Abstract:
:Background and aims: Dysfunction of the immune regulatory system plays a role in the pathogenesis of allergic rhinitis (AR). The underlying mechanism needs to be further investigated. Published data indicate that soluble CD83 (sCD83) has immune regulatory activities. This study aims to investigate the role of sCD83 in the alleviation of experimental AR. Methods: Peripheral blood samples were obtained from AR patients. Serum levels of sCD83 were determined by enzyme-linked immunosorbent assay. A murine AR model was developed to test the effects of sCD83 on suppressing experimental AR. Results: We found that serum levels of sCD83 in the AR group were lower than that in the healthy control group. A negative correlation was identified between the serum sCD83 levels and the frequency of T helper-2 (Th2) cells. The low serum sCD83 levels were also associated with the Bcl2L12 expression in antigen-specific Th2 cells. Exposure to sCD83 enhanced the responsiveness of antigen-specific Th2 cells to apoptosis inducers via suppressing the Bcl2L12 expression. Administration of sCD83 efficiently suppressed experimental AR. Conclusions: sCD83 contributes to immune homeostasis by regulating CD4+ T cell activities. Administration of sCD83 may have translational potential for the treatment of AR or other allergic diseases.
journal_name
Int J Biol Scijournal_title
International journal of biological sciencesauthors
Wu YJ,Song YN,Geng XR,Ma F,Mo LH,Zhang XW,Liu DB,Liu ZG,Yang PCdoi
10.7150/ijbs.38722subject
Has Abstractpub_date
2020-01-01 00:00:00pages
216-227issue
2issn
1449-2288pii
ijbsv16p0216journal_volume
16pub_type
杂志文章abstract::Interleukin-8 (IL-8) is a common inflammatory factor, which involves in various non-specific pathological processes of inflammation. It has been found that increased endothelial permeability accompanied with high expression of IL-8 at site of injured endothelium and atherosclerotic plaque at early stages, suggesting t...
journal_title:International journal of biological sciences
pub_type: 杂志文章
doi:10.7150/ijbs.6996
更新日期:2013-09-23 00:00:00
abstract::Despite significant progressions in treatment modalities over the last decade, either cancer incidence or mortality is continuously on the rise throughout the world. Current anticancer agents display limited efficacy, accompanied by severe side effects. In order to improve therapeutic outcomes in patients with cancer,...
journal_title:International journal of biological sciences
pub_type: 杂志文章,评审
doi:10.7150/ijbs.33710
更新日期:2019-05-07 00:00:00
abstract::Ovarian cancer is the fifth common cause of death in woman worldwide. The tripartite motif-containing (TRIM) proteins consist of more than 70 known protein members. Studies have showed that TRIM proteins are involved in cancer and play important roles in cancer cell proliferation, migration, adhesion and metastasis. R...
journal_title:International journal of biological sciences
pub_type: 杂志文章
doi:10.7150/ijbs.28757
更新日期:2018-11-03 00:00:00
abstract::The mineralization-front theory is historically rooted in mineralization research fields for many decades. This theory is widely used to describe mineralization events in both osteogenesis and dentinogenesis. However, this model does not provide enough evidence to explain how minerals are propagated from the pulp-end ...
journal_title:International journal of biological sciences
pub_type: 杂志文章
doi:10.7150/ijbs.25712
更新日期:2018-04-30 00:00:00
abstract::Ionizing radiation (IR) is a well-known carcinogen, however the mechanism of radiation induced thymic lymphoma is not well known. Moreover, an easy and effective method to protect mice from radiation induced thymic lymphoma is still unknown. Hydrogen, or H(2), is seldom regarded as an important agent in medical usage,...
journal_title:International journal of biological sciences
pub_type: 杂志文章
doi:10.7150/ijbs.7.297
更新日期:2011-03-25 00:00:00
abstract::To investigate the effects of Genistein on the osteogenic related gene expression profiles during osteoblastic differentiation of human bone marrow mesenchymal stem cell (hBMSC) cultures, the hBMSCs were cultured under osteogenic differentiation medium with the addition of Genistein (10(-8)∼10(-5) M) for 12 days. The ...
journal_title:International journal of biological sciences
pub_type: 杂志文章
doi:10.7150/ijbs.7367
更新日期:2013-11-21 00:00:00
abstract::Retrospective and prospective studies show that lean mass or strength is positively associated with metabolic health. Mice deficient in myostatin, a growth factor that negatively regulates skeletal muscle mass, have increased muscle and body weights and are resistant to diet-induced obesity. Their leanness is often at...
journal_title:International journal of biological sciences
pub_type: 杂志文章
doi:10.7150/ijbs.13525
更新日期:2016-04-01 00:00:00
abstract::We collected clinical data from 308 prostate cancer (PCa) patients to investigate the clinical characteristics and independent risk factors of bone metastasis (BM) and to establish a prediction model for BM of PCa and determine the necessity of bone scans. Univariate and multivariate analyses were performed based on a...
