听力与言语-语言病理学

行为科学

医学伦理学

你正在浏览International Journal of Biological Sciences期刊下所有文献
  • ACE2 Correlated With Immune Infiltration Serves As A Novel Prognostic Biomarker In Clear Cell Renal Cell Carcinoma: Implication For COVID-19.

    abstract::The current severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused a global infection, and is seriously threatening human life, especially cancer patients. Thus, we sought to determine the clinical roles of ACE2 (the cell entry receptor of SARS-CoV-2) in ccRCC (clear cell renal cell carcinoma). TCGA, ...

    journal_title:International journal of biological sciences

    pub_type: 杂志文章

    doi:10.7150/ijbs.51969

    authors: Yang W,Li L,Zhang K,Ma K,Xie H,Gong Y,Zhou J,Gong K

    更新日期:2021-01-01 00:00:00

  • Ferroptosis in a sarcopenia model of senescence accelerated mouse prone 8 (SAMP8).

    abstract::As a systemic syndrome characterized by age-associated degenerative skeletal muscle atrophy, sarcopenia leads to a risk of adverse outcomes in the elderly. Age-related iron accumulation is found in the muscles of sarcopenia animal models and patients, but the role of iron in sarcopenia remains poorly understood. It ha...

    journal_title:International journal of biological sciences

    pub_type: 杂志文章

    doi:10.7150/ijbs.53126

    authors: Huang Y,Wu B,Shen D,Chen J,Yu Z,Chen C

    更新日期:2021-01-01 00:00:00

  • Novel Functions of CD147 in the Mitochondria Exacerbates Melanoma Metastasis.

    abstract::Melanoma is an aggressive form of skin cancer characterized by rapid invasion and metastasis. CD147 is known to be functioning in cell invasion. In this study, we showed that CD147 was translocated from the cell membrane to the mitochondria in advanced melanoma. Melanoma patients with CD147 localized to the mitochondr...

    journal_title:International journal of biological sciences

    pub_type: 杂志文章

    doi:10.7150/ijbs.52043

    authors: Lu L,Zhang J,Gan P,Wu L,Zhang X,Peng C,Zhou J,Chen X,Su J

    更新日期:2021-01-01 00:00:00

  • Regulation of energy metabolism by combination therapy attenuates cardiac metabolic remodeling in heart failure.

    abstract::Cardiac metabolic remodeling is recognized as an important hallmark of heart failure (HF), while strategies that target energy metabolism have therapeutic potential in treating HF. Shen-Fu formula (S-F) is a standardized herbal preparation frequently used in clinical practice and is a promising combinatorial therapy f...

    journal_title:International journal of biological sciences

    pub_type: 杂志文章

    doi:10.7150/ijbs.49520

    authors: Huang Y,Zhang K,Jiang M,Ni J,Chen J,Li L,Deng J,Zhu Y,Mao J,Gao X,Fan G

    更新日期:2020-10-16 00:00:00

  • Repression of FGF signaling is responsible for Dnmt3b inhibition and impaired de novo DNA methylation during early development of in vitro fertilized embryos.

    abstract::Well-orchestrated epigenetic modifications during early development are essential for embryonic survival and postnatal growth. Erroneous epigenetic modifications due to environmental perturbations such as manipulation and culture of embryos during in vitro fertilization (IVF) are linked to various short- or long-term ...

    journal_title:International journal of biological sciences

    pub_type: 杂志文章

    doi:10.7150/ijbs.51607

    authors: Fu W,Yue Y,Miao K,Xi G,Zhang C,Wang W,An L,Tian J

    更新日期:2020-10-03 00:00:00

  • The small molecule PSSM0332 disassociates the CRL4ADCAF8 E3 ligase complex to decrease the ubiquitination of NcoR1 and inhibit the inflammatory response in a mouse sepsis-induced myocardial dysfunction model.

    abstract::Sepsis-induced myocardial dysfunction (SIMD) is a life-threatening complication caused by inflammation, but how it is initiated is still unclear. Several studies have shown that extracellular high mobility group box 1 (HMGB1), an important cytokine triggering inflammation, is overexpressed during the pathogenesis of S...

