Loop nucleotide polymorphism in a putative miRNA precursor associated with seed length in rice (Oryza sativa L.).

abstract：:Solid tumors consist of various types of stromal cells in addition to cancer cells. Cancer-associated fibroblasts (CAFs) are a major component of the tumor stroma and play an essential role in tumor progression and metastasis in a variety of malignancies, including gastric cancer. However, the effects of CAFs on gastr...

journal_title：International journal of biological sciences

authors： Xu G,Zhang B,Ye J,Cao S,Shi J,Zhao Y,Wang Y,Sang J,Yao Y,Guan W,Tao J,Feng M,Zhang W

更新日期：2019-08-22 00:00:00

abstract：:Upon salinity challenge, the Na(+)-K(+)-ATPase (NKA) of fish kidney plays a crucial role in maintaining ion and water balance. Moreover, the FXYD protein family was found to be a regulator of NKA. Our preliminary results revealed that fxyd12 was highly expressed in the kidneys of the two closely related euryhaline med...

journal_title：International journal of biological sciences

authors： Yang WK,Kang CK,Hsu AD,Lin CH,Lee TH

更新日期：2016-04-28 00:00:00

abstract：:Mutations in the gene ELOVL4 have been shown to cause stargardt-like macular dystrophy. ELOVL4 is part of a family of fatty acid elongases and is yet to have a specific elongase activity assigned to it. We generated Elovl4 Y270X mutant mice and characterized the homozygous mutant as well as homozygous Elovl4 knockout ...

journal_title：International journal of biological sciences

authors： Cameron DJ,Tong Z,Yang Z,Kaminoh J,Kamiyah S,Chen H,Zeng J,Chen Y,Luo L,Zhang K

更新日期：2007-02-06 00:00:00

abstract：:After spinal cord injury (SCI), the destruction of blood-spinal cord barrier (BSCB) is shown to accelerate gathering of noxious blood-derived components in the nervous system, leading to secondary neurodegenerative damages. SCI activates endoplasmic reticulum stress (ER stress), which is considered to evoke secondary ...

journal_title：International journal of biological sciences

authors： Zheng B,Zhou Y,Zhang H,Yang G,Hong Z,Han D,Wang Q,He Z,Liu Y,Wu F,Zhang X,Tong S,Xu H,Xiao J

更新日期：2017-11-27 00:00:00

abstract：:Pacemaker activity of the sinoatrial node has been studied extensively in various animal species, but is virtually unexplored in man. As such, it is unknown whether the fast sodium current (I(Na)) plays a role in the pacemaker activity of the human sinoatrial node. Recently, we had the unique opportunity to perform pa...

journal_title：International journal of biological sciences

authors： Verkerk AO,Wilders R,van Borren MM,Tan HL

更新日期：2009-01-01 00:00:00

abstract：:The objective of this work was to evaluate the bioavailability of heme iron added to biscuit filling. It comprised two stages: first, the development of the heme iron enriched biscuit filling; second, the evaluation of the bioavailability of the mineral in fattening piglets. Two groups were selected randomly and fed: ...

journal_title：International journal of biological sciences

authors： Quintero-Gutiérrez AG,González-Rosendo G,Sánchez-Muñoz J,Polo-Pozo J,Rodríguez-Jerez JJ

更新日期：2008-02-18 00:00:00

abstract：:Mitochondrial dysfunction is an important contributor to the development of osteoarthritis (OA). Sirtuin 3 (SIRT3) regulates diverse mitochondrial proteins to maintain mitochondrial homeostasis, and dihydromyricetin (DHM) is reported as a potential SIRT3 activator. This study aims to explore the relevance of SIRT3 and...

journal_title：International journal of biological sciences

authors： Wang J,Wang K,Huang C,Lin D,Zhou Y,Wu Y,Tian N,Fan P,Pan X,Xu D,Hu J,Zhou Y,Wang X,Zhang X

更新日期：2018-10-20 00:00:00

abstract：: Objectives: Skeletal development is a complex process. Little is known about the different response of limb or spine growth plate chondrocytes (LGP or SGP) to the estrogen level and the role of estrogen receptor (ER) during postnatal stage. Methods...

journal_title：International journal of biological sciences

authors： Shi S,Zheng S,Li XF,Liu ZD

更新日期：2017-01-11 00:00:00

abstract：:The discovery of rare subpopulations of cancer stem cells (CSCs) has created a new focus in cancer research. As CSCs demonstrate resistance to chemoradiation therapy relative to other cancer cells, this allows the enrichment of CSC populations by killing apoptosis-susceptible cancer cells. In this study, three commonl...

journal_title：International journal of biological sciences

authors： Wang L,Huang X,Zheng X,Wang X,Li S,Zhang L,Yang Z,Xia Z

更新日期：2013-05-15 00:00:00

abstract：:CKLF-like MARVEL transmembrane domain-containing member (CMTM) is a new gene family first cloned and reported in 2001. The CMTM family consists of nine members including CKLF and CMTM1-CMTM8, which are located on different chromosomes. Besides exhibiting extensive chemotactic activity, the CMTM family plays an importa...

