Abstract:
:Mutations in the gene ELOVL4 have been shown to cause stargardt-like macular dystrophy. ELOVL4 is part of a family of fatty acid elongases and is yet to have a specific elongase activity assigned to it. We generated Elovl4 Y270X mutant mice and characterized the homozygous mutant as well as homozygous Elovl4 knockout mice in order to better understand the function or role of Elovl4. We found that mice lacking a functional Elovl4 protein died perinatally. The cause of death appears to be from dehydration due to faulty permeability barrier formation in the skin. Further biochemical analysis revealed a significant reduction in free fatty acids longer than C26 in homozygous mutant and knockout mouse skin. These results implicate the importance of these long chain fatty acids in skin barrier development. Furthermore, we suggest that Elovl4 is likely involved in the elongation of C26 and longer fatty acids.
journal_name
Int J Biol Scijournal_title
International journal of biological sciencesauthors
Cameron DJ,Tong Z,Yang Z,Kaminoh J,Kamiyah S,Chen H,Zeng J,Chen Y,Luo L,Zhang Kdoi
10.7150/ijbs.3.111subject
Has Abstractpub_date
2007-02-06 00:00:00pages
111-9issue
2issn
1449-2288journal_volume
3pub_type
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