    journal_title:International journal of biological sciences

    pub_type: 杂志文章

    doi:10.7150/ijbs.50186

    authors: Peng Q,Xu H,Xiao M,Wang L

    更新日期:2020-09-19 00:00:00

  • Rictor promotes cell migration and actin polymerization through regulating ABLIM1 phosphorylation in Hepatocellular Carcinoma.

    abstract::As one of the most ominous malignancies, hepatocellular carcinoma (HCC) is frequently diagnosed at an advanced stage, owing to its aggressive invasion and metastatic spread. Emerging evidence has demonstrated that Rictor, as a unique component of the mTORC2, plays a role in cell migration, as it is dysregulated in var...

    journal_title:International journal of biological sciences

    pub_type: 杂志文章

    doi:10.7150/ijbs.46285

    authors: Dong X,Feng M,Yang H,Liu H,Guo H,Gao X,Liu Y,Liu R,Zhang N,Chen R,Kong R

    更新日期:2020-09-01 00:00:00

  • Pleiotropic use of Statins as non-lipid-lowering drugs.

    abstract::Statins, known as HMG-CoA reductase (HMGCR) inhibitors, have primarily been utilized for metabolic and angiographic medical applications because of their cholesterol-lowering effects. Similar to other drugs, statins may also induce a series of potential side effects. Statins inhibit the HMGCR (rate-limiting enzyme) ac...

    journal_title:International journal of biological sciences

    pub_type: 杂志文章,评审

    doi:10.7150/ijbs.42965

    authors: Zhang Q,Dong J,Yu Z

    更新日期:2020-08-13 00:00:00

  • MiR-216a-5p inhibits tumorigenesis in Pancreatic Cancer by targeting TPT1/mTORC1 and is mediated by LINC01133.

    abstract::MiR-216a-5p has opposite effects on tumorigenesis and progression in the context of different tumors, acting as either a tumor suppressor or an oncogene. However, the expression and function of miR-216a-5p in pancreatic cancer (PC) is not well characterized. In this study, we found miR-216a-5p was significantly downre...

    journal_title:International journal of biological sciences

    pub_type: 杂志文章

    doi:10.7150/ijbs.46822

    authors: Zhang J,Gao S,Zhang Y,Yi H,Xu M,Xu J,Liu H,Ding Z,He H,Wang H,Hao Z,Sun L,Liu Y,Wei F

    更新日期:2020-07-19 00:00:00

  • A Novel Ferroptosis-related Gene Signature for Overall Survival Prediction in Patients with Hepatocellular Carcinoma.

    abstract::Hepatocellular carcinoma (HCC) is a highly heterogeneous disease, which makes the prognostic prediction challenging. Ferroptosis, an iron-dependent form of regulated cell death, can be induced by sorafenib. However, the prognostic value of ferroptosis-related genes in HCC remains to be further elucidated. In this stud...

    journal_title:International journal of biological sciences

    pub_type: 杂志文章

    doi:10.7150/ijbs.45050

    authors: Liang JY,Wang DS,Lin HC,Chen XX,Yang H,Zheng Y,Li YH

    更新日期:2020-07-06 00:00:00

  • Bile acids mediated potential functional interaction between FXR and FATP5 in the regulation of Lipid Metabolism.

    abstract::Perturbation in lipid homeostasis is one of the major bottlenecks in metabolic diseases, especially Non-alcoholic Fatty Liver Disease (NAFLD), which has emerged as a leading global cause of chronic liver disease. The bile acids (BAs) and their derivatives exert a variety of metabolic effects through complex and intert...

    journal_title:International journal of biological sciences

    pub_type: 杂志文章,评审

    doi:10.7150/ijbs.44774

    authors: Kumari A,Pal Pathak D,Asthana S

    更新日期:2020-06-14 00:00:00

  • Circ-100290 Positively Regulates Angiogenesis Induced by Conditioned Medium of Human Amnion-Derived Mesenchymal Stem Cells Through miR-449a/eNOS and miR-449a/VEGFA Axes.