journal_title：International journal of biological sciences

authors： Wu K,Li X,Gu H,Yang Q,Liu Y,Wang L

更新日期：2019-09-07 00:00:00

abstract：:In order to find a blood host and to select appropriate oviposition sites female Anopheles gambiae mosquitoes rely on olfactory cues which are sensed by olfactory sensory neurons (OSNs) located within morphologically different sensilla hairs. While the sharp type trichoid sensilla are most abundant and intensely studi...

journal_title：International journal of biological sciences

authors： Schultze A,Breer H,Krieger J

更新日期：2014-03-22 00:00:00

abstract：:Cardiac and skeletal muscle tissue engineering provides a smart approach to overcome problems associated with organ transplantation and cardiac tissue and also lays a platform for superior alternative approaches in muscle regeneration. The aim of the study was to demonstrate cryogel scaffold potential in the field of ...

journal_title：International journal of biological sciences

authors： Singh D,Nayak V,Kumar A

更新日期：2010-07-03 00:00:00

abstract：:Melanoma is an aggressive form of skin cancer characterized by rapid invasion and metastasis. CD147 is known to be functioning in cell invasion. In this study, we showed that CD147 was translocated from the cell membrane to the mitochondria in advanced melanoma. Melanoma patients with CD147 localized to the mitochondr...

journal_title：International journal of biological sciences

authors： Lu L,Zhang J,Gan P,Wu L,Zhang X,Peng C,Zhou J,Chen X,Su J

更新日期：2021-01-01 00:00:00

abstract：:Transforming growth factor β (TGF-β) signaling pathway plays important roles in many biological processes, including cell growth, differentiation, apoptosis, migration, as well as cancer initiation and progression. SMAD4, which serves as the central mediator of TGF-β signaling, is specifically inactivated in over half...

journal_title：International journal of biological sciences

authors： Zhao M,Mishra L,Deng CX

更新日期：2018-01-12 00:00:00

abstract：:The genetic landscape of pancreatic cancer shows nearly ubiquitous mutations of K-RAS. However, oncogenic K-Ras(mt) alone is not sufficient to lead to pancreatic ductal adenocarcinoma (PDAC) in either human or in genetically modified adult mouse models. Many stimulants, such as high fat diet, CCK, LPS, PGE2 and others...

journal_title：International journal of biological sciences

authors： Logsdon CD,Lu W

更新日期：2016-01-28 00:00:00

abstract：:Embryonic stem (ES) cells have immortality for self-renewal and pluripotency. Differentiated human cells undergo replicative senescence. In human, the telomerase reverse transcriptase (Tert), namely the catalytic subunit of telomerase, exhibits differential expression to regulate telomerase activity governing cellular...

journal_title：International journal of biological sciences

authors： Rao F,Wang T,Li M,Li Z,Hong N,Zhao H,Yan Y,Lu W,Chen T,Wang W,Lim M,Yuan Y,Liu L,Zeng L,Wei Q,Guan G,Li C,Hong Y

更新日期：2011-04-15 00:00:00

abstract：:During the immune response, neutrophils display localized mechanical events by interacting with their environment through the micro-vascular transit, trans-endothelial, and trans-epithelial migration. Nano-mechanical studies of human neutrophils on localized nano-domains could provide the essential information for und...

journal_title：International journal of biological sciences

authors： Lee YJ,Patel D,Park S

更新日期：2011-01-20 00:00:00

abstract：:Carbon monoxide (CO) is a vasoactive molecule that is generated by vascular cells as a byproduct of heme catabolism and it plays an important physiological role in circulation system. In order to investigate whether exogenous CO can mediate the growth and proliferation of vascular cells, in this study, we used 250 par...

journal_title：International journal of biological sciences

authors： Li Y,Wang H,Yang B,Yang J,Ruan X,Yang Y,Wakeland EK,Li Q,Fang X

更新日期：2012-01-01 00:00:00

abstract：:When pathogenic stresses are recognized by innate immune cells, inflammasomes are assembled and caspase-1 is activated, resulting in the conversion of pro-IL-18 into mature IL-18. Because natural killer (NK) cells express IL-18 receptors, IL-18 may play roles in immune functions of NK cells. In the present study, we e...

journal_title：International journal of biological sciences

authors： Senju H,Kumagai A,Nakamura Y,Yamaguchi H,Nakatomi K,Fukami S,Shiraishi K,Harada Y,Nakamura M,Okamura H,Tanaka Y,Mukae H

更新日期：2018-03-09 00:00:00

abstract：:As one of the most ominous malignancies, hepatocellular carcinoma (HCC) is frequently diagnosed at an advanced stage, owing to its aggressive invasion and metastatic spread. Emerging evidence has demonstrated that Rictor, as a unique component of the mTORC2, plays a role in cell migration, as it is dysregulated in var...

journal_title：International journal of biological sciences

authors： Dong X,Feng M,Yang H,Liu H,Guo H,Gao X,Liu Y,Liu R,Zhang N,Chen R,Kong R

