Abstract:
:The objective of this work was to evaluate the bioavailability of heme iron added to biscuit filling. It comprised two stages: first, the development of the heme iron enriched biscuit filling; second, the evaluation of the bioavailability of the mineral in fattening piglets. Two groups were selected randomly and fed: a) Low iron feed and biscuits with heme iron supplemented filling; b) Normal feed (with ferrous sulphate). Weight and blood parameters were measured every fifteen days. Averages were compared after duplicate analyses. The filling had a creamy appearance, chocolate taste and smell, appropriate spreadability, heme iron content of 2.6 mg per gram and a shelf-life of a month. The heme iron supplemented pigs registered a greater (P<0.05) weight gain (27.8% more than the control group). Mortality in the heme iron group was 10%, compared to 50% in the control group. The amount of iron measured in the different compartment was greater in the heme group (3315 mg) than in the control group (2792 mg). However, the amount of iron consumed in the latter was greater. We show that an acceptable product with high heme iron content can be formulated, suitable for use as biscuit filling. The heme iron supplement produced better weight increase and lesser mortality in fattening pigs. The bioavailability of heme iron was 23% greater (P<0.05) compared to ferrous sulphate.
journal_name
Int J Biol Scijournal_title
International journal of biological sciencesauthors
Quintero-Gutiérrez AG,González-Rosendo G,Sánchez-Muñoz J,Polo-Pozo J,Rodríguez-Jerez JJdoi
10.7150/ijbs.4.58subject
Has Abstractpub_date
2008-02-18 00:00:00pages
58-62issue
1issn
1449-2288journal_volume
4pub_type
杂志文章,随机对照试验abstract::We collected clinical data from 308 prostate cancer (PCa) patients to investigate the clinical characteristics and independent risk factors of bone metastasis (BM) and to establish a prediction model for BM of PCa and determine the necessity of bone scans. Univariate and multivariate analyses were performed based on a...
journal_title:International journal of biological sciences
pub_type: 杂志文章
doi:10.7150/ijbs.27537
更新日期:2019-01-01 00:00:00
abstract::To investigate the effects of Genistein on the osteogenic related gene expression profiles during osteoblastic differentiation of human bone marrow mesenchymal stem cell (hBMSC) cultures, the hBMSCs were cultured under osteogenic differentiation medium with the addition of Genistein (10(-8)∼10(-5) M) for 12 days. The ...
journal_title:International journal of biological sciences
pub_type: 杂志文章
doi:10.7150/ijbs.7367
更新日期:2013-11-21 00:00:00
abstract::Lung cancer is one of the most common and deadly malignancies worldwide, in spite of advances in targeted therapy in recent years. An effective strategy for lung cancer prevention remains a major problem. Advances in next-generation sequencing have helped in understanding the RNA and identifying novel circular RNAs (c...
journal_title:International journal of biological sciences
pub_type: 杂志文章,评审
doi:10.7150/ijbs.39212
更新日期:2020-01-16 00:00:00
abstract::Objective: Recent studies demonstrate circulating serum spexin levels are reduced in obesity or type 2 diabetes mellitus (T2DM) patients and may play a role in glucose metabolism. The mechanism underlying is not known. In this study, we explore whether spexin has a role in insulin resistance and hepatic glucose metabo...
journal_title:International journal of biological sciences
pub_type: 杂志文章
doi:10.7150/ijbs.31781
更新日期:2019-11-01 00:00:00
abstract::Glucocorticoid medication is one of the most common causes of atraumatic osteonecrosis of the femoral head (ONFH), and vitamin K2 (VK2) has been shown to play an important and beneficial role in bone metabolism. In this study, we hypothesized that VK2 could decrease the incidence of glucocorticoid-induced ONFH in a ra...
journal_title:International journal of biological sciences
pub_type: 杂志文章
doi:10.7150/ijbs.13269
更新日期:2016-01-28 00:00:00
abstract::Basigin is a highly glycosylated transmembrane protein that is expressed in a broad range of tissues and is involved in a number of physiological and pathological processes. However, the in vivo role of basigin remains unknown. To better understand the physiological and pathological functions of basigin in vivo, we ge...
journal_title:International journal of biological sciences
pub_type: 杂志文章
doi:10.7150/ijbs.6818
更新日期:2013-12-13 00:00:00
abstract::The catalytic subunit of DNA-dependent protein kinase (DNA-PKcs) is a critical component of the non-homologous end-joining pathway of DNA double-stranded break repair. DNA-PKcs has also been shown recently functioning in mitotic regulation. Here, we report that DNA-PKcs negatively regulates the stability of Cyclin B1 ...
journal_title:International journal of biological sciences
pub_type: 杂志文章
doi:10.7150/ijbs.12443
更新日期:2015-07-14 00:00:00
abstract::Non-coding RNAs (ncRNAs) are transcribed from genome but not translated into proteins. Many ncRNAs are key regulators of plants growth and development, metabolism and stress tolerance. In order to make the web-based ncRNA resources for plant science research be more easily accessible and understandable, we made a comp...