    abstract::The powerful pro-angiogenic capacity of human amnion-derived mesenchymal stem cells (hAMSCs) could be a valuable therapeutic angiogenesis strategy for bone regeneration. However, the molecular mechanisms underlying this process remain largely unknown. Herein, we report upregulated expression of circular RNA 100290 (ci...

    journal_title:International journal of biological sciences

    pub_type: 杂志文章

    doi:10.7150/ijbs.39895

    authors: Tang Z,Wu X,Hu L,Xiao Y,Tan J,Zuo S,Shen M,Yuan X

    更新日期:2020-05-18 00:00:00

  • Mechanical tumor microenvironment and transduction: cytoskeleton mediates cancer cell invasion and metastasis.

    abstract::Metastasis is a complicated, multistep process that is responsible for over 90% of cancer-related death. Metastatic disease or the movement of cancer cells from one site to another requires dramatic remodeling of the cytoskeleton. The regulation of cancer cell migration is determined not only by biochemical factors in...

    journal_title:International journal of biological sciences

    pub_type: 杂志文章,评审

    doi:10.7150/ijbs.44943

    authors: Li X,Wang J

    更新日期:2020-04-27 00:00:00

  • Function and evolution of RNA N6-methyladenosine modification.

    abstract::N6-methyladenosine (m6A) is identified as the most prevalent and abundant internal RNA modification, especially within eukaryotic mRNAs, which has attracted much attention in recent years since its importance for regulating gene expression and deciding cell fate. m6A modification is installed by RNA methyltransferases...

    journal_title:International journal of biological sciences

    pub_type: 杂志文章,评审

    doi:10.7150/ijbs.45231

    authors: Zhu ZM,Huo FC,Pei DS

    更新日期:2020-04-15 00:00:00

  • The effect of HMGA1 in LPS-induced Myocardial Inflammation.

    abstract::Aims: The High Mobility Group A1 (HMGA1) proteins, serving as a dynamic regulator of gene transcription and chromatin remodeling, play an influential part in the pathological process of a large number of cardiovascular diseases. However, the precise role of HMGA1 in sepsis induced cardiomyopathy (SIC) remains unintell...

    journal_title:International journal of biological sciences

    pub_type: 杂志文章

    doi:10.7150/ijbs.39947

    authors: Cai ZL,Shen B,Yuan Y,Liu C,Xie QW,Hu TT,Yao Q,Wu QQ,Tang QZ

    更新日期:2020-03-26 00:00:00

  • Targeting the Endocytic Pathway and Autophagy Process as a Novel Therapeutic Strategy in COVID-19.

    abstract::Coronaviruses (CoVs) are a group of enveloped, single-stranded positive genomic RNA viruses and some of them are known to cause severe respiratory diseases in human, including Severe Acute Respiratory Syndrome (SARS), Middle East Respiratory Syndrome (MERS) and the ongoing coronavirus disease-19 (COVID-19). One key el...

    journal_title:International journal of biological sciences

    pub_type: 杂志文章,评审

    doi:10.7150/ijbs.45498

    authors: Yang N,Shen HM

    更新日期:2020-03-15 00:00:00

  • Is intensive glucose control bad for critically ill patients? A systematic review and meta-analysis.

    abstract::Background: The monitoring and management of blood glucose concentration are standard practices in critical settings as hyperglycaemia has been shown close association with poorer outcomes. Several meta-analyses have revealed that intensive glucose control has no benefit in decreasing short-term mortality among critic...

    journal_title:International journal of biological sciences

    pub_type: 杂志文章

    doi:10.7150/ijbs.43447

    authors: Yao RQ,Ren C,Wu GS,Zhu YB,Xia ZF,Yao YM

    更新日期:2020-03-12 00:00:00

  • Bisdemethoxycurcumin Enhances the Sensitivity of Non-small Cell Lung Cancer Cells to Icotinib via Dual Induction of Autophagy and Apoptosis.