更新日期：2020-09-01 00:00:00

abstract：:The powerful pro-angiogenic capacity of human amnion-derived mesenchymal stem cells (hAMSCs) could be a valuable therapeutic angiogenesis strategy for bone regeneration. However, the molecular mechanisms underlying this process remain largely unknown. Herein, we report upregulated expression of circular RNA 100290 (ci...

journal_title：International journal of biological sciences

authors： Tang Z,Wu X,Hu L,Xiao Y,Tan J,Zuo S,Shen M,Yuan X

更新日期：2020-05-18 00:00:00

abstract：:BRCA1-deficient breast cancer is a very well-known hereditary cancer. However, except for resection of normal mammary glands and ovaries, there is no acceptable measure for proactively preventing tumor development. Importantly, inherited BRCA1 mutations are closely associated with tumors in hormone-responsive tissues....

journal_title：International journal of biological sciences

authors： Baek HJ,Kim SE,Choi EK,Kim JK,Shin DH,Park EJ,Kim TH,Kim JY,Kim KG,Deng CX,Kim SS

更新日期：2018-10-03 00:00:00

abstract：:The standard of care for patients who suffer from non-organ confined prostate cancer (CaP) is androgen deprivation therapy (ADT). ADT exploits the reliance of CaP cells on androgen receptor (AR) signaling throughout CaP progression from androgen-stimulated (AS) to castration-recurrent (CR) disease. AR is a member of t...

journal_title：International journal of biological sciences

authors： Heemers HV

更新日期：2014-06-01 00:00:00

abstract：:Wee1 kinase regulates the G2/M cell cycle checkpoint by phosphorylating and inactivating the mitotic cyclin-dependent kinase 1 (Cdk1). Loss of Wee1 in many systems, including yeast and drosophila, leads to premature mitotic entry. However, the developmental role of Wee1 in mammals remains unclear. In this study, we es...

journal_title：International journal of biological sciences

authors： Tominaga Y,Li C,Wang RH,Deng CX

更新日期：2006-01-01 00:00:00

abstract：:Patent ductus arteriosus (PDA) can cause morbidity and mortality in neonates. Vascular remodeling, characterized by proliferation and migration of smooth muscle cells (SMCs), is an essential process for postnatal DA closure. Notch signaling is an important mediator of vascular remodelling but its role in DA is unkonwn...

journal_title：International journal of biological sciences

authors： Wu JR,Yeh JL,Liou SF,Dai ZK,Wu BN,Hsu JH

更新日期：2016-07-18 00:00:00

abstract：:Autism is a neurodevelopmental disorder with unknown etiology. In some cases, typically developing children regress into clinical symptoms of autism, a condition known as regressive autism. Protein kinases are essential for G-protein-coupled receptor-mediated signal transduction, and are involved in neuronal functions...

journal_title：International journal of biological sciences

authors： Ji L,Chauhan A,Chauhan V

更新日期：2012-01-01 00:00:00

abstract：:Background: The preoperative controlling nutritional status (CONUT) score and circulating tumour cell (CTC) status are associated with poor prognosis of colorectal cancer (CRC). The aim of the present study is to determine whether the combination of CONUT and CTC (CONUT-CTC) could better predict the prognosis of CRC p...

journal_title：International journal of biological sciences

authors： Yang C,Wei C,Wang S,Han S,Shi D,Zhang C,Lin X,Dou R,Xiong B

更新日期：2019-05-12 00:00:00

abstract：:Recent studies have reported that cancer stem cells (CSCs) could be isolated from solid cancer cell lines, in which the purity of CSCs was higher than that from tumor tissues. Separation of CSCs from leukemic cell lines was rarely reported. In this study, CD34(+)CD38(-)stem-like cell subsets in human KG-1a leukemic ce...

journal_title：International journal of biological sciences

authors： Zhang L,Yang S,He YJ,Shao HY,Wang L,Chen H,Gao YJ,Qing FX,Chen XC,Zhao LY,Tan S

更新日期：2010-08-03 00:00:00

abstract：:Genuine racial differences in prostate cancer (PCa) biology have been considered among the potential reasons to explain PCa disparities. There is no animal model to represent all aspects of human PCa and, more specifically, to be used for PCa disparity research. The lack of a spontaneously transformed in vitro cell-ba...

journal_title：International journal of biological sciences

authors： Koochekpour S,Willard SS,Shourideh M,Ali S,Liu C,Azabdaftari G,Saleem M,Attwood K

更新日期：2014-07-26 00:00:00

abstract：:Reverting activated hepatic stellate cells (HSCs) to less activation or quiescent status is a promising strategy for liver fibrosis. Histone deacetylase inhibitor (HDACI) could suppress HSCs activation. Our previous study demonstrated a critical role of miRNAs in HSCs activation. Here, we explored the involvement of m...

journal_title：International journal of biological sciences

authors： Lu P,Yan M,He L,Li J,Ji Y,Ji J

更新日期：2019-01-06 00:00:00