journal_title:International journal of biological sciences
pub_type: 杂志文章
doi:10.7150/ijbs.27537
更新日期:2019-01-01 00:00:00
abstract::Lead (Pb) is a well-known neurotoxicant and a risk factor for neurologic disorders. The blood brain barrier (BBB) plays an important role in the maintenance of optimal brain function. BBB is a target of Pb, and studies have shown that Pb induced barrier loss and decreased the expression of tight junction proteins, but...
journal_title:International journal of biological sciences
pub_type: 杂志文章
doi:10.7150/ijbs.20670
更新日期:2017-10-31 00:00:00
abstract::Glucocorticoid medication is one of the most common causes of atraumatic osteonecrosis of the femoral head (ONFH), and vitamin K2 (VK2) has been shown to play an important and beneficial role in bone metabolism. In this study, we hypothesized that VK2 could decrease the incidence of glucocorticoid-induced ONFH in a ra...
journal_title:International journal of biological sciences
pub_type: 杂志文章
doi:10.7150/ijbs.13269
更新日期:2016-01-28 00:00:00
abstract::Colon cancer is a malignant type of cancer with high prevalence and is one of the primary causes of cancer-related deaths. Oxaliplatin plays a significant role in the treatment of cancer, but the application of oxaliplatin is restricted due to its toxic side effects and drug resistance in clinical practice. Therefore,...
journal_title:International journal of biological sciences
pub_type: 杂志文章
doi:10.7150/ijbs.35265
更新日期:2019-06-04 00:00:00
abstract::Genuine racial differences in prostate cancer (PCa) biology have been considered among the potential reasons to explain PCa disparities. There is no animal model to represent all aspects of human PCa and, more specifically, to be used for PCa disparity research. The lack of a spontaneously transformed in vitro cell-ba...
journal_title:International journal of biological sciences
pub_type: 杂志文章
doi:10.7150/ijbs.9406
更新日期:2014-07-26 00:00:00
abstract::Background: There is no information regarding transarterial chemoembolization (TACE) as a postoperative management after hepatic resection for patients with hepatitis B virus (HBV)-associated intrahepatic cholangiocarcinoma (ICC). Methods: Forty-two patients with pathological confirmation of HBV-associated ICC were en...
journal_title:International journal of biological sciences
pub_type: 杂志文章
doi:10.7150/ijbs.21149
更新日期:2017-09-21 00:00:00
abstract::Osteonecrosis of the femoral head (ONFH) represents a debilitating complication following glucocorticoid (GC)-based therapy. Synovial-derived mesenchymal stem cells (SMSCs) can exert protective effect in the animal model of GC-induced ONFH by inducing cell proliferation and preventing cell apoptosis. Recent studies in...
journal_title:International journal of biological sciences
pub_type: 杂志文章
doi:10.7150/ijbs.16150
更新日期:2016-10-17 00:00:00
abstract::Hox genes are organized as clusters and specify regional identity along the anteroposterior body axis by sequential expression at a specific time and region during embryogenesis. However, the precise mechanisms underlying the sequential spatio-temporal, collinear expression pattern of Hox genes are not fully understoo...
journal_title:International journal of biological sciences
pub_type: 杂志文章
doi:10.7150/ijbs.4438
更新日期:2012-01-01 00:00:00
abstract::Vasorin (VASN) is a type I transmembrane protein that plays important roles in tumor development and vasculogenesis. In this paper, we showed that VASN could be a key mediator of communication between tumor cells and endothelial cells. We confirmed for the first time that HepG2-derived VASN can be transferred to human...
journal_title:International journal of biological sciences
pub_type: 杂志文章
doi:10.7150/ijbs.11943
更新日期:2015-06-11 00:00:00
abstract::TAR DNA-binding protein (TDP-43) and fused in sarcoma (FUS) are two highly conserved ribonucleoproteins. Pathogenic mutations of the TDP-43 or the FUS gene are all linked to amyotrophic lateral sclerosis (ALS) that is characterized by progressive degeneration of motor neurons. To better understand the correlation of A...
journal_title:International journal of biological sciences
pub_type: 杂志文章
doi:10.7150/ijbs.6.396
更新日期:2010-07-04 00:00:00
abstract::MiR-216a-5p has opposite effects on tumorigenesis and progression in the context of different tumors, acting as either a tumor suppressor or an oncogene. However, the expression and function of miR-216a-5p in pancreatic cancer (PC) is not well characterized. In this study, we found miR-216a-5p was significantly downre...
journal_title:International journal of biological sciences
pub_type: 杂志文章
doi:10.7150/ijbs.46822
更新日期:2020-07-19 00:00:00
abstract::Objective: Recent studies demonstrate circulating serum spexin levels are reduced in obesity or type 2 diabetes mellitus (T2DM) patients and may play a role in glucose metabolism. The mechanism underlying is not known. In this study, we explore whether spexin has a role in insulin resistance and hepatic glucose metabo...