    abstract::Non-small cell lung cancer (NSCLC) with epidermal growth factor receptor (EGFR) wild-type is intrinsic resistance to EGFR-tyrosine kinase inhibitors (TKIs). In this study, we assessed whether the combination of bisdemethoxycurcumin (BDMC) and icotinib could surmount primary EGFR-TKI resistance in NSCLC cells and inves...

    journal_title:International journal of biological sciences

    pub_type: 杂志文章

    doi:10.7150/ijbs.40042

    authors: Xiang M,Jiang HG,Shu Y,Chen YJ,Jin J,Zhu YM,Li MY,Wu JN,Li J

    更新日期:2020-03-05 00:00:00

  • Phosphoinositide specific phospholipase Cγ1 inhibition-driven autophagy caused cell death in human lung adenocarcinoma A549 cells in vivo and in vitro.

    abstract::Our previous studies indicated that phosphoinositide specific phospholipase Cγ1 (PLCγ1) was involved in autophagy induction in colon and hepatic carcinoma cells. However, whether and how PLCγ1 regulation in human lung adenocarcinoma is linked to autophagy remains unclear. Here, we assessed the protein expression of PL...

    journal_title:International journal of biological sciences

    pub_type: 杂志文章

    doi:10.7150/ijbs.42962

    authors: Lu X,Fu H,Chen R,Wang Y,Zhan Y,Song G,Hu T,Xia C,Tian X,Zhang B

    更新日期:2020-02-21 00:00:00

  • Selective targeting of the TLR4 co-receptor, MD2, prevents colon cancer growth and lung metastasis.

    abstract::Toll-like receptor (TLR) signaling is an emerging pathway in tumor cell invasion and metastasis. Myeloid differentiation protein-2 (MD2) contributes to ligand recognition and activation of TLRs in response to exogenous microbial insults or endogenous agents. We hypothesized that blocking MD2 using a specific inhibitor...

    journal_title:International journal of biological sciences

    pub_type: 杂志文章

    doi:10.7150/ijbs.39098

    authors: Rajamanickam V,Yan T,Xu S,Hui J,Xu X,Ren L,Liu Z,Liang G,Wang O,Wang Y

    更新日期:2020-02-17 00:00:00

  • Parkinson's Disease: A Comprehensive Analysis of Fungi and Bacteria in Brain Tissue.

    abstract::Parkinson's disease (PD) is characterized by motor disorders and the destruction of dopaminergic neurons in the substantia nigra pars compacta. In addition to motor disability, many patients with PD present a spectrum of clinical symptoms, including cognitive decline, psychiatric alterations, loss of smell and bladder...

    journal_title:International journal of biological sciences

    pub_type: 杂志文章

    doi:10.7150/ijbs.42257

    authors: Pisa D,Alonso R,Carrasco L

    更新日期:2020-02-10 00:00:00

  • SASH1 promotes melanin synthesis and migration via suppression of TGF-β1 secretion in melanocytes resulting in pathologic hyperpigmentation.

    abstract::Dyschromatosis universalis hereditaria (DUH) is an autosomal dominant pigmentary genodermatosis characterized by the presence of patches of hyperpigmentation and hypopigmented macules distributed over the body, with most cases reported in Asia. DUH is a heterogeneous disease and a small portion of patients carry the A...

    journal_title:International journal of biological sciences

    pub_type: 杂志文章

    doi:10.7150/ijbs.38415

    authors: Cui H,Guo S,He H,Guo H,Zhang Y,Wang B

    更新日期:2020-02-10 00:00:00

  • Wnt5a/CaMKII/ERK/CCL2 axis is required for tumor-associated macrophages to promote colorectal cancer progression.

    abstract::Tumor-associated macrophages (TAMs) are closely correlated with tumor occurrence, invasion, and metastasis. However, factors affecting the biological functions of TAMs in colorectal cancer (CRC) are incompletely understood. Here, we found that Wnt5a was mainly expressed on TAMs of tumor stroma but not on CRC cells. Su...

    journal_title:International journal of biological sciences

    pub_type: 杂志文章

    doi:10.7150/ijbs.40535

    authors: Liu Q,Song J,Pan Y,Shi D,Yang C,Wang S,Xiong B

    更新日期:2020-02-04 00:00:00

  • Circular RNA in Lung Cancer Research: Biogenesis, Functions, and Roles.

