of primary miRNA transcripts is an important determinant controlling miRNA function in human, animals and plants. However, the effects of polymorphisms in loop region of miRNA precusors on phenotypic variation have not been reported, especially on agronomic traits in rice. From rice japonica v...
journal_title:International journal of biological sciences
pub_type: 杂志文章
doi:10.7150/ijbs.6357
更新日期:2013-06-16 00:00:00
abstract::The loss of wild type p53 tumor suppressive function and oncogenic gain-of-function of p53 mutants have been showing important implications in tumorigenesis. The p53(N236S) (p53(N239S) in human, p53S) mutation has been shown to lose wild type p53 function by yeast assay. However, its gain of function is still not clea...
journal_title:International journal of biological sciences
pub_type: 杂志文章
doi:10.7150/ijbs.4176
更新日期:2012-01-01 00:00:00