journal_title:International journal of biological sciences
pub_type: 杂志文章
doi:10.7150/ijbs.31781
更新日期:2019-11-01 00:00:00
abstract::Pancreatic cancer (PC) is one of the most lethal diseases, characterized by early metastasis and high mortality. Subunits of the SWI/SNF complex have been identified in many studies as the regulators of tumor progression, but the role of SMARCAD1, one member of the SWI/SNF family, in pancreatic cancer has not been elu...
journal_title:International journal of biological sciences
pub_type: 杂志文章
doi:10.7150/ijbs.29562
更新日期:2019-01-01 00:00:00
abstract::This study aims to investigate the effect and mechanism of type 2 voltage-gated chloride channel (ClC-2) on myelin development of newborn rats' cerebral white matter with gestational diabetes mellitus (GDM). In this study, GDM model was induced in late pregnant rat model. The alteration of ClC-2 expression in various ...
journal_title:International journal of biological sciences
pub_type: 杂志文章
doi:10.7150/ijbs.17716
更新日期:2017-01-15 00:00:00
abstract::Cirrhosis is the final outcome of liver fibrosis. Kupffer cell-mediated hepatic inflammation is considered to aggravate liver injury and fibrosis. Alternatively-activated macrophages are able to control chronic inflammatory events and trigger wound healing processes. Nevertheless, the role of alternative Kupffer cell ...
journal_title:International journal of biological sciences
pub_type: 杂志文章
doi:10.7150/ijbs.7.1273
更新日期:2011-01-01 00:00:00
abstract:BACKGROUND:The unfolded protein response, autophagy and endoplasmic reticulum (ER) stress-induced apoptosis regulate tumor cell fate and have become novel signaling targets for the development of cancer therapeutic drugs. Curcumin has been used to treat several different cancers, including ovarian cancer, in clinical t...
journal_title:International journal of biological sciences
pub_type: 杂志文章
doi:10.7150/ijbs.5711
更新日期:2013-08-14 00:00:00
abstract::The Zucker diabetic fatty (ZDF) rat is a model of type II diabetes and metabolic syndrome based on impaired glucose tolerance caused by the inherited insulin-resistance gene. The ZDF rat exhibits progressive nephropathy; however, the detailed mechanisms have remained unclear. This study was performed to examine the po...
journal_title:International journal of biological sciences
pub_type: 杂志文章
doi:10.7150/ijbs.3.40
更新日期:2006-11-01 00:00:00
abstract::Cell-matrix interactions play critical roles in cell adhesion, tissue remodeling and cancer metastasis. Discoidin domain receptor 2 (DDR2) is a collagen receptor belonging to receptor tyrosine kinase (RTK) family. It is a powerful regulator of collagen deposition in the extracellular matrix (ECM). Although the oligome...
journal_title:International journal of biological sciences
pub_type: 杂志文章
doi:10.7150/ijbs.24765
更新日期:2018-04-30 00:00:00
abstract::Since extracellular vesicles (EVs) were discovered in 1983 in sheep reticulocytes samples, they have gradually attracted scientific attention and become a topic of great interest in the life sciences field. EVs are small membrane particles, released by virtually every cell that carries a variety of functional molecule...
journal_title:International journal of biological sciences
pub_type: 杂志文章,评审
doi:10.7150/ijbs.39629
更新日期:2020-01-01 00:00:00
abstract::Excessive bone resorption plays a central role in the development of inflammatory bone diseases, including osteoporosis and rheumatoid arthritis. Thus, identification of agents that can effectively suppress excessive osteoclast formation and function is crucial for the prevention and treatment of inflammatory bone los...
journal_title:International journal of biological sciences
pub_type: 杂志文章
doi:10.7150/ijbs.28609
更新日期:2019-09-07 00:00:00
abstract::Well-orchestrated epigenetic modifications during early development are essential for embryonic survival and postnatal growth. Erroneous epigenetic modifications due to environmental perturbations such as manipulation and culture of embryos during in vitro fertilization (IVF) are linked to various short- or long-term ...
journal_title:International journal of biological sciences
pub_type: 杂志文章
doi:10.7150/ijbs.51607
更新日期:2020-10-03 00:00:00
abstract::Diosgenin, a traditional Yam extraction, has been used in hormone replacement for menopausal women. We aimed to investigate the influences of diosgenin administration upon the MMP-2 and -9 activity and expression and reproductive hormones of ovariectomized (OVX) rats, a model of menopausal status. Seven-week old femal...
journal_title:International journal of biological sciences
pub_type: 杂志文章
doi:10.7150/ijbs.7.837
更新日期:2011-01-01 00:00:00
abstract::D-Xylitol is found in low content as a natural constituent of many fruits and vegetables. It is a five-carbon sugar polyol and has been used as a food additive and sweetening agent to replace sucrose, especially for non-insulin dependent diabetics. It has multiple beneficial health effects, such as the prevention of d...
journal_title:International journal of biological sciences
pub_type: 杂志文章,评审
doi:10.7150/ijbs.6.834
更新日期:2010-12-15 00:00:00