    abstract::Lung cancer is one of the most common and deadly malignancies worldwide, in spite of advances in targeted therapy in recent years. An effective strategy for lung cancer prevention remains a major problem. Advances in next-generation sequencing have helped in understanding the RNA and identifying novel circular RNAs (c...

    journal_title:International journal of biological sciences

    pub_type: 杂志文章,评审

    doi:10.7150/ijbs.39212

    authors: Zhang C,Ma L,Niu Y,Wang Z,Xu X,Li Y,Yu Y

    更新日期:2020-01-16 00:00:00

  • Soluble CD83 alleviates experimental allergic rhinitis through modulating antigen-specific Th2 cell property.

    abstract::Background and aims: Dysfunction of the immune regulatory system plays a role in the pathogenesis of allergic rhinitis (AR). The underlying mechanism needs to be further investigated. Published data indicate that soluble CD83 (sCD83) has immune regulatory activities. This study aims to investigate the role of sCD83 in...

    journal_title:International journal of biological sciences

    pub_type: 杂志文章

    doi:10.7150/ijbs.38722

    authors: Wu YJ,Song YN,Geng XR,Ma F,Mo LH,Zhang XW,Liu DB,Liu ZG,Yang PC

    更新日期:2020-01-01 00:00:00

  • G721-0282 inhibits cell growth and induces apoptosis in human osteosarcoma through down-regulation of the STAT3 pathway.

    abstract::Osteosarcoma (OS) is considered the most common type of primary malignant bone tumor, which has an urgent need for more effective treatment. Recently, chitinase 3 like 1 (Chi3L1) expression has been found in a variety of cancer cells. However it is not known whether Chi3L1 regulates the STAT3 pathway in OS cells. Here...

    journal_title:International journal of biological sciences

    pub_type: 杂志文章

    doi:10.7150/ijbs.37781

    authors: Park KR,Yun HM,Hong JT

    更新日期:2020-01-01 00:00:00

  • Potential roles of extracellular vesicles in the pathophysiology, diagnosis, and treatment of autoimmune diseases.

    abstract::Since extracellular vesicles (EVs) were discovered in 1983 in sheep reticulocytes samples, they have gradually attracted scientific attention and become a topic of great interest in the life sciences field. EVs are small membrane particles, released by virtually every cell that carries a variety of functional molecule...

    journal_title:International journal of biological sciences

    pub_type: 杂志文章,评审

    doi:10.7150/ijbs.39629

    authors: Tian J,Casella G,Zhang Y,Rostami A,Li X

    更新日期:2020-01-01 00:00:00

  • Reno-protection of Urine-derived Stem Cells in A Chronic Kidney Disease Rat Model Induced by Renal Ischemia and Nephrotoxicity.

    abstract::Purpose: Drug-induced nephrotoxicity can occur in patients with pre-existing renal dysfunction or renal ischemia, potentially leading to chronic kidney disease (CKD) and end-stage renal disease (ESRD). Prompt treatment of CKD and the related side effects is critical in preventing progression to ESRD. The goal of this ...

    journal_title:International journal of biological sciences

    pub_type: 杂志文章

    doi:10.7150/ijbs.37550

    authors: Zhang C,George SK,Wu R,Thakker PU,Abolbashari M,Kim TH,Ko IK,Zhang Y,Sun Y,Jackson J,Lee SJ,Yoo JJ,Atala A

    更新日期:2020-01-01 00:00:00

  • Current Status of Therapeutic Approaches against Peripheral Nerve Injuries: A Detailed Story from Injury to Recovery.

    abstract::Peripheral nerve injury is a complex condition with a variety of signs and symptoms such as numbness, tingling, jabbing, throbbing, burning or sharp pain. Peripheral nerves are fragile in nature and can easily get damaged due to acute compression or trauma which may lead to the sensory and motor functions deficits and...