journal_title:International journal of biological sciences
pub_type: 杂志文章,评审
doi:10.7150/ijbs.24593
更新日期:2018-05-22 00:00:00
abstract::Congenital hypothyroidism (CH) can lead to irreversible central nervous system (CNS) damage. However, the pathogenesis of the developmental brain disorders caused by CH has not been completely elucidated. ARPC5 and CRMP2 are closely associated with neurite outgrowth in brain development. Thus, the aim of the present s...
journal_title:International journal of biological sciences
pub_type: 杂志文章
doi:10.7150/ijbs.5646
更新日期:2013-01-01 00:00:00
abstract::The vertebrate body plan externally is largely symmetrical across the midline but internal organs develop asymmetrically. The biological basis of asymmetric organ development has been investigated extensively for years, although the proposed mechanisms remain controversial. By comparison, the biological origin of exte...
journal_title:International journal of biological sciences
pub_type: 杂志文章,评审
doi:10.7150/ijbs.9886
更新日期:2014-09-10 00:00:00
abstract::Wee1 kinase regulates the G2/M cell cycle checkpoint by phosphorylating and inactivating the mitotic cyclin-dependent kinase 1 (Cdk1). Loss of Wee1 in many systems, including yeast and drosophila, leads to premature mitotic entry. However, the developmental role of Wee1 in mammals remains unclear. In this study, we es...
journal_title:International journal of biological sciences
pub_type: 杂志文章
doi:10.7150/ijbs.2.161
更新日期:2006-01-01 00:00:00
abstract::Vγ9Vδ2 (also termed Vγ2Vδ2) T cells, a major human peripheral blood γδ T cell subset, recognize microbial (E)-4-hydroxy-3-methylbut-2-enyl diphosphate and endogenous isopentenyl diphosphate in a TCR-dependent manner. The recognition does not require specific accessory cells, antigen uptake, antigen processing, or MHC ...
journal_title:International journal of biological sciences
pub_type: 杂志文章,评审
doi:10.7150/ijbs.7823
更新日期:2014-01-10 00:00:00
abstract::Evodiamine has therapeutic potential against cancers. This study was designed to investigate whether combination therapy with gemcitabine and evodiamine enhanced antitumor efficacy in pancreatic cancer. In vitro application of the combination therapy triggered significantly higher frequency of pancreatic cancer cells ...
journal_title:International journal of biological sciences
pub_type: 杂志文章
doi:10.7150/ijbs.8.1
更新日期:2012-01-01 00:00:00
abstract::The Zucker diabetic fatty (ZDF) rat is a model of type II diabetes and metabolic syndrome based on impaired glucose tolerance caused by the inherited insulin-resistance gene. The ZDF rat exhibits progressive nephropathy; however, the detailed mechanisms have remained unclear. This study was performed to examine the po...
journal_title:International journal of biological sciences
pub_type: 杂志文章
doi:10.7150/ijbs.3.40
更新日期:2006-11-01 00:00:00
abstract::Sepsis-induced myocardial dysfunction (SIMD) is a life-threatening complication caused by inflammation, but how it is initiated is still unclear. Several studies have shown that extracellular high mobility group box 1 (HMGB1), an important cytokine triggering inflammation, is overexpressed during the pathogenesis of S...
journal_title:International journal of biological sciences
pub_type: 杂志文章
doi:10.7150/ijbs.50186
更新日期:2020-09-19 00:00:00
abstract::A LIM-homeobox gene, AmphiLim1/5, from the Florida amphioxus (Branchiostoma floridae) encodes a protein that phylogenetic analysis positions at the base of a clade comprising vertebrate Lim1 and Lim5. Amphioxus AmphiLim1/5 is expressed in domains that are a composite of those of vertebrate Lim1 and Lim5, which evident...
journal_title:International journal of biological sciences
pub_type: 杂志文章
doi:10.7150/ijbs.2.110
更新日期:2006-01-01 00:00:00
abstract::Background and aim: Mesenchymal stem cells (MSCs) are capable of impacting tumor progression but its role in tumor stroma remodeling still remains unclear. This present study was aimed to evaluate the potential function of MSCs on tumor stroma remodeling using rabbits VX2 bladder tumor model. Methods: The VX2 bladder ...
journal_title:International journal of biological sciences
pub_type: 杂志文章
doi:10.7150/ijbs.25200
更新日期:2018-06-03 00:00:00
abstract::Type 2 diabetes mellitus is characterized by insulin resistance. However, the complete molecular mechanism remains unclear. In this study, zebrafish were fed a long-term high-fat diet to induce type 2 diabetes, which resulted in a higher body weight, body mass index, more lipid vacuoles in liver, increased insulin tra...
journal_title:International journal of biological sciences
pub_type: 杂志文章
doi:10.7150/ijbs.19249
更新日期:2017-07-18 00:00:00
abstract::This study aims to investigate the effect and mechanism of type 2 voltage-gated chloride channel (ClC-2) on myelin development of newborn rats' cerebral white matter with gestational diabetes mellitus (GDM). In this study, GDM model was induced in late pregnant rat model. The alteration of ClC-2 expression in various ...