    journal_title:International journal of biological sciences

    pub_type: 杂志文章,评审

    doi:10.7150/ijbs.35653

    authors: Hussain G,Wang J,Rasul A,Anwar H,Qasim M,Zafar S,Aziz N,Razzaq A,Hussain R,de Aguilar JG,Sun T

    更新日期:2020-01-01 00:00:00

  • Spexin alleviates insulin resistance and inhibits hepatic gluconeogenesis via the FoxO1/PGC-1α pathway in high-fat-diet-induced rats and insulin resistant cells.

    abstract::Objective: Recent studies demonstrate circulating serum spexin levels are reduced in obesity or type 2 diabetes mellitus (T2DM) patients and may play a role in glucose metabolism. The mechanism underlying is not known. In this study, we explore whether spexin has a role in insulin resistance and hepatic glucose metabo...

    journal_title:International journal of biological sciences

    pub_type: 杂志文章

    doi:10.7150/ijbs.31781

    authors: Gu L,Ding X,Wang Y,Gu M,Zhang J,Yan S,Li N,Song Z,Yin J,Lu L,Peng Y

    更新日期:2019-11-01 00:00:00

  • RMP/URI inhibits both intrinsic and extrinsic apoptosis through different signaling pathways.

    abstract::The evading apoptosis of tumor cells may result in chemotherapy resistance. Therefore, investigating what molecular events contribute to drug-induced apoptosis, and how tumors evade apoptotic death, provides a paradigm to explain the relationship between cancer genetics and treatment sensitivity. In this study, we foc...

    journal_title:International journal of biological sciences

    pub_type: 杂志文章

    doi:10.7150/ijbs.36829

    authors: Ji Y,Shen J,Li M,Zhu X,Wang Y,Ding J,Jiang S,Chen L,Wei W

    更新日期:2019-10-15 00:00:00

  • Research Advances in CKLF-like MARVEL Transmembrane Domain-containing Family in Non-small Cell Lung Cancer.

    abstract::CKLF-like MARVEL transmembrane domain-containing member (CMTM) is a new gene family first cloned and reported in 2001. The CMTM family consists of nine members including CKLF and CMTM1-CMTM8, which are located on different chromosomes. Besides exhibiting extensive chemotactic activity, the CMTM family plays an importa...

    journal_title:International journal of biological sciences

    pub_type: 杂志文章,评审

    doi:10.7150/ijbs.33733

    authors: Wu K,Li X,Gu H,Yang Q,Liu Y,Wang L

    更新日期:2019-09-07 00:00:00

  • Umbelliferone Prevents Lipopolysaccharide-Induced Bone Loss and Suppresses RANKL-Induced Osteoclastogenesis by Attenuating Akt-c-Fos-NFATc1 Signaling.

    abstract::Excessive bone resorption plays a central role in the development of inflammatory bone diseases, including osteoporosis and rheumatoid arthritis. Thus, identification of agents that can effectively suppress excessive osteoclast formation and function is crucial for the prevention and treatment of inflammatory bone los...

    journal_title:International journal of biological sciences

    pub_type: 杂志文章

    doi:10.7150/ijbs.28609

    authors: Kwak SC,Baek JM,Lee CH,Yoon KH,Lee MS,Kim JY

    更新日期:2019-09-07 00:00:00

  • Exosomal miRNA-139 in cancer-associated fibroblasts inhibits gastric cancer progression by repressing MMP11 expression.

    abstract::Solid tumors consist of various types of stromal cells in addition to cancer cells. Cancer-associated fibroblasts (CAFs) are a major component of the tumor stroma and play an essential role in tumor progression and metastasis in a variety of malignancies, including gastric cancer. However, the effects of CAFs on gastr...

    journal_title:International journal of biological sciences

    pub_type: 杂志文章

    doi:10.7150/ijbs.33750

    authors: Xu G,Zhang B,Ye J,Cao S,Shi J,Zhao Y,Wang Y,Sang J,Yao Y,Guan W,Tao J,Feng M,Zhang W

    更新日期:2019-08-22 00:00:00

  • Trends in Alzheimer's Disease Research Based upon Machine Learning Analysis of PubMed Abstracts.

    abstract::About 29.8 million people worldwide had been diagnosed with Alzheimer's disease (AD) in 2015, and the number is projected to triple by 2050. In 2018, AD was the fifth leading cause of death in Americans with 65 years of age or older, but the progress of AD drug research is very limited. It is helpful to identify the k...

    journal_title:International journal of biological sciences

    pub_type: 杂志文章

    doi:10.7150/ijbs.35743

    authors: Guan R,Wen X,Liang Y,Xu D,He B,Feng X

    更新日期:2019-08-06 00:00:00

  • p53 Mutant p53N236S Induces Neural Tube Defects in Female Embryos.

    abstract::The p53 is one of the most important tumor suppressors through surveillance of DNA damages and abnormal proliferation signals, and activation the cell cycle arrest and apoptosis in response to stress. However, the mutation of p53 is known to be oncogenic by both loss of function in inhibiting cell cycle progress and g...

    journal_title:International journal of biological sciences

    pub_type: 杂志文章

    doi:10.7150/ijbs.31451

    authors: Zhao J,Tian Y,Zhang H,Qu L,Chen Y,Liu Q,Luo Y,Wu X

    更新日期:2019-07-25 00:00:00

  • An Autocrine IL-6/IGF-1R Loop Mediates EMT and Promotes Tumor Growth in Non-small Cell Lung Cancer.

    abstract::Epithelial-to-mesenchymal transition (EMT) is a key process in EGFR-TKI resistance but the detailed mechanism is largely unknown. We aim to evaluate the role of interleukin-6 (IL-6) and insulin-like growth factor-1 receptor (IGR-1R) in EMT in non-small cell lung cancer (NSCLC). We used IL-6 to induce EMT in EGFR-TKI s...

    journal_title:International journal of biological sciences

    pub_type: 杂志文章

    doi:10.7150/ijbs.31999

    authors: Zheng X,Lu G,Yao Y,Gu W

    更新日期:2019-07-20 00:00:00

  • Enhancement of oxaliplatin-induced colon cancer cell apoptosis by alantolactone, a natural product inducer of ROS.

    abstract::Colon cancer is a malignant type of cancer with high prevalence and is one of the primary causes of cancer-related deaths. Oxaliplatin plays a significant role in the treatment of cancer, but the application of oxaliplatin is restricted due to its toxic side effects and drug resistance in clinical practice. Therefore,...

    journal_title:International journal of biological sciences

    pub_type: 杂志文章

    doi:10.7150/ijbs.35265

    authors: Cao P,Xia Y,He W,Zhang T,Hong L,Zheng P,Shen X,Liang G,Cui R,Zou P

    更新日期:2019-06-04 00:00:00

  • miR-1204 promotes hepatocellular carcinoma progression through activating MAPK and c-Jun/AP1 signaling by targeting ZNF418.

    abstract::Emerging evidence has indicated that abnormal microRNAs (miRNAs) participated in carcinogenesis and tumor progression in hepatocellular carcinoma (HCC). Better understanding the association between miRNAs and HCC may contribute to discover novel therapeutic approaches for diagnosis and treatments. In the current study...

    journal_title:International journal of biological sciences

    pub_type: 杂志文章

    doi:10.7150/ijbs.33658

    authors: Wang L,Sun L,Wang Y,Yao B,Liu R,Chen T,Tu K,Liu Q,Liu Z

    更新日期:2019-06-02 00:00:00

  • Caffeine Inhibits NLRP3 Inflammasome Activation by Suppressing MAPK/NF-κB and A2aR Signaling in LPS-Induced THP-1 Macrophages.

    abstract::Excessive inflammation induced by various risk factors is associated with the development of bronchopulmonary dysplasia (BPD). Caffeine exerts potent anti-inflammatory effects as a clinical preventive medicine for BPD. Recently, NLRP3 inflammasome activation has been demonstrated to be essential for the pathogenesis o...

    journal_title:International journal of biological sciences

    pub_type: 杂志文章

    doi:10.7150/ijbs.34211

    authors: Zhao W,Ma L,Cai C,Gong X

    更新日期:2019-06-02 00:00:00

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