journal_title:International journal of biological sciences
pub_type: 杂志文章
doi:10.7150/ijbs.17716
更新日期:2017-01-15 00:00:00
abstract::Different stimuli often activate the same intracellular signaling molecules but trigger distinct cell responses. We explored whether or not MAPK signaling induced by macrophage colony-stimulating factor (M-CSF), which is responsible for osteoclast proliferation, differs from that induced by receptor activator of NF-κB...
journal_title:International journal of biological sciences
pub_type: 杂志文章
doi:10.7150/ijbs.13814
更新日期:2016-01-01 00:00:00
abstract::Rheumatoid arthritis (RA) is characterized by synovial lining hyperplasia, which involves abnormal growth of fibroblast-like synoviocytes (FLSs). This study aimed to investigate the function and molecular mechanism of peptidylarginine deiminase type 4 (PADI4) in FLSs isolated from RA patients (RA-FLSs). FLSs were isol...
journal_title:International journal of biological sciences
pub_type: 杂志文章
doi:10.7150/ijbs.16879
更新日期:2017-02-25 00:00:00
abstract::Telomere dysfunction is closely associated with human diseases such as cancer and ageing. Inappropriate changes in telomere length and/or structure result in telomere dysfunction. Telomeres have been considered to be transcriptionally silent, but it was recently demonstrated that mammalian telomeres are transcribed in...
journal_title:International journal of biological sciences
pub_type: 杂志文章,评审
doi:10.7150/ijbs.10528
更新日期:2015-02-05 00:00:00
abstract::Esophageal squamous cell carcinoma (ESCC) occurs with the highest frequency in China, especially in the high-risk Northern Chinese. Recent studies have reported that SLC22A3 is significantly downregulated in non-tumor (NT) esophageal tissues from familial ESCC patients compared with those from sporadic ESCC. However, ...
journal_title:International journal of biological sciences
pub_type: 杂志文章
doi:10.7150/ijbs.28482
更新日期:2018-09-07 00:00:00
abstract:: Objectives: Skeletal development is a complex process. Little is known about the different response of limb or spine growth plate chondrocytes (LGP or SGP) to the estrogen level and the role of estrogen receptor (ER) during postnatal stage. Methods...
journal_title:International journal of biological sciences
pub_type: 杂志文章
doi:10.7150/ijbs.17696
更新日期:2017-01-11 00:00:00
abstract::The cephalochordate amphioxus occupies a central place in evolutionary thoughts to the origin of Vertebrates. With a prototypical vertebrate-like body plan and a preduplicative genome, the friendly lancelet seems to be in morphological and genetic motionless since its separation from the major branch of evolution that...
journal_title:International journal of biological sciences
pub_type: 社论
doi:10.7150/ijbs.2.30
更新日期:2006-01-01 00:00:00
abstract::Dendritic cells (DCs) are the most potent specialized antigen-presenting cells as now known, which play a crucial role in initiating and amplifying both the innate and adaptive immune responses. Immunologically, the motilities and T cell activation capabilities of DCs are closely related to the resulting immune respon...
journal_title:International journal of biological sciences
pub_type: 杂志文章
doi:10.7150/ijbs.33412
更新日期:2019-05-20 00:00:00
abstract::Protein phosphatase 2A (PP2A) is a major protein phosphatase with important cell functions. Known and utilized as a potent inhibitor of PP2A, microcystin-LR (MCLR) targets PP2A as a core element that affects numerous cellular mechanisms. But apart from direct inhibition, the exact effect of MCLR on PP2A in cell is lar...
journal_title:International journal of biological sciences
pub_type: 杂志文章
doi:10.7150/ijbs.7.740
更新日期:2011-01-01 00:00:00
abstract::Cardiac and skeletal muscle tissue engineering provides a smart approach to overcome problems associated with organ transplantation and cardiac tissue and also lays a platform for superior alternative approaches in muscle regeneration. The aim of the study was to demonstrate cryogel scaffold potential in the field of ...
journal_title:International journal of biological sciences
pub_type: 杂志文章
doi:10.7150/ijbs.6.371
更新日期:2010-07-03 00:00:00
abstract::Background: There is no information regarding transarterial chemoembolization (TACE) as a postoperative management after hepatic resection for patients with hepatitis B virus (HBV)-associated intrahepatic cholangiocarcinoma (ICC). Methods: Forty-two patients with pathological confirmation of HBV-associated ICC were en...
journal_title:International journal of biological sciences
pub_type: 杂志文章
doi:10.7150/ijbs.21149
更新日期:2017-09-21 00:00:00
abstract::During the immune response, neutrophils display localized mechanical events by interacting with their environment through the micro-vascular transit, trans-endothelial, and trans-epithelial migration. Nano-mechanical studies of human neutrophils on localized nano-domains could provide the essential information for und...
journal_title:International journal of biological sciences
pub_type: 杂志文章
doi:10.7150/ijbs.7.102
更新日期:2011-01-20 00:00:00